Neither inflammatory bowel disease nor immunosuppressants are associated with an increased risk of severe COVID-19: an observational Dutch cohort study염증성 장질환이나 면역억제제는 심각한 COVID-19의 위험 증가와 관련이 없습니다: 관찰 네덜란드 코호트 연구Observational Study Published on 2022-08-012022-09-11 Journal: Clinical and experimental medicine [Category] SARS, 임상, 치료기술, [키워드] 95% confidence interval Admission affected Biological bowel Characteristics children clinical Cohort cohort characteristics cohort study Comorbidity COVID-19 COVID-19 case COVID-19 cases Crohn's disease Deceased determinant died disease examined Follow-up General population had no healthcare healthcare providers Hospital admission Hospitalized IBD ICD-10 Immunosuppressant immunosuppressants Immunotherapy increased risk Inflammatory bowel disease intensive care medication Mortality National observational study occurred Older outbreak Patient patients regions Respiratory Support Result retrospective risk factor Risk factors SARS-CoV-2 Seven severe COVID-19 significantly more the SARS-CoV-2 Thiopurine. Treatment was performed women [DOI] 10.1007/s10238-021-00755-3 PMC 바로가기 [Article Type] Observational Study
Glucocorticoid-Induced Hyperglycemia Including Dexamethasone-Associated Hyperglycemia in COVID-19 Infection: A Systematic ReviewReview article Published on 2022-08-012022-10-05 Journal: Endocrine practice : official journal of the American College of [Category] 임상, 진단, [키워드] added article clinical guideline Cochrane Library conducted Controlled trial COVID-19 COVID-19 pandemic database Dexamethasone diabetes effective End points evaluated glucocorticoid hyperglycemia Including insulin management objective Patient patients with COVID-19 RCT RCTs regimens Respiratory Support Result review Standard of care steroid Support synonym systematic review treatment strategy variety Web of Science widespread [DOI] 10.1016/j.eprac.2022.07.014 [Article Type] Review article
Semiquantitative Chest CT Severity Score Predicts Failure of Noninvasive Positive-Pressure Ventilation in Patients Hospitalized for COVID-19 PneumoniaObservational Study Published on 2022-08-012022-10-04 Journal: Journal of cardiothoracic and vascular anesthesia [Category] 임상, [키워드] Analysis calculated Care Chest Chest computed tomography Chest CT confidence interval COVID-19 effective Endpoint Factor failure group Hospital admission In-hospital In-hospital death independent intubation measurement Mortality nine Non-invasive non-invasive ventilation observational study other variables oxygen Patient patients with COVID-19 Pneumonia primary endpoint receiver operator characteristics reported Respiratory Support responding poorly score secondary endpoint Treatment Ventilation [DOI] 10.1053/j.jvca.2021.09.010 PMC 바로가기 [Article Type] Observational Study
Genetic variants in the NF-κB signaling pathway (NFKB1, NFKBIA, NFKBIZ) and risk of critical outcome among COVID-19 patientsNF-κB 신호 전달 경로(NFKB1, NFKBIA, NFKBIZ)의 유전적 변이와 COVID-19 환자의 중대한 결과 위험Article Published on 2022-08-012022-09-11 Journal: Human immunology [Category] COVID19(2023년), SARS, 변종, [키워드] Cohort component Control COVID-19 COVID-19 patient Critical D-dimer value Deceased explain form Gene polymorphisms genetic association Genetic variation Genotype healthy Homozygosis hyperinflammatory state ICU ICU admission implicated Inflammation insertion lower expression mice Mortality NF-κB NF-κB signaling NF-κB signaling pathway NFkB1 NFKBIA NFKBIZ NFKBIZ. outcome pathway Patient patients populations predisposition RATs Respiratory Support risk risk of death SARS-COV-2 infection Sepsis severe COVID-19 severe forms of COVID-19 significant effect Spanish patient Survivors the patient total blood transcript variant variants viral disease was increased [DOI] 10.1016/j.humimm.2022.06.002 PMC 바로가기 [Article Type] Article
Serum concentration of extracellular cold-inducible RNA-binding protein is associated with respiratory failure in COVID-19Observational Study Published on 2022-07-292022-10-05 Journal: Frontiers in Immunology [Category] 임상, [키워드] adjusted age aggravate association BMI Chest computed tomography Chest CT CIRP Cohort Comorbidity Concentration contribute correlated correlation COVID-19 damage-associated molecular pattern DAMP DAMPs defined determine disease dysregulated eCIRP evaluate external validation Extracellular extracellular CIRP FiO2 HFNO High-flow nasal oxygen highest Hospitalized hospitalized patient Host immune response Hypoxemia induce Inflammation inflammatory biomarkers Linear regression lung involvement mechanical ventilation Mild oxygen Pathogenesis Patient patients with COVID-19 peak prospective observational study Protein pulmonary involvement reduce Respiratory failure Respiratory Support risk Sepsis serum Serum level severe COVID-19 severe hypoxemia severity Severity of disease Sex suggested symptom duration tissue injury Treatment uncontrolled university was used were used [DOI] 10.3389/fimmu.2022.945603 PMC 바로가기 [Article Type] Observational Study
