IL6-mediated HCoV-host interactome regulatory network and GO/Pathway enrichment analysisResearch Article Published on 2020-09-302022-10-28 Journal: PLoS Computational Biology [Category] COVID-19, SARS, [키워드] added Analysis analyzed Biology Biomarker candidate Cluster COVID-19 disease COVID-19 progression drug drug interaction enrichment analysis experiments Gene ontology help IL-6 information initial Interaction interactions involved lab miRNA outbreak pathway performed Protein Proteins provide reconstructed regulatory network researcher Result SARS-CoV-2 SARS-CoV-2 research significantly Support System Treatment urgency [DOI] 10.1371/journal.pcbi.1008238 PMC 바로가기 [Article Type] Research Article
Role of SARS-CoV-2 in Altering the RNA-Binding Protein and miRNA-Directed Post-Transcriptional Regulatory Networks in HumansArticle Published on 2020-09-252022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, SARS, [키워드] abundantly expressed alteration Altering Analysis analyzed caused characterized computational analysis contribute contributed Coronaviruses COVID-19 COVID-19 pandemic dataset differentially expressed gene dissect dysregulated dysregulation enrichment analysis event ExoN expressed functional Genes genomic genomic sequence gonadal Host immune response Human Human genome human tissue human tissues immune cells immune response Interaction lung cell majority micro-RNA miRs mock-treated modulate motif network novel coronavirus SARS-CoV-2 outbreak outcome performed post-transcriptional regulation progression Protein provided public health emergency RBPs Regulation regulatory network responsible RNA role SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2-infected cell Signaling the SARS-CoV-2 genome tissue viral infection [DOI] 10.3390/ijms21197090 PMC 바로가기 [Article Type] Article
Consensus transcriptional regulatory networks of coronavirus-infected human cellsAnalysis Published on 2020-09-222022-10-29 Journal: Scientific Data [Category] COVID-19, SARS, [키워드] airway Analysis Cell cells cellular signaling pathway Cellular signalling networks Consensus coronavirus CoV CoV infection Data integration dataset differential expression DNA replication driver E2F epithelial Establishing Evidence exchange Gene regulatory networks HCT human cell human gene hypothese Infection inflammatory signaling Intersection involved MERS MERS-CoV network progesterone receptor signaling Regulatory regulatory network Repository represse SARS-CoV-1 SARS-CoV-2 SARS1 SARS2 signaling pathway target transcriptional transcriptomic Viral host response [DOI] 10.1038/s41597-020-00628-6 PMC 바로가기 [Article Type] Analysis
Investigating the human protein-host protein interactome of SARS-CoV-2 infection in the small intestineOriginal Article Published on 2020-01-012022-10-31 Journal: Gastroenterology and Hepatology From Bed to Bench [Category] COVID-19, [키워드] ACE2 Antiviral association biological processes Biomarker categories COVID-19 patients database digestion disease DPP4 drug candidate drug targets drug-target interaction element expression functional Gastrointestinal symptom HNF1A HNF1B HNF4A host protein identify IMPROVE Infection Inflammation Interaction interactome investigated mechanism mechanisms MEP1A MEP1B Ontology organ pathway Pathways potential mechanism PPI Protein protein interaction Protein interaction network protein-protein interaction Public receptor ACE2 Regulatory regulatory network SARS-CoV-2 SARS-COV-2 infection small intestine the SARS-CoV-2 therapeutic target tissue transcription factor transcription factors Treatment strategies were used XPNPEP2 PMC 바로가기 [Article Type] Original Article
MicroRNA profile in HBV-induced infection and hepatocellular carcinomaResearch Article Published on 2017-12-012023-06-02 Journal: BMC Cancer [Category] B형 간염, [키워드] Hepatitis B virus Hepatocellular carcinoma microRNA regulatory network [DOI] 10.1186/s12885-017-3816-1 PMC 바로가기 [Article Type] Research Article
Shared genetic regulatory networks for cardiovascular disease and type 2 diabetes in multiple populations of diverse ethnicities in the United States미국 내 다양한 민족의 여러 인구에서 심혈관 질환 및 제2형 당뇨병에 대한 공유 유전 조절 네트워크Research Article Published on 2017-09-282022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] activity African Americans alterations American Americans Amino acid amino acid metabolism amino acids biological processe biological processes branched-chain amino acids cardiovascular cardiovascular disease cardiovascular diseases cause causes CAV1 Cell culture co-expression Cohort commonality complex disease connection Critical CVD data-driven death diabetes disease Diseases Diversity driven by driver ENCODE Epidemics eQTLs expression expression quantitative trait loci Extracellular matrix finding FIVE functional