Propagation of SARS-CoV-2 in Calu-3 Cells to Eliminate Mutations in the Furin Cleavage Site of SpikeArticle Published on 2021-12-042022-10-28 Journal: Viruses [Category] COVID-19, SARS, [키워드] accumulate accumulated accumulated mutation animal model animal models arising B.1.351 Calu-3 Calu-3 cell Care Cell culture cell cultures cell lines cleavage Deletion eliminated evaluate furin furin cleavage site generate hamsters highly pathogenic in vivo independent infect lung epithelial Mutation nucleotide position pathogenic Polymorphisms Population produced Propagation remained SARS-CoV-2 SARS-CoV-2 isolate SARS-CoV-2 pathogenesis SARS-CoV-2 variant Site spike stock preparation therapeutic Vaccine variant Vero Cell virus virus stock was used wild-type [DOI] 10.3390/v13122434 PMC 바로가기 [Article Type] Article
Integro-differential approach for modeling the COVID-19 dynamics – Impact of confinement measures in ItalyCOVID-19 역학 모델링을 위한 적분-차동 접근법 - 이탈리아의 격리 조치의 영향Article Published on 2021-12-012022-09-11 Journal: Computers in biology and medicine [Category] SARS, 변종, 치료기술, [키워드] adoption approach available data coefficient complicate condition conditions consequence Contagion Containment measure containment measures country COVID-19 COVID-19 epidemic COVID-19 pandemic criteria deaths detectable disorganized doctrine driven by Effectiveness English Epidemic Evolution failure Government health system health systems highlighting Impact incisive indication Infection involved Italian region Italian regions Italy lack limit management mathematical Mathematical modelling measure parameter parameters predict Propagation reactivity regions reliability robust SARS-CoV-2 security Spread stability Transmissibility Vaccinations Variability variant virus variants zone [DOI] 10.1016/j.compbiomed.2021.105013 PMC 바로가기 [Article Type] Article
Mobile computed tomography for the efficient allocation of medical resources in patients with COVID-19 pneumonia A case report코로나19 폐렴 환자의 효율적인 의료자원 배분을 위한 이동형 컴퓨터단층촬영 증례보고Case Reports Published on 2021-11-192022-09-10 Journal: Medicine [Category] MERS, SARS, 진단, 치료제, [키워드] allocation of resources Antibiotics Antiviral agents Burnout Care Case report Chest computed tomography Chest CT chest CT scan chest X-ray clinical condition clinician Computed tomography cone-beam computed tomography conservative treatment consolidation contagious coronavirus Coronavirus 2019 cough COVID-19 COVID-19 patients COVID-19 pneumonia CT scan CT scanning Dyspnea events Exhaustion Fever Ground-glass opacities ground-glass opacity Healthcare systems Infection Isolation medical resource Medical resources medical staff Mobile Mobile application Nurse Patient patient with COVID-19 patients patients with COVID-19 performed Pneumonia presenting problem problems Propagation radiologist raise required resource Safe scanning subpleural syndrome Treatment Treatment response [DOI] 10.1097/MD.0000000000027872 PMC 바로가기 [Article Type] Case Reports
Age-dependency of the Propagation Rate of Coronavirus Disease 2019 Inside School Bubble Groups in Catalonia, Spain2019년 스페인 카탈로니아 학교 버블 그룹 내부 코로나바이러스 질병 전파율의 연령 의존성Article Published on 2021-11-012022-09-11 Journal: The Pediatric Infectious Disease Journal [Category] SARS, 치료기술, [키워드] addition age Analysis analyzed attack rate attack rates average calculation childhood classroom Contagion coronavirus disease Coronavirus disease 2019 event group health system High School index case index cases individual infected case infected individuals Infection Isolation mandatory nonpharmaceutical intervention number of infected organized pediatric positive Preschool Propagation Rate reported reproductive required School secondary attack rate Spain super-spreading events Surveillance Transmission triggered [DOI] 10.1097/INF.0000000000003279 PMC 바로가기 [Article Type] Article
Genomics-guided targeting of stress granule proteins G3BP1/2 to inhibit SARS-CoV-2 propagationSARS-CoV-2 전파를 억제하기 위한 스트레스 과립 단백질 G3BP1/2의 유전체학 유도 표적화Article Published on 2021-11-012022-09-11 Journal: International journal of biological macromolecules [Category] SARS, 유전자 메커니즘, 치료법, [키워드] Analysis candidate drug candidate drugs COVID-19 mitigation Decitabine docking drug drugs enrichment expression FOXA1 G3BP1 G3BP1/2 G3BP2 Gene Expression Gene set enrichment Genes GTPase Host host cells identify Imatinib inhibit inhibit SARS-CoV-2 Meta-analysis modulating molecular docking analysis much higher N protein nucleocapsid nucleocapsid protein Panel Propagation Protein Proteins regulatory element SARS-CoV-2 SARS-CoV-2 N protein SARS-CoV-2 nucleocapsid SIN3A SRF Stress stress granule SYK TGFBR2 the SARS-CoV-2 upstream YY1 [DOI] 10.1016/j.ijbiomac.2021.09.018 PMC 바로가기 [Article Type] Article
