Effects of an Existential Nursing Intervention for College Students in the COVID-19 Pandemic SituationArticle Published on 2021-05-152022-10-29 Journal: International Journal of Environmental Research an [Category] Coronavirus, SARS, [키워드] baseline college concerning control group control groups correlation COVID-19 COVID-19 pandemic Depression determine Effect estimating equation exhibited experimental group help Interaction Intervention Korean logotherapy Nursing participant post-intervention pursuit reduce reducing significantly lower situation Stress student students was used were assessed [DOI] 10.3390/ijerph18105268 PMC 바로가기 [Article Type] Article
Pharmacophore Modelling-Based Drug Repurposing Approaches for SARS-CoV-2 TherapeuticsChemistry Published on 2021-05-102022-10-31 Journal: Frontiers in Chemistry [Category] COVID-19, [키워드] acute respiratory syndrome approved drugs average backbone binding binding pocket caused CDOCKER co-crystallized complex Compound compounds computational method coronavirus coronavirus disease COVID-19 COVID-19 therapeutics demonstrated deviation Discovery Studio docking drug Drug repurposing DrugBank DrugBank database effective Hydrogen bond inhibitor MDs Molecular docking study Molecular dynamics simulation Novel coronavirus outbreak PDB pharmacophore pharmacophore modelling Protein pursuit Remdesivir repurposing resulting S-adenosyl methionine SAM SARS-CoV-2 shown target the selected model Therapeutics Treatment was used [DOI] 10.3389/fchem.2021.636362 PMC 바로가기 [Article Type] Chemistry
Mining of high throughput screening database reveals AP-1 and autophagy pathways as potential targets for COVID-19 therapeutics고 처리량 스크리닝 데이터베이스의 마이닝은 COVID-19 치료제의 잠재적 표적으로서 AP-1 및 자가포식 경로를 나타냅니다Article Published on 2021-03-242022-09-10 Journal: Scientific Reports [Category] SARS, 신약개발, 유전자 메커니즘, 임상, 치료제, [키워드] addition Anti-SARS-CoV-2 Activity Antiviral AP-1 approved approved drug approved drugs autophagy autophagy pathway Candidates caused class coronavirus coronavirus disease Coronavirus disease 2019 correlated COVID-19 COVID-19 therapeutics CPE Cytopathic effect Data mining database drug drug activity drug library effective effort global pandemic High-throughput screening Hope house human clinical trials in vivo mechanism New coronavirus new coronavirus SARS-CoV-2 phenotypic Potential treatment potential treatments profile pursuit reveal SARS-CoV-2 SARS-COV-2 infection signaling pathway significantly target Target identification therapeutic Viral [DOI] 10.1038/s41598-021-86110-8 PMC 바로가기 [Article Type] Article
China and the global search for health security: history, vaccines, and governanceOriginal Paper Published on 2021-03-242022-10-31 Journal: China International Strategy Review [Category] COVID-19, [키워드] Access to vaccines affecting China China’s history of influenza pandemics Chinese country COVID-19 COVID-19 pandemic effective element Final Health identify International relations knowledge offer outbreak plague public health pursuit relation Vaccines [DOI] 10.1007/s42533-021-00066-y PMC 바로가기 [Article Type] Original Paper
Immunomodulatory Effects of Azithromycin Revisited: Potential Applications to COVID-19Immunology Published on 2021-02-122022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, [키워드] accelerated alteration Antiviral effect application autophagy Azithromycin benefit clearance Clinical use contribute Course COVID-19 COVID-19 immune response COVID-19 pandemic Cytokine storm death defined early stage Effect effective Efficacy Evidence Factor function identify immune mechanism immune response immunomodulation immunomodulatory immunomodulatory effect immunomodulatory therapy immunosuppressive Infection Inflammation inflammatory cell infiltration investigated late stage Lung pathology macrophages mechanism Multiple neutrophil patients patients with COVID-19 Potential pro-inflammatory cytokine progression pursuit Regulatory severe disease shown Stage Support the disease therapeutic therapy viral burden virus while [DOI] 10.3389/fimmu.2021.574425 PMC 바로가기 [Article Type] Immunology
Virus-Host Interactome and Proteomic Survey Reveal Potential Virulence Factors Influencing SARS-CoV-2 Pathogenesis바이러스-숙주 상호작용 및 단백질체 조사, SARS-CoV-2 발병에 영향을 미치는 잠재적인 독성 요인 밝혀Article Published on 2021-01-152022-09-11 Journal: Med (New York, N.Y.) [Category] SARS, 유전자 메커니즘, [키워드] Academy acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 antiviral therapy Appointment Blood coagulation CAS caused cellular challenge chemotaxis China Chinese clinical Coagulation Commission contribute coronavirus disease Coronavirus disease 2019 Coronavirus-2 COVID-19 COVID-19 patients cytokine Cytokine storms development downregulation effective facilitate Factor foundation global public health Host host inflammatory response host protein host proteins IL-8 Infrastructure Innovative Research institution interact interactome interleukin interleukin-8 lack learning maintenance Major mechanism molecular mechanism mononuclear cell natural neutrophil neutrophil activation Neutrophils NF-κB NKRF non-structural protein nsp10 pandemic PBMC PBMCs Peripheral blood Potential Professor Program Protein proteome proteomics pursuit representing research and development resource respiratory reveal SARS-CoV-2 SARS-CoV-2 pathogenesis Scholar Science Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 severe COVID-19 Shanghai Signaling significantly SII survey T cell T cell receptor target team technology therapeutic interventions Transmission Trigger triggers university upregulation was used [DOI] 10.1016/j.medj.2020.07.002 PMC 바로가기 [Article Type] Article
