SARS-CoV-2 infection results in immune responses in the respiratory tract and peripheral blood that suggest mechanisms of disease severityArticle Published on 2022-05-192022-10-04 Journal: Nature Communications [Category] COVID19(2023년), MERS, SARS, 바이오마커, 진단, 치료기술, 치료법, 치료제, [키워드] Adaptive immunity Affect Blood cellular COVID-19 COVID-19 patients cytokine response Dexamethasone disease severity domain Hospital stay hospitalized COVID-19 patients humoral Humoral response IFN-α2 IgA IgG IgM IgM and IgG IL-12p70 immune immune component immune parameter immune response immunopathology infection with SARS-CoV-2 Inflammation mechanism neutralization Neutrophils not affect Peripheral blood plasma Prognosis respiratory respiratory sample Respiratory samples respiratory specimen respiratory specimens respiratory tract SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 neutralization activity Seroconversion sputum subset therapy Treatment viral infection [DOI] 10.1038/s41467-022-30088-y PMC 바로가기 [Article Type] Article
Investigation of SARS-CoV-2 Epsilon Variant and Hospitalization Status by Genomic Surveillance in a Single Large Health System During the 2020-2021 Winter Surge in Southern California남부 캘리포니아의 2020-2021년 겨울 서지 동안 단일 대형 의료 시스템에서 게놈 감시에 의한 SARS-CoV-2 엡실론 변이체 및 입원 상태 조사Article Published on 2022-05-042022-09-11 Journal: American journal of clinical pathology [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Admission B.1.427 B.1.429 California collected coronavirus COVID-19 Epsilon Epsilon variant frequencies Frequency genomic Genomic surveillance health system Hospitalization hospitalized patients ICU ICU admission ICU patient ICU Patients intensive care intensive care unit investigation outpatients patients respiratory sample Respiratory samples SARS-CoV-2 severe acute respiratory syndrome Coronavirus severe disease status Surveillance System unique variant virulent was performed Winter [DOI] 10.1093/ajcp/aqab203 PMC 바로가기 [Article Type] Article
Profiling of SARS-CoV-2 Subgenomic RNAs in Clinical Specimens임상 표본에서 SARS-CoV-2 서브게놈 RNA의 프로파일링Article Published on 2022-04-272022-09-11 Journal: Microbiology Spectrum [Category] COVID19(2023년), SARS, 변종, 치료기술, 치료제, [키워드] accessory protein age applied association canonical canonical sgRNA canonical sgRNAs changes in Characteristics clinical Clinical characteristics clinical samples collected COVID-19 COVID-19 patient COVID-19 patients deleted diagnostic discontinuous transcription event expression profile followed by Frame frameshift full-length genomic RNA identify independent Infection Isolation large cohort life cycle majority management marker MONITOR monitoring Next-generation sequencing Numerous Open reading frame ORF10 ORF3a ORF6 ORF7a ORF7b ORF8 Patient PCR positive Potential biomarker potential biomarkers produced profile Profiling progression Protein provide real-time RT-PCR respiratory respiratory sample Respiratory samples RNA RNA-Seq RT-PCR SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 sgRNA SARS-CoV-2 sgRNAs sgRNA sgRNAs specimen specimen collection Stool stool samples subgenomic RNA subgenomic RNAs subgenomic. the patient transcript translation Treatment treatment of COVID-19 patients undetectable variant Viral load [DOI] 10.1128/spectrum.00182-22 PMC 바로가기 [Article Type] Article
Gastrointestinal, hepatic and pancreatic manifestations of COVID-19 in children소아에서 COVID-19의 위장, 간 및 췌장 발현Review Published on 2022-04-012022-09-11 Journal: Clinics and research in hepatology and gastroenter [Category] COVID19(2023년), SARS, 치료기술, [키워드] abdominal pain acute respiratory syndrome acute respiratory syndrome coronavirus analysed Asymptomatic children coronavirus disease Coronavirus disease-19 Coronavirus-19 Coronavirus-2 COVID-19 diarrhoea Evidence faece Faeces Gastrointestinal Inflammatory liver manifestation nausea pancreas pancreatic pathogen Patient recent respiratory sample Respiratory samples respiratory tract SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 RNA Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 shown syndrome tested Transmission vomiting [DOI] 10.1016/j.clinre.2021.101818 PMC 바로가기 [Article Type] Review
Seropositivity of Anti-SARS CoV2 IgG antibodies in health care workers of an Indian tertiary care hospital during COVID-19COVID-19 기간 동안 인도 3차 의료 병원의 의료 종사자에서 Anti-SARS CoV2 IgG 항체의 혈청 양성Article Published on 2022-04-012022-09-11 Journal: Indian journal of medical microbiology [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, [키워드] Anti-COVID IgG antibodies antibody association Asymptomatic Asymptomatic case Asymptomatic cases Care Clinical data close contact COVID-19 Ct value Demographic and clinical data eight enrolled General population HCW HCWs Health care Health care worker health care workers higher risk hospital IgG antibody Infection patients with COVID-19 positive questionnaire rate of seroconversion respiratory respiratory sample RT- PCR RT-PCR SARS CoV2 SARS-CoV-2 IgG Sero-surveillance. Seroconversion Seropositivity serum sample serum samples statistically significant tested Viral was used [DOI] 10.1016/j.ijmmb.2022.02.004 PMC 바로가기 [Article Type] Article
