Heterozygote Advantage of the Type II Deiodinase Thr92Ala Polymorphism on Intrahospital Mortality of COVID-19Observational Study Published on 2022-05-172022-10-05 Journal: The Journal of Clinical Endocrinology and Metaboli [Category] 임상, [키워드] acute lung injury adjusted Admission association Biochemistry Clinical outcome Comorbidities complications conducted consecutive patient covariate COVID-19 cumulative mortality Deiodinase evaluate Evidence Genotype heterozygote heterozygous homozygous median age Mortality multivariate logistic regression overall mortality Patient patients with COVID-19 phenotype phenotypical polymorphism polymorphism and COVID-19 prospective cohort study protective effect protective role pulmonary fibrosis ranged reduced risk reduction Severity Score stratified Thyroid Thyroid function tests Type type II deiodinase. while [DOI] 10.1210/clinem/dgac075 PMC 바로가기 [Article Type] Observational Study
Breakthrough SARS-CoV-2 infections after COVID-19 mRNA vaccination in MS patients on disease modifying therapies during the Delta and the Omicron waves in ItalyResearch article Published on 2022-05-052022-10-05 Journal: EBioMedicine [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] antibody Blood breakthrough infections calculated COVID-19 COVID-19 mRNA Vaccination cumulative Delta Delta wave disease Disease modifying treatments dose enrolled finding Follow-up funding humoral immune response identify incidence Infection Italian Italy MONITOR mRNA vaccination multicenter cohort study Multiple multiple sclerosis omicron Patient preserved Probability protective role reduced reduction risk risk of infection SARS-CoV-2 SARS-CoV-2 antibody SARS-COV-2 infection sclerosis second dose significantly therapy Vaccine vaccine dose vaccine doses [DOI] 10.1016/j.ebiom.2022.104042 [Article Type] Research article
In COVID-19, NLRP3 inflammasome genetic variants are associated with critical disease and these effects are partly mediated by the sickness symptom complex: a nomothetic network approachCOVID-19에서 NLRP3 인플라마좀 유전적 변이체는 중대한 질병과 관련이 있으며 이러한 효과는 부분적으로 질병 증상 복합체에 의해 매개됩니다: 노모테틱 네트워크 접근Article Published on 2022-04-012022-09-11 Journal: Molecular Psychiatry [Category] COVID19(2023년), SARS, 바이오마커, 변종, [키워드] Abnormalities accompanied activated acute infections acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 age Analysis Anosmia approach association BMI body mass body mass index Chest computed tomography complex Computed tomography conserved coronavirus coronavirus disease COVID-19 COVID-19 patients COVID-19 symptom Critical Critical disease death detrimental diabete diabetes domain dysgeusia Effect explained gastrointestinal symptoms Genetic variant Genotype hyperinflammation hypertension include Increased Increasing increasing age individual Infection Inflammasome Inflammation Intersection leucine male Male sex Mild disease moderate NLRP3 NLRP3 inflammasome nucleotide oxygen oxygen saturation Partial Partial Least Squares analysis PROTECT Protective protective role protein 3 recruited reduce reduced risk SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus Sex Sickness significantly square SSC Symptom variance variant with mild disease [DOI] 10.1038/s41380-021-01431-4 PMC 바로가기 [Article Type] Article
The (apparent) antibody paradox in COVID-19COVID-19의 (겉보기) 항체 역설Article Published on 2022-04-012022-09-11 Journal: Expert review of clinical immunology [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] antibodies antibody Antibody Response Area benefit convalescent plasma COVID-19 defined Delayed dominance dominant elevated Evidence expert Host Humoral immunity Immunity Immunological response increasingly Infection inflammatory reaction lack magnitude monoclonal monoclonal antibodies observation Omicron variant Patient Protective protective mechanism protective role reaction SARS-CoV-2 severe COVID-19 severe disease syndrome T cell T cell response T cell responses T cells T-cell Response the antibody response therapeutic Trigger triggered triggers vaccination Viral viral loads virus [DOI] 10.1080/1744666X.2022.2044797 PMC 바로가기 [Article Type] Article
Does admission acetylsalicylic acid uptake in hospitalized COVID-19 patients have a protective role? Data from the Spanish SEMI-COVID-19 RegistryObservational Study Published on 2022-04-012022-10-04 Journal: Internal and Emergency Medicine [Category] COVID19(2023년), SARS, 임상, [키워드] Acetylsalicylic acid Admission affected Analysis analyzed Cardiovascular disorders collected coronavirus COVID-19 COVID-19 patients determine evaluate evaluated group Health Hospital admission hospitalized COVID-19 patient hospitalized COVID-19 patients ICU ICU admission in-hospital mortality Inflammation intensive care large sample Mortality no difference outcome Patient patients with COVID-19 Pneumonia Propensity score Protective protective role PSM receiving registry retrospective cohort study Spanish symptomatic thrombosis Treatment was performed [DOI] 10.1007/s11739-021-02870-1 PMC 바로가기 [Article Type] Observational Study
