Genomic surveillance of Nevada patients revealed prevalence of unique SARS-CoV-2 variants bearing mutations in the RdRp gene네바다 환자의 게놈 감시는 RdRp 유전자에 돌연변이가 있는 독특한 SARS-CoV-2 변이체의 유행을 나타냈습니다Article Published on 2021-01-202022-09-11 Journal: Journal of genetics and genomics = Yi chuan xue ba [Category] 변종, [키워드] accessory protein accessory proteins amplification association changed circulating circulation Community COVID-19 COVID-19 patient Culture determine diagnostic domain Evolution Frequency genome coverage Genome enrichment Genomic surveillance geographic locations humans Mutation Nsp12 Occurrence ORF1b orf1b 314. other variant other variants outbreak Patient Phenylalanine Phylogenetic relationship platform polymerase Prevalence proline public health RdRP RdRp gene reported required RNA RNA-dependent RNA polymerase robust RT-PCR SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants sequenced Sequencing specimen swabs tested unique variant variants variants of SARS-CoV-2 Viral viral loads Wuhan-Hu-1 [DOI] 10.1016/j.jgg.2021.01.004 PMC 바로가기 [Article Type] Article
Identification and characterization of a silent mutation in RNA binding domain of N protein coding gene from SARS-CoV-2SARS-CoV-2의 N 단백질 코딩 유전자의 RNA 결합 도메인에서 침묵 돌연변이의 식별 및 특성화Comparative Study Published on 2021-01-062022-09-10 Journal: BMC Research Notes [Category] 변종, 유전자 메커니즘, 치료기술, 치료법, [키워드] acute respiratory syndrome addition affinity Base excision repair binding domain changed China Chinese coding gene coding sequence COVID-19 cytosine DNA DNA sequence DNA sequences human body human immunity human-to-human transmission identification IMPROVE Iran leucine Missense mutation mutated Mutation N protein nucleocapsid nucleotide objective Occurrence pathogenicity proline repair mechanism respiratory Result resulting risk RNA RNA binding domain RNA sequence RNA sequences SARS-CoV-2 Severe acute respiratory syndrome silent single nucleotide TDG thymine Thymine DNA glycosylase (TDG) Transcription uracil Viral Viral RNA Zinc [DOI] 10.1186/s13104-020-05439-x PMC 바로가기 [Article Type] Comparative Study
Identification and characterization of a silent mutation in RNA binding domain of N protein coding gene from SARS-CoV-2Comparative Study Published on 2021-01-062022-10-27 Journal: BMC Research Notes [Category] COVID-19, [키워드] acute respiratory syndrome addition Base excision repair binding domain changed China Chinese coding gene coding sequence COVID-19 cytosine DNA DNA sequence human immunity human-to-human transmission identification IMPROVE Iran leucine Missense mutation mutated Mutation N protein nucleocapsid objective Occurrence pathogenicity proline repair mechanism Result resulting risk RNA RNA binding domain RNA sequence SARS-CoV-2 silent single nucleotide TDG thymine Thymine DNA glycosylase (TDG) Transcription uracil Viral RNA Zinc [DOI] 10.1186/s13104-020-05439-x PMC 바로가기 [Article Type] Comparative Study
Identification and characterization of a silent mutation in RNA binding domain of N protein coding gene from SARS-CoV-2Comparative Study Published on 2021-01-062022-10-27 Journal: BMC Research Notes [Category] Coronavirus, COVID-19, [키워드] acute respiratory syndrome addition Base excision repair binding domain changed China Chinese coding gene coding sequence COVID-19 cytosine DNA DNA sequence human immunity human-to-human transmission identification IMPROVE Iran leucine Missense mutation mutated Mutation N protein nucleocapsid objective Occurrence pathogenicity proline repair mechanism Result resulting risk RNA RNA binding domain RNA sequence SARS-CoV-2 silent single nucleotide TDG thymine Thymine DNA glycosylase (TDG) Transcription uracil Viral RNA Zinc [DOI] 10.1186/s13104-020-05439-x PMC 바로가기 [Article Type] Comparative Study
