A modified vaccinia Ankara vaccine expressing spike and nucleocapsid protects rhesus macaques against SARS-CoV-2 Delta infection스파이크와 뉴클레오캡시드를 발현하는 변형된 백시니아 앙카라 백신은 SARS-CoV-2 Delta 감염으로부터 붉은털 원숭이를 보호합니다Article Published on 2022-06-242022-09-11 Journal: Science Immunology [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료법, [키워드] added Beta Beta variant binding Blood CD4 CD8 T cell correlated cross-reactive cross-reactive antibody Delta delta variant Efficacy elicited expressed expressing FCS function furin furin cleavage site Heterologous homologous human ACE2 humoral IgG inactivated inactivation induce Infection intramuscular less lung mice moderate neutralized Neutralizing Neutralizing antibodies neutralizing antibody non-neutralizing antibody nose nucleocapsid positively correlated PROTECT rectum response rhesus macaque rhesus macaques robust SARS-CoV-2 SARS-CoV-2 vaccines secretion serum spike spike-specific IgG T cell T cell response T cell responses tested the SARS-CoV-2 vaccination Vaccine variant variants of concern virus VoC VOCs [DOI] 10.1126/sciimmunol.abo0226 PMC 바로가기 [Article Type] Article
Low-dose self-amplifying mRNA COVID-19 vaccine drives strong protective immunity in non-human primates against SARS-CoV-2 infectionArticle Published on 2022-06-072022-10-04 Journal: Nature Communications [Category] COVID19(2023년), MERS, SARS, 변종, 임상, 진단, 치료기술, 치료법, [키워드] acute respiratory syndrome benefit boost cellular clinical trial convalescent coronavirus coronavirus disease COVID-19 COVID-19 vaccine dose doses driving effective vaccine Efficacy evaluated geometric mean titer GMT greater Heterologous highlighting homologous human sera humoral immune response immune response immunize low dose lower airways mice mRNA mRNA vaccine NAb neutralizing antibody non-human primate non-human primates offer pandemic populations prefusion prime-boost regimen Protective protective immunity provided reduction regimen regimens replicate rhesus macaque rhesus macaques RNA vaccines Safe SAM SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 vaccine spike glycoprotein Spread T cell response tested Translational immunology vaccination Vaccine viral replication [DOI] 10.1038/s41467-022-31005-z PMC 바로가기 [Article Type] Article
Modeling explains prolonged SARS-CoV-2 nasal shedding relative to lung shedding in remdesivir-treated rhesus macaquesResearch article Published on 2022-05-252022-10-05 Journal: iScience [Category] 비임상, [키워드] blunting cells clinical trials decrease explain FIVE Hospitalization hospitalized patient increases in Infection innate immune response intensity lung lung damage lung viral load Lungs mathematical modeling Molecular modeling nasal nasal passage nasal passages occur Pneumonia prevented raise reducing reduction in Remdesivir rhesus macaque rhesus macaques SARS- CoV-2 SARS-CoV-2 shedding relative therapy Viral load viral loads Virology [DOI] 10.1016/j.isci.2022.104448 [Article Type] Research article
Longitudinal analyses reveal distinct immune response landscapes in lung and intestinal tissues from SARS-CoV-2-infected rhesus macaquesArticle Published on 2022-05-242023-07-09 Journal: Cell Reports [Category] COVID19(2023년), [키워드] CP: Immunology intestinal mucosal immunity rhesus macaque SARS-CoV-2 Single-cell transcriptomics [DOI] 10.1016/j.celrep.2022.110864 PMC 바로가기
Prime-boost vaccination regimens with INO-4800 and INO-4802 augment and broaden immune responses against SARS-CoV-2 in nonhuman primatesINO-4800 및 INO-4802를 사용한 프라임-부스트 백신 요법은 비인간 영장류에서 SARS-CoV-2에 대한 면역 반응을 증대 및 확대합니다.Article Published on 2022-05-092022-09-11 Journal: Vaccine [Category] Coronavirus, COVID19(2023년), SARS, 변종, 비임상, [키워드] ACE2 Antibody Response Antibody responses blocking activity Booster vaccine booster vaccines characterized clinical evaluation COVID-19 DNA DNA vaccine Electroporation evaluated expansion homologous or heterologous immune evasion immune response Immunity immunogenicity INO-4800 Intradermal macaque natural infection Neutralizing pandemic portion question regimen regimens rhesus macaque rhesus macaques SARS-CoV-2 SARS-CoV-2 sequence SARS-CoV-2 variant SARS-CoV-2 variants shifting Strains Support T cell T cells These data Transmissibility vaccination Vaccine variant variants of concern wild-type SARS-CoV-2 Wuhan-Hu-1 [DOI] 10.1016/j.vaccine.2022.03.060 PMC 바로가기 [Article Type] Article
