Systematic virtual screening in search of SARS CoV-2 inhibitors against spike glycoprotein: pharmacophore screening, molecular docking, ADMET analysis and MD simulationsArticle Published on 2022-10-012022-11-15 Journal: Molecular diversity [Category] COVID19(2023년), SARS, 치료제, [키워드] absence acting acute respiratory syndrome Amino acid Analysis Anti-viral binding site catalytic coronavirus disease Coronavirus-2 COVID-19 distribution docking score effective Entry inhibitor glycoprotein host cell in silico inhibitor Interaction less Ligand MD simulation MD simulations medications metabolism molecular molecular docking nucleic acid offered performed Precision research finding residue SARS CoV-2 spike spike glycoprotein spike glycoprotein. stability starting point target Toxicity viral entry Virtual screening [DOI] 10.1007/s11030-022-10394-9 PMC 바로가기
Variable duration of viral shedding in cancer patients with coronavirus disease 2019 (COVID-19)Article Published on 2022-10-012023-07-06 Journal: Infection Control and Hospital Epidemiology [Category] COVID19(2023년), [키워드] Cancer COVID-19 SARS CoV-2 Viral shedding. [DOI] 10.1017/ice.2021.378 PMC 바로가기
Characterization of pathogen-inactivated COVID-19 convalescent plasma and responses in transfused patientsArticle Published on 2022-10-012022-11-15 Journal: Transfusion [Category] COVID19(2023년), SARS, 진단, [키워드] 28-day mortality acute respiratory syndrome administration adverse effects adverse event adverse events antibody antibody assay Antibody Response Antibody titers Antigen assays binding case-control study CCP Characteristics characterization Control Controlled trial convalescent convalescent plasma coronavirus COVID-19 COVID-19 convalescent plasma died disease severity Donor donors enrolled evaluated group had no heterogeneous hospital Hospitalized immune response Immunosuppressed median median age Microarray NAb Neutralizing Neutralizing activity Neutralizing antibodies neutralizing antibody neutralizing antibody assays neutralizing capacity not affect pathogen-reduction treatment. Patient Pneumonia recipient recipients response responses SARS CoV-2 SARS-CoV-2 SARS-CoV-2 antigen SARS-CoV2 single-center survival symptom onset transfused transfusion treated Treatment variable with COVID-19 [DOI] 10.1111/trf.17083 PMC 바로가기
Hybrid and vaccine-induced immunity against SAR-CoV-2 in MS patients on different disease-modifying therapiesArticle Published on 2022-10-012022-11-15 Journal: Annals of Clinical and Translational Neurology [Category] COVID19(2023년), SARS, 진단, [키워드] age analysis antibody Antibody Response assays association cellular cellular response Cellular responses center COVID-19 infection COVID-19 vaccination ELISPOT evaluated examined groups hybrid IFNγ IL-2 immune response immune responses Immunity immunoassay immunologic response independent independent predictor Infection laboratory-confirmed Live virus microneutralization mRNA vaccines multivariate multivariate analyses New York no difference Patient post-vaccination response post-vaccine response receptor recruited SAR-CoV-2 SARS CoV-2 Sex significantly increased subset therapy vaccination Vaccine Vaccine-induced immunity were assessed [DOI] 10.1002/acn3.51664 PMC 바로가기
Risk of vertical transmission of SARS CoV-2 infection to neonates born to covid positive mothers: A pilot study from a tertiary care hospital of North India코로나 바이러스 양성 산모에게서 태어난 신생아에게 SARS CoV-2 감염의 수직 전파 위험: 북인도의 3차 병원에서 실시한 파일럿 연구Article Published on 2022-10-012022-09-11 Journal: Journal of infection and chemotherapy : official j [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, [키워드] amniotic Amniotic fluid Analysis anti-SARS-CoV-2 IgG anti-SARS-CoV-2 IgG antibodies anti-SARS-CoV-2 IgG antibody anti-SARS-CoV-2 IgM antibody biological sample Blood Breast breast milk Care Cervicovaginal secretion clinical implication conducted Cord blood Cord blood IgG-IGM COVID-19 demonstrated disease disease severity fetal fetal membrane greater hospital IgG IgM antibodies Immunoglobulin India Infection material mechanism membrane mother Nasopharyngeal swab Neonatal Neonate Neonates North passive immunity performed pilot study positive positive correlation pregnant women Presence Prospective Study risk RT-PCR SARS CoV-2 SARS-CoV-2 SARS-COV-2 infection secretion shown tested Transmission unlikely vertical transmission Vertical transmission. virus women [DOI] 10.1016/j.jiac.2022.06.004 PMC 바로가기 [Article Type] Article
Humoral cross-coronavirus responses against the S2 region in children with Kawasaki diseaseArticle Published on 2022-10-012022-11-15 Journal: Virology [Category] COVID19(2023년), SARS, 진단, [키워드] antibodies antibody approach children Control Coronary Coronary aneurysms coronavirus correlated CoV CoVs Cross-immunity cross-reactive cross-reactivity effort explain feature febrile humoral Immunity Infection Inflammatory Kawasaki disease MIS-C multisystem inflammatory syndrome in children OC43 pathology Protein raise reactivity recent Region responses against Safe SARS CoV-2 SARS-CoV-2 SARS-CoV-2 S2 SARS-CoV-2. shown Support syndrome the Spike Vaccine vascular inflammation [DOI] 10.1016/j.virol.2022.08.010 PMC 바로가기
