Monoclonal antibodies capable of binding SARS‐CoV‐2 spike protein receptor‐binding motif specifically prevent GM‐CSF inductionConcise Report Published on 2021-03-242022-10-29 Journal: Journal of leukocyte biology [Category] COVID-19, [키워드] ACE2 acute respiratory syndrome Affect antibody binding blocked boost caused coronavirus COVID‐19 cultures cytokine antibody array disease effort enzyme GM‐CSF GM‐CSF Host human ACE2 infections Inflammatory response inhibit inhibited Interaction Like mAb mAbs Macrophage monoclonal antibody mononuclear cell mononuclear cells motif murine pandemic Peripheral blood Prevent Protective antibody protective mechanism Protein purified RBM SARS‐CoV‐2 SARS‐CoV‐2 spike secretion Spike protein suggested surface plasmon resonance the spike protein Vaccine Vaccines viral entry viral spike [DOI] 10.1002/JLB.3COVCRA0920-628RR PMC 바로가기 [Article Type] Concise Report
A dramatic rise in serum ACE2 activity in a critically ill COVID-19 patientCase report Published on 2021-02-012022-10-05 Journal: International Journal of Infectious Diseases [Category] SARS, 바이오마커, [키워드] ACE2 Activation acute respiratory distress acute respiratory syndrome angiotensin-converting enzyme 2 Biomarker Biomarkers Cell circulating clinical status coronavirus Course COVID-19 COVID-19 patient Critical Critically ill disease E-selectin effective therapy Endothelial cell Endothelium Express expression ferritin IL-6 levels Infection Inflammation intravenous main receptor MONITOR nonspecific Patient Prognosis promote protective mechanism recombinant ACE2 reported SARS-CoV-2 SARS-COV-2 infection serum severe COVID-19 subject syndrome target cells upregulated viral entry [DOI] 10.1016/j.ijid.2020.11.184 [Article Type] Case report
Sex differences in COVID-19: candidate pathways, genetics of ACE2, and sex hormonesCOVID-19의 성별 차이: 후보 경로, ACE2의 유전학 및 성 호르몬Review Published on 2021-01-012022-09-11 Journal: American journal of physiology. Heart and circulat [Category] SARS, 유전자 메커니즘, [키워드] ACE2 Activation ADAM17 added angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 antiviral response Biological canonical cardiovascular disease caused contribute coronavirus COVID-19 COVID-19 pandemic Critical dependent on disease disease pathogenesis disease severity disintegrin epidemiological data exacerbate female females Gender genetics Health highlight increase in increasingly innate immune response innate immune system involved leads Loss male mechanism membrane metalloproteinase Mortality outcomes Pathways plasma positive positive feedback potential mechanism potential mechanisms protective mechanism proteolytic cleavage RAS receptor Renin renin-angiotensin system SARS epidemic SARS-CoV-2 SARS-CoV-2 coronavirus SARS-COV-2 infection severe disease Sex sex differences sex hormone Sex hormones susceptibility the SARS-CoV-2 Viral viral entry worsened [DOI] 10.1152/ajpheart.00755.2020 PMC 바로가기 [Article Type] Review
Assessment of Maternal and Neonatal SARS-CoV-2 Viral Load, Transplacental Antibody Transfer, and Placental Pathology in Pregnancies During the COVID-19 PandemicCOVID-19 팬데믹 기간 동안 임산부 및 신생아 SARS-CoV-2 바이러스 부하, Transplacental Antibody Transfer 및 태반 병리 평가Research Published on 2020-12-222022-09-10 Journal: JAMA Network Open [Category] MERS, SARS, 진단, 치료기술, 치료법, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus age Analysis angiotensin angiotensin-converting enzyme 2 anti-SARS-CoV-2 antibodies anti-SARS-CoV-2 antibody antibody antibody transfer assessment Asymptomatic binding domain biofluids Biological Blood Boston Care Chain Reaction Characteristics cohort study Colocalization Compromised conducted Cord blood coronavirus COVID-19 Critical disease defined detectable disease distribution enrolled enzyme Evidence evidence of exposure expression of SARS-CoV-2 fetoplacental