Patients with severe COVID-19 do not have elevated autoantibodies against common diagnostic autoantigens중증 COVID-19 환자는 일반적인 진단 자가항원에 대한 자가항체가 상승하지 않습니다.Article Published on 2022-04-282022-09-12 Journal: Clinical chemistry and laboratory medicine [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] acute respiratory syndrome Affect autoantibodies autoantibody autoantigen Autoantigens Autoimmune disease Autoimmunity autoinflammatory response Care causative pathogen circulating cohorts controls coronavirus disease Coronavirus-2 COVID-19 Diagnosis diagnostic Electrochemiluminescence elevated Elevation groups healthy hospital ICU IgG individuals infection with SARS-CoV-2 intensive care unit (ICU) Level marker Meso Scale Discovery moderate MSD outcome Patient prognostic Prognostic markers quantified response sample collection SARS-CoV-2 self-antigen serum serum sample severe COVID-19 severe disease tested uninfected uninfected control was collected were measured [DOI] 10.1515/cclm-2022-0239 PMC 바로가기 [Article Type] Article
Identification of SARS-CoV-2 variants using viral sequencing for the Centers for Disease Control and Prevention genomic surveillance program질병 통제 예방 센터의 게놈 감시 프로그램을 위한 바이러스 시퀀싱을 사용한 SARS-CoV-2 변이체 식별Article Published on 2022-04-252022-09-11 Journal: BMC Infectious Diseases [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, [키워드] Affect Analysis association B.1.617.2 Brazil CDC center Centers for Disease Control Chain Reaction choice Control Coverage COVID COVID-19 Critical Ct value Ct values cycle cycle threshold Delta diagnostics disease control disease severity Effectiveness Gamma genetic change Genetic changes genomic genomic sequencing GISAID highlight identification Illumina India initial Laboratory Lineage Metrics nasopharyngeal Nasopharyngeal swab NCBI next generation sequencing NovaSeq 6000 nucleic acid omicron oropharyngeal swab P.1 Patient performed platform polymerase chain polymerase chain reaction positive positive sample prevention protocol public health Quality control reverse transcription polymerase chain reaction RT-PCR RT-PCR Ct Saliva saliva samples sample collection SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 sequencing SARS-CoV-2 surveillance SARS-CoV-2 variant SARS-CoV-2 viral selected sequence sequenced Sequencing sequencing coverage sequencing depth sequencing method submission Surveillance the SARS-CoV-2 genome the United State Therapeutics Transcription Transmission Treatment United States Vaccine Vaccines variant variant call variant calls variants was performed whole genome [DOI] 10.1186/s12879-022-07374-7 PMC 바로가기 [Article Type] Article
Enhancing epidemiological surveillance of the emergence of the SARS-CoV-2 Omicron variant using spike gene target failure data, England, 15 November to 31 December 2021스파이크 유전자 표적 실패 데이터를 사용하여 SARS-CoV-2 Omicron 변이의 출현에 대한 역학 감시 강화, 2021년 11월 15일부터 12월 31일까지 영국Article Published on 2022-03-012022-09-11 Journal: Eurosurveillance [Category] SARS, 변종, [키워드] applied COVD-19 delta variant differentiation disease Disease surveillance dominant England Enhancing epidemiological growth management omicron public health S gene S gene target failure s-gene target failure. sample collection SARS-CoV-2 spike gene Surveillance the SARS-CoV-2 variant [DOI] 10.2807/1560-7917.ES.2022.27.11.2200143 PMC 바로가기 [Article Type] Article
Development of rapid antigen test prototype for detection of SARS-CoV-2 in saliva samples타액 샘플에서 SARS-CoV-2 검출을 위한 신속 항원 검사 프로토타입 개발Original Article Published on 2022-02-252022-09-10 Journal: Upsala Journal of Medical Sciences [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, [키워드] Accuracy acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 anti-RBD anti-receptor-binding domain Anti-spike antibody Antigen antigen test Asymptomatic capture Chain Reaction clinical analysis Cohort Combination combinations coronavirus coronavirus disease COVID-19 demonstrated detect detection antibody development diagnostic Diagnostic accuracy Diagnostic method diagnostic methods domain early stage ELISA ENhance enzyme enzyme-linked immunosorbent enzyme-linked immunosorbent assay evaluated exhibited followed by hospitalized COVID-19 patient hospitalized COVID-19 patients immunized improvement individual Infection interquartile range lateral flow lateral flow assay median time NPV onset of symptom pilot study point-of-care testing polyclonal antibodies polyclonal antibody polymerase chain reaction positive PPV RBD reference method respiratory Result reverse transcription Reverse transcription-polymerase chain reaction rRBD rRT-PCR Saliva saliva samples sample collection SARS-CoV-2 SARS-CoV-2 detection SARS-COV-2 infection SARS-CoV-2 spike protein SARS-CoV-2 virus sensitivity severe acute respiratory syndrome Coronavirus specificity Spike protein stratified symptomatic patient tested the median the SARS-CoV-2 validation study virus was used were used [DOI] 10.48101/ujms.v127.8207 PMC 바로가기 [Article Type] Original Article
