Multiplex Detection of Antibody Landscapes to Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)/Influenza/Common Human Coronaviruses Following Vaccination or Infection With SARS-CoV-2 and InfluenzaArticle Published on 2022-10-032022-11-15 Journal: Clinical Infectious Diseases: An Official Publicat [Category] COVID19(2023년), SARS, 진단, 치료기술, [키워드] acute respiratory illness acute respiratory syndrome Adsorption analyzed antibody antibody immunity antibody landscape Antibody Response ARI Clinical presentations collected common human coronaviruses coronavirus coronavirus 2 cross-reactive antibody detection exhibited Human human coronavirus human coronaviruses in-depth analysis individual Infection Influenza influenza infection influenza vaccine Influenza virus landscape Last multiplex multiplex detection. no interaction protective immunity public health threat representing respiratory respiratory infection response responses SARS-CoV-2 SARS-CoV-2 infections SARS-CoV-2 vaccination Sensitivity and specificity sera serological evidence serum Spike protein vaccination Vaccine [DOI] 10.1093/cid/ciac472 PMC 바로가기
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) immunoglobulins using chemiluminescence immunoassay and its correlation with neutralizing antibodiesArticle Published on 2022-10-022022-11-15 Journal: Virus research [Category] COVID19(2023년), SARS, 진단, 치료기술, [키워드] acute respiratory syndrome analyzed anti-SARS-CoV-2 antibodies antibody Asymptomatic asymptomatic individual Asymptomatic individuals AUC can be used chemiluminescence chemiluminescence immunoassay chemiluminescent immunoassay clinical comparable coronavirus correlation enrolled evaluated group IgG immune Immunoglobulin in both groups microneutralization NAb NAbs negative RT-PCR neutralization activity neutralization titer Neutralizing antibodies neutralizing antibody participant positive positive serology predict Previously symptomatic Protective protective immunity random reactive RT-PCR SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 patients screened serology Significant significantly higher symptomatic symptomatic individual symptomatic individuals symptomatic patient Symptomatic patients total Ig USA were measured [DOI] 10.1016/j.virusres.2022.198852 PMC 바로가기
Intranasal administration of cold-adapted live-attenuated SARS-CoV-2 candidate vaccine confers protection against SARS-CoV-2Article Published on 2022-10-022022-11-15 Journal: Virus research [Category] COVID19(2023년), SARS, 진단, [키워드] administration animal model attenuate Attenuated vaccines can be used candidate vaccine cleavage COVID-19 COVID-19 pandemic Deletion elicit examined furin cleavage site furin protease glycoprotein hamster hamsters histopathological Host Immunity Infection lesion motif mucosal neutralizing antibody parental pathogenesis of SARS-CoV-2 polybasic protective immunity proteolytic reduce required robust S1/S2 S1/S2 glycoprotein SARS-CoV-2 sequence Spike protein subsequent suggested unique Vaccine virus wild-type WT SARS-CoV-2 [DOI] 10.1016/j.virusres.2022.198857 PMC 바로가기
Afucosylated IgG responses in humans – structural clues to the regulation of humoral immunityArticle Published on 2022-10-012022-11-15 Journal: Trends in immunology [Category] 진단, [키워드] adaptive complement conserved COVID-19 disease domain ENhance erythrocytes exacerbate excessive inflammation expressed Fc-receptors fucosylation Galactosylation glycosylation Health HIV-1 Human Humoral immunity IgG IgG antibodies IgG response immune response Immunoglobulin implication Infectious disease Interaction malaria plasma IgG Plasmodium falciparum protective immunity Protein raised recent Regulation Regulatory response responses vaccination virus [DOI] 10.1016/j.it.2022.08.001 PMC 바로가기
Predicting a Positive Antibody Response After 2 SARS-CoV-2 mRNA Vaccines in Transplant Recipients: A Machine Learning Approach With External ValidationArticle Published on 2022-10-012022-11-15 Journal: Transplantation [Category] COVID19(2023년), SARS, 진단, [키워드] Antibody Response Antibody testing association BNT162b2 calculator characteristic clinical factor clinical factors Cohort contributing to dose External external validation facilitate Follow-up help Houston identify immunosuppressants less machine learning moderate mRNA mRNA vaccines mRNA-1273 mycophenolate mofetil negative antibody response Older age organ Other Patient Precision predictor protective immunity recipient recommendations response risk factor risk stratification SARS-CoV-2 Sex solid organ Transplant understanding Vaccination strategy Vaccine vaccine dose vaccine response validation was performed [DOI] 10.1097/TP.0000000000004259 PMC 바로가기
