Prospective – Page 3 – Communicable Diseases Research

Prospective two-arm study of the testicular function in patients with COVID-19

COVID-19 환자의 고환 기능에 대한 전향적 양군 연구

Clinical Trial

Published on 2022-09-012022-09-11
Journal: Andrology [Category] COVID19(2023년), SARS, 임상, 치료기술,

Prospective Evaluation of Coronavirus Disease 2019 (COVID-19) Vaccine Responses Across a Broad Spectrum of Immunocompromising Conditions: the COVID-19 Vaccination in the Immunocompromised Study (COVICS)

광범위한 면역 손상 조건에 걸친 코로나바이러스 질병 2019(COVID-19) 백신 반응의 전향적 평가: 면역 손상 연구(COVICS)의 COVID-19 백신 접종

Article

Published on 2022-08-242022-09-12
Journal: Clinical Infectious Diseases: An Official Publicat [Category] SARS, 진단,

[키워드] acute respiratory syndrome adenovirus vector vaccine age anti-CD20 antibody antibody level Antibody Response approach autoimmune condition autoimmune conditions BNT162b2 cause comparison coronavirus coronavirus disease correlated correlation COVID-19 COVID-19 vaccine COVID-19 vaccines domain Factor greater HCW HCWs healthcare worker Hematologic malignancy Hematological malignancy HIV Human immunodeficiency virus Humoral response identify Immunocompromised immunocompromised adult immunocompromised individual Immunocompromised patient immunodeficiency Immunoglobulin Immunosuppression Logistic regression lowest Messenger RNA Moderna monoclonal monoclonal antibodies mRNA-1273 neutralization titer neutralization titers outcome participant Pfizer Primary outcome proportion Prospective pseudovirus reactive recipient recipients response SARS-CoV-2 SARS-CoV-2 antibody SARS-CoV-2 neutralization secondary seropositive seropositive participant significantly lower solid cancers solid organ transplant solid tumor SOT Spearman Spectrum vaccination Vaccine was used
[DOI] 10.1093/cid/ciac103 PMC 바로가기 [Article Type] Article

Facilitating Safe Discharge Through Predicting Disease Progression in Moderate Coronavirus Disease 2019 (COVID-19): A Prospective Cohort Study to Develop and Validate a Clinical Prediction Model in Resource-Limited Settings

Clinical Trial

Published on 2022-08-242022-10-04
Journal: Clinical Infectious Diseases: An Official Publicat [Category] SARS, 임상,

[키워드] acute respiratory syndrome age biochemical Biomarker C-reactive protein clinical clinical parameter clinical utility clinician Cohort coronavirus coronavirus disease COVID-19 D-dimer death defined demonstrated develop evaluated expressed external validation Facilitating greater health system help hospital identify IL-6 India infections laboratory-confirmed LMIC low- and middle-income country management Model moderate Neutrophil-to-lymphocyte ratio NLR participant Patient patients with moderate prediction presenting Primary outcome procalcitonin prognostic prognostic model progression Prospective provided Rapid test receptor recruited resources respiratory rate SARS-CoV-2 setting Sex soluble Triggering Receptor SpO2 SpO2/FiO2 suPAR supplemental oxygen Symptom Triage utility Vaccines validation cohort
[DOI] 10.1093/cid/ciac224 PMC 바로가기 [Article Type] Clinical Trial

Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)-Specific T Cells and Antibodies in Coronavirus Disease 2019 (COVID-19) Protection: A Prospective Study

중증 급성 호흡기 증후군 코로나바이러스 2(SARS-CoV-2) 특이적 T 세포 및 항체, 코로나바이러스 질병 2019(COVID-19) 보호: 전향적 연구

