A comprehensive review on promising anti-viral therapeutic candidates identified against main protease from SARS-CoV-2 through various computational methodsReview Published on 2020-11-032022-10-30 Journal: Journal of Genetic Engineering & Biotechnology [Category] COVID-19, [키워드] 3CLpro Abstract Anti-viral antibiotic applied binding biological activity candidate cause caused complexes computational method COVID-19 pandemic cysteine protease derivatives drug drug-repurposing functional generate identify imperative in silico in silico Approach Infection information inhibit inhibitor inhibitors interacting residues interaction pattern intermolecular interaction Ligand-based virtual screening (LBVS) ligand-bound molecular nucleotide analogues parameter peptides potential therapeutic agent protease protease inhibitors Proteins provide replicase polyprotein SARS-CoV-2 shown stability Structure Structure-based virtual screening (SBVS) structures therapeutic viral replication Virtual screening virulent virus [DOI] 10.1186/s43141-020-00085-z PMC 바로가기 [Article Type] Review
Safety perspectives on presently considered drugs for the treatment of COVID‐19현재 고려 중인 코로나19 치료제에 대한 안전성 관점Review Published on 2020-08-132022-09-10 Journal: British Journal of Pharmacology [Category] 신약개발, 치료제, [키워드] Administered benefit clinical factor COVID‐19 COVID‐19 crisis disease drug Drug repurposing Drug safety effort evaluate exceeded identify imperative information patients Perspective pharmacological potential risk potential safety issues potential therapeutic agent potential therapeutic agents Prophylaxis repurposing respond risk Safety Stage the disease the stage therapeutic agents Therapies therapy toxicology Treatment [DOI] 10.1111/bph.15204 PMC 바로가기 [Article Type] Review
COVID-19 Therapeutic Options Under InvestigationPharmacology Published on 2020-08-062022-10-31 Journal: Frontiers in Pharmacology [Category] COVID-19, [키워드] Adjunctive therapy Antiviral antivirals China clinical study Compound compounds COVID-19 COVID-19 patients death Dexamethasone effective globe identify Immunity immunomodulatory investigation management mitigate option pandemic potential therapeutic agent Preclinical reduce reduce mortality rate Remdesivir Safe SARS-CoV-2 shown Spread Therapeutics Treatment [DOI] 10.3389/fphar.2020.01196 PMC 바로가기 [Article Type] Pharmacology
A Multi-Targeting Approach to Fight SARS-CoV-2 AttachmentMolecular Biosciences Published on 2020-08-032022-10-31 Journal: Frontiers in Molecular Biosciences [Category] COVID-19, [키워드] ACE-2 ACE2 antibodies attachment binding binding site diagnostics domain effective facilitate galectin ganglioside glycoprotein inhibitor integrin International New coronavirus pandemic potential therapeutic agent public health Region representing S protein SARS-CoV-2 Severe infection Spike protein Spread sugar target targets the RBD the SARS-CoV-2 therapeutic therapy Vaccines virus [DOI] 10.3389/fmolb.2020.00186 PMC 바로가기 [Article Type] Molecular Biosciences
Rationale for targeting complement in COVID‐19Review Published on 2020-07-122022-11-01 Journal: EMBO Molecular Medicine [Category] COVID-19, MERS, SARS, [키워드] activated Activation acute lung injury acute respiratory distress acute respiratory illness ARDS cascade caused cell entry China clinical trials clinically collected Community complement complement pathways complement proteins component COVID‐19 COVID‐19 Cytokine storm disease dysfunction evade Evidence health emergency immunology Immunopathogenesis immunopathology Infection information innate immune lectin pathway Macrophage manifestation Microbiology, Virology & Host Pathogen Interaction Mild multiorgan failure neutrophil Novel coronavirus offer Pathogens potential therapeutic agent rationale SARS‐CoV‐1 SARS‐CoV‐2 SARS‐CoV‐2 Sepsis Spread Support syndrome therapeutic Therapeutic strategies Therapeutics virus [DOI] 10.15252/emmm.202012642 PMC 바로가기 [Article Type] Review