Recent advances in the vaccine development for the prophylaxis of SARS Covid-19Review article Published on 2022-10-012022-10-05 Journal: International immunopharmacology [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, 임상, [키워드] acute respiratory syndrome approach co-morbid conditions coronavirus COVID-19 COVID-19 outbreak COVID-19 pandemic COVID-19 vaccine Critical develop Disadvantages Effectiveness Fatality rate global pandemic Government healthcare professionals immune immunization include involved management medication pandemic Pathogenesis platform Prevent Prophylaxis protective immunity public health reactivity recent SARS-CoV-2 Scientific community Spanish flu Spread the vaccine Trial vaccination Vaccinations Vaccine Vaccine development virus [DOI] 10.1016/j.intimp.2022.109175 [Article Type] Review article
Computational exploration of the dual role of the phytochemical fortunellin: Antiviral activities against SARS-CoV-2 and immunomodulatory abilities against the hostArticle Published on 2022-10-012022-11-15 Journal: Computers in biology and medicine [Category] COVID19(2023년), SARS, 유전자 메커니즘, 치료제, [키워드] activity acute respiratory syndrome analyses Analysis Antiviral antiviral activity apoptosis pathway approach bind binding site Colon coronavirus disease Coronavirus-2 COVID-19 COVID-19 patients effective endoribonuclease enrichment enrichment analysis evaluate Fortunellin generate Genetic growth Host identify immunomodulation immunomodulatory immunomodulatory capability Infection inherent inhibiting Invasion liver lung cell majority mechanism MM-GBSA analysis molecular molecular docking molecular dynamics Molecular dynamics simulation Multi-target mutability network network pharmacology NHBE Ontology Organoid pancreatic pathway per day pro-inflammatory cytokine protective immunity protein-protein interaction SARS-CoV-2 Support target target proteins targets the SARS-CoV-2 therapeutic tissue damage tissues treating COVID-19 viral replication virion virus [DOI] 10.1016/j.compbiomed.2022.106049 PMC 바로가기
A novel assessment method for COVID-19 humoral immunity duration using serial measurements in naturally infected and vaccinated subjectsArticle Published on 2022-09-292022-11-15 Journal: PLoS ONE [Category] SARS, 변종, 진단, [키워드] antibodies antibody Antigen applied Characteristics Collecting COVID-19 defined determine Dilution dilutions dose doses help humoral Humoral immunity immune response Infection information intensity linear long-lasting MONITOR Pfizer Prevent profile protective immunity quantification quantitative assay RBD reactivity Reinfection Sample SARS-CoV-2 SARS-CoV-2 antigens serological serology test serum sample subject two group vaccination Vaccination strategies Vaccine variant Viral antigen was used were used [DOI] 10.1371/journal.pone.0274553 PMC 바로가기
Kinetics of vaccine-induced neutralizing antibody titers and estimated protective immunity against wild-type SARS-CoV-2 and the Delta variant: A prospective nationwide cohort study comparing three COVID-19 vaccination protocols in South KoreaArticle Published on 2022-09-232022-11-15 Journal: Frontiers in Immunology [Category] SARS, 변종, 진단, [키워드] baseline BNT BNT162b2 ChAdOx1 cohort study collected comparable conducted convalescent COVID-19 patients convalescent sera correlation COVID-19 COVID-19 pandemic COVID-19 vaccination cumulative Decreased Delta delta variant dose estimation explain groups HCW HCWs healthcare worker Heterologous highest homologous IQR Kinetics median Neutralizing neutralizing antibody Neutralizing antibody titer outbreak performed PRNT Protective protective immunity protocol SARS-CoV-2 sera serum sample significantly higher South Korea the mean vaccination Vaccine development variants of concern VoC VOCs was used wild type wild-type SARS-CoV-2 WT SARS-CoV-2 [DOI] 10.3389/fimmu.2022.968105 PMC 바로가기
Long-term quantitative assessment of anti-SARS-CoV-2 spike protein immunogenicity (QUASI) after COVID-19 vaccination in older people living with HIV (PWH)Article Published on 2022-09-212022-11-15 Journal: BMC Infectious Diseases [Category] SARS, 진단, 치료기술, [키워드] age analyzed anti-SARS-CoV-2 Anti-spike Antiretroviral therapy black BNT162b2 booster CD4 CD8 cells clinically COVID-19 COVID-19 vaccination COVID-19 vaccine decrease demographics detectable dose exploratory female HIV Humoral immunity IgG IgG levels immune response immunogenicity majority male marker median MOST occurred offered Older outcome participant positive presenting primary analysis protective immunity quantitative assessment reactogenicity recruited responses SARS-CoV-2 secondary single-center Spike protein subject suppressed T-cell T-cell Response vaccination Viremia virus-specific T-cell response white Wilcoxon signed-rank test with HIV [DOI] 10.1186/s12879-022-07737-0 PMC 바로가기