Characterization of the cytokine storm reflects hyperinflammatory endothelial dysfunction in COVID-19사이토카인 폭풍의 특성은 COVID-19의 과염증성 내피 기능 장애를 반영합니다Article Published on 2021-01-012022-09-11 Journal: The Journal of Allergy and Clinical Immunology [Category] SARS, 바이오마커, 유전자 메커니즘, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 ADP-ribose Adult patients age Analysis analyzed assays association attenuate Baricitinib Biomarker Biomarkers blood sample Blood samples cardiovascular cardiovascular disease characterization characterized circulating circulation coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 CXCL10 CXCL5 CXCL9 cytokine Cytokine storm Cytokine storms disease severity dominant dysregulation endothelial damage Endothelial dysfunction healthy control healthy controls help host inflammatory response host response Hyperinflammatory identify IFN-γ IL-10 IL-1ra IL-6 immune response immune responses increasingly Infection Inflammation Intervention marker MCP-3 mechanism Mild moderate monocyte observé Ordinal Scale Pathogenesis Patient patients hospitalized patients with COVID-19 physician platform polymerase Protein proteomic pursuit reduce reflect Regulation reliability reproducibility respiratory Result scale severe acute respiratory syndrome Coronavirus Spectrum statistically significant stratified the cytokine storm therapeutic options Vascular with COVID-19 [DOI] 10.1016/j.jaci.2020.08.031 PMC 바로가기 [Article Type] Article
Psychological responses during the COVID-19 outbreak among university students in Bangladesh방글라데시 대학생들의 코로나19 발생 시 심리적 반응Clinical Trial Published on 2020-12-312022-08-13 Journal: PLoS ONE [Category] MERS, SARS, 임상, [키워드] age Analysis Anxiety association Causality conducted COVID-19 COVID-19 outbreak cross-sectional DASS DASS-21 dependent variable Depression disadvantage effect size estimate exercise Factor Factors family income) feasible Health health monitoring health problems Impact lack mental health problems mild symptoms moderate moderate symptoms pandemic Prevalence prevalent problem psychological response public health pursuit Regression Regression analyses reported Satisfaction severe symptom severe symptoms Stress Symptom Symptoms university students was related [DOI] 10.1371/journal.pone.0245083 PMC 바로가기 [Article Type] Clinical Trial
Threading the Pieces Together: Integrative Perspective on SARS-CoV-2Review Published on 2020-11-042022-10-28 Journal: Pathogens [Category] COVID-19, [키워드] acute respiratory syndrome approach Asymptomatic individuals Clinical data Clinical outcome clinical symptom Co-infection Community comorbid condition Comorbidities Comorbidity coronavirus COVID-19 COVID-19 pandemic domain drugs effort facilitate genetic variants heterogeneity host response include Infection information integrative genomics metagenome microbial modulated Mortality outcome pandemic phenotype piece predisposition produced Protective pursuit Research researcher SARS-CoV-2 SARS-CoV-2 genome symptomatic symptomatic individuals Therapeutics Transcriptome Vaccines variables [DOI] 10.3390/pathogens9110912 PMC 바로가기 [Article Type] Review
Opportunistic Diagnosis of Extensive Pulmonary Embolus Following “COVID-19 Blood Battery” in Very Frail Older Patients매우 허약한 고령 환자에서 "COVID-19 혈액 배터리"에 따른 광범위한 폐색전증의 기회주의적 진단Case Reports Published on 2020-01-012022-09-11 Journal: The journal of nutrition, health & aging [Category] MERS, SARS, 바이오마커, [키워드] absence affected Ambulance Appropriate Biomarker Blood cause Clinical improvement Comorbidities Comorbidity Complication condition COVID-19 COVID-19 infection COVID-19 infections CTPA D-dimer D-dimers decrease diagnosed Diagnosis diagnostic dimer Echocardiogram Efficiency elevated Embolus emergency department Evidence evidence of Extensive False negative hospital IMPROVE include indicated Nasopharyngeal swab Older older patient older patient. older patients other conditions pathway Patient Prevalence Prevent pulmonary Pulmonary emboli Pulmonary embolus pursuit radiation exposure raised Severe infection significantly specificity suspected patient suspected patients swabs Symptom thromboembolic disease transferred Treatment Venous Thromboembolism [DOI] 10.1007/s12603-020-1450-0 PMC 바로가기 [Article Type] Case Reports