Lineage abundance estimation for SARS-CoV-2 in wastewater using transcriptome quantification techniquesArticle Published on 2022-11-082022-11-16 Journal: Genome Biology [Category] SARS, 변종, 유전자 메커니즘, [키워드] Algorithm can be used clinical samples effort high variability Lineage MONITOR mutant pandemic Prevalence quantification SARS-CoV-2 SARS-CoV-2 mutant SARS-CoV-2 RNA Sequencing Spread Surveillance Transcriptome [DOI] 10.1186/s13059-022-02805-9 PMC 바로가기
Enhanced Label-Free Nanoplasmonic Cytokine Detection in SARS-CoV-2 Induced Inflammation Using Rationally Designed Peptide AptamerArticle Published on 2022-11-022022-11-15 Journal: ACS applied materials & interfaces [Category] COVID19(2023년), SARS, 치료기술, 치료제, [키워드] acute respiratory syndrome Analysis Antibody-derived peptide aptamer (ADPA) applied aptamer Biomarker coronavirus COVID-19 patients cytokine detection Detection limit Disease progression disorders enhanced IL-6 immune pathway Immune status immunoassay immunoassays in vitro induced Inflammation inflammatory status information interleukin 6 (IL-6 Interluekin-6 (IL-6) Interpretation limit of detection localized surface plasmon resonance (LSPR) magnitude nanoplasmonic immunoassay pandemic pathogenic inflammation Patient peptide Predictive profile Prognosis provide quantification Rapid SARS-CoV-2 serum serum cytokine severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) [DOI] 10.1021/acsami.2c14748 PMC 바로가기
Multiplex Hybrid Antigen-Capture LC-MRM Quantification in Sera and Nasal Lining Fluid of AZD7442, a SARS-CoV-2-Targeting Antibody CombinationArticle Published on 2022-11-012022-11-15 Journal: Analytical Chemistry [Category] COVID19(2023년), SARS, 진단, 치료기술, 치료제, [키워드] antibodies antibody applicability approach binding capture reagent clinical analysis Combination complementarity-determining region conditions coronavirus disease Critical demonstrated domain extension Final hybrid implementation Infection Ligand limit lining mAb macromolecules Magnetic beads matrix effect monoclonal antibody multidimensional nasal offer patient population peptide performed platform quantification reagent reagents reproducibility required sensitivity serum significantly Tandem mass spectrometry Treatment vaccination viral spike protein [DOI] 10.1021/acs.analchem.2c01320 PMC 바로가기
Covid-MANet: Multi-task attention network for explainable diagnosis and severity assessment of COVID-19 from CXR imagesResearch article Published on 2022-11-012022-10-05 Journal: Sensors (Basel, Switzerland) [Category] 진단, 치료기술, [키워드] Accuracy approach assigned automated Bacterial chest X-ray CNN conducted COVID-19 COVID-19 case COVID-19 cases COVID-19 diagnosis COVID-19 disease COVID-19 infection Critical CXR dataset deep learning develop Diagnosis disease early diagnosis eight experiment Explainable AI False negative Final first stage Health highlight IMPROVE Infection Infection Segmentation initial Interpretation lung Lung segmentation Lungs measure Mild moderate outbreak outperform Pneumonia predicted proportion quantification radiological examination reduced Region reported Research research finding RT-PCR test scoring system sensitivity sensitivity analysis severity severity of COVID-19 Stage Support transfer learning Tuberculosis Viral pneumonia with COVID-19 [DOI] 10.1016/j.patcog.2022.108826 [Article Type] Research article
Clinical decision analysis of elective delivery vs expectant management for pregnant individuals with COVID-19–related acute respiratory distress syndromeResearch article Published on 2022-11-012022-10-05 Journal: American journal of obstetrics & gynecology MFM [Category] 임상, [키워드] acute respiratory distress acute respiratory distress syndrome age Analysis cesarean delivery children clinical decision Clinical decision analysis comparable Complication Computer simulation COVID-19 Critical illness death Decision analysis determine Elective Evidence gestation hospital individual individuals iteration lack likelihood management Maternal Model Mortality mortality risk Neonatal Neonates neonatology obstetrics outcome outcomes parameter performed Pregnancy pregnant premature birth quantification risk sensitivity analysis severity spontaneous labor survival syndrome the mean utility Ventilated [DOI] 10.1016/j.ajogmf.2022.100697 [Article Type] Research article
