Rationale and Design for the LOnger-term effects of SARS-CoV-2 INfection on blood Vessels And blood pRessure (LOCHINVAR): an observational phenotyping study혈관 및 혈압(LOCHINVAR)에 대한 SARS-CoV-2 감염의 장기 효과에 대한 이론적 근거 및 설계: 관찰 표현형 연구Observational Study Published on 2022-06-012022-09-11 Journal: Open Heart [Category] COVID19(2023년), SARS, 임상, 치료기술, [키워드] All participant All participants All study participants angiotensin approved baseline Biomarkers Blood blood pressure blood sample Blood samples blood vessels brachial calculated Confirmed COVID-19 infection consequence Control controls COVID-19 COVID-19 infection detect discharge Effect Elizabeth endothelial Endothelium Ethics ethics committee Evidence evidence of Hospital admission hypertension Immune status include individual Interaction International mean difference medication Myocardial infarction normal blood pressure participant Patient peer-reviewed pilot study Primary outcome protocol provided rationale recruited registration number Renin renin-angiotensin system Research Research design Research Ethics Research Ethics Committee Sample Sample size SARS-CoV-2 SARS-COV-2 infection SBP stroke Study participants submitted systolic undergo university Urine Vascular vascular inflammation West with COVID-19 written Informed Consent [DOI] 10.1136/openhrt-2022-002057 PMC 바로가기 [Article Type] Observational Study
Structural insights revealed by crystal structure of B38-CAP, an isoenzyme of carboxypeptidase ACE2, the receptor of SARS-CoV-2SARS-CoV-2의 수용체인 카르복시펩티다제 ACE2의 동종효소인 B38-CAP의 결정 구조로 밝혀진 구조적 통찰력Article Published on 2022-05-282022-09-11 Journal: Biochemical and Biophysical Research Communication [Category] COVID19(2023년), SARS, 변종, [키워드] ACE2 ACE2 carboxypeptidase acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 anti-SARS-CoV-2 B38-CAP carboxypeptidase catalysis catalytic coincidence complex interplay conformational flexibility coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 crystal structure dimeric domain drugs enzyme feature Host Isoenzyme problem provide provided RAS receptor Renin renin-angiotensin system sACE2 SARS-CoV-2 SARS-CoV-2 variants severe acute respiratory syndrome Coronavirus specificity Structural analysis Treatment treatment of COVID-19 triggered variety weakened worldwide pandemic worsened [DOI] 10.1016/j.bbrc.2022.03.077 PMC 바로가기 [Article Type] Article
The Pathophysiology of Long COVID throughout the Renin-Angiotensin SystemReview Published on 2022-05-022023-07-09 Journal: Molecules [Category] COVID19(2023년), [키워드] Angiotensin II receptor type 1 Angiotensin II Receptor Type 2 angiotensin-converting enzyme 2 COVID-19 immunity disorders Infectious disease Long COVID renin-angiotensin system SARS-CoV-2 [DOI] 10.3390/molecules27092903 PMC 바로가기 [Article Type] Review
Angiotensin-converting enzyme 2 (ACE2): Two decades of revelations and re-evaluation안지오텐신 전환 효소 2(ACE2): 20년 간의 폭로와 재평가Review Published on 2022-05-012022-09-11 Journal: Peptides [Category] Coronavirus, COVID19(2023년), SARS, 유전자 메커니즘, [키워드] ACE ACE2 acting Amino acid amyloid angiotensin Angiotensin II Angiotensin-converting enzyme angiotensin-converting enzyme-2 binding cardiovascular caused cell membrane cell type conversion coronavirus counterbalance COVID COVID-19 pandemic driving ectoenzyme enzyme event expressed Factor homology implicated Inflammatory mechanisms membrane protein neprilysin pathological conditions Pathologies pathology Pathways peptide peptides physiological producing Protective provide provided receptor regulate Renin renin-angiotensin system sACE2 SARS SARS virus SARS-CoV2 specificity susceptibility therapeutic target Transport Treatment Vascular Vasoactive Vasopeptidase. virus Zinc [DOI] 10.1016/j.peptides.2022.170766 PMC 바로가기 [Article Type] Review
Type 1 diabetes is associated with significant changes of ACE and ACE2 expression in peripheral blood mononuclear cellsArticle Published on 2022-05-012023-07-08 Journal: Nutrition, metabolism, and cardiovascular diseases [Category] COVID19(2023년), [키워드] ACE2 COVID-19 diabetes Gender renin-angiotensin system Type 1 diabetes [DOI] 10.1016/j.numecd.2022.01.029