Article

Published on 2022-08-242022-09-11
Journal: Clinical Infectious Diseases: An Official Publicat [Category] SARS, 진단, 치료법,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus analyzed antibody Antibody Response Antibody responses CD4+ CD8+ T cell CD8+ T cells clinical comparable coronavirus coronavirus 2 coronavirus disease Coronavirus disease 2019 correlated COVID-19 demonstrated ELISPOT enzyme enzyme-linked immunosorbent evaluated flow cytometry followed by fraction Fractions frequencies Frequency healthcare highest IFN-γ IgG immune immune response Immunoglobulin Immunoglobulin G immunoglobulin M individual Infection interferon gamma interleukin interleukin 2 Kaplan-Meier estimator membrane nucleocapsid pandemic positive Probability Prospective PROTECT protective effect question Registration respiratory response SARS-CoV-2 SARS-COV-2 infection Spike protein Spike proteins staining T cell T cells T-cell T-cell and antibody responses T-cell Response T-cell responses the SARS-CoV-2 virus virus-specific antibodies Virus-specific IgG were infected with infection
[DOI] 10.1093/cid/ciac278 PMC 바로가기 [Article Type] Article

Remdesivir Plus Dexamethasone Versus Dexamethasone Alone for the Treatment of Coronavirus Disease 2019 (COVID-19) Patients Requiring Supplemental O2 Therapy: A Prospective Controlled Nonrandomized Study

코로나바이러스 질병 2019(COVID-19) 환자 치료를 위한 렘데시비르 플러스 덱사메타손 대 덱사메타손 단독 요법: 보충 O2 요법이 필요한 환자: 전향적 통제된 비무작위 연구

Controlled Clinical Trial

Published on 2022-08-242022-09-11
Journal: Clinical Infectious Diseases: An Official Publicat [Category] SARS, 임상, 치료제,

[키워드] 30-Day mortality Antiviral baseline calculated clinical outcomes cohorts Combination Controlled coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient CRP D-dimer Dexamethasone drug effective Endpoint enrolled evaluate evaluated faster fibrinogen FiO2 group groups Hospitalization IMPROVE independent Inflammatory inflammatory markers Kaplan-Meier Kaplan-Meier curve Kaplan-Meier curves laboratory characteristics log-rank test median Mortality neutrophil neutrophil/lymphocyte ratio no differences occurred primary endpoint primary endpoints Prospective reducing mortality reduction in reduction in mortality Remdesivir Respiratory failure Respiratory function Sample size SARS-CoV-2 clearance secondary Secondary endpoints shown significant difference significant differences survival the log-rank test therapy treat Treatment viral clearance were used
[DOI] 10.1093/cid/ciac014 PMC 바로가기 [Article Type] Controlled Clinical Trial

Robust T-Cell Responses in Anti-CD20-Treated Patients Following COVID-19 Vaccination: A Prospective Cohort Study

COVID-19 백신 접종 후 항-CD20 치료 환자의 강력한 T-세포 반응: 전향적 코호트 연구

Observational Study

Published on 2022-08-242022-09-11
Journal: Clinical Infectious Diseases: An Official Publicat [Category] SARS, 임상, 진단, 치료기술,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus anti-CD20 anti-CD20 therapy anti-CD20 treatment antibodies antibody Antibody Response Arthritis Breakthrough infection CD20 CD4 CD4 T cell CD8 T cell CD8 T cells cohort study Complication Control controls coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 vaccination COVID-19 vaccine detectable dose Effectiveness effector molecule effector molecules expressed Follow-up had no humoral humoral responses individual Mild mRNA COVID-19 vaccines mRNA-based COVID-19 vaccine multiple sclerosis Ocrelizumab Patient patients treated Prospective prospective observational cohort reduction respiratory response response rate response rates rheumatic disease Rheumatic diseases rheumatoid arthritis risk rituximab seroconverted severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 severe coronavirus disease severe COVID-19 significantly lower specific antibodies spike T cell T cells T-cell T-cell Response T-cell responses Th1 phenotype treated treated patient vaccination
[DOI] 10.1093/cid/ciab954 PMC 바로가기 [Article Type] Observational Study

Decline in Pneumococcal Disease in Young Children During the Coronavirus Disease 2019 (COVID-19) Pandemic in Israel Associated With Suppression of Seasonal Respiratory Viruses, Despite Persistent Pneumococcal Carriage: A Prospective Cohort Study

코로나바이러스 질병 2019(COVID-19) 동안 어린이의 폐렴구균 질병 감소, 지속적인 폐렴구균 감염에도 불구하고 계절성 호흡기 바이러스 억제와 관련된 이스라엘의 유행성: 전향적 코호트 연구

Article

Published on 2022-08-242022-09-11
Journal: Clinical Infectious Diseases: An Official Publicat [Category] SARS, 치료기술, 폐렴구균 감염증,

