Repurposed drug – Page 3 – Communicable Diseases Research

Randomised controlled trial of intravenous nafamostat mesylate in COVID pneumonitis: Phase 1b/2a experimental study to investigate safety, Pharmacokinetics and Pharmacodynamics

COVID 폐렴에서 정맥내 나파모스타트 메실레이트의 무작위 대조 시험: 안전성, 약동학 및 약력학을 조사하기 위한 1b/2a상 실험 연구

Clinical Trial

Published on 2022-02-012022-09-11
Journal: EBioMedicine [Category] COVID19(2023년), MERS, SARS, 바이오마커, 신약개발, 임상, 치료제,

Naphthoquine: A Potent Broad-Spectrum Anti-Coronavirus Drug In Vitro

Article

Published on 2022-01-212022-10-30
Journal: Molecules [Category] COVID-19,

Implications of the NADase CD38 in COVID pathophysiology

COVID 병태생리학에서 NADase CD38의 의미

Review

Published on 2022-01-012022-09-12
Journal: Physiological reviews [Category] Fulltext, SARS, 진단,

[키워드] accompanied approach CD38 characterized COVID COVID-19 COVID-19 immune response COVID-19 infection COVID-19 pandemic Critical develop disease Effect effective therapy effort Evidence hyperimmune response Hypothesis Immune-mediated immunization implicated individual Inflammation Lung pathology metabolism monoclonal multiple organ failure NAD nicotinamide adenine dinucleotide nicotinamide adenine dinucleotide. observation outcome pathophysiology Population randomized clinical trial Repurposed drug resulting SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 virus Severe case Spread Support susceptibility therapeutic target tissues virus
[DOI] 10.1152/physrev.00007.2021 PMC 바로가기 [Article Type] Review

Progress, pitfalls, and path forward of drug repurposing for COVID-19 treatment

Article

Published on 2022-01-012022-11-15
Journal: Therapeutic Advances in Respiratory Disease [Category] SARS, 신약개발, 치료제,

Target identification for repurposed drugs active against SARS-CoV-2 via high-throughput inverse docking

고 처리량 역 도킹을 통해 SARS-COV-2에 대해 활성화 된 용도 된 약물에 대한 목표 식별

Article

Published on 2022-01-012022-08-31
Journal: Journal of computer-aided molecular design [Category] MERS, SARS, 신약개발, 치료기술, 치료제,

Drugs repurposed: An advanced step towards the treatment of breast cancer and associated challenges

Review article

Published on 2022-01-012022-10-05
Journal: Biomedicine & pharmacotherapy = Biomédecine & phar [Category] 신약개발,