Detection of SARS-CoV-2 nucleocapsid antigen from serum can aid in timing of COVID-19 infection혈청에서 SARS-CoV-2 뉴클레오캡시드 항원 검출은 COVID-19 감염 시기에 도움이 될 수 있습니다Article Published on 2022-04-012022-09-11 Journal: Journal of virological methods [Category] COVID19(2023년), SARS, 진단, 치료기술, 치료법, [키워드] acute COVID-19 Analytical specificity Antibody testing Antigen antigenemia Combination convalescent phase COVID-19 COVID-19 disease COVID-19 infection COVID-19 patient demonstrated detection diagnostic disease enzyme enzyme immunoassay enzyme-linked immunosorbent enzyme-linked immunosorbent assay information Kinetics marker median N antigen nucleocapsid nucleocapsid antigen onset of disease onset of symptoms Patient PCR PCR positive PCR-confirmed PCR-confirmed COVID-19 plasma samples positive positive PCR resolved respiratory respiratory sample Respiratory samples RNA SARS-CoV-2 SARS-CoV-2 antigen SARS-CoV-2 nucleocapsid SARS-CoV-2 RNA sensitivity serum serum and plasma serum sample serum samples specificity specimen specimens upper respiratory tract URT was collected [DOI] 10.1016/j.jviromet.2022.114469 PMC 바로가기 [Article Type] Article
Sensitivity and specificity of 14 SARS-CoV-2 serological assays and their diagnostic potential in RT-PCR negative COVID-19 infections14가지 SARS-CoV-2 혈청학적 분석의 민감도 및 특이성 및 RT-PCR 음성 COVID-19 감염에서의 진단 가능성Case Reports Published on 2022-04-012022-09-11 Journal: Acta clinica Belgica [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, [키워드] added applied assays calculated Case report complement COVID-19 COVID-19 case COVID-19 diagnosis COVID-19 infection cross-reactive detect diagnose Diagnosis diagnosis of COVID-19 diagnostic evaluate Final gold gold standard help highest IgG illustration Interpretation lack molecular Molecular diagnosis molecular test Patient performance positive presenting remained respiratory respiratory sample Respiratory samples retrospective retrospective cohort RT-PCR SARS-CoV-2 SARS-CoV-2 test selected sensitivity Sensitivity and specificity sera serological Serological assay serology serology testing specificity symptom onset tested Viral viral loads [DOI] 10.1080/17843286.2020.1861885 PMC 바로가기 [Article Type] Case Reports
Sequential dynamics of virological and serological changes in the serum of SARS-CoV-2 infected patientsSARS-CoV-2 감염 환자의 혈청 내 바이러스 및 혈청학적 변화의 순차적 역학Article Published on 2022-04-012022-09-11 Journal: Journal of medical virology [Category] COVID19(2023년), SARS, 진단, 치료기술, [키워드] acquisition acute respiratory syndrome acute respiratory syndrome coronavirus Admission analyzed antibody Antibody Response Chain Reaction changes in collected coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient Culture cytopathic discharge dropped faster Follow-up highest Hospitalization IgG immune response Immunological response infected patient infected patients investigated knowledge median Mild Mild symptom mild symptoms moderate moderate symptoms neutralization test Neutralizing antibodies neutralizing antibody Patient polymerase chain polymerase chain reaction Protein provide real-time polymerase chain reaction remained respiratory respiratory sample Respiratory samples Ribonucleic acid Sample SARS-CoV-2 SARS-CoV-2 infected patient SARS-CoV-2 spike protein SARS-CoV-2 viral load serological serum serum sample severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 spike Spike protein surrogate surrogate virus neutralization test Symptoms Test Total undetectable Viral viral culture Viral load Viremia Virological virus [DOI] 10.1002/jmv.27518 PMC 바로가기 [Article Type] Article
COVID-19-associated mixed mold infection: A case report of aspergillosis and mucormycosis and a literature review코로나19 관련 혼합곰팡이 감염: 아스페르길루스증 및 점막염 증례 보고 및 문헌 고찰Review Published on 2022-03-012022-09-11 Journal: Journal de mycologie médicale [Category] SARS, 바이오마커, 진단, 치료기술, [키워드] aspergillosis Aspergillus Blood Case report Chain Reaction Characteristics Co-infection Corticosteroids COVID-19 COVID-19 pandemic detect Diabetic diagnostic fungal fungal disease fungi hematology highlight identify increasingly India Infection invasive invasive fungal disease literature review Mucorale Mucorales Mucormycosis Patient polymerase chain polymerase chain reaction presenting Prevalence Quantitative quantitative polymerase chain reaction reported respiratory sample Respiratory samples SARS-CoV-2 SARS-COV-2 infection severe SARS severe SARS-CoV-2 Simultaneous Specific [DOI] 10.1016/j.mycmed.2021.101231 PMC 바로가기 [Article Type] Review
Total infectome characterization of respiratory infections in pre-COVID-19 Wuhan, China코로나19 이전 중국 우한에서 발생한 호흡기 감염의 총 감염체 특성Research Article Published on 2022-02-172022-09-10 Journal: PLoS Pathogens [Category] COVID19(2023년), MERS, SARS, 유전자 메커니즘, [키워드] Acute respiratory infection acute respiratory infections Analysis approaches Atypical Atypical pneumonia average Bacteria Bronchoalveolar lavage fluid causative agent Chlamydia Co-infection collected complex COVID-19 DNA viruses Evidence focus fungi global pandemic healthy controls highlighting human diseases Influenza influenza viruses less metagenomic sequencing Novel coronavirus outbreak pathogen Pathogens Patient PCR phylogenetic analyses Pneumonia presenting provide public health qPCR related virus respiratory Respiratory disease respiratory infection respiratory infections respiratory pathogen Respiratory pathogens respiratory sample respiratory virus rhinovirus rhinoviruses RNA viruses Sample SARS-CoV-2 Sequencing single hospital These data Total total RNA Transmission viruses was performed Wuhan Wuhan, China zoonotic [DOI] 10.1371/journal.ppat.1010259 PMC 바로가기 [Article Type] Research Article