Dose-related effects of ketamine for antidepressant-resistant symptoms of posttraumatic stress disorder in veterans and active duty military: a double-blind, randomized, placebo-controlled multi-center clinical trial Research Published on 2022-01-192022-10-05 Journal: Neuropsychopharmacology [Category] 임상, [키워드] Administered administration ameliorated Analysis baseline checklist clinical trial Depression determine disorder dose double-blind DSM-5 Effect Effects Efficacy Evidence Interaction intravenous Ketamine less low dose participant Placebo placebo-controlled Posttraumatic Stress primary outcome measure produced PTSD Randomized reduce repeated returned scale secondary secondary outcome measure significantly more Standard dose suggested Symptom Symptoms tested Tolerability Treatment veteran were assessed [DOI] 10.1038/s41386-022-01266-9 [Article Type] Research
Prospective longitudinal study of ‘Sleepless in Lockdown’: unpacking differences in sleep loss during the coronavirus pandemic in the UKEpidemiology Published on 2022-01-032022-10-28 Journal: BMJ Open [Category] Coronavirus, Fulltext, SARS, [키워드] 95% CI Affect analysed analytical sample Asian association Bame baseline being black children collected concern coronavirus covariate COVID-19 COVID-19 infection COVID-19 symptom defined Deprivation Epidemiology female Gender group Health indirect effect individual information men Mental mental health objective pandemic participant physical Predictive primary outcome measure Prospective Regression model Result reversed risk setting Seven social determinant understanding women [DOI] 10.1136/bmjopen-2021-053094 PMC 바로가기 [Article Type] Epidemiology
Testing an early online intervention for the treatment of disturbed sleep during the COVID-19 pandemic in self-reported good and poor sleepers (Sleep COVID-19): study protocol for a randomised controlled trialCOVID-19 대유행 동안 수면 장애 치료를 위한 조기 온라인 중재 테스트(수면 COVID-19): 무작위 통제 시험을 위한 연구 프로토콜Update Published on 2021-12-112022-09-10 Journal: Trials [Category] SARS, 임상, [키워드] Acute insomnia administration All participant All participants analysed approach assigned Baseline assessment baseline assessments behavioural can be used Cognitive behavioural therapy Complete COVID-19 COVID-19 pandemic disorder effective enrolled events expected face-to-face therapy feasibility Good include individuals Insomnia Insomnia Severity Index intention-to-treat Intervention intervention group leaflet life Online intervention outcome measure participant Poor post intervention Prevent primary outcome measure problem randomised controlled trial Randomly receive reduce Registered secondary secondary outcome measures severity short-term disruptions Sleep Sleep disturbances Specific stratified Stress Study protocol Symptom Testing transition treat Treatment [DOI] 10.1186/s13063-021-05888-0 PMC 바로가기 [Article Type] Update
Protocol for a prospective double-blind, randomised, placebo-controlled feasibility trial of octreotide infusion during liver transplantation간 이식 중 Octreotide 주입의 전향 적 이중 맹검, 무작위, 위약 대조 타당성 시험에 대한 프로토콜Anaesthesia Published on 2021-12-022022-09-10 Journal: BMJ Open [Category] Fulltext, SARS, 임상, [키워드] Acute kidney injury Administered administration adult anaesthesia adult intensive & critical care adverse event Analysis anticipated approval blinded blood pressure Blood Transfusion bradycardia clinical clinician completion complex Data collection death determine dissemination division double-blind Efficacy and safety End points ENhance enrolment Ethics ethics committee feasibility Feasibility study Formal group help hepatobiliary disease hepatobiliary surgery hepatology Hypotension improvement incidence include increased risk Interpretation Intervention intraoperative life liver liver transplant Liver transplantation management manuscript multicentre octreotide office outcome measure outcomes Patient Placebo placebo-controlled Primary outcome primary outcome measure Primary outcome measures Primary outcomes QT prolongation Quality of life randomised randomised controlled trial recipients recruit recruitment reduce reduced refusal Registered renal renal dysfunction renal failure report Research Ethics Science secondary secondary outcome measures serious complication Sponsor statistical test Study design study outcome Study protocol submitted surgery survival transplant surgery Trial Trial registration University College London [DOI] 10.1136/bmjopen-2021-055864 PMC 바로가기 [Article Type] Anaesthesia
Psilocybin-assisted therapy for the treatment of resistant major depressive disorder (PsiDeR): protocol for a randomised, placebo-controlled feasibility trial내성 주요 우울 장애의 치료를위한 psilocybin- 보조 요법 (PSIDER) : 무작위, 위약 대조 타당성 시험의 프로토콜Mental Health Published on 2021-12-012022-09-10 Journal: BMJ Open [Category] Fulltext, SARS, 임상, [키워드] adult psychiatry All participant All participants Analysis Biomarker blinded clinical trials collected CTA Depression depression & mood disorders depressive depressive disorder disorder dissemination dose dropout rate Ethics ethics committee extension feasibility Follow-up Health Research Authority Healthcare Products Regulatory Agency independent London major depressive disorder measure mechanism media National Research Ethics Committee Neuroimaging occur offer open open label package parallel-group participant peer-reviewed Placebo placebo-controlled primary endpoint Primary outcome primary outcome measure Primary outcomes product protocol psilocybin psychological therapy randomised receive recruitment registration numbers required Research Ethics scale therapy Treatment Trial trials variance written Informed Consent [DOI] 10.1136/bmjopen-2021-056091 PMC 바로가기 [Article Type] Mental Health