Evaluation of the Performance of a Multiplexed Serological Assay in the Detection of SARS-CoV-2 Infections in a Predominantly Vaccinated Population백신 접종이 우세한 집단에서 SARS-CoV-2 감염 감지에 대한 다중 혈청학적 분석의 성능 평가Observation Published on 2022-02-232022-09-10 Journal: Microbiology Spectrum [Category] MERS, 진단, 치료법, [키워드] Antibody detection AUC value AUC values calculated Canada Cohort coronavirus COVID-19 COVID-19 infection COVID-19 infections cutoff value defined detection Elecsy Evidence evidence of excluded group highest identify IgG individual individuals Infection investigated Meso Scale Discovery MSD nucleocapsid Panel paramedics Participants PCR test performance Population positive SARS-CoV-2 PCR positive SARS-CoV-2 PCR test positive serology postvaccination prospective cohort required Roche sample collection SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infections SARS-CoV-2 seroprevalence sensitivities sensitivity Sensitivity and specificity serology serum sample serum samples significantly significantly higher Specificities specificity subgroup subgroups test performance threshold vaccinated individuals vaccination Vaccination Status [DOI] 10.1128/spectrum.01454-21 PMC 바로가기 [Article Type] Observation
Feasibility of Specimen Self-collection in Young Children Undergoing SARS-CoV-2 Surveillance for In-Person Learning대면 학습을 위해 SARS-CoV-2 감시를 받는 어린 아동의 표본 자체 수집 가능성Research Published on 2022-02-172022-09-12 Journal: JAMA Network Open [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] 95% CI African Asian black Can children cohort study collected conducted Consent Course COVID-19 Data collection decrease demographic data enrolled error error rate evidenced feasibility finding highest Importance learning measure median multiracial nasal swab nasal swabs objective occurred Older option parameter participant Participants Point Quantitative data Relevance Research Result sample collection SARS-CoV-2 SARS-CoV-2 surveillance SARS-CoV-2 testing scalability School setting specimen specimen collection student Surveillance surveillance testing Swab Testing waiver [DOI] 10.1001/jamanetworkopen.2021.48988 PMC 바로가기 [Article Type] Research
Efficacy of Niclosamide vs Placebo in SARS-CoV-2 Respiratory Viral Clearance, Viral Shedding, and Duration of Symptoms Among Patients With Mild to Moderate COVID-19 A Phase 2 Randomized Clinical Trial경증에서 중등도의 COVID-19 A 2상 무작위 임상 시험에서 SARS-CoV-2 호흡기 바이러스 제거, 바이러스 배출 및 증상 지속 기간에서 니클로사미드 대 위약의 효능Randomized Controlled Trial Published on 2022-02-092022-09-10 Journal: JAMA Network Open [Category] COVID19(2023년), SARS, 신약개발, 임상, 치료제, [키워드] 1:1 95% CI accounted addition adverse event adverse events age All trial participants analyzed antiviral activity assigned blind by mouth calculated center Chain Reaction Characteristics clearance of SARS-CoV-2 clinical clinical trial confirmation contagious period cough COVID COVID-19 COVID-19 testing decrease determined by diagnose Duration duration of symptom Efficacy enrolled Enrollment exclusion criteria fecal Fecal sample finding group groups headache Headaches Hospitalization Importance in vitro individual Infection intention-to-treat investigators Laboratory Massachusett Massachusetts mean difference mean survival time measure men Mild mild to moderate Mild to moderate COVID-19 mild to moderate symptoms moderate Moderate COVID-19 MONITOR mouth network niclosamide no significant difference objective oral Oropharyngeal participant Participants Patient patients receiving placebo Phase 2 Placebo placebo group placebo-controlled clinical trial platform Point polymerase chain polymerase chain reaction positive primary end point proportion Randomized randomized clinical trial Randomly receive receiving Registration Relevance reported respiratory respiratory sample Respiratory samples Result Safe sample collection Sample size SAR-CoV-2 SARS-CoV-2 SARS-CoV-2 clearance setting shedding significant effect significantly Standard of care statistically Symptom symptom duration symptom resolution Symptoms the placebo group therapy treat Treatment treatment for COVID-19 treatment groups Trial trial participants Tuft vaccination Viral viral clearance viral shedding was collected [DOI] 10.1001/jamanetworkopen.2021.44942 PMC 바로가기 [Article Type] Randomized Controlled Trial
