Comparative efficacy and safety of pharmacological interventions for severe COVID-19 patients: An updated network meta-analysis of 48 randomized controlled trialsArticle Published on 2022-10-142022-11-15 Journal: Medicine [Category] meta-analysis, 진단, [키워드] Abstract ACM all-cause mortality Characteristics Colchicine Comparative convalescent plasma database decrease dosage effective Efficacy and safety hyperimmune Imatinib Immunoglobulin Intravenous immunoglobulin medication Methylprednisolone Network meta-analysis Older participant Patient pharmacological intervention Placebo Randomized controlled trial RCT RCTs Remdesivir Safe sarilumab searched severe COVID-19 Severe COVID-19 Infection severe COVID-19 patients suggested TEAE TEAEs treatment-emergent adverse event Trial [DOI] 10.1097/MD.0000000000030998 PMC 바로가기
COVIDMED – An early pandemic randomized clinical trial of losartan treatment for hospitalized COVID-19 patientsShort communication Published on 2022-10-012022-10-30 Journal: Contemporary Clinical Trials Communications [Category] COVID-19, 임상, 치료법, [키워드] AE/SAE Analysis Angiotensin converting enzyme inhibitor (ACEi) Angiotensin II receptor Blocker (ARB) Arm baseline controls COVID-19 COVID-19 patients double-blinded Efficacy and safety Enrollment Final hospitalized COVID-19 patient hospitalized COVID-19 patients Hydroxychloroquine IMPROVE Lopinavir-ritonavir losartan Mortality MOST objective outcome pandemic parameter Patient Placebo placebo-controlled platform primary endpoint Randomized randomized clinical trial Randomized clinical trial (RCT) RCT Result SARS-CoV-2 score slow standard care the mean Treatment [DOI] 10.1016/j.conctc.2022.100968 [Article Type] Short communication
Safety and efficacy of COVID-19 vaccines in children and adolescents: A systematic review of randomized controlled trials소아 및 청소년에 대한 COVID-19 백신의 안전성 및 효능: 무작위 대조 시험의 체계적인 검토Review Published on 2022-10-012022-09-11 Journal: Journal of medical virology [Category] Fulltext, MERS, 임상, [키워드] Abstract age Analysis bias risk children Children and adolescents Chinese clinical clinical trial Cochrane Library code common adverse event common adverse events coronavirus coronavirus disease cough COVID-19 COVID-19 infection COVID-19 vaccine COVID-19 vaccines data extraction Efficacy evaluated fatigue Fever groups headache ICTRP immunization Injection-site pain investigated Local Messenger RNA Microsoft Excel Mild mild to moderate moderate MOST mRNA mRNA vaccine mRNA vaccines muscle pain Pain participant pediatric Placebo profile Randomized controlled trial Randomized controlled trials RCT RCTs reaction Reactions registry reported Safety searched Serious Adverse Events Seven stratified suggested systematic review systemic adverse event the vaccine title Trial vaccination Vaccine was used Web of Science website were used [DOI] 10.1002/jmv.27940 PMC 바로가기 [Article Type] Review
A review of clinical efficacy data supporting emergency use authorization for COVID-19 therapeutics and lessons for future pandemicsArticle Published on 2022-10-012022-11-15 Journal: Clinical and translational science [Category] COVID19(2023년), SARS, 치료제, [키워드] Anti-inflammatory Antiviral approved authorization chloroquine/hydroxychloroquine Clinical data Clinical efficacy clinical evidence clinical study clinical trial coronavirus disease COVID-19 COVID-19 pandemic COVID-19 therapeutics Critical demonstrated drug Efficacy Emergency Emergency use authorization EUA Evidence FDA food Guidance majority medication Pandemics public health emergency question Randomized controlled trial RCT Regulatory Resilience statistically significant submitted subsequent Support supported therapeutic withdrawn [DOI] 10.1111/cts.13384 PMC 바로가기
COVID-19 Convalescent Plasma and Clinical Trials: Understanding Conflicting OutcomesArticle Published on 2022-09-212022-11-16 Journal: Clinical microbiology reviews [Category] Fulltext, MERS, 변종, [키워드] acute respiratory syndrome administration analyzed antibody approaches benefit case sery CCP clinical Clinical improvement clinical settings clinician Confusion convalescent convalescent plasma coronavirus COVID-19 COVID-19 pandemic criteria defined demonstrated Diagnosis disease severity dose Efficacy Emergency use authorization Epidemics EUA FDA Hospitalization include less mechanism Molecular diagnosis Mortality Neutralizing Neutralizing antibodies Neutralizing titer omicron onset of symptoms outcome Patient plasma Pneumonia polyclonal propensity score-matched randomization Randomized randomized clinical trial Randomized controlled trial RCT RCTs reductions in reported resulting SARS-CoV-2 serostatus Survivors Therapies Treatment Trial understanding variable variant Ventilation Viral neutralization tests WHO guideline [DOI] 10.1128/cmr.00200-21 PMC 바로가기