Is pregnancy a risk factor for in-hospital mortality in reproductive-aged women with SARS-CoV-2 infection? A nationwide retrospective observational cohort studyObservational Study Published on 2022-04-012022-10-05 Journal: International journal of gynaecology and obstetric [Category] COVID19(2023년), SARS, 임상, [키워드] acute respiratory syndrome adjusted age Analysis analyzed Brazil calculated Characteristics Co-infection coronavirus coronavirus disease coronavirus disease-2019 covariate COVID-19 database Factor favorable effect gestation hazard ratio hypothetical Immunosuppressed In-hospital death in-hospital mortality independent Infection inhibit Intervention lower risk Medical conditions Mortality multivariate Cox regression multivariate logistic regression Observational cohort study Odds ratio polymerase chain Pregnancy pregnant pregnant women Proinflammatory cytokine protective role reproductive retrospective risk factor SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome coronavirus 2 shown sociodemographic factors survival weaker immune response women [DOI] 10.1002/ijgo.14066 PMC 바로가기 [Article Type] Observational Study
CD8 + T cells specific for conserved coronavirus epitopes correlate with milder disease in COVID-19 patientsArticle Published on 2022-03-152022-11-01 Journal: Science Immunology [Category] COVID-19, Fulltext, SARS, [키워드] Antigen Asymptomatic CD8 complexes conserved coronavirus COVID-19 patient disease disease course displaying epitope individual individuals Mild pandemic peptide phenotype platform protective role recognizing SARS-CoV-2 sequence specificity staining T cell the SARS-CoV-2 unique with mild disease [DOI] 10.1126/sciimmunol.abg5669 PMC 바로가기 [Article Type] Article
Changes in work and health of Australians during the COVID-19 pandemic: a longitudinal cohort studyArticle Published on 2022-03-122022-10-04 Journal: BMC Public Health [Category] 임상, [키워드] addition association Australian baseline being benefit change changes in clinical contributing to COVID-19 COVID-19 pandemic declined described early stage Effect Effects employment Engagement examined form greater Health improvement lockdown long-lasting longitudinal longitudinal cohort study Longitudinal studies loss of work Mental mental health New occupational health outcome pandemic participant physical physical activity protective role Psychological distress public health measure reduce Regression model returned Support sustained Viral transmission work [DOI] 10.1186/s12889-022-12897-4 PMC 바로가기 [Article Type] Article
Preschool Teachers’ Psychological Distress and Work Engagement during COVID-19 Outbreak: The Protective Role of Mindfulness and Emotion RegulationArticle Published on 2022-02-242022-10-29 Journal: International Journal of Environmental Research an [Category] Coronavirus, COVID19(2023년), MERS, SARS, [키워드] adaptive affected COVID-19 COVID-19 outbreak COVID-19 pandemic distress early stage emotion Emotion regulation emotional emotional distress Engagement ENhance evaluated event implementation Intervention mental health mindfulness Mindfulness-based outbreak pandemic participated Preschool Prevalence protective role Psychological distress Questionnaires Regulation reported resource role teacher teachers Teaching work Work engagement [DOI] 10.3390/ijerph19052645 PMC 바로가기 [Article Type] Article
Limited Recognition of Highly Conserved Regions of SARS-CoV-2SARS-CoV-2의 고도로 보존된 지역에 대한 제한된 인식Research Article Published on 2022-02-232022-09-10 Journal: Microbiology Spectrum [Category] COVID19(2023년), MERS, SARS, 치료법, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus antigen-specific CD8+ T cells approach CD8 circulating Community Comparative conservation conserved conserved regions convalescent coronavirus coronavirus disease coronavirus strains COVID-19 Critical cross-protective immunity cross-reactive disease encoded protein epitope epitope mapping Epitopes exposure to FIVE Frame generate immune protection immune response immune responses immunodominant implication individuals less likelihood Limited memory memory T cells nucleocapsid observation Open reading frame ORF1 ORF1ab overcome pandemic Participants polyprotein Preexisting immunity protective role Protein Recognition Region required respiratory robust SARS-CoV-2 SARS-CoV-2 infected cells seasonal coronaviruses Sequence analysis severe acute respiratory syndrome Coronavirus severe COVID-19 severe disease T cell T cell response T cell responses T cells T-cell epitope T-cell epitopes T-cell Response T-cell responses understanding unlikely vaccination volunteers [DOI] 10.1128/spectrum.02780-21 PMC 바로가기 [Article Type] Research Article