Sensitivity and Specificity of SARS-CoV-2 Rapid Antigen Detection Tests Using Oral, Anterior Nasal, and Nasopharyngeal Swabs: a Diagnostic Accuracy Study구강, 전방 비강 및 비인두 면봉을 사용한 SARS-CoV-2 신속 항원 검출 검사의 민감도 및 특이성: 진단 정확도 연구Research Article Published on 2022-02-022022-09-10 Journal: Microbiology Spectrum [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, [키워드] 95% CI 95% confidence interval Accuracy Anterior Antigen antigen detection calculated Cohort collected cycle threshold detection determined by diagnostic evaluate evaluated followed by gold gold standard head hospital Hospitalized Infection Infectious disease investigator nasal nasal swab nasopharyngeal sample Nasopharyngeal samples Nasopharyngeal swab nasopharyngeal swabs negative sample oral parameter participant Participants Patient PCR performed positive questionnaire Rapid Rapid antigen detection reliability respiratory respiratory tract infection Respiratory tract infections reverse transcriptase reverse transcriptase PCR RT-PCR sample collection SARS-CoV-2 SARS-CoV-2 detection SARS-COV-2 infection sensitivity Sensitivity and specificity specificity specimen Spread Swab swabbing Test test performance test result test results tolerable Usability Vienna while widespread [DOI] 10.1128/spectrum.02029-21 PMC 바로가기 [Article Type] Research Article
Alternative SARS-CoV-2 detection protocol from self-collected saliva for mass diagnosis and epidemiological studies in low-incoming regions유입량이 적은 지역의 대량 진단 및 역학 연구를 위한 자가 수집 타액의 대체 SARS-CoV-2 검출 프로토콜Article Published on 2022-02-012022-09-11 Journal: Journal of virological methods [Category] COVID19(2023년), SARS, 치료기술, [키워드] 95 % CI ABC acute respiratory syndrome adopted Betacoronavirus Chain Reaction circulation cotton develop diagnosed Diagnosis diagnostic Diagnostic Criteria Diagnostic method diagnostic protocol Endpoint epidemiological studies Epidemiological study evaluated foci healthcare facility hydrophilic initial Laboratory Local mass vaccination material medical school Molecular diagnosis nasopharynx pandemic Patient polymerase chain polymerase chain reaction positive protocol qRT-PCR Quantitative Region regions RT-endpoint-PCR Saliva saliva samples sample collection SARS-CoV-2 SARS-CoV-2 detection SARS-CoV-2 qRT-PCR School Severe acute respiratory syndrome social distancing Support the SARS-CoV-2 Transmission vaccination Viral RNA viral RNA detection virus [DOI] 10.1016/j.jviromet.2021.114382 PMC 바로가기 [Article Type] Article
Risk of contamination of semen, vaginal secretions, follicular fluid and ovarian medulla with SARS-CoV-2 in patients undergoing ARTART를 받는 환자에서 SARS-CoV-2에 의한 정액, 질 분비물, 난포액 및 난소 수질의 오염 위험Observational Study Published on 2022-01-282022-09-11 Journal: Human reproduction (Oxford, England) [Category] SARS, 임상, 치료기술, [키워드] activities activity acute COVID-19 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 analysed Analysis ART asymptomatic patient asymptomatic patients Can caution chance clinics Cohort collected conducted conflict of interest Contamination coronavirus COVID-19 cryopreservation cycle detectable follicular Follicular fluid implication Informed consent IVF/ICSI measure mRNA nasopharyngeal Nasopharyngeal swab no risk number of sample Oocyte ovarian ovarian tissue pandemic Patient positive Prevent processed questionnaire Questionnaires recommendations registration number reported reproductive reproductive system residual material RNA RT-PCR RT-qPCR sample collection SARS-CoV-2 SARS-CoV-2 pandemic SARS-CoV-2 RNA detection SARS-CoV-2 test secretion Semen Semen analysis severe acute respiratory syndrome Coronavirus suggested Swab swabs symptomatic infections tissue Trial undergo undetectable vaginal secretions. Viral RNA [DOI] 10.1093/humrep/deab255 PMC 바로가기 [Article Type] Observational Study