Relevant SARS-CoV-2 Genome Variation through Six Months of Worldwide MonitoringResearch Article Published on 2021-06-292022-10-27 Journal: BioMed Research International [Category] Coronavirus, COVID-19, MERS, SARS, [키워드] Analysis analyzed Antiviral treatment Asia changed Cluster Clustering analysis D614G diagnostic event Evolution of SARS-CoV-2 False-positive Frequency Genome Genome sequencing geographical location GISAID database hotspot information monitoring Month Mutation nonsynonymous mutation occurred Oceania ORF3a outbreak pandemic provide Q57H reference genome SARS-CoV-2 SARS-CoV-2 genome the SARS-CoV-2 transition Vaccination strategies variant Variation was used [DOI] 10.1155/2021/5553173 PMC 바로가기 [Article Type] Research Article
Towards complete and error-free genome assemblies of all vertebrate speciesArticle Published on 2021-04-282022-10-04 Journal: Nature [Category] 유전자 메커니즘, [키워드] breakpoint canonical chromosome Complete complex develop disease duplications effort evaluate Evolutionary genetics GC-rich generate Genome genome assembly Genome assembly algorithms genomes Genomes Project Haplotype help include increases in independent International lineages molecular evolution protein-coding gene reference genome regions Regulatory repeated representing Research data sequence sequencing technology Vertebrate [DOI] 10.1038/s41586-021-03451-0 PMC 바로가기 [Article Type] Article
The Mutation Profile of SARS-CoV-2 Is Primarily Shaped by the Host Antiviral DefenseSARS-CoV-2의 돌연변이 프로필은 주로 숙주 항바이러스 방어에 의해 형성됩니다Article Published on 2021-03-022022-09-10 Journal: Viruses [Category] SARS, 변종, 유전자 메커니즘, [키워드] ADAR Antiviral APOBEC approach contribute COVID-19 COVID-19 pandemic effort event Evolution Genome genomes heterogeneous Host independent independent of mechanism Mutagenesis Mutation number of infected oxygen Phylogenetic tree phylogenetics profile Proteins reactive oxygen species reference genome ROS SARS-CoV-2 SARS-CoV-2 evolution SARS-CoV-2 genomes SARS-CoV-2 isolates understanding virus virus genome virus genomes ZAP [DOI] 10.3390/v13030394 PMC 바로가기 [Article Type] Article
Current mutatome of SARS-CoV-2 in Turkey reveals mutations of interestArticle Published on 2021-02-092022-10-29 Journal: Turkish Journal of Biology [Category] COVID-19, [키워드] affected analyzed complicate coronavirus COVID-19 COVID-19 pandemic current database demographics Effect facilitate Genome genome analysis global genomes highest host proteins information isolate Local Mutation Mutation profiling mutations pathogen Protein reference genome replicate Replication Research reveal SARS-CoV-2 SARS-CoV-2 isolate SARS-CoV-2 mutation the disease Treatment Turkey viral genome virus virus genome [DOI] 10.3906/biy-2008-56 PMC 바로가기 [Article Type] Article
Full-length genome characterization and phylogenetic analysis of SARS-CoV-2 virus strains from Yogyakarta and Central Java, IndonesiaBioinformatics Published on 2020-12-212022-10-28 Journal: PeerJ [Category] COVID-19, [키워드] Analysis appear applied Asia circulating clade Cluster collected Complete COVID-19 COVID-19 patient COVID-19 situation D614G mutation dataset dissemination distribution Europe full-length full-length genome sequence Genome GISAID Hospitalized Illumina Miseq Indonesia NC_045512.2 Next-generation sequencing NGS Patient Phylogenetic analysis reference genome Region Result retrieved SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 virus SARS-CoV-2 virus strain sequence severity variant virus virus genome virus sample was performed WGS Whole genome sequencing [DOI] 10.7717/peerj.10575 PMC 바로가기 [Article Type] Bioinformatics
The ninth life of the cat reference genome, Felis_catus고양이 참조 게놈 Felis_catus의 아홉 번째 수명Perspective Published on 2020-10-222022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] reference genome [DOI] 10.1371/journal.pgen.1009045 PMC 바로가기 [Article Type] Perspective
