Preclinical In Silico Evidence Indicates the Pharmacological Targets and Mechanisms of Mogroside V in Patients With Ovarian Cancer and Coronavirus Disease 20192019년 난소암 및 코로나바이러스 질환 환자에서 모그로사이드 V의 약리학적 표적 및 메커니즘을 나타내는 전임상 인 실리코 증거Article Published on 2022-04-062022-09-11 Journal: Frontiers in Endocrinology [Category] COVID19(2023년), SARS, 변종, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 anticancer biological processe China clinical clinical observations coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19-related death docking drug target Effects endothelial enrichment analysis growth factor Hsp90 HSP90AA1 IL2 indicated ingredient Injury mechanism medication Mitigation Mogroside mogroside V molecular docking network pharmacology observation ovarian ovarian cancer pathway Pathways Patient Preclinical preclinical report PRKCA PRKCB reduce remedial targets. reported SARS-CoV-2 Siraitia STAT3 suggested target target protein targets therapeutic therapeutic agent therapeutic efficacy TLR7 TLR9 Transmission Vaccine variant Vascular VEGFA with COVID-19 [DOI] 10.3389/fendo.2022.845404 PMC 바로가기 [Article Type] Article
Dealing with a mucosal viral pandemic: lessons from COVID-19 vaccines점막 바이러스 전염병 대처: COVID-19 백신의 교훈Review Published on 2022-04-012022-09-12 Journal: Mucosal Immunology [Category] COVID19(2023년), SARS, 임상, 진단, [키워드] administration approaches booster dose cell-mediated response Combination contribute COVID-19 COVID-19 vaccine death demonstrated effective humoral IgA Immunity Infection infection with SARS-CoV-2 intramuscularly intranasal limitation Local lymphocyte response mucosal mucosal IgA response nasal mucosa New penetrate Preclinical Prevent primary site question reduce Safe SARS-CoV-2 severe disease Spread sustained tested Transmission Trial vaccination Vaccination strategy Vaccine viral strain [DOI] 10.1038/s41385-022-00517-8 PMC 바로가기 [Article Type] Review
Preclinical Studies on Convalescent Human Immune Plasma-Derived Exosome: Omics and Antiviral Properties to SARS-CoV-2회복기 인간 면역 혈장 유래 엑소좀에 대한 전임상 연구: SARS-CoV-2에 대한 오믹스 및 항바이러스 특성Article Published on 2022-03-242022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 진단, 치료제, [키워드] biochemical convalescence plasma convalescent convalescent plasma COVID-19 COVID-19 pandemic Efficacy Exosome Exosomes Extracellular extracellular vehicles (EVs) Extracellular vesicles Gene ontology Good good manufacturing practice Human immune measure Ministry of Health passive immunity Practice Preclinical property SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infections Society Support Treatment Turkish Red Crescent Viral viral treatment. [DOI] 10.3389/fimmu.2022.824378 PMC 바로가기 [Article Type] Article
A Pilot Study on the Feasibility of Developing and Implementing a Mobile App for the Acquisition of Clinical Knowledge and Competencies by Medical Students Transitioning from Preclinical to Clinical YearsArticle Published on 2022-02-272022-10-29 Journal: International Journal of Environmental Research an [Category] Coronavirus, COVID19(2023년), MERS, SARS, [키워드] approach average benefit Cardiology clinical Clinical Competence Cohort collected COVID-19 pandemic defined develop Developing education educational models Effectiveness evaluate expected feasibility Implementing IMPROVE medical education methodology Mobile overlapping participant Preclinical qualitative data Research resources Satisfaction Smartphone statistically student subject utility Year [DOI] 10.3390/ijerph19052777 PMC 바로가기 [Article Type] Article
Preclinical evaluation of a SARS-CoV-2 mRNA vaccine PTX-COVID19-BSARS-COV-2 mRNA 백신 PTX-Covid19-B의 전임상 평가Research Article Published on 2022-01-192022-09-10 Journal: Science Advances [Category] 변종, 비임상, 신약개발, 진단, [키워드] adverse effect adverse effects Alpha Beta breath candidate Cellular immune response clinical trial clinical trials COVID-19 pandemic Delta description effective effective vaccine elicited Gamma hamster hamsters Health Canada humoral immune immune responses immunogenic indicated initial lineages lung mice mouse mRNA vaccine neutralize Neutralizing antibody response Phase 2 Preclinical respiratory robust Safe SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variant SARS-CoV-2 variants sera the strongest upper respiratory tract vaccination [DOI] 10.1126/sciadv.abj9815 PMC 바로가기 [Article Type] Research Article