Asunaprevir, a Potent Hepatitis C Virus Protease Inhibitor, Blocks SARS-CoV-2 Propagation강력한 C형 간염 바이러스 프로테아제 억제제인 Asunaprevir, SARS-CoV-2 전파 차단Article Published on 2021-09-302022-09-11 Journal: Molecules and cells [Category] SARS, 신약개발, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 antiviral activity asunaprevir binding block blocked calu-3 cells candidate coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 Cytopathic effect cytopathic effects daclatasvir direct-acting antiviral Drug repurposing evaluated Health hepatitis C hepatitis C virus human lung human lung Calu-3 cells include infected cells inhibited inhibitor life cycle NS5A pandemic potent Propagation Protease inhibitor protein level protein levels RNA RNA polymerase inhibitor SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 propagation SARS-CoV-2 vaccine SARS-CoV-2-infected cells severe acute respiratory syndrome Coronavirus significantly sofosbuvir therapeutic agent Treatment vaccination Vero E6 VERO E6 cells viral life cycle virion [DOI] 10.14348/molcells.2021.0076 PMC 바로가기 [Article Type] Article
Mild and Asymptomatic COVID-19 Convalescents Present Long-Term Endotype of Immunosuppression Associated With Neutrophil Subsets Possessing Regulatory Functions경증 및 무증상 COVID-19 회복기 조절 기능을 보유한 호중구 하위 집합과 관련된 면역 억제의 장기 엔도타입 제시Immunology Published on 2021-09-292022-09-11 Journal: Frontiers in Immunology [Category] SARS, 진단, 치료기술, [키워드] activated addition affecting Analysis anti-CD3 anti-SARS-CoV-2 Asymptomatic Asymptomatic COVID-19 asymptomatic infection autologous Blood Cancer CD8 Cell Complication Concentration convalescent convalescent sera coronavirus disease Coronavirus disease 2019 Course COVID-19 COVID-19 convalescents described disease elevated endotype enrolled expansion FACS function functions GM-CSF granulocyte-macrophage colony stimulating factor (GM-CSF) Granulocytic granulocytic myeloid-derived suppressor cells (PMN-MDSCs) healthy donor IgG immune response Immunosuppression immunosuppressive Infection inhibit long-COVID low-density low-density neutrophils (LDNs) lymphopenia mAb Mild myeloid cell myeloid cells NDN Neutralizing Neutralizing antibodies neutrophil neutrophil dysfunction Neutrophils normal density neutrophils past PCR test PD-L1 positive result present proliferation Propagation Regulatory responsible SARS-CoV-2 SARS-COV-2 infection serum sample serum samples severe lymphopenia significantly higher subpopulation suppressor cells T cell T cells T-cell tendency These cells was used were used Whole blood [DOI] 10.3389/fimmu.2021.748097 PMC 바로가기 [Article Type] Immunology
Path Analysis to Assess Socio-Economic and Mitigation Measure Determinants for Daily Coronavirus Infections일상적인 코로나 바이러스 감염에 대한 사회 경제적 및 완화 조치 결정 요인을 평가하기 위한 경로 분석Article Published on 2021-09-252022-09-10 Journal: International Journal of Environmental Research an [Category] SARS, 치료기술, [키워드] addition Affect Awareness China coefficient Complete contribute coronavirus disease Coronavirus disease 2019 country COVID-19 COVID-19 infections COVID-19 pandemic criteria Daily decrease density detect determinant direct and indirect effects effective events Factor identify indirect effect indirect effects Infection infections Iran Italy key factor lockdown Masks measure Measures medical resource Medical resources Mitigation mitigation factor National path path analysis population density Propagation quarantine recorded reduce resource resources seasonal flu social distancing Society socio-economic factor Spread the disease wearing masks [DOI] 10.3390/ijerph181910071 PMC 바로가기 [Article Type] Article
Global variation in SARS-CoV-2 proteome and its implication in pre-lockdown emergence and dissemination of 5 dominant SARS-CoV-2 cladesSARS-CoV-2 프로테옴의 글로벌 변이와 5개의 지배적인 SARS-CoV-2 clades의 사전 잠금 출현 및 보급에 미치는 영향Article Published on 2021-09-012022-09-11 Journal: Infection, genetics and evolution : journal of mol [Category] SARS, 변종, [키워드] addition Analysis Antigen can be used clade clades Comparative analysis curated D614G Diagnosis dissemination dominant early stage facilitate Frequency gene sequence globe Highly recurring mutations independent independent of L37F lack Moderately recurring mutations Mutation Mutational susceptibility mutations N protein nsp10 Nsp12 NSP2 NSP6 occur Occurrence ORF3a ORF8 P323L pandemic performed persistence Phyloproteomics Propagation proteome proteome analysis Q57H SARS-CoV-2 SARS-CoV-2 proteome SARS-CoV-2 viromics. sequence T85I the SARS-CoV-2 Transmission Variation viral evolution whole genome sequence [DOI] 10.1016/j.meegid.2021.104973 PMC 바로가기 [Article Type] Article
Transient and stabilized complexes of Nsp7, Nsp8, and Nsp12 in SARS-CoV-2 replicationSARS-COV-2 복제에서 NSP7, NSP8 및 NSP12의 과도 및 안정화 된 복합체Articles Published on 2021-08-032022-09-10 Journal: Biophysical Journal [Category] MERS, SARS, 유전자 메커니즘, [키워드] activities addition amplify atomic Combination complex complexation complexes component components conducted conformation Coordinate crystal structure crystal structures Crystallography defined Disruption DNA form functions greater high-resolution crystal structure Host host immune responses immune responses Interaction make up mechanism mRNA new virus Nsp12 Nsp7 NSP8 Propagation Protein Proteins recognizing Replication reported responsible RNA RNA-dependent RNA polymerase RTC SANS SARS-CoV-2 SARS-CoV-2 replication SAXS scattering size exclusion chromatography Structure Transcription Transient viability Viral Viral proteins Viral RNA virus [DOI] 10.1016/j.bpj.2021.06.006 PMC 바로가기 [Article Type] Articles