[키워드] coiled-coil-containing protein kinase 1 17β-HSD17β-Hydroxysteroid dehydrogenase specificity 17β-Hydroxysteroid dehydrogenase specificity 3β-HSD3β-Hydroxysteroid dehydrogenase specificity 3β-Hydroxysteroid dehydrogenase specificity 4-Hydroxy-trans-2-NonEnal 8-Oxo-2'-deoxyguanosine 8-Oxo-dG8-Oxo-2'-deoxyguanosine AAArachidonic acid ABCATP Binding Cassette ABCG2ATP-binding cassette superfamily G member 2 active transport adverse effect AEadverse effect ALSAmyotrophic lateral sclerosis Amyotrophic lateral sclerosis anthracyclines arachidonic acid ATactive transport ATP Binding Cassette ATP-binding cassette superfamily G member 2 BCBreast cancer beta actin BRAC1breast cancer type 1 Breast Breast cancer breast cancer type 1 Cancer cancer causing genes Cancer stem cells cancerous cells candidate CCcancerous cells CCGscancer causing genes CDKcyclin-dependent kinase clinical trials complications Computational approaches costly COX-2Cyclo-oxygenase 2 CSCscancer stem cells CTsclinical trials cyclin-dependent kinase Cyclo-oxygenase 2 DBFdrug binding frequency DBSdrug binding site death Dehydroepiandrosterone Dehydroepiandrosterone sulfate DHEADehydroepiandrosterone DHEASDehydroepiandrosterone sulfate Di phosphomevalonate decarboxylase Diabetes Mellitus DIdrug induced DMDiabetes mellitus DNA Topoisomerase II Alpha DRdrug resistance drug drug binding frequency drug binding site drug induced drug resistance drug transporters DTsdrug transporters ECMextra cellular matrix EHRselectronic health records Electronic health records EMTEpithelia-Mesenchymal transition EP1prostaglandin E2 receptor 1 Epithelia-Mesenchymal transition ER+Estrogen Receptor-Positive ERCC2Excision repair cross-complementing group 2 EREsestrogen receptor binding elements ERestrogen receptor ERKextracellular signal-regulated kinases estrogen receptor estrogen receptor binding elements Estrogen Receptor-Positive Excision repair cross-complementing group 2 extra cellular matrix extracellular signal-regulated kinases Factors FAKfocal adhesion kinase focal adhesion kinase glutathione S-transferase Glycogen synthase kinase 3 beta GSKβGlycogen synthase kinase 3 beta GSTglutathione S-transferase H-rasHarvey Rat sarcoma virus Harvey Rat sarcoma virus HDHuntington disease HER1/2Human epidermal growth factor receptor 1/2 HER2-Human Epidermal growth factor receptor 2 negative HER2+Human Epidermal growth factor receptor 2 positive HERhuman epidermal growth factor receptor HMG-CoA reductase HMG-CoA Synthase HMGCRHMG-CoA reductase HMGCSHMG-CoA Synthase HNE4-Hydroxy-trans-2-NonEnal HPTHypertension human epidermal growth factor receptor Human epidermal growth factor receptor 1/2 Human Epidermal growth factor receptor 2 negative Human Epidermal growth factor receptor 2 positive Huntington disease hypertension IBDInflammatory bowel disease IGF-1insulin-like growth factor 1 Inflammatory bowel disease information inhibitor insulin-like growth factor 1 Lanosterol synthase LHRHluteinizing hormone-releasing hormone LSSLanosterol synthase luteinizing hormone-releasing hormone malignant cells malondialdehyde mammalian target of rapamycin MAPKmitogen- activated protein kinase matrix metalloproteinase MCmalignant cells MDAmalondialdehyde MDmedian duration MDRmulti-drug resistance median duration membrane transporters MetAP2methionine aminopeptidase-2 methionine aminopeptidase-2 MHS2MutS Homolog 2 microtubules mitogen- activated protein kinase mitoxantrone resistant cells MLH1MutL homolog 1 MMPmatrix metalloproteinase molecular mechanism Mortality MRCmitoxantrone resistant cells MTmicrotubules mTORmammalian target of rapamycin MTsmembrane transporters multi-drug resistance MutL homolog 1 MutS Homolog 2 MVDDi phosphomevalonate decarboxylase NAD(P)H dehydrogenase [quinone] 1 NCCnon-cancerous cells NCENew chemical entity New chemical entity NF-κBNuclear factor kappa-light-chain-enhancer of activated B cell Nitric Oxide Synthase 3 non-cancerous cells Non-profit organisations non-steroidal anti-inflammatory medicine NOS3Nitric Oxide Synthase 3 NPONon-profit organisations NQO1NAD(P)H dehydrogenase [quinone] 1 NSAIDnon-steroidal anti-inflammatory medicine Nuclear factor kappa-light-chain-enhancer of activated B cell occur OCT1organic cation transporter 1 organic cation transporter 1 P-glycoprotein P-gpP-glycoprotein p53Tumor protein p53 PEG2/PGH2prostaglandin E2 PR+Progesterone Positive Progesterone Positive progesterone receptor prostaglandin E2 prostaglandin E2 receptor 1 proteomics provide PRprogesterone receptor Rac1Ras-related C3 botulinum toxin substrate 1 Randomised clinical trials Ras homolog family member A Ras-related C3 botulinum toxin substrate 1 RCTsRandomised clinical trials reactive oxygen species Receptor tyrosine kinase Repurposed drug responsible Rho-ARas homolog family member A rho-associated Ribosomal protein S6 kinase rising ROCK1rho-associated ROSreactive oxygen species RTKReceptor tyrosine kinase S6KRibosomal protein S6 kinase Scientific community SCstromal cells SCTssolute carrier transporters selective estrogen receptor degrader selective estrogen receptor modulator sequential strategies SERDselective estrogen receptor degrader SERM Side effects signal transducer and activator of transcription 3 SIRT1/2sirtuin (silent mating type information regulation 2 homolog) ½ sirtuin (silent mating type information regulation 2 homolog) ½ SLC22A16Solute Carrier Family 22 Member 16 SMAD 2/3/4SMAD family member 2/3/4 SMAD family member 2/3/4 Solute Carrier Family 22 Member 16 solute carrier transporters Sp1/3/4specificity protein 1/3/4 specificity protein 1/3/4 SQLESqualene monooxygenase Squalene monooxygenase SSsequential strategies STAT3signal transducer and activator of transcription 3 stromal cells subject survival TAEtopoisomerase alteration expression Tamoxifen TAMTamoxifen TCtumour cells TGFαTransforming growth factor-alpha TGFβ-RITransforming growth factor-beta type 1 receptor TGFβ1/β2Transforming growth factor beta1/2 TOP2ADNA Topoisomerase II Alpha topoisomerase alteration expression TP53tumor protein Transforming growth factor beta1/2 Transforming growth factor-alpha Transforming growth factor-beta type 1 receptor Treatment treatment-related side effects TRPtumour resistance profile TSEtreatment-related side effects tumor protein Tumor protein p53 tumour cells tumour resistance profile vascular endothelial growth factor VEGFvascular endothelial growth factor women xanthine dehydrogenase XDHxanthine dehydrogenase β-actbeta actin
[DOI] 10.1016/j.biopha.2021.112375 [Article Type] Review article

