Molecular modelling identification of phytocompounds from selected African botanicals as promising therapeutics against druggable human host cell targets of SARS-CoV-2SARS-CoV-2의 약물 가능한 인간 숙주 세포 표적에 대한 유망한 치료제로서 선택된 아프리카 식물의 식물 화합물의 분자 모델링 식별Article Published on 2022-07-012022-09-11 Journal: Journal of molecular graphics & modelling [Category] COVID19(2023년), SARS, 치료제, [키워드] active site acute respiratory syndrome coronavirus African Amino acid amino acid residue angiotensin Angiotensin converting enzyme-2 bafilomycin binding binding energy candidate drug cathepsin cathepsin L caused Cell clinical evaluation clinical evaluations Compound compounds Computational methods coronavirus 2 coronavirus disease Coronavirus disease 2019 COVID-19 Critical enzyme galactoside hACE2 highly pathogenic host cell Host cell targets human cell human cells human host in vitro inhibitor inhibitors of TMPRSS2 inhibitory inhibitory action investigated kaempferol mechanism MLN-4760 Modification modifications modulate molecular dynamics Molecular dynamics simulation myricetin nafamostat Phytocompounds Protein Proteins Replication Research respiratory Respiratory disease respiratory diseases rutinoside SARS-CoV-2 selected Serine severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Structural analysis subjects subsequent target Therapeutic benefit these compound these compounds TMPRSS2 transmembrane serine protease Verbascoside viral entry viral spike protein viral spike proteins while [DOI] 10.1016/j.jmgm.2022.108185 PMC 바로가기 [Article Type] Article
LUNG ULTRASOUND IN OUTPATIENTS WITH COVID-19 INFECTION ASSOCIATED PNEUMONIAConference abstract Published on 2022-06-202022-10-05 Journal: Ultrasound in medicine & biology [Category] 진단, [키워드] 95% CI abnormality Accuracy Analysis blinded calculated chronic heart failure computer tomography correlated COVID-19 COVID-19 infection CT scan cut-off diagnosing Diagnosis diagnostic Diagnostic Criteria disease evaluate examined False positive feature Infection interstitial Interstitial lung disease lung Lung ultrasound material median men Mild moderate nasopharynx objective Outpatient parenchymal consolidation Patient patients Pneumonia point-of-care ultrasonography polymerase chain protocol quantitative assessment respiratory diseases Result Safe SARS-CoV-2 severity significantly subpleural the epidemic transcriptase Ultrasound was performed WHO with COVID-19 women zone [DOI] 10.1016/j.ultrasmedbio.2022.04.023 [Article Type] Conference abstract
Gelatin Stabilizes Nebulized Proteins in Pulmonary Drug Delivery against COVID-19젤라틴은 COVID-19에 대한 폐 약물 전달에서 분무된 단백질을 안정화합니다Article Published on 2022-06-132022-09-11 Journal: ACS Biomaterials Science & Engineering [Category] Coronavirus, COVID19(2023년), SARS, 변종, [키워드] ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus addition Aerogen airway angiotensin angiotensin-converting enzyme 2 biological molecule biological molecules can be used coordination coronavirus CoV-19 COVID-19 delivery distribution domain dosage drug effective ENhance enzyme experiment experiments feasibility fraction Fractions gelatin gelatin stabilization generate IFN-α2 infection with SARS-CoV-2 inhalation inhalation therapy inhibit interferon lung Lungs medication nebulization noninvasive pandemic Protein protocol pulmonary pulmonary delivery RBD-62 respiratory diseases SARS-CoV-2 significantly therapy transfer Vaccines variants [DOI] 10.1021/acsbiomaterials.2c00419 PMC 바로가기 [Article Type] Article
