The Host Response to Influenza A Virus Interferes with SARS-CoV-2 Replication during CoinfectionArticle Published on 2022-08-102023-06-24 Journal: Journal of Virology [Category] COVID19(2023년), SARS, 신종인플루엔자, [키워드] Anosmia Endemic H1N1 host response Interference interferon Long COVID pandemic. PASC RNA sequencing [DOI] 10.1128/jvi.00765-22 PMC 바로가기
Multiplexed LNP-mRNA vaccination against pathogenic coronavirus species병원성 코로나바이러스 종에 대한 다중 LNP-mRNA 백신 접종Article Published on 2022-08-022022-09-12 Journal: Cell Reports [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] activated adaptive animal models antibody antibody immunity Antibody Response antigen-specific antibody B cell coronavirus Coronavirus vaccines COVID-19 vaccine CP: Immunology cross-reactivity Delta develop Differential gene expression effective feasibility immune immune cells Immune profile immune response immunology increase in induce MERS-CoV mRNA mRNA vaccine multiplexed vaccination multispecies coronavirus vaccine offer pathogenic coronavirus profile responses responses against RNA sequencing SARS-CoV SARS-CoV-2 sequential vaccination significantly single-cell single-cell profiling systems immunology. Transcriptome triplex vaccination vaccination schedule vaccine candidate [DOI] 10.1016/j.celrep.2022.111160 PMC 바로가기 [Article Type] Article
Single-cell RNA sequencing to decipher the immunogenicity of ChAdOx1 nCoV-19/AZD1222 and mRNA-1273 vaccines in patients with autoimmune rheumatic diseases자가면역 류마티스 질환 환자에서 ChAdOx1 nCoV-19/AZD1222 및 mRNA-1273 백신의 면역원성을 해독하기 위한 단일 세포 RNA 시퀀싱Article Published on 2022-08-012022-09-12 Journal: Frontiers in Immunology [Category] SARS, 진단, [키워드] Analysis analyzed anti-rheumatic medications anti-SARS-CoV-2 IgG antibodies Antigen presentation Arthritis Autoimmune AZD1222 CD16 CD4 ChAdOx1 COVID-19 COVID-19 vaccine database domain dose electrochemiluminescence immunoassay enriched pathway enrolled exhibited Gene Expression Omnibus GEO healthy controls HLA-DRA immunized inhibitor Interaction Janus kinase methotrexate MHC class Moderna monocyte mononuclear cell mRNA-1273 mRNA-1273 vaccine mRNA-based vaccine Necrosis Oxford-AstraZeneca participant pathway Patient patients PBMC PBMCs Peripheral blood predominant quantified receiving rheumatic disease RNA sequencing scRNA-seq serum IgG antibody Single-cell RNA sequencing single-cell RNA sequencing. the SARS-CoV-2 vaccination Vaccine [DOI] 10.3389/fimmu.2022.920865 PMC 바로가기 [Article Type] Article
In Vivo Profiling of Individual Multiciliated Cells during Acute Influenza A Virus InfectionArticle Published on 2022-07-272023-06-14 Journal: Journal of Virology [Category] Fulltext, 신종인플루엔자, [키워드] Gene Expression interferon-stimulated genes reporter virus RNA sequencing Single Cell Transgenic mouse. [DOI] 10.1128/jvi.00505-22 PMC 바로가기
A diagnostic classifier for gene expression-based identification of early Lyme disease Research Published on 2022-07-222022-10-05 Journal: Communications Medicine [Category] 바이오마커, 진단, [키워드] Accuracy Algorithm association Bacteremia Borrelia cause Cell culture Classifier clinical investigation clinical utility controls database described Diagnosis diagnostic diagnostic test differentially expressed gene evaluated false-discovery rate Gene Expression highlight identify in vitro independent Infection Influenza lack Lyme disease mononuclear cell New Patient patients Peripheral blood positive Result RNA sequencing selected sensitivity Sensitivity and specificity serologic testing seronegative patient specificity subject subjects The United States Transcriptome Tuberculosis uninfected control [DOI] 10.1038/s43856-022-00127-2 [Article Type] Research
A paper-based assay for the colorimetric detection of SARS-CoV-2 variants at single-nucleotide resolution Research Published on 2022-07-142022-10-05 Journal: Nature biomedical engineering [Category] COVID19(2023년), SARS, 변종, 진단, 치료기술, [키워드] acute respiratory syndrome amplify Beta changes in cleavage colorimetric detection Concordance coronavirus diagnostic Evolution facilitate Gamma Mutation nucleic acid polymerase chain Quantitative Reactions RNA sequencing SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants single-nucleotide Surveillance the SARS-CoV-2 thermodynamic throat swab urea variant Viral RNA virus virus [DOI] 10.1038/s41551-022-00907-0 [Article Type] Research
