Hydroxypropyl-beta-cyclodextrin (HP-BCD) inhibits SARS-CoV-2 replication and virus-induced inflammatory cytokines
하이드록시프로필-베타-사이클로덱스트린(HP-BCD)은 SARS-CoV-2 복제 및 바이러스 유발 염증성 사이토카인을 억제합니다
Article
[키워드] accompanied
ACE2
Affect
affected
Alter
antiviral activity
Beta
Beta-cyclodextrin
Calu
Calu-3
Cell
cell line
cell lines
cholesterol
COVID-19
COVID-19 disease
cyclodextrin
Cytokines
cytopathic effects
demonstrated
disease
drug
Drug repurposing
evidenced
excipient
experimental models
expression
Human
Hyperinflammatory syndrome
immunomodulatory effect
in vitro
in vivo
Inflammation
Inflammatory cytokine
Inflammatory response
inhibit
inhibited
inhibiting
investigated
microbial products
mitigate
Monocytes
Particles
pathophysiology
primary human cells
Proinflammatory cytokine
proinflammatory cytokines
protein levels
reducing
reduction in
Replication
replication complexes
required
Respiratory system
safety profile
SARS-CoV-2
SARS-CoV-2 replication
SARS-CoV-2 variant
SARS-CoV-2 variants
SARS-CoV2
selected
selective
significantly
systemic manifestations
the disease
therapeutic
therapeutic agent
therapeutic strategy
These data
treating
Treatment
viral cytopathic effect
virus
virus replication
virus RNA
[DOI] 10.1016/j.antiviral.2022.105373 PMC 바로가기 [Article Type] Article
[DOI] 10.1016/j.antiviral.2022.105373 PMC 바로가기 [Article Type] Article