Chemical profiling and unraveling of anti-COVID-19 biomarkers of red sage (Lantana camara L.) cultivars using UPLC-MS/MS coupled to chemometric analysis, in vitro study and molecular docking화학 측정 분석, 시험관 내 연구 및 분자 도킹과 결합된 UPLC-MS/MS를 사용하여 레드 세이지(Lantana camara L.) 품종의 항-COVID-19 바이오마커의 화학적 프로파일링 및 해명Article Published on 2022-06-122022-09-11 Journal: Journal of ethnopharmacology [Category] COVID19(2023년), SARS, 바이오마커, 유전자 메커니즘, 치료기술, 치료제, [키워드] (RdRp acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Analysis anti-COVID-19 activity. antiviral activity approach Asia Biomarker Biomarkers Brazil Candidates Chain Reaction Chemical chemometrics Compound Concentration coronavirus COVID-19 cytotoxicity Data analysis detect determine docked docking docking score E-gene Effect Efficacy except for exhibited exhibiting expression expression levels flavonoids flower followed by highest in vitro study In-vitro India infections inhibitor inhibitory activity interaction pattern Kenya Lantana Lantana camara L. cultivars leprosy Luteolin material mechanism metabolites metabolomics molecular docking multivariate Multivariate analysis Nigeria PCA PCA plot PCA plots plaque polymerase chain polymerase chain reaction principle profile progressed RdRP RdRp gene real-time RT-PCR Red Remdesivir required respiratory respiratory diseases respiratory virus respiratory viruses reverse transcription polymerase chain reaction rheumatism RNA-dependent RNA polymerase RT-PCR SARS-CoV-2 selectivity indices severe acute respiratory syndrome Coronavirus Spread spreading Structure sunset TaqMan target tested Transcription UPLC UPLC-MS/MS Verbenaceae Viral [DOI] 10.1016/j.jep.2022.115038 PMC 바로가기 [Article Type] Article
Towards Multimodal Equipment to Help in the Diagnosis of COVID-19 Using Machine Learning Algorithms기계 학습 알고리즘을 사용하여 COVID-19 진단에 도움이 되는 다중 모드 장비를 향하여Article Published on 2022-06-082022-09-11 Journal: Sensors (Basel, Switzerland) [Category] COVID19(2023년), SARS, 치료기술, [키워드] Accuracy Algorithm applied Area AUC biomedical sensors body temperature can be used chain Chain Reaction collected cough coughs COVID-19 COVID-19 infection COVID-19 pandemic Curve dataset decision Decision tree detect Diagnosis diagnosis of COVID-19 equipment heart rate help individual Infection lab machine learning Machine learning algorithms Medical assistant Metrics occur oxygen oxygen saturation polymerase chain reaction reaction real-time polymerase chain reaction released reported respiratory diseases respiratory droplet Respiratory droplets RT-PCR SARS-CoV-2 virus significant delay sneezes speech SpO2 support vector machine SUS System System Usability Scale Telemedicine the SARS-CoV-2 virus tree Usability virus Volunteer [DOI] 10.3390/s22124341 PMC 바로가기 [Article Type] Article
Visualizing a Field of Research for the Coronavirus Replication in Humans with Knowledge Mapping: Evidence from Web of Science지식 매핑으로 인간의 코로나바이러스 복제 연구 분야 시각화: Web of Science의 증거Article Published on 2022-06-012022-09-11 Journal: Interdisciplinary sciences, computational life sci [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, [키워드] Analysis Apoptosis apoptotic assembly cause caused Cell cell receptor Clustering cognitive coronavirus Coronavirus replication COVID-19 damaged database Evolution Factors fatal disease feature field Frequency fusion gene sequence global health security globe host adaptation hotspot Human humans indicated inhibit Knowledge mapping living environment mapping mechanism MERS mutant Mutation mutations outbreak package pathogenicity Prevent promote R software Replication replication mechanism Research respiratory diseases S protein severe respiratory disease severe respiratory diseases spike Spike protein Spread the epidemic Transmission unique Variation viral infection Viral protein viral replication virus Virus evolution virus infection Web of Science widespread zone [DOI] 10.1007/s12539-022-00504-4 PMC 바로가기 [Article Type] Article
