Computational study and design of effective siRNAs to silence structural proteins associated genes of Indian SARS-CoV-2 strains인도 SARS-CoV-2 균주의 구조 단백질 관련 유전자를 침묵시키는 효과적인 siRNA의 계산 연구 및 설계Article Published on 2022-06-012022-09-11 Journal: Computational biology and chemistry [Category] COVID19(2023년), SARS, 치료법, 치료제, [키워드] absence acute respiratory disease Ago2 Algorithm animal models antiviral drug antiviral drugs Antiviral treatment binding candidate collected complementary Consensus COVID-19 deaths docking Effect effective envelope protein feature free energy GC content gene silencing Genes Genome Health Organization heat capacity Human Human genome in vitro in vivo India melting temperature membrane protein molecular docking analysis nucleic acid nucleocapsid nucleotide nucleotides outbreak pandemic parameter pathogenic coronavirus pathway Post-transcriptional gene silencing Protein public health Region reported Respiratory disease RNA RNA interference RNAi SARS-CoV-2 SARS-CoV-2 strain SARS-CoV-2 strains selected sequence sequenced siRNA siRNA molecule siRNA molecules siRNAs structural protein structural proteins Surface glycoprotein target target gene target mRNA temperature Therapeutic treatment triggered viral pathogenesis WHO World Health Organization [DOI] 10.1016/j.compbiolchem.2022.107687 PMC 바로가기 [Article Type] Article
Characterization and antiviral susceptibility of SARS-CoV-2 Omicron BA.2 Research Published on 2022-05-162022-10-05 Journal: Nature [Category] COVID19(2023년), SARS, 변종, 진단, 치료기술, 치료제, [키워드] addition Antiviral Antiviral compound antiviral drug B.1.1.529 characterization chimeric COVID-19 delta variant dominant effective Effectiveness evaluated expressing hamster hamsters individual isolate less Lineage mice molnupiravir monoclonal antibody Mutation Neutralizing activity omicron organ pathogenicity plasma raised recipient reduction in REGN10933 REGN10987 Replication replicative restrict rodent S309 SARS-CoV-2 SARS-CoV-2 strain SARS-CoV-2 strains Strains susceptibility the spike protein therapeutic Vaccine Vaccines variant variants viral infection [DOI] 10.1038/s41586-022-04856-1 [Article Type] Research
Ex vivo and in vivo suppression of SARS-CoV-2 with combinatorial AAV/RNAi expression vectors조합 AAV/RNAi 발현 벡터를 사용한 SARS-CoV-2의 생체외 및 생체내 억제Article Published on 2022-05-042022-09-11 Journal: Molecular therapy : the journal of the American So [Category] COVID19(2023년), SARS, 변종, 치료제, [키워드] AAV acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition adeno-associated virus Antiviral Antiviral agents antiviral RNAi Cell clinically cocktail complement coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 disease symptom effective escape mutant escape mutants experiment expression vector flexible Genetic global effort Gut hACE2 in vivo infected cell infected cells intestinal cells intranasal mice mutational escape. N gene N genes organoids pandemic prevented RdRP RNA RNAi SARS virus SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 RdRp SARS-CoV-2 strains severe acute respiratory syndrome Coronavirus suppressed the SARS-CoV-2 therapeutic translation triggers Vaccine vector vectors viral adaptation Viral load viral loads virus wild-type [DOI] 10.1016/j.ymthe.2022.01.024 PMC 바로가기 [Article Type] Article
Limited cross-species transmission and absence of mutations associated with SARS-CoV-2 adaptation in cats: A case study of infection in a small household setting고양이의 SARS-CoV-2 적응과 관련된 제한된 종간 전파 및 돌연변이 부재: 소규모 가정 환경에서의 감염 사례 연구Article Published on 2022-05-012022-09-11 Journal: Transboundary and emerging diseases [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] absence adaptation adaptive Anosmia Asymptomatic cat cats chain Clinical signs close contact collected Concentration concentrations Course COVID-19 Cross-species transmission Diagnosis Epidemiology fatigue flat highlight Human human SARS-CoV-2 strain human SARS-CoV-2 strains immunosuppressive Infection infections initial Interaction investigated Limited loss of taste Mutation naïve natural infection retroviral RT-PCR SARS-CoV-2 SARS-CoV-2 RNA SARS-CoV-2 strains SARS-CoV-2 transmission Seroconversion Serological testing sneezing Support Swab symptom onset Taste titre Transmission Viral RNA virus virus titre virus transmission were measured whole-genome sequencing [DOI] 10.1111/tbed.14132 PMC 바로가기 [Article Type] Article
Epidemiological Features of COVID-19 in Northwest Russia in 20212021년 러시아 북서부 COVID-19의 역학적 특징Article Published on 2022-04-292022-09-11 Journal: Viruses [Category] COVID19(2023년), SARS, 변종, [키워드] age Alpha Analysis assessment AT.1 variant base Beta carried changes in characteristic characterized China circulating Coronavirus infection COVID-19 COVID-19 incidence COVID-19 pandemic decrease Delta delta variant epidemiological epidemiological situation epidemiological surveillance Europe feature Federal District fluctuation fluctuations Genetic Genetic variant genetic variants global health globe Health highlight increase International Lineage lineages megacity morbidity mortality rate mortality rates Northwest Russia Novel coronavirus Novel coronavirus infection occurred omicron pandemic Pasteur Institute Phylogenetic Phylogenetic tree population density progression provided reached replaced Russia Saint Petersburg SARS-CoV-2 SARS-CoV-2 strains severe COVID-19 severity shown Spread strain Surveillance Transport vaccination variant variants variants of concern VoC Wuhan [DOI] 10.3390/v14050931 PMC 바로가기 [Article Type] Article