OnTrack Chile for people with early psychosis: a study protocol for a Hybrid Type 1 trialArticle Published on 2022-09-052022-10-05 Journal: Trials [Category] 임상, [키워드] adaptation Administered age approach approaches assessment Care Chilean clinics conducted Controlled trial Coordinated specialty care country Course COVID-19 pandemic determine dynamic Early psychosis Effectiveness engage Enrollment episode evaluate expected facilitator feasibility finding Global mental health group help hybrid Hybrid Type 1 trial implementation include individual Intervention Latin Latin America lesson Mental mental health National offered outcome over participant Participants primary care Process protocol provided Psychosis public health RCT Research secondary Specialized coordinated services for first episode psychosis. Study protocol Support Symptom Symptoms Treatment Trial Type unique USA [DOI] 10.1186/s13063-022-06661-7 PMC 바로가기 [Article Type] Article
Building Emotional Awareness and Mental Health (BEAM): study protocol for a phase III randomized controlled trial of the BEAM app-based program for mothers of children 18-36 monthsArticle Published on 2022-09-052022-10-05 Journal: Trials [Category] 임상, [키워드] Anxiety anxiety symptoms assessment Awareness build building children Cohort COVID-19 pandemic Depression Efficacy elevated emotion evaluate finding Follow-up Health IMPROVE improvement individual Intervention Maternal mental health mental health disorders mental illness mother occur pandemic Parenting pregnant Prevalence Primary outcome programming Psychoeducation Randomized Randomized controlled trial RCT RCT. recruited reducing repeated measure risk Secondary outcomes Stress Study protocol Support Symptom Symptoms symptoms of depression Tau treatment as usual treatment group Trial Two-arm used to evaluate [DOI] 10.1186/s13063-022-06512-5 PMC 바로가기 [Article Type] Article
A home-based, multidisciplinary liver optimisation programme for the first 28 days after an admission for acute-on-chronic liver failure (LivR well): a study protocol for a randomised controlled trialArticle Published on 2022-09-052022-10-05 Journal: Trials [Category] 임상, [키워드] 1:1 28-day mortality addition Admission Admissions Analysis Appendix 1 benefit Care changes in chronic chronic condition chronic disease chronic liver disease cirrhosis clinical Clinical improvement Clinicians Cohort conducted COVID-19 COVID-19 pandemic criteria disease evaluated exploratory subgroup analysis feasibility generalisability generate global healthcare Health Health Service health team healthcare Healthcare systems heart failure hospitalisation implementation implication include Interdisciplinary health team. interim analysis Intervention intervention arm liver Liver disease Melbourne, Australia Mortality mortality risk New outcome participant Patient performed Prevalence Primary outcome Quality of life randomisation randomised randomised controlled trial RCT readmission recruit recruited recruitment reduced reducing Registered Registration registry required resource rising robust Safe secondary severity small sample size social work Study protocol suggested Treatment Trial well WHO [DOI] 10.1186/s13063-022-06679-x PMC 바로가기 [Article Type] Article
Study protocol for a pilot randomized controlled trial to increase COVID-19 testing and vaccination among people who inject drugs in San Diego CountyArticle Published on 2022-09-052022-10-05 Journal: Addiction Science & Clinical Practice [Category] SARS, 임상, [키워드] analyses Antigen board cohort study Community condition COVID-19 COVID-19 testing COVID-19 vaccination develop Diego drug effect size Efficacy estimate event facilitate finding Follow-up harm reduction health authorities Health status impacted include information intake Intervention intravenous lesson Local Motivational interviewing offer organization outcomes participant pilot study Population populations Precision protocol Randomized Randomized controlled trial RCT recruit reduction Registered SARS-CoV-2 severe disease state health department Study design substance Substance use Support Trial vaccination Vulnerable populations [DOI] 10.1186/s13722-022-00328-z PMC 바로가기 [Article Type] Article
Research interrupted: applying the CONSERVE 2021 Statement to a randomized trial of rehabilitation during critical illness affected by the COVID-19 pandemicRandomized Controlled Trial Published on 2022-09-022022-10-05 Journal: Trials [Category] SARS, 임상, [키워드] active site activity affected applied approaches assessment assessments Canada CONSORT COVID-19 pandemic creating Critical Critical care Critical illness Cycling data entry determine discharge Endpoint enrolled extremity Guidance ICU ICUs In-hospital intensive care unit International Intervention Lower management Modification outcomes pandemic Patient Patient care physical Primary outcome Primary outcomes protocol provide Randomized Randomized controlled trial Randomized controlled trials randomized trial RCT receiving recruitment rehabilitation required Research Research design Research personnel Research report. retained risk strength Trial [DOI] 10.1186/s13063-022-06640-y PMC 바로가기 [Article Type] Randomized Controlled Trial