Efficacy and Safety of ELOM-080 as Add-On Therapy in COVID-19 Patients with Acute Respiratory Insufficiency: Exploratory Data from the Prospective Placebo-Controlled COVARI TrialRandomized Controlled Trial Published on 2022-06-012022-10-05 Journal: Advances in therapy [Category] COVID19(2023년), SARS, 임상, [키워드] breath clearance clinical status COVID-19 double-blind Dyspnoea ELOM-080 enhancement enhancer enrolment EudraCT evaluated exploratory exploratory study had no hospitalisation hospitalised IMPROVE Inflammatory less MCC MCC enhancement Mucociliary clearance Patient patients treated patients with COVID-19 per-protocol Placebo PPS Prospective randomised recruitment required respiratory respiratory diseases Safety Shortness of breath. significant effect supplemental oxygen the placebo group therapy treat treating COVID-19 Trial [DOI] 10.1007/s12325-022-02135-z PMC 바로가기 [Article Type] Randomized Controlled Trial
Complete blood cells count abnormalities in COVID-19 patients and their prognostic significance: Single center study in Makkah, Saudi Arabia전체 혈액 세포는 COVID-19 환자의 이상과 그 예후 중요성을 계산합니다: 사우디 아라비아 Makkah의 단일 센터 연구Article Published on 2022-06-012022-09-11 Journal: Saudi medical journal [Category] COVID19(2023년), SARS, 치료기술, [키워드] abnormality Admission age Anemia Blood blood cell blood count C-reactive protein clinical disease clinically Complete complete blood count coronavirus disease COVID-19 COVID-19 patient COVID-19 severity CRP Decision making decrease detectable disease effective intervention elevated evaluate feature female ferritin force group Inclusion Inflammation Inflammatory marker inflammatory markers leucocyte leucocytosis lymphopenia male management moderate N/L N/L ratio neutrophil neutrophil count neutrophilia non-survivor Non-survivors occurred Older age Organ failure outcome parameter Patient patients Peripheral blood Platelets platelets count prognostic prognostic significance. Rapid test regimen regimens Respiratory disease respiratory diseases Saudi Arabia security Serum ferritin Serum level Severe case severe COVID-19 disease severity Significant significant decrease significantly viral infection were excluded [DOI] 10.15537/smj.2022.43.6.20210893 PMC 바로가기 [Article Type] Article
Functional reconstitution of the MERS CoV receptor binding motifMERS CoV 수용체 결합 모티프의 기능적 재구성Article Published on 2022-05-012022-09-11 Journal: Molecular immunology [Category] COVID19(2023년), SARS, 변종, [키워드] 229E beta-coronaviruses catastrophic caused Co-infection Combinatorial phage display common cold coronavirus Coronaviruses CoV COVID-19 develop disease Diseases epitope Epitope reconstitution Epitope-based vaccine etiologic agent event Evolution Fatality rate followed by Human human coronavirus human-to-human transmission Implementing incidence independent Isolation less life-threatening MERS MERS CoV. Middle East neutralizing monoclonal antibodies OC43 omicron Omicron variants pandemic Population Prevalence Protein RBM receptor binding motif Recombination reported Respiratory disease respiratory diseases SARS CoV Saudi Arabia Seven shown spike Spike protein subsequent summer variants of concern viruses [DOI] 10.1016/j.molimm.2022.03.006 PMC 바로가기 [Article Type] Article
Repurposing dyphylline as a pan-coronavirus antiviral therapy범 코로나 바이러스 항 바이러스 요법으로 디필린 용도 변경Article Published on 2022-05-012022-09-11 Journal: Future Medicinal Chemistry [Category] COVID19(2023년), SARS, 신약개발, 치료제, [키워드] Alpha Antiviral antiviral agent antiviral therapy bind catalytic dyad Cell culture coronavirus COVID-19 pandemic CoVs Cystine Drug discovery dyphylline FDA-approved drug functional enzyme functional enzymes HCoV HCoV-229E HCoV-NL63 HCoV-OC43 HCoVs highly pathogenic histidine Human human coronavirus human coronaviruses human coronaviruses (HCoVs) humans inhibited life cycle Mild MPro NL63 OC43 protease repurposing respiratory diseases SARS-CoV-2 severe respiratory disease severe respiratory diseases structures Support targets therapeutically target viral replication Virtual screening virus Virus life cycle viruses xanthine zoonotic [DOI] 10.4155/fmc-2021-0311 PMC 바로가기 [Article Type] Article