Inhibition of cytokine gene expression and induction of chemokine genes in non-lymphatic cells infected with SARS coronavirusResearch Published on 2006-03-292022-10-28 Journal: Virology Journal [Category] Coronavirus, [키워드] activate acute respiratory syndrome Antiviral antiviral gene Caco-2 Cell cell line cell lines cell types cells chemokine chemokine gene Colon Course cytokine cytokine profile cytokine response determine disease dissemination embryonic kidney Gene Expression Host IFN-α IFN-β IFN-λ1 IL-6 IL-8 Immune cell infect Infected infiltration inhibition investigated IP-10 lung marker non-immune RANTES Result SARS Coronavirus SARS patient SARS-CoV suppresse the interferon tissue Transcription triggered virus [DOI] 10.1186/1743-422X-3-17 PMC 바로가기 [Article Type] Research
A simple and rapid approach for screening of SARS-coronavirus genotypes: an evaluation studyResearch Article Published on 2005-10-182022-10-28 Journal: BMC Infectious Diseases [Category] Coronavirus, [키워드] accurate allelic Analysis approach assay can be used carried caused characteristic clinical sample Cohort different Epidemic epidemiological epidemiologically Epidemiology Genotype genotypes Infection Infectious disease information isolate MONITOR outbreak Patient probe recruited related reported respiratory Result SARS patient SARS-coronavirus Sequencing Sequencing analysis severe TaqMan the epidemic viral evolution [DOI] 10.1186/1471-2334-5-87 PMC 바로가기 [Article Type] Research Article
Molecular signature of clinical severity in recovering patients with severe acute respiratory syndrome coronavirus (SARS-CoV)Research Article Published on 2005-09-212022-10-28 Journal: BMC Genomics [Category] Coronavirus, [키워드] 2003 acute respiratory syndrome approach Asia biological systems Blood caused change changes in Clinical severity Clustering Control controls coronavirus correlated disease distress Epidemic expression profile Gene Gene Expression Genes Host human disease immunopathological damage Innate immunity International involved mortality rate Novel coronavirus pathophysiology Patient Peripheral blood Pulmonary infection recovering patient regulated reported Result SARS patient SARS patients SARS-CoV several gene severe severity significantly Spread upregulated while World Health Organization [DOI] 10.1186/1471-2164-6-132 PMC 바로가기 [Article Type] Research Article
Persistence of lung inflammation and lung cytokines with high-resolution CT abnormalities during recovery from SARSResearch Published on 2005-05-112022-10-28 Journal: Respiratory Research [Category] Coronavirus, [키워드] abnormality acute phase acute respiratory syndrome alveolar cell alveolar macrophage Alveolar macrophages BALF Bronchoalveolar lavage Bronchoalveolar lavage fluid CD4/CD8 CD8 cell count cells clearance compared Computed tomography controls coronavirus correlated Course cytokine Cytokines described desquamation detected determine dysregulation Factor Fever High-resolution High-resolution CT HRCT hyaline membrane formation IL-6 IL-8 independent infiltration Inflammatory investigated lung Lung inflammation MCP-1 Microscopy mononuclear cell non-randomized occur Particle Patient patients persistence persistent Plasma cytokine profiles RANTES Resolution Result Retrospective analysis SARS SARS patient significantly subpopulations T lymphocyte T-cell therapy TNF-α [DOI] 10.1186/1465-9921-6-42 PMC 바로가기 [Article Type] Research
Longitudinally Profiling Neutralizing Antibody Response to SARS Coronavirus with PseudotypesResearch Published on 2005-03-012022-10-31 Journal: Emerging Infectious Diseases [Category] Coronavirus, [키워드] 2003 229E against SARS-CoV antibody coronavirus coronavirus strain correlated cross-neutralization determine develop emerging handling Hong Kong human sera Immunity in vitro Infectious diseases long-lasting microneutralization natural infection neutralization tests Neutralizing antibodies Neutralizing antibody response Neutralizing titer NO OC43 occurred outbreak Profiling pseudotype recovered patients Research response SARS patient SARS virus SARS-CoV SARS-CoV neutralizing antibodies SARS-CoV S SARS-CoV spike protein serum sample Spike protein Vaccines was used [DOI] 10.3201/eid1103.040906 PMC 바로가기 [Article Type] Research