Distance-based detection of out-of-distribution silent failures for Covid-19 lung lesion segmentationResearch article Published on 2022-11-012022-10-05 Journal: Medical image analysis [Category] 치료기술, [키워드] 68T30 68T37 68T45 approach Automatic chest computer tomography Chest CT clinically consolidation deep learning detect distribution Ground glass opacity lung magnetic resonance imaging Prostate quantification radiologist resource silent [DOI] 10.1016/j.media.2022.102596 [Article Type] Research article
Repurposing of HIV/HCV protease inhibitors against SARS-CoV-2 3CLproArticle Published on 2022-11-012022-11-15 Journal: Antiviral Research [Category] SARS, 변종, 신약개발, 치료제, [키워드] 3CL pro 3CLpro acute respiratory syndrome Anti-coronavirus drug antiviral drug applied caused cleavage Compound coronavirus COVID-19 outbreak dose-dependent manner Efficiency energy transfer exhibited feasibility HCV in vitro inhibited inhibitor inhibitors Mutation omicron pathogen predicted protease Protease inhibitor protease inhibitors quantification reproducibility repurposing SARS-CoV-2 Screening Screening assay severe acute respiratory syndrome coronavirus 2 Support variants virus replication [DOI] 10.1016/j.antiviral.2022.105419 PMC 바로가기
SARS-CoV-2 wastewater monitoring using a novel PCR-based method rapidly captured the Delta-to-Omicron ΒΑ.1 transition patterns in the absence of conventional surveillance evidenceArticle Published on 2022-10-202022-11-15 Journal: The Science of the total environment [Category] COVID19(2023년), SARS, 변종, 치료기술, 치료제, [키워드] absence acquisition amplify Analysis applicability approach characterized clinical sample Conventional Delta delta variant Delta wave dependent on described doubling early warning epidemic wave epidemiological situation Epidemiology Evidence genomic genomic region genotyping Greece influence information Measures methodology omicron Omicron BA.1 PCR amplification PCR-based method plant Prevalence proportion provide Public health interventions quantification rapid increase reached real-time RT-PCR reported SARS-CoV-2 SARS-CoV-2 surveillance selective Sequencing state Surveillance surveillance data Thessaloniki variant Viral load virus wastewater Wastewater-based epidemiology [DOI] 10.1016/j.scitotenv.2022.156932 PMC 바로가기
Forty Years of Molecular Diagnostics for Infectious DiseasesArticle Published on 2022-10-192022-11-15 Journal: Journal of Clinical Microbiology [Category] 유전자 메커니즘, 진단, 치료기술, [키워드] amplification assumed Care coronavirus disease COVID-19 detect diagnostic diagnostic molecular microbiology diagnostics DNA DNA sequencing elapsed Factors Health in vitro Infectious disease Intersection knowledge Magnetic beads microbial molecular nucleic acid nucleic acids nucleotide nucleotide array pandemic pathophysiologic PCR Perspective point of care progression quantification Quantitative real-time quantitative PCR Sequencing syndromic panel. turn Year [DOI] 10.1128/jcm.02446-21 PMC 바로가기
Wastewater-based epidemiology in countries with poor wastewater treatment – Epidemiological indicator function of SARS-CoV-2 RNA in surface waters폐수 처리가 열악한 국가의 폐수 기반 역학 - 지표수에서 SARS-CoV-2 RNA의 역학 지표 기능Article Published on 2022-10-152022-09-11 Journal: The Science of the total environment [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, 치료법, 치료제, [키워드] adaptation adoption affected alternative analysed applied approach Bacteria Belgrade collected complex complex systems Concentration country COVID-19 Danube effort epidemiological epidemiological purposes Epidemiology Factor Factors Faecal pollution Genes Genetic human populations identify indicated methodology N1 and N2 nucleocapsid outbreak parameter physicochemical primer set primer sets Protein qualitative data quantification quantified Quantitative recipient river RNA RT-qPCR SARS-CoV-2 SARS-CoV-2 RNA SARS-CoV-2 surveillance Sava Serbia surface Surface waters Surveillance Treatment Untreated wastewaters. Volume water [DOI] 10.1016/j.scitotenv.2022.156964 PMC 바로가기 [Article Type] Article