Programmed -1 Ribosomal Frameshifting in coronaviruses: A therapeutic targetArticle Published on 2021-02-012023-07-12 Journal: Virology [Category] SARS, [키워드] Antiviral coronavirus COVID-19 frameshifting ribosome SARS-CoV SARS-CoV-2 Therapeutics Vaccine virus. [DOI] 10.1016/j.virol.2020.12.010 PMC 바로가기
Nonstructural Protein 1 of SARS-CoV-2 Is a Potent Pathogenicity Factor Redirecting Host Protein Synthesis Machinery toward Viral RNASARS-CoV-2의 비구조 단백질 1은 숙주 단백질 합성 기계를 바이러스 RNA로 리디렉션하는 강력한 병원성 인자입니다Article Published on 2020-12-172022-09-11 Journal: Molecular Cell [Category] MERS, SARS, 유전자 메커니즘, 진단, [키워드] 40S Alter Cell cell viability cellular cellular transcriptome complex COVID-19 pandemic cryo cryo-EM cryo-EM structure Differential expression analysis Factor Host human lung Impact inhibit mechanism mechanisms mRNA nonstructural protein 1 nsp1 paralysis pathogenicity potent protein synthesis ribosome RNA SARS-CoV-2 suppress synthesis the cells Transcriptome transcriptome alteration translation translation inhibition mechanism. viability Viral Viral proteins virus [DOI] 10.1016/j.molcel.2020.10.034 PMC 바로가기 [Article Type] Article
SARS-CoV-2 Disrupts Splicing, Translation, and Protein Trafficking to Suppress Host DefensesSARS-CoV-2는 호스트 방어를 억제하기 위해 스플라이싱, 번역 및 단백질 트래피킹을 방해합니다.Article Published on 2020-11-252022-09-11 Journal: Cell [Category] MERS, SARS, 유전자 메커니즘, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus bind cause cell membrane cellular cellular processe coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 disrupt Disruption domain engage function Host host defenses Infection Interaction interfere interferon interferon response leads molecular basis mRNA mRNA splicing mRNA translation nsp1 nsp16 NSP8 Nsp9 Protein protein trafficking protein translation respiratory Respiratory disease ribosomal RNA ribosome RNA RNA-protein interactions RNAs SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 pathogenesis SARS-CoV-2 protein SARS-CoV-2 proteins severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 snRNA splicing suppress the cell the interferon translation Viral viral infection [DOI] 10.1016/j.cell.2020.10.004 PMC 바로가기 [Article Type] Article
Mammalian Hbs1L deficiency causes congenital anomalies and developmental delay associated with Pelota depletion and 80S monosome accumulation포유류 Hbs1L 결핍은 Pelota 고갈 및 80S 모노솜 축적과 관련된 선천적 기형 및 발달 지연을 유발합니다Research Article Published on 2019-02-012022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] 4EBP1 accompanied accumulation addition affecting aggregation Anomaly baseline biallelic mutation biallelic mutations binding cause caused Cell cells Characteristics characterized coding region conditions control mechanisms controls Critical deficiency demonstrated Depletion developmental delay downstream Effect Efficiency element expression facial fibroblast fibroblasts functional growth Hbs1L human cell human cells humans hypotonia implicated increase in inhibition involved knockdown lack lead Loss mechanism mice monosome mouse model mRNA mRNA level mTOR mTOR expression murine Mutation ortholog pathway Patient pelo phenotype phenotypic Phosphorylation polysome proteasomal proteasome Protein protein expression Quality control reduced Regulation reported rescued restored resulting ribosomal RNA ribosome ribosomes RNA RT-PCR Sequencing Support the patient These data tissues transcript translation translational upregulation utilization western blot Western blot analyses Western blot analysis yeast [DOI] 10.1371/journal.pgen.1007917 PMC 바로가기 [Article Type] Research Article
Tissue- and Time-Specific Expression of Otherwise Identical tRNA Genes다른 동일한 tRNA 유전자의 조직 및 시간 특이적 발현Research Article Published on 2016-08-252022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] abrogate adaptive addition Affect affected age aggregation Amino acid Caenorhabditis Caenorhabditis elegan Caenorhabditis elegans can not changes in codon codon usage conserved disease Diseases dynamic eight element expressed expression expression level expression levels fluorescent Genes genome-wide analysis GFP hallmark Host identity intrinsic intron Intronic introns lead MONITOR mutations nematodes neurodegeneration observation orthologous gene orthologous genes Pairing predict promoter promoters Protein Protein misfolding protein sequences protein translation protein-coding gene protein-coding genes recognize regulated Regulating reporter ribosome sequence synonymous tissue tissues transcribed tRNA tRNAs Tryptophan [DOI] 10.1371/journal.pgen.1006264 PMC 바로가기 [Article Type] Research Article