COVID-19 variants that escape vaccine immunity: Global and Indian context-are more vaccines needed?백신 면역을 벗어나는 COVID-19 변종: 전 세계 및 인도 상황에서 더 많은 백신이 필요합니까?Review Published on 2021-01-012022-09-11 Journal: Journal of biosciences [Category] MERS, 변종, 진단, [키워드] ACE2 receptor Antigen bind Cell claimed complex convalescent plasma COVID-19 COVID-19 pandemic cryo-EM structure docked Efficacy Evolution exhibited followed by furin furin cleavage site Infection junction Mutation N terminal domain Neutralizing NTD occur proline RBM receptor binding motif residue responsible RNA virus S protein S1 domain S1 subunit S2 subunit SARS-CoV-2 selection pressure subunit the S1 subunit Vaccine vaccine candidate Vaccine development variant variants Viral viral envelope was used Wuhan [DOI] 10.1007/s12038-021-00226-7 PMC 바로가기 [Article Type] Review
Comprehensive Structural and Molecular Comparison of Spike Proteins of SARS-CoV-2, SARS-CoV and MERS-CoV, and Their Interactions with ACE2Review Published on 2020-12-082022-10-31 Journal: Cells [Category] COVID-19, MERS, SARS, [키워드] ACE2 acute respiratory syndrome Analysis angiotensin-converting enzyme 2 approach articles binding caused Characteristics China cleavage Comprehensive coronavirus disease Coronavirus-2 Coronaviruses CoV COVID-19 disease Effect element Evolution genes encoding Genome Host implication infect initial Interaction interactions investigated involved MERS-CoV Middle East Mutation other coronaviruses outbreak Pathogenesis performed priming proline Protein RBM receptor-binding motif Research S protein SARS-CoV SARS-CoV-2 shown significant difference spike Spike protein Spread sustained syndrome terminal region the S protein Transcriptome transmission of SARS-CoV-2 undergo Variation virus [DOI] 10.3390/cells9122638 PMC 바로가기 [Article Type] Review
Ad26 vector-based COVID-19 vaccine encoding a prefusion-stabilized SARS-CoV-2 Spike immunogen induces potent humoral and cellular immune responsesPrefusion-stabilized SARS-CoV-2 Spike 면역원을 인코딩하는 Ad26 벡터 기반 COVID-19 백신은 강력한 체액 및 세포 면역 반응을 유도합니다Article Published on 2020-09-282022-09-10 Journal: NPJ Vaccines [Category] 변종, 비임상, 임상, [키워드] Ad26 Ad26.COV2.S best binding breath Cellular immune response cellular immunity cleavage clinical trial coronavirus coronavirus S coronavirus S protein COVID-19 COVID-19 vaccine Critical demonstrated development effective element elicited etiologic agent evaluated folded protein furin furin cleavage site Heterologous hinge region humoral Humoral immunity IFN-γ induce Intervention membrane-bound mice Mutation Neutralizing Neutralizing antibodies neutralizing antibody non-neutralizing antibody observation peptide peptides Phase I prefusion conformation proline prolines prophylactic measure prophylactic measures Protein S protein S protein-based vaccine SARS-CoV-2 SARS-CoV-2 vaccine shown signal peptide signal peptides spike Substitution substitutions Th1 the S protein translated Vaccine Vaccines Viral viral infection viral replication viral surface wild-type [DOI] 10.1038/s41541-020-00243-x PMC 바로가기 [Article Type] Article
Enhanced receptor binding of SARS-CoV-2 through networks of hydrogen-bonding and hydrophobic interactions530 Published on 2020-06-232022-10-29 Journal: Proceedings of the National Academy of Sciences of [Category] COVID-19, SARS, [키워드] 2019 novel coronavirus 80R ACE2 acute respiratory syndrome antibody binding carried cause complex Contact contagious contribute coronavirus coronavirus disease COVID-19 Diagnosis Effect electrostatic enhanced enzyme Epidemic FIVE greater help homology host receptor hydrophobic hydrophobic interaction hydrophobic packing Lancet molecular dynamics Mutation NAT Nature Neutralizing nonspecific outbreak polar proline Protein–protein interaction protein–protein interaction Receptor binding Receptor binding domain receptor protein relative free energy of binding residue responsible reveal Salt Bridge SARS Coronavirus SARS-CoV SARS-CoV-2 sequence Significance similarity Surveillance the SARS-CoV-2 trajectory transmission rate [DOI] 10.1073/pnas.2008209117 PMC 바로가기 [Article Type] 530