SARS-CoV-2 biology – Page 3 – Communicable Diseases Research

Pathogenesis of Multiple Organ Injury in COVID-19 and Potential Therapeutic Strategies

Physiology

Published on 2021-01-282022-10-31
Journal: Frontiers in Physiology
[Category] COVID-19,

[키워드] 2019-nCoV ACE2 Activation acute respiratory disease Ang II binding biological activity bowel Brain cell type claimed confirmed cases coronavirus coronavirus disease COVID-19 COVID-19 pathogenesis described downregulation downstream Effect effective therapy enzyme Express expressed Fatality rate feature global effort highlight host cell human cell identify infect infected individual Injury kidney life-threatening liver lung Multiple multiple organ dysfunction Novel coronavirus other organs pandemic pathophysiology Potential potential therapeutic target Protective Protein RAAS reduced Respiratory disease resulting Safe SARS-CoV-2 SARS-CoV-2 biology SARS-COV-2 infection Strategy Structure susceptible syndrome systemic inflammation the disease therapy tissues viral infection
[DOI] 10.3389/fphys.2021.593223 PMC 바로가기 [Article Type] Physiology

Repurposing Nimesulide, a Potent Inhibitor of the B0AT1 Subunit of the SARS-CoV-2 Receptor, as a Therapeutic Adjuvant of COVID-19

Discussion

Published on 2020-12-012022-10-05
Journal: SLAS discovery : advancing life sciences R & D
[Category] SARS, 신약개발,

Pervasive generation of non-canonical subgenomic RNAs by SARS-CoV-2

SARS-CoV-2에 의한 비정규 서브게놈 RNA의 광범위한 생성

Research

Published on 2020-12-012022-08-13
Journal: Genome Medicine
[Category] MERS, SARS, 유전자 메커니즘,

[키워드] 3′ end 5′ UTR abundance accessory protein addition analysis approaches canonical canonical sgRNA canonical sgRNAs caused Cell culture condition Consistency Coordinate coronavirus disease Coronavirus disease 2019 Coverage COVID-19 determine Direct RNA sequencing eight Evidence family Coronaviridae FIVE generate Genome highlight homology Host identify in viral increase in independent Infection information Integrative analysis junction landscape leader sequence make up nc-sgRNA nc-sgRNAs non-canonical sgRNA non-canonical sgRNAs non-canonical subgenomic RNA offer open reading frames ORF ORF1a ORFs positive-sense RNA virus Region reported Result RNA RNA virus SARS-CoV-2 SARS-CoV-2 biology SARS-CoV-2 genome SARS-CoV-2 pathogenesis SARS-CoV-2 RNA SARS-CoV-2 sgRNA SARS-CoV-2 sgRNAs SARS-CoV-2 transcriptome SARS-CoV-2 transcriptomes sequence sequences Sequencing Seven sgRNA sgRNAs subgenomic RNA subgenomic RNAs supplementary material the SARS-CoV-2 genome Transcription transcriptional activity transcriptional regulatory sequence transcriptional regulatory sequences transcriptomes TRS TRS-B TRS-L Viral viral isolate viral isolates viral RNAs was used worldwide pandemic
[DOI] 10.1186/s13073-020-00802-w PMC 바로가기 [Article Type] Research