finding Follow-up Immunity implication Importance incidence inefficient Infection Influenza load Massachusetts Maternal maternal plasma measure mechanism Mild Mild disease moderate disease Nasopharyngeal swab Neonatal Neonate Neonates no evidence of nucleocapsid objective occurred outcome participant pathology Placenta placental Placental infection Placentas plasma Point positive pregnancies Pregnancy pregnant women presenting prospective cohort study protective mechanism protective mechanisms provided quantification quantified receptor recruited reduced Relevance respiratory respiratory fluid Result risk robust RT-PCR SARS-CoV-2 SARS-CoV-2 antibodies SARS-CoV-2 antibody SARS-COV-2 infection SARS-CoV-2 receptor SARS-CoV-2 RNA SARS-CoV-2 viral load Serine setting severe disease significantly lower tertiary care center tested transfer transmembrane serine protease transmembrane serine protease 2 Transmission transmission of SARS-CoV-2 Transplacental transplacental passage umbilical Umbilical cord underlie vertical transmission Viral Viral load Viremia women [DOI] 10.1001/jamanetworkopen.2020.30455 PMC 바로가기 [Article Type] Research
Mechanisms and evidence of vertical transmission of infections in pregnancy including SARS-CoV-2sSARS-CoV-2를 포함한 임신 중 감염의 수직 전파 메커니즘 및 증거Review Published on 2020-12-012022-09-11 Journal: Prenatal diagnosis [Category] SARS, 치료기술, [키워드] ACE-2 amniotic Amniotic fluid Blood breast milk Chain Reaction Child clinical sample clinical samples co-expression concerning Consensus Cord blood COVID-19 cytoplasmic demonstrated determine diagnostic eight entry of SARS-CoV-2 Evidence explain histological examination Infection Inflammation Interaction involved lack membrane Migration mother Neonatal Neonatal COVID-19 pathogen performed Placenta placental placental barrier polymerase chain polymerase chain reaction Pregnancy pregnant women Prevent protective mechanism protective mechanisms question real-time polymerase chain reaction receptor reported SARS-CoV-2 SARS-CoV-2 IgM screened secretion susceptibility Swab tissue TMPRSS2 Transmission transplacental infection Umbilical cord umbilical cord blood Vascular Viral Viral particles with COVID-19 [DOI] 10.1002/pd.5765 PMC 바로가기 [Article Type] Review
Ifit2 deficiency restricts microglial activation and leukocyte migration following murine coronavirus (m-CoV) CNS infectionResearch Article Published on 2020-11-302022-10-29 Journal: PLoS Pathogens [Category] Coronavirus, [키워드] absence accompanied Activation Antiviral effect Brain caused CD4 T cell cellular chemokine Chemokine receptor Clinical sign CNS contributing to coronavirus Coronavirus infection Critical CX3CL1 CX3CR1 cytokine deficiency develop dissemination expression functions IFN IFNs immune protection Infection infiltration interferon-induced protein ISG ISGs lack leukocyte mechanism mice microglial Migration morbidity and mortality murine Neurological deficit neurotropic NK1.1 Pathogenesis PROTECT protective mechanism Protein receptor recruitment reduced regulate restrict significantly Spread stimulated Symptom T cell tissue homeostasis viral clearance Viral load viral replication virus virus load virus replication viruses wild-type [DOI] 10.1371/journal.ppat.1009034 PMC 바로가기 [Article Type] Research Article
Protective Regulatory T Cell Immune Response Induced by Intranasal Immunization With the Live-Attenuated Pneumococcal Vaccine SPY1 via the Transforming Growth Factor-β1-Smad2/3 Pathway비강 면역화에 의해 유도된 보호적 조절 T 세포 면역 반응: 변형 성장 인자-β1-Smad2/3 경로를 통한 생백신 폐렴구균 백신 SPY1Original Research Published on 2018-08-022024-07-31 Journal: Frontiers in immunology [Category] 폐렴구균 감염증, [키워드] protective mechanism regulatory T cells Streptococcus pneumoniae transforming growth factor β1 Vaccine [DOI] 10.3389/fimmu.2018.01754 PMC 바로가기 [Article Type] Original Research