Preclinical Evaluation of Chicken Egg Yolk Antibody (IgY) Anti-RBD Spike SARS-CoV-2—A Candidate for Passive Immunization against COVID-19Article Published on 2022-01-172022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] absence accumulated anti-RBD anti-receptor-binding domain antibody biodistribution study can be used candidate Cell Characteristics chicken coronavirus disease COVID-19 effective Egg evaluate Ex vivo exceeded feasibility Health IgY anti-RBD spike SARS-CoV-2 immunization in vitro in vivo International intranasal mice Mortality neutralize other organs Passive passive immunization Preclinical preclinical data preclinical evaluation preclinical studies Prophylactic radiolabeled radiolabeled IgY RBD resulting safety profile SARS-CoV-2 spike the SARS-CoV-2 Treatment virus yolk [DOI] 10.3390/vaccines10010128 PMC 바로가기 [Article Type] Article
Preclinical Validation of a Novel Injection-Molded Swab for the Molecular Assay Detection of SARS-CoV-2Article Published on 2022-01-152022-10-31 Journal: Diagnostics [Category] COVID-19, [키워드] benefit Care clinical study clinically comparable COVID-19 COVID-19 emergency detection diagnostic diagnostic testing equipment expand gold standard greater Health help in vitro inactivated independent initial Laboratory nasal swab nasal tissue novel offer Patient positive sample Preclinical Protective public health emergency quantified reduction in replicate respond Safe SARS-CoV-2 standard flocked swabs statistically significant difference Support Swab swabbing swabs therapeutic tissue model validation Virological testing virus Volume [DOI] 10.3390/diagnostics12010206 PMC 바로가기 [Article Type] Article
Advances and gaps in SARS-CoV-2 infection modelsSARS-CoV-2 감염 모델의 발전과 격차Review Published on 2022-01-132022-09-10 Journal: PLoS Pathogens [Category] SARS, 변종, [키워드] advance age animal model animal models Comorbidities Comorbidity coronavirus disease Coronavirus disease 2019 COVID-19 demographic variable disease escape evaluate Health Organization Immune escape Pathogenesis Preclinical Research SARS-COV-2 infection SARS-CoV-2 variant SARS-CoV-2 variants Therapies Transmission Vaccine virulence VoC VOCs WHO World Health Organization [DOI] 10.1371/journal.ppat.1010161 PMC 바로가기 [Article Type] Review
Preclinical and randomized phase I studies of plitidepsin in adults hospitalized with COVID-19COVID-19로 입원한 성인을 대상으로 한 플리티뎁신의 전임상 및 무작위 1상 연구Clinical Trial Published on 2022-01-102022-09-10 Journal: Life Science Alliance [Category] COVID19(2023년), SARS, 변종, 비임상, 신약개발, 임상, [키워드] adults hospitalized adverse event adverse events affecting baseline breath Concentration conducted Consent diarrhea died dose elongation factor End points eukaryotic translation grade 3 hospital hospitalized patient host protein hypersensitivity inhibit initiated intensive care intensive care support invasive ventilation log lung Mortality nausea once daily one patient Open-label Patient patients with COVID-19 peptide Phase I plasma Plitidepsin Preclinical preclinical studies Randomized required respiratory Respiratory Support safety profile SARS-COV-2 infection SARS-CoV-2 replication SARS-CoV-2 variant Spanish Support Treatment Viral Viral load viral load reduction vomiting with COVID-19 [DOI] 10.26508/lsa.202101200 PMC 바로가기 [Article Type] Clinical Trial
Preclinical immunological evaluation of an intradermal heterologous vaccine against SARS-CoV-2 variantsSARS-CoV-2 변이체에 대한 피내 이종 백신의 전임상 면역학적 평가Coronaviruses Published on 2022-01-072022-09-10 Journal: Emerging Microbes & Infections [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] administration Antibody titers B.1.617.2 booster dose Challenge test composed COVID-19 Delta dose effective Efficacy ENhance FIVE heterologous vaccine immune immune response immunized immunological IMPROVE Inactivated vaccine intradermal administration mutated Neutralizing antibodies neutralizing antibody Neutralizing antibody titer neutralizing antibody titers Preclinical RBD protein S antigen S1 protein SARS-CoV-2 SARS-CoV-2 variant stimulate T cell T cell response the RBD protein Vaccine variant variants Viral viral challenge [DOI] 10.1080/22221751.2021.2021807 PMC 바로가기 [Article Type] Coronaviruses