The Adverse Impact of the COVID-19 Pandemic on Abdominal Emergencies: A Retrospective Clinico-Pathological AnalysisArticle Published on 2021-11-112022-10-30 Journal: Journal of Clinical Medicine [Category] COVID-19, [키워드] abdominal emergency Admission Admissions Adverse analyzed Appendicitis assessments assigned caused condition COVID-19 COVID-19 pandemic demonstrated disease severity emergency department Impact management pandemic pathological finding pathology performed primary outcome measure selected Severe case severity surgical surgical emergency Surgical Procedure urgency [DOI] 10.3390/jcm10225254 PMC 바로가기 [Article Type] Article
CATALYST trial protocol: a multicentre, open-label, phase II, multiarm trial for an early and accelerated evaluation of the potential treatments for COVID-19 in hospitalised adults촉매 시험 프로토콜 : 입원 성인의 COVID-19에 대한 잠재적 치료의 초기 및 가속 평가를위한 멀티 센터, 오픈 라벨, 2 단계, 다중 암 시험.Intensive Care Published on 2021-11-112022-09-10 Journal: BMJ Open [Category] Fulltext, MERS, SARS, 임상, [키워드] accelerated Admission adult intensive & critical care Analysis approval approved Biomarker C reactive protein candidate drugs chest X-ray clinical clinical picture COVID-19 CRP CT scan death dissemination dysregulated immune response East Efficacy eligible Ethics ethics committee Evidence evidence of hospital discharge hospitalised Hospitalised patients identify immunomodulation IMPROVE improvement include Infectious diseases inflammatory monocyte inflammatory monocytes initial International Macrophage macrophages MHRA Monocytes multicentre National Open-label outcome Patient peer-reviewed platform Platform trial Pneumonia positive Potential treatment primary outcome measure proinflammatory protocol public health registration numbers Research Ethics reverse transcription PCR rheumatology SARS-COV-2 infection SARS-CoV-2 pneumonia scale secondary Secondary outcomes severe SARS the WHO therapeutic strategy thoracic medicine Treatment Trial trials usual care with COVID-19 [DOI] 10.1136/bmjopen-2021-050202 PMC 바로가기 [Article Type] Intensive Care
Analysis of mental and physical disorders associated with COVID-19 in online health forums: a natural language processing studyHealth Informatics Published on 2021-11-052022-10-28 Journal: BMJ Open [Category] COVID-19, Fulltext, MERS, SARS, [키워드] analysed change comorbid disorder Comorbidities Comorbidity COVID-19 COVID-19 pandemic data extraction disorder Evolution feasible Health health informatics HealthBoards implementation information technology lockdown Mental mental health objective over pandemic physical primary outcome measure proportion Result setting social media Surveillance unique with COVID-19 [DOI] 10.1136/bmjopen-2021-056601 PMC 바로가기 [Article Type] Health Informatics
Outcomes of COVID-19 infection in multiple sclerosis and related conditions: One-year pandemic experience of the multicenter New York COVID-19 Neuroimmunology Consortium (NYCNIC)Observational Study Published on 2021-10-012022-10-05 Journal: Multiple sclerosis and related disorders [Category] SARS, 임상, [키워드] age anti-CD20 anti-CD20 therapy antibody autoimmune disorder blunt CNS conditions Confirmed COVID-19 infection COVID-19 COVID-19 in patient COVID-19 infection Critically ill death demonstrated determine diagnosed died female Hospitalization Hospitalized Humoral response ICU care implication Infection mechanical ventilation multicenter Multiple multiple sclerosis Neuroimmunology neurological New York Observational cohort study Older age outcome outcomes pandemic Patient patients treated PCR-confirmed COVID-19 phenotype Post-infection predicted predictor primary outcome measure sclerosis seropositive significantly treated vaccine-mediated immunity was measured [DOI] 10.1016/j.msard.2021.103153 PMC 바로가기 [Article Type] Observational Study
Are there benefits to maintaining Covid-19 pandemic pathways for the long-term? A surgical assessment unit based studyObservational Study Published on 2021-10-012022-10-05 Journal: Medicina [Category] 임상, [키워드] 30-Day mortality 30-day mortality rate 95% CI approach benefit Care change Clinical practice Community COVID-19 determine Follow-up general surgery group Hospital stay management no difference no significant difference Observational cohort study pandemic pathway Pathways Patient primary outcome measure readmission required resource retrospective Sample size secondary outcome measure significantly surgical Surgical assessment unit. [DOI] 10.1016/j.surge.2020.08.015 PMC 바로가기 [Article Type] Observational Study