[키워드] activity Adenovirus adjusted age alveolar Chain Reaction chest X-ray chest X-rays children Cohort colonization COVID-19 COVID-19 pandemic Decline declined density disappearance disease distribution Ethnicity expected followed by human metapneumovirus Hypothesis implicated incidence incidence rate Influenza influenza viruses invasive pneumococcal disease lockdown lower respiratory infections magnitude métapneumovirus monthly rate nasopharyngeal Nonpharmaceutical interventions nonpneumonia parainfluenza Pathogens persistent pneumococcal pneumococcal pneumoniae pneumococcus Pneumonia pneumoniae polymerase chain polymerase chain reaction Prevalence Previous studies previous study Prospective reduced reduction reductions respiratory respiratory infection respiratory infections respiratory syncytial virus respiratory virus respiratory viruses resulting rhinovirus SARS-CoV-2 seasonal serotype suppression Surveillance Transmission
[DOI] 10.1093/cid/ciab1014 PMC 바로가기 [Article Type] Article

Immunologic phenotype of patients with long-COVID syndrome of 1-year duration

Article

Published on 2022-08-242022-11-15
Journal: Frontiers in Immunology [Category] SARS, 치료기술,

[키워드] 95% confidence interval Adjusted analysis adjusted hazard ratio analyzed antibody Antibody Response antibody response, antinuclear antibodies (ANA) Autoimmunity Biomarker blood sample C-reactive protein cellular Cellular immune response cellular immune responses chronic inflammation COVID-19 COVID-19 symptom D-dimer detectable discharged Follow-up Frequency groups hospital hospitalized COVID-19 patient humoral humoral immune response ICU admission immune immune response Immunologic include Inflammation information Level Long COVID long-COVID mitigate myalgia neutralizing antibody no difference not different One year pathophysiology Patient phenotype positive Post-COVID-19 syndrome Prospective questionnaire reported SARS-CoV-2 antibody serological Smokers Symptom symptomatic patient Symptomatic patients syndrome T-cell T-cell immune response WHO severity score women
[DOI] 10.3389/fimmu.2022.920627 PMC 바로가기

Impact of COVID-19 on Health-Related Quality of Life: A Longitudinal Study in a Spanish Clinical Sample

COVID-19가 건강 관련 삶의 질에 미치는 영향: 스페인 임상 샘플에 대한 종단 연구

Observational Study

Published on 2022-08-212022-09-11
Journal: International Journal of Environmental Research an [Category] SARS, 임상, 치료기술,

[키워드] Administered asthenia cause change chest X-ray clinical clinical history coronavirus disease Coronavirus disease 2019 Course COVID-19 COVID-19 pneumonia defined Deterioration domain Dyspnea emotional General population Health status health-related quality of life Impact Infection life life quality longitudinal observational study over Participants Patient patients patients who survived physical Physical examination Pneumonia Prospective prospective observational study Pulmonary function test Quality questionnaire respiratory infection Sample SARS-CoV-2 SARS-CoV-2 pneumonia Sequelae Spanish survivor Symptoms the disease
[DOI] 10.3390/ijerph191610421 PMC 바로가기 [Article Type] Observational Study

Lower brachial artery flow-mediated dilation is associated with a worse prognosis and more lung parenchymal involvement in Covid-19: Prospective observational study

Observational Study

Published on 2022-08-192022-10-05
Journal: Medicine [Category] 임상,

[키워드] acute respiratory disease acute respiratory syndrome angiotensin-converting enzyme 2 Biochemical parameters brachial caused Coagulopathy coronavirus disease Coronavirus-2 cutoff point D-dimer Diagnosis died discharged disease Endothelial dysfunction endothelial function evaluate evaluated ferritin Hospitalized ICU ICU admission ICU patient intensive care investigated lactate dehydrogenase Lower lung lung involvement lung parenchyma moderate Mortality mortality rate multicenter negative correlation pandemic parenchymal pathogenic coronavirus patients patients hospitalized Prognosis Prospective prospective observational study receptor resulting risk factor shown significantly lower the patient vascular inflammation virus White blood cell worse prognosis
[DOI] 10.1097/MD.0000000000030001 PMC 바로가기 [Article Type] Observational Study