Multi-omics personalized network analyses highlight progressive disruption of central metabolism associated with COVID-19 severityResearch article Published on 2022-07-082022-10-05 Journal: Cell Systems [Category] 바이오마커, 치료기술, [키워드] age Analysis analysis Butyrate Cell central metabolism Clinical outcome Comorbidities coronavirus disease COVID-19 COVID-19 severity determinant Digital disease severity explained fatality flow cytometry heterogeneous highlight identify Immune cell indicated metabolic metabolite metabolomics monocyte mononuclear phagocyte pathway personalized genome-scale metabolic model Perturbation plasma metabolomics progression quantification RNA sequencing severe COVID-19 severity similarity network fusion SLC16A6 SLC29A1 System biology TCA cycle the disease Treatment Whole blood with COVID-19 [DOI] 10.1016/j.cels.2022.06.006 [Article Type] Research article
Transcriptional landscape of human neuroblastoma cells in response to SARS-CoV-2SARS-CoV-2에 대한 인간 신경모세포종 세포의 전사적 풍경Article Published on 2022-07-062022-09-11 Journal: BMC neuroscience [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] Activation acute respiratory syndrome acute respiratory syndrome coronavirus analysis applied approach Cell cells Central nervous system changes in chemokines contagious coronavirus Cytokines decrease differentially expressed gene Differentially expressed genes downregulated function functions Gene ontology host mRNA identify Infection Injury involved knowledge Kyoto mechanism mRNA mRNAs Neuroinflammation Neurological symptom Neurological symptoms NF-κB pathogenic Pathways Patient performed receptors reported RNA RNA sequencing SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 signaling pathways significantly SK-N-SH cells. transcriptional profile transcriptional profiles transcriptomic Treatment upregulated [DOI] 10.1186/s12868-022-00728-6 PMC 바로가기 [Article Type] Article
Recapitulating infection, thermal sensitivity and antiviral treatment of seasonal coronaviruses in human airway organoids인간 기도 오르가노이드에서 계절성 코로나바이러스의 감염, 열 민감도 및 항바이러스 치료 요약Article Published on 2022-07-012022-09-11 Journal: EBioMedicine [Category] 치료제, [키워드] 229E Airway organoids Analysis analysis antiviral activity antiviral therapy Antiviral treatment approved conditions Coronavirus infection Coronavirus infections COVID COVID19 development experimental model facilitate favor funding help host response Human human airway Infection infections Infectious virus inhibited interactions Kinetics medication medications Mild molnupiravir Netherland NL63 OC43 occur organization Organoid Pathogenesis phenotype populations Remdesivir replicate Replication Research research and development resulting RNA sequencing robust seasonal seasonal coronavirus seasonal coronaviruses severe complication severe complications Society Support supported temperature tested therapeutic thermal Thermal sensitivity Transcriptome transcriptomic Transmissibility upper respiratory tract viral replication virus replication Virus-host interaction Virus-host interactions virus-host interactions. was performed was tested [DOI] 10.1016/j.ebiom.2022.104132 PMC 바로가기 [Article Type] Article
Spontaneous NLRP3 inflammasome-driven IL-1-β secretion is induced in severe COVID-19 patients and responds to anakinra treatmentResearch article Published on 2022-07-012022-10-05 Journal: The Journal of Allergy and Clinical Immunology [Category] COVID19(2023년), SARS, 변종, 치료법, [키워드] Activation acute respiratory syndrome Analysis analyzed Anti-inflammatory therapy apoptotic ASC Blood cDNA cell line circulating monocyte circulating monocytes coding confocal microscopy coronavirus COVID-19 Critically ill cytokine cytokine secretion Cytokine storm syndrome disease dissect driving effective Efficacy Evidence Frame IL-1 receptor antagonist IL-1β in vitro Infection Inflammasome inflammasomes Inflammation Inflammatory inflammatory parameters manifestation maturation mechanism NLRP3 NLRP3 inflammasome objective ORF3a pathway Patient patients with COVID-19 Phenotypes Plasma cytokine receptor protein reducing mortality regulated respond Result RNA sequencing SARS-CoV-2 SARS-CoV-2 protein secrete secretion severe coronavirus disease severe COVID-19 patient severe pneumonia shown Spontaneous transfection Treatment Trigger with COVID-19 [DOI] 10.1016/j.jaci.2022.05.029 [Article Type] Research article