A CLEIA Antigen Assay in Diagnosis and Follow-Up of SARS-CoV-2-Positive SubjectsSARS-CoV-2-양성 피험자의 진단 및 후속 조치에 대한 CLEIA 항원 분석Article Published on 2022-06-292022-09-11 Journal: Microbiology Spectrum [Category] COVID19(2023년), SARS, 치료기술, [키워드] Accuracy Analysis Antigen antigenic antigenic test association chemiluminescence clinical recovery clinical status covariate Cox model Cutoff cutoff value diagnostic enzyme enzyme immunoassay Evolution faster Follow-up immunoassay include Infection kinetic log-transformed longitudinal molecular molecular test Nasopharyngeal swab nasopharyngeal swabs negative swabs performed persistence positive Probability raising reached receiver operating characteristic required resulting ROC SARS-CoV-2 SARS-CoV-2 test sensitivity Sensitivity and specificity specificity subject subjects Swab Symptoms test result tested [DOI] 10.1128/spectrum.01032-21 PMC 바로가기 [Article Type] Article
An engineered ACE2 decoy neutralizes the SARS-CoV-2 Omicron variant and confers protection against infection in vivo조작된 ACE2 미끼는 SARS-CoV-2 Omicron 변이체를 중화하고 생체 내 감염으로부터 보호합니다.Article Published on 2022-06-222022-09-11 Journal: Science Translational Medicine [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료제, [키워드] ACE2 Alpha alpha and delta variants Analysis analyzed angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 antibodies B.1.1.529 BNT162b2 breakthrough infections Casirivimab chimeric Complete conserved conserved region contributed convalescent serum deep delta variant Delta variants demonstrated dose drugs effective enzyme escape escaped evade exhibited Frequency hamster hamsters human ACE2 Imdevimab immunized in vivo individual Infection multiple mutation multiple mutations Mutation N-terminal domain neutralization neutralization titer neutralize neutralized of BNT162b2 omicron parental prevented pseudo-virus raising Receptor binding domain sarbecovirus SARS-CoV-2 variant SARS-CoV-2 variants sensitivity serum serum sample serum samples Sotrovimab Spike protein Spike proteins target the SARS-CoV-2 the spike protein theory therapeutic therapeutic antibodies therapeutic effect transgenic mice vaccination Vaccines variant variants Viral viral mutation virus virus-neutralizing Wuhan strain [DOI] 10.1126/scitranslmed.abn7737 PMC 바로가기 [Article Type] Article
Evaluation of the safety and immunogenicity of different COVID-19 vaccine combinations in healthy individuals: study protocol for a randomized, subject-blinded, controlled phase 3 trial [PRIBIVAC]건강한 개인에서 다양한 COVID-19 백신 조합의 안전성 및 면역원성 평가: 무작위, 피험자 맹검, 대조 3상 시험을 위한 연구 프로토콜 [PRIBIVAC]Article Published on 2022-06-162022-09-11 Journal: Trials [Category] COVID19(2023년), MERS, SARS, 변종, 임상, 진단, [키워드] adverse event adverse events anti-SARS-CoV-2 antibodies antibody approval best blood sample Blood samples BNT162b2 boost booster booster dose booster vaccinations cellular Cellular immune response collected Combination Comprehensive control arm Controlled clinical trial CoronaVac country COVID-19 COVID-19 vaccination COVID-19 vaccine COVID-19 vaccines demonstration different time point different time points dose Effectiveness Eligible participants Endpoint enrolment evade excluded group healthy Heterologous homologous host immunity humoral immune immune profiling immune response Immunity Immunocompromised immunogenicity Immunoglobulin immunoglobulins Inactivated vaccine Infection Intervention intervention arm Laboratory test Laboratory tests Local maintain mRNA mRNA vaccine mRNA-1273 omicron over parameters participant performed persistence phase Phase 3 phase 3 trial physical population immunity pregnant primary endpoint Probability quantity raising randomization Randomized Randomized controlled trial regimen Regulatory SARS-CoV-2 SARS-COV-2 infection Serious Adverse Event Serious Adverse Events Singapore Study protocol vaccination Vaccine vaccine availability vaccine booster vaccine candidate variants variants of concern volunteers wildtype [DOI] 10.1186/s13063-022-06345-2 PMC 바로가기 [Article Type] Article
A cross-sectional multicenter linkage study of hospital admissions and mortality due to methanol poisoning in Iranian adults during the COVID-19 pandemic Research Published on 2022-06-132022-10-05 Journal: Scientific Reports [Category] 치료법, [키워드] Admission age alcohol alcohol poisoning average collected conducted coronavirus disease COVID-19 COVID-19 infection COVID-19 pandemic cross-sectional deaths Diagnosis died East Epidemiology evaluate facilitate Hemodialysis hospital Hospital admission Hospitalization Hospitalized ingestion initial Iran Medicine methanol morbidity Mortality mortality data multicenter non-survivor not significantly different occurred organization outbreak outcome pandemic Patient Prevent raising reduce reduction risk scale significantly lower study period survivor Symptom Treatment [DOI] 10.1038/s41598-022-14007-1 [Article Type] Research