Randomized controlled phase 2 trial of hydroxychloroquine in childhood interstitial lung diseaseClinical Trial Published on 2022-07-232022-10-05 Journal: Orphanet Journal of Rare Diseases [Category] COVID19(2023년), SARS, 임상, [키워드] absence adverse event age all subject approval ARMS calculated Child childhood children Controlled trial double-blind effect size Endpoint evaluated four subject groups HCQ Health Hydroxychloroquine identify Interstitial lung disease Interstitial lung diseases lack lung Lung function multicentre Munich not differ not different offered outcome Oxygenation participated phase 2 trial Placebo placebo-controlled primary endpoint Pulmonary function Quality of life Randomized randomized-controlled trial Registered Registration respiratory rate Respiratory Support secondary study population subject Treatment treatment effects treatment period Trial university were given Withdrawal [DOI] 10.1186/s13023-022-02399-2 PMC 바로가기 [Article Type] Clinical Trial
Usefulness of monocyte distribution width and presepsin for early assessment of disease severity in COVID-19 patientsCOVID-19 환자의 질병 중증도 조기 평가를 위한 단핵구 분포 폭 및 프리셉신의 유용성Article Published on 2022-07-082022-09-11 Journal: Medicine [Category] COVID19(2023년), MERS, SARS, 바이오마커, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Admission antibody Blood blood count C-reactive protein Complete complete blood count coronavirus coronavirus disease Coronavirus disease 2019 correlated COVID-19 COVID-19 patient COVID-19 patients COVID-19 severity disease severity distribution early diagnosis elevated enrolled erythrocyte sedimentation erythrocyte sedimentation rate exhibited ferritin group groups high-flow nasal cannula oxygen therapy Hospital stay identify Inpatient intensive care Lactate lactate dehydrogenase mechanical ventilation monocyte Mortality nasal nasal cannula neutralization Neutralizing antibodies neutralizing antibody not differ on admission oxygen Oxygen therapy Patient predictor procalcitonin respiratory Respiratory Support SARS-CoV-2 sedimentation rate Sepsis severe acute respiratory syndrome Coronavirus severe coronavirus disease severity significantly significantly higher Symptom utility with COVID-19 [DOI] 10.1097/MD.0000000000029592 PMC 바로가기 [Article Type] Article
Onasemnogene abeparvovec for presymptomatic infants with three copies of SMN2 at risk for spinal muscular atrophy: the Phase III SPR1NT trial Research Published on 2022-06-172022-10-05 Journal: Nature Medicine [Category] 변종, 유전자 메커니즘, 임상, 진단, [키워드] biallelic children Deletion develop developmental effective Efficacy and safety Infant Intervention investigated investigator MOST multicenter muscular Mutation phase presymptomatic required Respiratory Support risk Serious Adverse Event single-arm trial SMN1 SMN2 Support survived symptom onset treated Trial urgency Ventilation WHO [DOI] 10.1038/s41591-022-01867-3 [Article Type] Research
Onasemnogene abeparvovec for presymptomatic infants with two copies of SMN2 at risk for spinal muscular atrophy type 1: the Phase III SPR1NT trial Research Published on 2022-06-172022-10-05 Journal: Nature Medicine [Category] 변종, 유전자 메커니즘, 임상, [키워드] biallelic children Clinical research Cohort develop developmental effective Efficacy and safety enrolled expected Final highlighting Infant investigator multicenter muscular Mutation Neuromuscular Newborn phase presymptomatic Respiratory Support risk Serious Adverse Event single-arm study SMN1 SMN2 survived treated Treatment Trial urgency Ventilation WHO [DOI] 10.1038/s41591-022-01866-4 [Article Type] Research
Clinical Characteristics and Risk Factors for Mortality in Critical Coronavirus Disease 2019 Patients 50 Years of Age or Younger During the Delta Wave: Comparison With Patients > 50 Years in Korea2019년 델타파 중 50세 이하 환자 중대 코로나바이러스 감염증의 임상적 특성 및 사망률 위험인자: 국내 50세 이상 환자와의 비교Article Published on 2022-06-062022-09-11 Journal: Journal of Korean medical science [Category] COVID19(2023년), SARS, 변종, [키워드] 95% CI 95% confidence interval Adult patients age analyses Analysis analyzed Blood stream infection BMI body mass body mass index Case fatality rate clinical Clinical characteristics clinical feature Clinical features condition conditions coronavirus disease Coronavirus disease 2019 COVID-19 creatinine Critical critical condition death Delta delta variant diabetes Diabetes Mellitus died dominant eight electronic medical record enrolled evaluate Factor Fatality rate General population globe highest highlight hospital Hospitalized hypertension identify independent predictor independent predictors Infection measure mechanical ventilation Mortality mortality risk factor mortality risk factors Multivariate analysis nasal nasal cannula Numerous obese obesity Odds ratio Older older patient older patients oxygen Oxygen therapy Patient PCR-confirmed COVID-19 Prevent progression respiratory Respiratory Support risk risk factor Risk factors Secondary infection severity statistically study period study population the patient therapy total patients underlying disease vaccination vaccination rate Vaccinations variant while women Year Young younger patient younger patients [DOI] 10.3346/jkms.2022.37.e175 PMC 바로가기 [Article Type] Article