The Dysregulation of the Renin-Angiotensin System in COVID-19 Studied by Serum Proteomics: Angiotensinogen Increases with Disease Severity혈청 단백질체학으로 연구한 COVID-19에서 레닌-안지오텐신 시스템의 조절장애: 질병의 중증도에 따라 안지오텐시노겐 증가Article Published on 2022-04-122022-09-11 Journal: Molecules [Category] 유전자 메커니즘, [키워드] ACE Activation AGT analyses Analysis angiotensin angiotensinogen bradykinin Cohort complement Complement activation Concentration convalescent coronavirus correlated COVID-19 COVID-19 infection CPN Critically ill critically ill patients disease severity expression expression analysis followed by group healthy probands hospitalized COVID-19 patients hospitalized patient hospitalized patients increase indicated Infection investigated Kallikrein Kallikrein-kinin system KLKB1 KNG1 mass spectrometry pathophysiological pathway patients plasminogen profile Protein protein expression proteomics RAS Renin renin-angiotensin system separated serum Serum protein significantly statistical System was performed [DOI] 10.3390/molecules27082495 PMC 바로가기 [Article Type] Article
The atlas of ACE2 expression in fetal and adult human hearts reveals the potential mechanism of heart-injured patients infected with SARS-CoV-2태아 및 성인 인간 심장에서 ACE2 발현의 아틀라스는 SARS-CoV-2에 감염된 심장 부상 환자의 잠재적 메커니즘을 보여줍니다Article Published on 2022-04-012022-09-11 Journal: American journal of physiology. Cell physiology [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, [키워드] ACE2 ACE2 expression acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition Analysis analyzed angiotensin angiotensin I angiotensin I converting enzyme 2 binding calcium Calcium signaling Cardiomyopathy coronavirus dilated cardiomyopathy embryonic embryonic development embryos enzyme expressed gene expressing expression expression level expression profile fetal heart heart failure hearts host cell host cells increase infect infected with SARS-CoV-2 molecular docking Myocyte Numerous organs pathway Pathway analysis Patient potential mechanism Protein protein-protein interaction RAS RAS system regulate Renin renin-angiotensin system reveal risk of infection SARS-CoV-2 Sequencing analysis severe acute respiratory syndrome Coronavirus shown single-cell Spike protein Stage transcription profile upregulated upregulation variant spike various tissue various tissues ventricular was increased was used Wnt signaling pathway [DOI] 10.1152/ajpcell.00169.2021 PMC 바로가기 [Article Type] Article
Role of the renin-angiotensin system in NETosis in the coronavirus disease 2019 (COVID-19)코로나바이러스 질병 2019(COVID-19)의 NETosis에서 레닌-안지오텐신 시스템의 역할Review Published on 2022-04-012022-09-11 Journal: Biomedicine & pharmacotherapy = Biomédecine & phar [Category] COVID19(2023년), SARS, 치료기술, [키워드] ACEi angiotensin Angiotensin II angiotensin II type 1 receptor blockers Angiotensin system angiotensin-converting enzyme inhibitor angiotensin-converting enzyme inhibitors antagonist ARBs blocker Blood blood pressure Brain cause Complication contribute coronavirus disease COVID-19 death endocytosis Evidence explain Extracellular help hypertension induce Infarction involved kidney Low-density granulocytes lung mechanism Myocardial infarction NET NETosis NETs neutrophil neutrophil activation Neutrophil extracellular trap Neutrophil extracellular traps neutrophil recruitment Numerous organ Patient patients with COVID-19 procoagulant promote recent recent findings receptor reduce regulate Renin renin-angiotensin system risk role severe COVID-19 stroke thrombosis Treatment Trigger virus [DOI] 10.1016/j.biopha.2022.112718 PMC 바로가기 [Article Type] Review
SARS-CoV-2 interacts with renin-angiotensin system: impact on the central nervous system in elderly patientsReview Published on 2022-04-012023-07-08 Journal: GeroScience [Category] COVID19(2023년), [키워드] Central nervous system COVID-19 elderly renin-angiotensin system SARS-CoV-2 [DOI] 10.1007/s11357-022-00528-0 PMC 바로가기 [Article Type] Review
Alveolar, Endothelial, and Organ Injury Marker Dynamics in Severe COVID-19심각한 COVID-19의 폐포, 내피 및 장기 손상 마커 역학Observational Study Published on 2022-03-012022-09-11 Journal: American Journal of Respiratory and Critical Care [Category] MERS, SARS, 바이오마커, 임상, [키워드] 95% CI 95% confidence interval alveolar alveolar epithelial cells alveolar injury angiopoietin angiotensin association Biomarker Biomarkers calculated cardiac change changes in contribute coronavirus coronavirus disease COVID-19 COVID-19 severity Day Disease progression distress Dynamics emergency department endothelial endothelial injury endothelial marker Endothelial markers Endothelium enrolled epithelial epithelial cells Health Organization Injury intubated patients invasive ventilation Kidney injury marker measurement multivariable observational study outcome outcomes Patient patients patients with COVID-19 RAGE rationale receptor renal Renin renin-angiotensin system respiratory respiratory distress Respiratory distress syndrome Respiratory Support severe COVID-19 severity significantly single-center syndrome troponin Troponin-I ventilated patient Ventilation ventilatory with COVID-19 World Health Organization [DOI] 10.1164/rccm.202106-1514OC PMC 바로가기 [Article Type] Observational Study