Dromedary camel nanobodies broadly neutralize SARS-CoV-2 variants
단봉 낙타 나노바디는 SARS-CoV-2 변종을 광범위하게 중화시킵니다.
Article
Published on
Journal: Proceedings of the National Academy of Sciences of [Category] COVID19(2023년), SARS, 변종,
Journal: Proceedings of the National Academy of Sciences of [Category] COVID19(2023년), SARS, 변종,
[키워드] ACE2 binding
acute respiratory syndrome
acute respiratory syndrome coronavirus
acute respiratory syndrome coronavirus 2
angiotensin
antibodies
antibody
apex
B.1.351
B.1.617.2
bind
CDR3
complex structure
conformational
coronavirus
CoV
COVID-19
cryo
cryo-EM
Cryoelectron microscopy
dose
Dromedary
dromedary camel nanobody VHH
Epitopes
expressing
hACE2
heterodimer
high affinity
human Angiotensin-converting enzyme
Human angiotensin-converting enzyme 2
humans
involved
MERS-CoV
Middle East
Middle East respiratory syndrome
Middle East Respiratory Syndrome CoV
nanobodies
nanobody
neutralization activity
neutralize
Neutralizing
neutralizing antibody
nonoverlapping epitope
nonoverlapping epitopes
platform
Protein
RBDs
Receptor-binding domain
receptor-binding domains
recognize
reservoir
residue
S1 subunit
S1/S2
S2 subunit
SARS-CoV-2
SARS-CoV-2 variant
SARS-CoV-2 variants
severe acute respiratory syndrome Coronavirus
single-domain antibody
syndrome
target
the RBD
the S1 subunit
therapeutic use
transgenic mice
transmitted
trimer
unique
variant
variants
variants of concern
viruses
[DOI] 10.1073/pnas.2201433119 PMC 바로가기 [Article Type] Article
[DOI] 10.1073/pnas.2201433119 PMC 바로가기 [Article Type] Article