Non-clinical immunogenicity, biodistribution and toxicology evaluation of a chimpanzee adenovirus-based COVID-19 vaccine in rat and rhesus macaque쥐 및 붉은털 원숭이에서 침팬지 아데노바이러스 기반 COVID-19 백신의 비임상 면역원성, 생체 분포 및 독성 평가Article Published on 2022-05-012022-09-12 Journal: Archives of Toxicology [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] acute respiratory syndrome addition Adenovirus adenovirus-based biodistribution candidate vaccine caused cellular Chimpanzee Chimpanzee adenovirus vector collected conditions coronavirus COVID-19 COVID-19 vaccine develop DNA dose effective Effective vaccines elicit ENCODE evaluated full-length spike protein global pandemic Humoral response immune response immunogenicity induce injected injection Intramuscular injection intramuscularly long-lasting morbidity and mortality Neutralizing antibody response organ polymerase chain profile qPCR quantified Quantitative rhesus rhesus macaque Safe safety profile SARS-CoV-2 serotype shown T cell responses Th1 toxicology Vaccine were given [DOI] 10.1007/s00204-021-03221-x PMC 바로가기 [Article Type] Article
Ultrasensitive detection and quantification of viral nucleic acids with Raindance droplet digital PCR (ddPCR)Raindance droplet 디지털 PCR(ddPCR)을 사용한 바이러스 핵산의 초고감도 검출 및 정량화Article Published on 2022-05-012022-09-11 Journal: Methods (San Diego, Calif.) [Category] COVID19(2023년), SARS, 치료기술, [키워드] animal models Antiretroviral therapy approaches assays caused Cell Combination cure Cure research ddPCR detect Detection sensitivity diagnosis and monitoring digital PCR disease DNA and RNA Efficacy example highlighting HIV HIV prevention HIV-1 HIV-1 infection HIV-1 viral immunodeficiency virus infected individual infected individuals Infection Infectious disease Infectious diseases inhibition inhibitors Interpretation model systems NHP non-human primate nucleic acid Nucleic acid detection nucleic acids outcome platform predictor progression quantification quantitation Raindance reduced required Research reverse transcription rhesus macaque rhesus macaques RNA RT-ddPCR SARS-CoV2 sensitive Simian simian immunodeficiency virus SIV step tissue tissues Treatment treatment intervention treatment interventions viral DNA viral nucleic acid viral nucleic acid detection viral nucleic acids Viral reservoir virus viruses [DOI] 10.1016/j.ymeth.2021.04.025 PMC 바로가기 [Article Type] Article
Sequential immunizations confer cross-protection against variants of SARS-CoV-2, including Omicron in Rhesus macaques순차 예방접종은 붉은털원숭이의 오미크론을 포함한 SARS-CoV-2 변종에 대한 교차 보호를 제공합니다.Article Published on 2022-04-182022-09-11 Journal: Signal Transduction and Targeted Therapy [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] Administered animal animals Antibody titers Beta booster dose booster vaccination CoronaVac cross-protection Delta determine dose effective Effectiveness histopathological Homologous vaccine immunization immunized Inactivated vaccine Inactivated Vaccines indicated majority mutations NAbs Neutralizing antibodies Neutralizing antibody titer neutralizing antibody titers omicron Omicron variants primates profile PROTECT reduced viral load rhesus macaque rhesus macaques SARS-CoV-2 neutralizing antibodies SARS-CoV-2 neutralizing antibody significantly Subunit vaccine these viruses Vaccine variant variants variants of SARS-CoV-2 Viral virus viruses VOCs wild-type [DOI] 10.1038/s41392-022-00979-z PMC 바로가기 [Article Type] Article
Ad26.COV2.S prevents upregulation of SARS-CoV-2 induced pathways of inflammation and thrombosis in hamsters and rhesus macaquesAd26.COV2.S는 햄스터와 붉은털 원숭이에서 SARS-CoV-2 유도 염증 및 혈전증 경로의 상향 조절을 방지합니다Article Published on 2022-04-082022-09-11 Journal: PLoS Pathogens [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, 진단, [키워드] Ad26 Ad26.COV2.S Adaptive immune response Adenovirus animal models B cell B.1.351 binding comparable complement COVID-19 COVID-19 pathogenesis expressing feature golden hamsters hamster hamsters human disease immune responses immunization induce Inflammation Inflammatory molecular mechanism molecular mechanisms mRNA expression profile mRNA expression profiles myeloid Neutralizing antibody response neutralizing antibody responses Pathogenesis pathway Pathways Prevent prevented Protective proteomics recent rhesus macaque rhesus macaques SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike protein SARS-CoV-2 WA1/2020 serotype severe COVID-19 severe disease shown Spike protein stimulate Syrian golden hamster Syrian Golden hamsters These data thrombosis transcriptional type I interferon uninfected upregulation vaccination Vaccine Vaccines weight loss with COVID-19 [DOI] 10.1371/journal.ppat.1009990 PMC 바로가기 [Article Type] Article
Infection and pathogenesis of the Delta variant of SARS-CoV-2 in Rhesus macaque붉은 털 원숭이에서 SARS-CoV-2의 델타 변이체의 감염 및 발병 기전Article Published on 2022-04-012022-09-11 Journal: Virologica Sinica [Category] COVID19(2023년), SARS, 변종, [키워드] delta variant disease severity disease spread faster infect Pathogenesis rhesus macaque SARS-CoV-2 shedding Support Viral load Wuhan [DOI] 10.1016/j.virs.2022.02.001 PMC 바로가기 [Article Type] Article