Immunogenicity of convalescent and vaccinated sera against clinical isolates of ancestral SARS-CoV-2, Beta, Delta, and Omicron variants조상 SARS-CoV-2, 베타, 델타 및 오미크론 변이체의 임상 분리주에 대한 회복기 및 백신 접종 혈청의 면역원성Article Published on 2022-06-102022-09-11 Journal: Med (New York, N.Y.) [Category] COVID19(2023년), MERS, SARS, 변종, 임상, 진단, [키워드] antibody Antibody titers Beta booster vaccination Canada CL3 clinical isolates convalescent convalescent individual convalescent individuals convalescent sera coronavirus coronavirus disease COVID-19 Delta delta variant demonstrated dose foundation Government immunogenicity individual induce initiative Innovation isolate long-term Major microneutralization Ministry of Agriculture Moderna multiple mutation multiple mutations neutralization Neutralizing Neutralizing activity Neutralizing antibodies neutralizing antibody Neutralizing antibody titer omicron Omicron variant Pfizer raising receive recipient reduced Research SARS-CoV-2 Science sera significantly higher Spike protein the spike protein vaccinated individual vaccinated individuals Vaccine variant variants variants of concern VIDO virus VoC VOCs [DOI] 10.1016/j.medj.2022.04.002 PMC 바로가기 [Article Type] Article
The COVID-19 pandemic – what have urologists learned?COVID-19 전염병 - 비뇨기과 전문의는 무엇을 배웠습니까?Review Published on 2022-06-012022-09-11 Journal: Nature reviews. Urology [Category] COVID19(2023년), SARS, 임상, 치료기술, 치료법, [키워드] ACE2 Acute kidney injury acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 affecting AKI androgen angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 caused cell damage changes in clinical study Complication complications coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 pandemic damage Deprivation Economy expressed genitourinary tract high risk hypogonadism impairment in urine Invasion organ organs outbreak pandemic patients with COVID-19 public health raising receptor reported respiratory tract SARS-CoV-2 secondary hypogonadism Semen severe acute respiratory syndrome Coronavirus spermatogenesis survival Symptom testes Testosterone the WHO therapy tract treating COVID-19 Urine [DOI] 10.1038/s41585-022-00586-1 PMC 바로가기 [Article Type] Review
Emergence of SARS-CoV-2 Omicron (B.1.1.529) variant, salient features, high global health concerns and strategies to counter it amid ongoing COVID-19 pandemicSARS-CoV-2 오미크론(B.1.1.529) 변종, 두드러진 특징, 높은 전 세계 건강 문제 및 진행중인 COVID-19 대유행 속에서 이에 대응하기 위한 전략의 출현Review Published on 2022-06-012022-09-11 Journal: Environmental research [Category] COVID19(2023년), MERS, SARS, 변종, 유전자 메커니즘, 진단, [키워드] accumulation Alpha Analysis animals appearance approach B.1.1.529 Beta booster doses China COVID-19 pandemic Delta Delta variants Diagnosis Efficacy emergence evade Evolution explain Features Gamma generate Genome genome analysis Health humans Immune escape immune pressure Immunity immunotherapies Immunotherapy implementation Infection late less lethality long term measure multivalent vaccine mutated Mutation mutation rate Mutation rates natural infection omicron Omicron origin patients persistence pre-existing immunity prevention Prevention and control raising receiving SARS-CoV-2 SARS-CoV-2 pandemic Spike protein the spike protein Therapies vaccination Vaccine Vaccine failure Vaccines variant variant of concern variants virus VoC [DOI] 10.1016/j.envres.2022.112816 PMC 바로가기 [Article Type] Review
Lung cancer and Covid-19: lessons learnt from the pandemic and where do we go from here?폐암과 코비드-19: 전염병으로부터 배운 교훈과 우리는 여기서 어디로 가야 합니까?Article Published on 2022-05-302022-09-11 Journal: NPJ Primary Care Respiratory Medicine [Category] 바이오마커, 변종, 임상, 치료기술, [키워드] broader impact Cancer cancer diagnosis COVID-19 pandemic Diagnosis diagnostic early diagnosis groups Health services healthcare impacted individual interval lung cancer overlapping pandemic primary care raising Recognition reduced Referral significantly Strategy Symptom Symptoms symptoms of COVID-19 Treatment variant [DOI] 10.1038/s41533-022-00283-x PMC 바로가기 [Article Type] Article
ClusTRace, a bioinformatic pipeline for analyzing clusters in virus phylogenies바이러스 계통발생의 클러스터를 분석하기 위한 생물정보학 파이프라인인 ClusTRaceArticle Published on 2022-05-282022-09-11 Journal: BMC Bioinformatics [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] accumulation aligning Analysis bioinformatic analysis clade clades Cluster cluster analysis complex coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 transmission cut down Early detection effective effort etiologic agent feature growth in-depth analysis Lineage marker mutations offer outlier Phylogenetic analysis Phylogenetic tree phylogenies Phylogeny provide public health raising Reporting SARS-CoV-2 sequence significantly super-spreading event super-spreading events Treatment treatment of COVID-19 variant Variant calling variants of SARS-CoV-2 virus Visualization [DOI] 10.1186/s12859-022-04709-8 PMC 바로가기 [Article Type] Article
Detecting Potentially Adaptive Mutations from the Parallel and Fixed Patterns in SARS-CoV-2 EvolutionSARS-CoV-2 진화의 병렬 및 고정 패턴에서 잠재적으로 적응 가능한 돌연변이 감지Article Published on 2022-05-182022-09-11 Journal: Viruses [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] adaptive complementary COVID-19 COVID-19 pandemic detect disease disease control dominant Evolution Evolution of SARS-CoV-2 fixed help identify Mutation mutations pattern Phylogenetic provide raising Recognition researcher SARS-CoV-2 SARS-CoV-2 sequencing Spike protein Support trajectory [DOI] 10.3390/v14051087 PMC 바로가기 [Article Type] Article