Non-proteolytic activity of 19S proteasome subunit RPT-6 regulates GATA transcription during response to infection19S proteasome subunit RPT-6의 비 단백질 분해 활성은 감염에 대한 반응 동안 GATA 전사를 조절합니다Research Article Published on 2018-09-282022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] activated affected ATPase Bacterial infection Bacterial infections binding Caenorhabditis elegan Caenorhabditis elegans component conserved Defense domain Evidence expression expression of gene GATA GATA transcription factor GATA transcription factors Gene Expression Genes immune function immune functions immune gene immune genes immune response Immunity in vivo independent independent of indicated Infection interact Interaction involved oxidative stress pathogen physically proteasome proteolytic activity Pseudomonas aeruginosa regulate Regulation required subunit Transcription transcription factor transcription factors [DOI] 10.1371/journal.pgen.1007693 PMC 바로가기 [Article Type] Research Article
Critical Assessment of the Important Residues Involved in the Dimerization and Catalysis of MERS Coronavirus Main ProteaseResearch Article Published on 2015-12-142022-10-28 Journal: PLoS ONE [Category] Coronavirus, [키워드] Analysis Asian assessment catalysis catalytic activity Coronaviral coronavirus correlation country CoV Critical demonstrated domain domain III enzyme European Fatality rate FIVE highly pathogenic indicate investigated Jeddah M pro MERS MERS-CoV Middle East monomer Mutagenesis Mutation peptide protease Protein proteolytic activity provide required residue respiratory syndrome coronavirus Result Saudi Arabia spread to ultracentrifugation virus wild-type [DOI] 10.1371/journal.pone.0144865 PMC 바로가기 [Article Type] Research Article
Structural and functional characterization of MERS coronavirus papain-like proteaseResearch Published on 2014-06-042022-10-29 Journal: Journal of Biomedical Science [Category] Coronavirus, [키워드] analysis antiviral drug antiviral target Circular Coronaviral coronavirus Coronaviruses CoV demonstrated Deubiquitination develop European country exhibit expressed Fatality rate functional functional consequence highly pathogenic indicated inhibiting Jeddah kinetic MERS coronavirus MERS-CoV Middle East monomer natural mutation organized Papain-like protease proteolytic proteolytic activity respiratory syndrome coronavirus Result SARS-CoV Saudi Arabia spread to therapy ultracentrifugation virus [DOI] 10.1186/1423-0127-21-54 PMC 바로가기 [Article Type] Research