High-Resolution Analysis of Coronavirus Gene Expression by RNA Sequencing and Ribosome ProfilingResearch Article Published on 2016-02-262022-10-29 Journal: PLoS Pathogens [Category] Coronavirus, [키워드] applicability approach Betacoronavirus carried Cell coronavirus Coronaviruses Course culture cell deep sequencing determine digestion Efficiency epidemic diarrhea family Coronaviridae feature Frame frameshift Gene Expression Genome genomic high mortality rate Host host-virus interactions identify Infection investigated knowledge living cell mapped member MERS-CoV MHV MHV-A59 Middle East MONITOR mouse hepatitis virus mRNA mRNAs murine nucleotide Open reading frame open reading frames ORF ORFs Other pandemic Pathogens polyprotein positive pp1a Precision Profiling profiling analysis PROTECT purified regions Regulation Regulatory Replication ribosome RNA RNA sequencing RNA virus RNA viruses SARS-CoV sensitivity tissue transcript Transcription Transcriptome transcripts translated translation translational Triplet upstream viral mRNA Viral RNA virus was performed [DOI] 10.1371/journal.ppat.1005473 PMC 바로가기 [Article Type] Research Article
Ribosomal Protein Mutations Induce Autophagy through S6 Kinase Inhibition of the Insulin Pathway리보솜 단백질 돌연변이는 인슐린 경로의 S6 키나제 억제를 통해 자가포식을 유도합니다Research Article Published on 2014-05-292022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] a major activated activating Activation affected affecting AKT Anemia antioxidant aplasia autophagy Blood blood cell Blood cells Bone marrow bone marrow failure Catabolism CD34 Cell cellular conserved Critical cytopenia deregulation disease Embryo etiology event example explanation feature Genes growth growth defects Hematopoiesis impair impairment include increase increase in induce inhibit inhibition insulin insulin resistance insulin-signaling pathway involved kinase lead maturation mechanism Mutation observé opens oxygen p53 pathophysiology pathway Pathways Patient patients phenotype Phenotypes Phosphorylation Potential treatment progenitor cell promote provide reactive oxygen species reactive oxygen specy red blood cell red blood cells Red cell red cell aplasia reduce regulated ribosomal protein ribosome ROS RPS19 SDS Shwachman-Diamond syndrome Signaling signaling pathway Treatment triggered Tumor tumor suppressor while zebrafish [DOI] 10.1371/journal.pgen.1004371 PMC 바로가기 [Article Type] Research Article
SARS Coronavirus nsp1 Protein Induces Template-Dependent Endonucleolytic Cleavage of mRNAs: Viral mRNAs Are Resistant to nsp1-Induced RNA CleavageResearch Article Published on 2011-12-082022-10-29 Journal: PLoS Pathogens [Category] Coronavirus, [키워드] 40S accelerated accompany acute respiratory syndrome Antiviral Author bind binding block cells characterized circumvent classical cleavage cleavage sites coronavirus cricket paralysis viruses Degradation demonstrated different element elements events exhibited facilitate Fever found function Hepatitis Host host gene expression host genes host mRNA host protein in vitro induce infected cells Infection inhibitor leader sequence Modification mRNA mRNAs nucleotide nucleotide sequence Protein protein synthesis recognize reporter Resistant ribosome RNA RNA modification SARS Coronavirus SARS infection severe severe symptom subunit suppress the expression susceptible translation type I type I interferon unique viral mRNA Viral protein virus virus replication [DOI] 10.1371/journal.ppat.1002433 PMC 바로가기 [Article Type] Research Article
Biochemical and Structural Insights into the Mechanisms of SARS Coronavirus RNA Ribose 2′-O-Methylation by nsp16/nsp10 Protein ComplexResearch Article Published on 2011-10-132022-10-29 Journal: PLoS Pathogens [Category] Coronavirus, [키워드] Analysis antiviral drug assays Author biochemical canonical catalytic catalyzed cellular cofactor complex composed coronavirus demonstrated different Donor drug target drugs ENCODE eukaryotic eukaryotic virus found function Immune escape in viral indicated innate immune insight inter-molecular Interaction methylated methyltransferase modify mRNA mRNA stability mRNAs non-structural protein nsp14 promote protein translation required ribose ribosome RNA RNA stability RNAs S-adenosyl-L-methionine SAM SARS Coronavirus SARS-CoV shown stimulatory Structural analysis subunit subunits unique Viral RNA virus [DOI] 10.1371/journal.ppat.1002294 PMC 바로가기 [Article Type] Research Article