Characteristics of SARS-CoV-2 transmission in a medium-sized city with traditional communities during the early COVID-19 epidemic in China중국의 초기 COVID-19 전염병 동안 전통 공동체가 있는 중소 도시의 SARS-CoV-2 전파 특성Article Published on 2022-04-012022-09-11 Journal: Virologica Sinica [Category] COVID19(2023년), SARS, 변종, [키워드] activities Analysis approach characterized China Chinese Cluster Community community transmission Complete COVID-19 case COVID-19 epidemic Culture effective Epidemics Epidemiology Evolution of SARS-CoV-2 Family size infections information Intrahost variant local outbreak MOST new SARS-CoV-2 occurred outbreak polymorphism profile profiles provided reference genome reported SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 genomes SARS-CoV-2 strains SARS-CoV-2 transmission sequenced single-nucleotide single-nucleotide polymorphism strain the early SARS-CoV-2 the epidemic the SARS-CoV-2 Transmission transmission pattern variant Wuhan Wuhan, China [DOI] 10.1016/j.virs.2022.01.030 PMC 바로가기 [Article Type] Article
Prediction of putative potential siRNAs for inhibiting SARS-CoV-2 strains, including variants of concern and interest관심 및 관심의 변이체를 포함하여 SARS-CoV-2 균주를 억제하기 위한 잠정적 잠재적 siRNA의 예측Article Published on 2022-04-012022-09-11 Journal: Future Microbiology [Category] COVID19(2023년), SARS, 변종, [키워드] binding Characteristics coding sequence coronavirus strain COVID-19 expected in vitro in vivo inhibit inhibiting Measures Metadata Novel coronavirus predict predicted prediction RdRP Region sampling SARS SARS-CoV-2 SARS-CoV-2 protein SARS-CoV-2 proteins SARS-CoV-2 strains siRNA siRNAs therapeutic therapeutic intervention Transcription variants variants of concern variants of SARS-CoV-2 viral replication were used [DOI] 10.2217/fmb-2021-0130 PMC 바로가기 [Article Type] Article
The mutational dynamics of the SARS-CoV-2 virus in serial passages in vitro시험관 내 연속 계대에서 SARS-CoV-2 바이러스의 돌연변이 역학Article Published on 2022-04-012022-09-11 Journal: Virologica Sinica [Category] COVID19(2023년), SARS, 변종, [키워드] accumulating acute respiratory syndrome coronavirus adaptation adaptive analysed boost Cell culture cell line change coding Combination Community competition coronavirus 2 directional effective Evolution explained Frequency Gene pool genetic change Genetic changes hotspot immune escape mutation in vitro insertions Mutation Mutational dynamics Neutral outbreak passage path performed potency Replication respiratory RT-qPCR SARS-CoV-2 SARS-CoV-2 strains Sequencing Serial passage in vitro severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 species speed strain Substitution the SARS-CoV-2 the SARS-CoV-2 virus unique variants WGS whole genome Whole genome sequencing Whole genome sequencing (WGS) [DOI] 10.1016/j.virs.2022.01.029 PMC 바로가기 [Article Type] Article
Pro108Ser mutation of SARS-CoV-2 3CL pro reduces the enzyme activity and ameliorates the clinical severity of COVID-19SARS-COV-2 3CL PRO의 PRO108SER 돌연변이는 효소 활성을 감소시키고 COVID-19의 임상 적 심각성을 개선시킨다.Article Published on 2022-01-252022-09-10 Journal: Scientific Reports [Category] 변종, 유전자 메커니즘, 임상, 진단, 치료기술, 치료법, 치료제, [키워드] 3CL pro Amino acid amino acid residue characterization chymotrypsin Clinical course Clinical severity clinical trial Controlled clinical trial COVID-19 COVID-19 in patient death demonstrated deuterium enzymatic activity enzyme enzyme activity Enzyme mechanisms hospital hydrogen infected with SARS-CoV-2 Infection inhibitor International Lineage lower risk mass spectrometry mutant Mutation oxygen oxygen supplementation Patient patients with SARS-CoV-2 PF-07321332 Placebo positioned proportion protease Randomized reduce reduced required SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 strains strain Support symptom onset the patient treated Trial viral infection virus [DOI] 10.1038/s41598-022-05424-3 PMC 바로가기 [Article Type] Article
Is the Alpha Variant of SARS-CoV-2 Associated with a Higher Viral Load than the Historical Strain in Saliva Samples in Patients with Mild to Moderate Symptoms?Article Published on 2022-01-212022-10-29 Journal: International Review of Cell and Molecular Biology [Category] COVID-19, [키워드] Acute respiratory infection Alpha variant Analysis collected COVID-19 COVID-19 pandemic Evolution Follow-up load Mild moderate no significant difference observé onset of symptom Patient performed positive primary care Saliva salivary Sample SARS-CoV-2 SARS-CoV-2 strains strain Strains Symptoms the SARS-CoV-2 Transmissibility used data variant Viral load [DOI] 10.3390/life12020163 PMC 바로가기 [Article Type] Article