An Off-the-Shelf Approach for the Production of Fc Fusion Proteins by Protein Trans -Splicing towards Generating a Lectibody In VitroArticle Published on 2020-06-032022-10-29 Journal: International Journal of Molecular Sciences [Category] Coronavirus, SARS, [키워드] antibodies antibody fragment approach binding binding domain binding site demonstrated domain domains Escherichia coli expression Fc functions fused fusion fusions Genetic HIV IgG Immunoglobulin G in vitro Infectious disease inhibit lectibody lectin N-terminus Organisms potential therapeutic agent produced producing Production Protein protein trans-splicing protein ligation SARS Coronavirus scytovirin segmental isotopic labeling split intein therapeutic Tran virus entry [DOI] 10.3390/ijms21114011 PMC 바로가기 [Article Type] Article
Natural Bioactive Compounds from Fungi as Potential Candidates for Protease Inhibitors and Immunomodulators to Apply for CoronavirusesReview Published on 2020-04-142022-10-30 Journal: Molecules [Category] COVID-19, [키워드] Antiviral agents antiviral drug candidate Clinical use Compound coronavirus Coronaviruses drug Drug discovery drug resistance drugs fungal fungal metabolites fungi HIV-1 immunomodulatory activity Immunomodulatory agents inhibitory natural natural products offer Potential potential therapeutic agent protease Protease activity Protease inhibitor protease inhibitors Side effect therapeutic potential Treatment viral disease [DOI] 10.3390/molecules25081800 PMC 바로가기 [Article Type] Review
Infection with MERS-CoV Causes Lethal Pneumonia in the Common MarmosetResearch Article Published on 2014-08-212022-10-29 Journal: PLoS Pathogens [Category] Coronavirus, MERS, [키워드] addition Analysis animal model cause common Comorbidities comparable complicate demonstrated different time point Dipeptidyl peptidase 4 disease Disease model Efficacy evaluate expression Extensive humans immune inflammatory pathways Interaction intranasal lack lesion lethal lung marmoset marmoset model MERS-CoV MERS-CoV infection Middle East Mild modeling moderate disease MOST ocular Pathogenesis post inoculation potential therapeutic agent predicted Protein receptor required respiratory syndrome coronavirus rhesus RNAseq robust severe disease severe pneumonia severity spike glycoprotein the disease translated treated treatment strategy Vaccine Viral load virus entry was tested while [DOI] 10.1371/journal.ppat.1004250 PMC 바로가기 [Article Type] Research Article
Cleavage of the SARS Coronavirus Spike Glycoprotein by Airway Proteases Enhances Virus Entry into Human Bronchial Epithelial Cells In VitroResearch Article Published on 2009-11-172022-10-28 Journal: PLoS ONE [Category] Coronavirus, [키워드] 16HBE ACE2 ACE2 binding Activation acute respiratory syndrome against SARS-CoV airway Amino acid Analysis arginine residue bronchial bronchial epithelial cell cell entry Chromatography cleavage cleaved coronavirus demonstrated dependent on different Efficacy Efficiency exhibited expand expressing expression Extracellular finding full-length glycoprotein host cell HPLC Human implication in vitro investigated lack liquid mechanism molecular basis mutant not affect performance potential therapeutic agent protease Proteases Protein R667 R797 Receptor binding regulate Respiratory system S-protein SARS-CoV SARS-CoV infection Sequencing shown spike susceptibility susceptible Treatment trimer trypsin viral entry viral envelope virus virus entry [DOI] 10.1371/journal.pone.0007870 PMC 바로가기 [Article Type] Research Article
Expanding the frontiers of existing antiviral drugs: Possible effects of HIV-1 protease inhibitors against SARS and avian influenzaArticle Published on 2005-05-122022-11-01 Journal: Journal of Clinical Virology [Category] Coronavirus, Fulltext, 조류인플루엔자, [키워드] acute respiratory syndrome antiretroviral Antiviral antiviral drug Clinical studies computational simulation coronavirus disease docking Effect Evidence HIV-1 protease inhibitor humans imperative in silico in vivo Influenza Influenza virus influenza viruses inhibition assay PI Possible potential benefit potential therapeutic agent protease provided public health RNA-dependent RNA polymerase Safe SARS SARS Coronavirus SARS-CoV subunit suggested therapy these compound Type-A influenza viral disease [DOI] 10.1016/j.jcv.2005.03.005 PMC 바로가기 [Article Type] Article