A new domestic cat genome assembly based on long sequence reads empowers feline genomic medicine and identifies a novel gene for dwarfism긴 서열 판독을 기반으로 한 새로운 국내 고양이 게놈 어셈블리는 고양이 게놈 의학에 힘을 실어주고 왜소증에 대한 새로운 유전자를 식별합니다Research Article Published on 2020-10-222022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] aligned allele analyses Analysis Author Biology Biosynthesis Cancer candidate cats chromosome complex correlated Deleterious disease distribution duplication dwarfism expansion facilitate FBXW7 Felis framework Genome genome assembly genomic genomic variation Glucose Health help Households human gene Human genetics humans identify Impact IMPROVE information involved landscape lead Lineage lymphoma Mutation mutations nucleotide patients phenotype Phenotypes predicted rare diseases reference genome resource screened sequence sequence variation significantly Single nucleotide variant single nucleotide variants SNV SNVs Structural variant structural variants susceptibility SVs Tumor tumor suppressor UGDH USA utility variant Variation whole genome sequence [DOI] 10.1371/journal.pgen.1008926 PMC 바로가기 [Article Type] Research Article
Anti-COVID-19 multi-epitope vaccine designs employing global viral genome sequencesBioinformatics Published on 2020-08-032022-10-28 Journal: PeerJ [Category] COVID-19, [키워드] alleles Analysis antigenic antigenicity approach approved B cell epitope binding binding affinity caused Complete consensus sequence coronavirus SARS-CoV-2 COVID-19 CTL epitope demonstrated develop epitope epitope mapping Escherichia coli expression Genome GISAID global pandemic global public health HLA HTL immune response Immunity immunogenic potential immunoinformatics in silico interferon molecular docking Multi-epitope vaccine NC_045512.2 non-allergenic ORFs overlapping Phylogeny predicted reading reference genome reference sequence reported Result retrieved SARS-CoV-2 SARS-CoV-2 strain screened significantly the Coronaviridae TLR8 Treatment Vaccine viral genome sequence viral strains was performed [DOI] 10.7717/peerj.9541 PMC 바로가기 [Article Type] Bioinformatics
Evolving geographic diversity in SARS-CoV2 and in silico analysis of replicating enzyme 3CL pro targeting repurposed drug candidatesResearch Published on 2020-07-092022-10-30 Journal: Journal of Translational Medicine [Category] COVID-19, SARS, [키워드] 3CL pro acute respiratory syndrome African analysed anti-malarial drug Anti-viral bat-CoV Clustal Omega collected Complete Compound cysteine protease database drug candidate enzyme fatality Genetic Genome genomic sequence GISAID high mutation rate host genome host immunity identity implication in silico analysis in silico approaches in-depth analysis individual infection rate inhibitor initiative Interaction isolate Local Multiple mutagenic mutations occurred pandemic Pandemics pangolin-CoV pathogen pathogenicity pharmacological populations provide recurrent mutation reference genome regulate reported Repurposed drug Result RNA SARS Coronavirus SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 infected patients SARS-CoV2 sequence South South America the SARS-CoV-2 unique viral genome viral pathogenicity viral replication viral sequence was collected was used Wuhan [DOI] 10.1186/s12967-020-02448-z PMC 바로가기 [Article Type] Research
Variant analysis of SARS-CoV-2 genomesResearch Published on 2020-07-012022-10-27 Journal: Bulletin of the World Health Organization [Category] COVID-19, [키워드] acute respiratory syndrome amino acid residues Analysis Bayesian changes clade clades coding region Coronavirus-2 D614G Deletion deletions downloaded finding Frame frameshift Genome genome variant genome variants identified variant indicated infected patient insertions Missense mutations Mutation mutations NC_045512 non-coding regions objective reference genome SARS CoV-2 SARS-CoV-2 SARS-CoV-2 genome several variant stop-gained subclades synonymous the SARS-CoV-2 genome the spike protein Transmission variant variants [DOI] 10.2471/BLT.20.253591 PMC 바로가기 [Article Type] Research