Repurposing of Drugs for SARS-CoV-2 Using Inverse Docking Fingerprints

Chemistry

Published on 2021-12-282022-10-31
Journal: Frontiers in Chemistry [Category] COVID-19,

[키워드] 3CL pro 3CL^pro acute respiratory syndrome Antiviral approach approved cause caused claimed Cold Compound compound repurposing compounds conducted controls coronavirus COVID-19 database direct-acting disease docking drug examined FDA-approved drug fingerprint fingerprints FIVE Health humans in silico inhibitors inverse Inverse docking main protease MERS MERS-CoV methodology Middle East molecular docking outbreak pathogenic protease inhibitors Protein Remdesivir reported Repurposed drug repurposing respiratory syndrome coronavirus SARS-CoV virus SARS-CoV-2 SARS-CoV-2 main protease subset Support syndrome the Coronaviridae therapeutic option Viral protein Virtual screening virus was performed was used
[DOI] 10.3389/fchem.2021.757826 PMC 바로가기 [Article Type] Chemistry

Understanding COVID-19 Pathogenesis: A Drug-Repurposing Effort to Disrupt Nsp-1 Binding to Export Machinery Receptor Complex

Article

Published on 2021-12-172022-10-28
Journal: Pathogens [Category] COVID-19,

[키워드] Antiviral beta coronavirus binding complex conformation COVID-19 COVID-19 infection crystal structure docking docking score drug drug antagonists drugs targeting export FDA-approved drug form Ganirelix Gene Expression GNRHR gonadotrophs hormone receptor Host include induce interact interfere knowledge Messenger RNA mRNA mRNA export adaptor nonstructural protein 1 nsp1 nuclear nuclear export NXF1 NXT1 offer Pituitary Protein recent receptor complex Repurposed drug RNA SARS-CoV-2 virus secretion shown Structural analysis structural docking structural modeling Transport understanding unlikely virulence
[DOI] 10.3390/pathogens10121634 PMC 바로가기 [Article Type] Article

Safety and efficacy of hydroxychloroquine for treatment of non-severe COVID-19 among adults in Uganda: a randomized open label phase II clinical trial

Clinical Trial

Published on 2021-12-062022-10-04
Journal: BMC Infectious Diseases [Category] SARS, 임상,

[키워드] adverse event adverse events alkaline phosphatase antiviral property ARMS assigned baseline benefit blocks Characteristics clearance clinical trial conducted control group Course COVID-19 Critical Ct values demonstrated diagnosed with COVID-19 diagnosis of COVID-19 drug ECG Efficacy elevated enrolled HCQ Hydroxychloroquine in vitro study intervention group investigated IQR limit median median time no significant difference not differ open label outcomes participant Patient phase Primary outcome progression QTc interval randomization Randomized receive reduction in Repurposed drug Result RT-PCR RT-PCR testing Safe Safety secondary outcome Standard of care Swab symptom resolution the disease Treatment treatment arm two group Uganda viral clearance Viral load viral replication was performed while with COVID-19
[DOI] 10.1186/s12879-021-06897-9 PMC 바로가기 [Article Type] Clinical Trial

Advances in the computational landscape for repurposed drugs against COVID-19

COVID-19에 대한 용도가있는 약물에 대한 계산 환경의 발전

Review

Published on 2021-12-012022-08-31
Journal: Drug discovery today [Category] 신약개발, 치료제,