Immunogenicity of two COVID-19 vaccines used in India: An observational cohort study in health care workers from a tertiary care hospitalArticle Published on 2022-09-232022-11-15 Journal: Frontiers in Immunology [Category] SARS, 진단, 치료기술, [키워드] adenoviral-vectored vaccine antibodies blood sample booster Care Cell collected Covaxin COVID-19 COVID-19 case COVID-19 vaccine Covishield diminished dose elicited ELISA full-length Health care worker hospital immune response Immunity immunization immunogenicity Immunogenicity. independent India initiated IQR long-term follow up median Neutralizing Neutralizing antibody titer Observational cohort study pandemic PBMC pre-vaccination progression recipient recipients remained SARS CoV-2 Seroconversion T cell T cell response T-cell Response tested Vaccine Vaccines were recorded were used [DOI] 10.3389/fimmu.2022.928501 PMC 바로가기
Label free detection of SARS CoV-2 Receptor Binding Domain (RBD) protein by fabrication of gold nanorods deposited on electrochemical immunosensor (GDEI)전기화학적 면역센서(GDEI)에 증착된 금 나노막대를 제작하여 SARS CoV-2 수용체 결합 도메인(RBD) 단백질의 무표지 검출Article Published on 2022-09-152022-09-11 Journal: Biosensors & bioelectronics [Category] COVID19(2023년), SARS, 치료기술, [키워드] AFM antibody binding Blot chain Chain Reaction characterized cloned collected coronavirus disease Coronavirus disease 2019 COVID-19 Cross reactivity cyclic Detection limit DPV dynamic early diagnosis Efficiency electrochemical electron electron carrier Electrophoresis ELISA enzyme enzyme-linked immunosorbent assay expressed fabrication flight fluorine followed by force FTO gel electrophoresis gold Gold nanorods house immobilization Infectious disease kDa lAbel Laser LIGHT MERS middle Middle East Middle East respiratory syndrome molecular weight nasopharyngeal sample Outbreaks output Oxide pandemic polyacrylamide Population Protein RBD RBD antigen RBD gene reaction Receptor binding domain respiratory reverse transcription Reverse transcription-polymerase chain reaction RT-PCR SARS CoV SARS CoV-2 SDS-PAGE shown Spectroscopy spike Spike protein spike protein. stability TEM tested the patient Tin Tin Oxide transmission electron microscopy viral transport media VTM was determined western blot [DOI] 10.1016/j.bios.2022.114406 PMC 바로가기 [Article Type] Article
Determinants of Neutralizing Antibody Response After SARS CoV-2 Vaccination in Patients With MyelomaArticle Published on 2022-09-102022-11-15 Journal: Journal of clinical oncology : official journal of [Category] SARS, 변종, 진단, 치료기술, [키워드] affected analyzed antibody B-cell malignancy BNT162b2 Booster vaccine Characteristics Critical Delta detect detectable determinant disease environmental exposure Factors greater hosts Immunocompromised implication increased risk induction initial lack Live virus Moderna MONITOR Mortality mRNA1273 much lower Multiple myeloma Myeloma NAb neutralization neutralize neutralizing antibody neutralizing capacity nucleocapsid Patient patients Pseudovirus neutralization assay quantified RBD receiving response SARS CoV-2 Seroconversion Serologic response significantly spike receptor-binding domain the vaccine Treatment vaccination Vaccine vaccine-induced antibody variant viral neutralization virus virus-neutralizing were measured [DOI] 10.1200/JCO.21.02257 PMC 바로가기
Clinical significance and role of coinfections with respiratory pathogens among individuals with confirmed severe acute respiratory syndrome coronavirus-2 infectionArticle Published on 2022-09-022022-11-15 Journal: Frontiers in Public Health [Category] SARS, 치료기술, [키워드] 229E acute respiratory syndrome Adenovirus AdV age analyzed average C-reactive protein (CRP cause children Clinical data clinical feature clinical picture Clinical significance Coinfection collected Combination complications Coronavirus-2 COVID-19 CRP detect determine Diseases distribution highest HKU1 Hospital stay hospitalized patient individual Infection Influenza influenza A Influenza virus involved lymphocyte métapneumovirus NL63 OC43 other respiratory virus outcome Outpatient parainfluenza virus Patient patients with SARS Prevalence Prevent proportion respiratory pathogen respiratory syncytial virus respiratory virus respiratory viruses rhinovirus RSV SARS CoV-2 SARS-CoV-2 SARS-CoV-2 positive patient Screening seasonal coronavirus specimen tested the disease the mean Treatment Viral load Viral load. virus was determined was used worsening [DOI] 10.3389/fpubh.2022.959319 PMC 바로가기