Functional genomics gene knockout gene network gene networks Genetic genetic risk Genome-wide association study Glucose graphical models GWAS GWAS hit help Hispanic HMGCR human population human populations hybrid identify IGF1 immune response in vitro in vivo information Integrative analysis knockdown lipids loci mechanism metabolism molecular molecular network mouse Mouse models multidimensional multiple tissues network models neuronal offer overlapping Panel Pathogenesis pathogenic pathogenic processe pathway Pathways PCOLCE Population populations Quantitative Regulatory regulatory network Risk factors shared pathway shared pathways siRNA Strains Support T2D the United State therapeutic therapeutic target tissues type 2 diabete type 2 diabetes [DOI] 10.1371/journal.pgen.1007040 PMC 바로가기 [Article Type] Research Article
Elucidation of the calcineurin-Crz1 stress response transcriptional network in the human fungal pathogen Cryptococcus neoformans인간 진균 병원체 크립토코커스 네오포르만스에서 칼시뉴린-Crz1 스트레스 반응 전사 네트워크의 해명Research Article Published on 2017-04-042022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] activated appear ascomycete ascomycetes Aspergillus fumigatus binding calcineurin calcium calmodulin Candida albican Candida albicans cascade Cell cell wall cellular cna1 conserved contribute Control Cryptococcus neoforman Cryptococcus neoformans docking domain down-regulated downstream Evidence expression of gene Factor function functions fungal fungal pathogen fungal pathogens fungi high temperature involved majority motif mRNA mRNA expression mutant mutants nuclear translocation nucleus P-bodies P-body pathogen pathogenic Pathogens pathway phenotype Phenotypes pheromone phosphatase post-transcriptional levels predicted promote promoter promoter region promoter regions Protein regulate regulated regulatory network responses RNA-sequencing Saccharomyces cerevisiae Serine Signal transduction Signaling small molecule Stress stress granule stress granules stress response survival target target gene Target genes targets threonine Transcription transcription factor transcriptional Transport virulence wild-type [DOI] 10.1371/journal.pgen.1006667 PMC 바로가기 [Article Type] Research Article
Systems Level Analyses Reveal Multiple Regulatory Activities of CodY Controlling Metabolism, Motility and Virulence in Listeria monocytogenes시스템 수준 분석을 통해 Listeria monocytogenes에서 대사, 운동성 및 독성을 제어하는 CodY의 여러 조절 활동이 밝혀졌습니다.Research Article Published on 2016-02-192022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] actA activate activator activity adaptation Affect Amino acid amino acids Analysis Bacteria bacterial pathogen Bacterial pathogens BCAA bind binding branch CodY condition conditions controlling dependent on DNA DNA binding environmental cues expression facilitate function functions Gene Expression Genes Genome gram Gram-positive bacteria growth Host identify identifying L . monocytogene Level Ligand ligands Listeria Listeria monocytogene Listeria monocytogenes mammalian metabolic genes metabolism modulate motility Multiple multiple pathway multiple pathways observation pathogen Pathogens pathway Pathways performed previous study prfA raised regulated regulator gene Regulatory regulatory network reported repress repressor respond response responses Sequencing Stress stress responses System Target genes thought traits Transcription transcription factor transcription factors virulence virulence gene virulence genes [DOI] 10.1371/journal.pgen.1005870 PMC 바로가기 [Article Type] Research Article
Microevolution of Candida albicans in Macrophages Restores Filamentation in a Nonfilamentous Mutant대식세포에서 칸디다 알비칸스의 소진화는 필라멘트가 아닌 돌연변이에서 필라멘트를 복원합니다Research Article Published on 2014-12-042022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] addition Antifungal treatment approach avirulent C. albican C. albicans Candida Candida albican Candida albicans Cdk8 Cell cell wall clinical setting complex component Compound connection drug resistance ENCODE environmental cue environmental cues Evolution example exhibited fungi gene encoding growth hosts hyphae hyphal identify in vivo Incubation induce Infection leads Macrophage macrophages maintain mechanism mediator Mediator complex microbe microevolution microevolutionary microorganism microorganisms Missense mutation murine mutant Mutation nucleotide pathogenic pathogenicity phagocytosis regulatory network responsible selection pressure Signaling signaling pathway single nucleotide strain subject the macrophage phagosome These data took place Transcription transcription factor transcription factors transcription regulation transcriptional transcriptional regulation undergo virulence whole genome yeast [DOI] 10.1371/journal.pgen.1004824 PMC 바로가기 [Article Type] Research Article