Dynamic changes of serum SARS-Coronavirus IgG, pulmonary function and radiography in patients recovering from SARS after hospital dischargeResearch Published on 2005-01-082022-10-28 Journal: Respiratory Research [Category] Coronavirus, [키워드] acute respiratory syndrome addition Avascular necrosis of femoral head Beijing change changes changes in chest X-ray China Chinese clinically Computerized tomography detected diagnosed diffusion discharge dynamic evaluate examined exhibited fibrosis finding Follow-up found hospital hospital discharge Hospitalized HRCT IgG IgG antibody incidence included individual joint lack lung Lung fibrosis Lung function magnetic resonance imaging MRI Necrosis objective Pain Patient patients positive predicted pulmonary fibrosis Pulmonary function receiving SARS Coronavirus SARS patient SARS-CoV SARS-CoV IgG antibody serum Serum level Severe acute respiratory syndrome (SARS) significantly subject subjects tested transfer were given [DOI] 10.1186/1465-9921-6-5 PMC 바로가기 [Article Type] Research
Anti–SARS-CoV Immunoglobulin G in Healthcare Workers, Guangzhou, ChinaResearch Published on 2005-01-012022-10-31 Journal: Emerging Infectious Diseases [Category] Coronavirus, [키워드] 2003 acute respiratory syndrome antibody China determine Epidemics Guangzhou, China healthcare healthcare worker Healthcare workers healthy hospital Immunity Immunoglobulin Immunoglobulin G Infection infection control measure performed Prevalence Prevent Research SARS SARS Coronavirus SARS patient SARS-CoV Seroprevalence Serosurvey tested [DOI] 10.3201/eid1101.040138 PMC 바로가기 [Article Type] Research
Clinical evaluation of real-time PCR assays for rapid diagnosis of SARS coronavirus during outbreak and post-epidemic periodsArticle Published on 2004-12-012022-11-01 Journal: Journal of Clinical Virology [Category] Coronavirus, [키워드] assays average clinical clinically suspected collected Course CoV detected Diagnosis disease Epidemic evaluate exhibited facilitated Germany highlight Hong Kong Laboratory lack nucleic acid extraction outbreak PCR assay PCR assays Positive predictive value protocol Rapid diagnosis Real-time PCR real-time PCR assay respiratory specimen reverse transcription RNA extraction Roche Roche Diagnostics RT-PCR SARS Coronavirus SARS CoV SARS epidemic SARS patient sensitivity serum sample shown specificity specimen specimens Stool tested the SARS epidemic Urine WHO [DOI] 10.1016/j.jcv.2004.09.029 PMC 바로가기 [Article Type] Article
A human in vitro model system for investigating genome-wide host responses to SARS coronavirus infectionResearch Article Published on 2004-09-092022-10-28 Journal: BMC Infectious Diseases [Category] Coronavirus, [키워드] 24 hours activated acute respiratory syndrome Analysis Antibody binding array assay Blood cell activation change chemokine clinical feature Coagulation coronavirus CoV cytokine production described disease pathology distress donors examined Gene Expression healthy donor high-density host response IL17 IL8 immune response in vitro indicated infecting Infection infiltration inhibited inoculated interstitial interstitial inflammation lung trafficking lymphopenia mechanism molecular basis monocyte-macrophage mononuclear cell Pathogenesis pathology pathway PBMC PBMCs Peripheral blood provide Quantitative assays Result SARS Coronavirus SARS patient SARS-CoV Signaling specific antibody the disease TLR9 upregulation viral replication viral replication kinetics [DOI] 10.1186/1471-2334-4-34 PMC 바로가기 [Article Type] Research Article
SARS in Healthcare Facilities, Toronto and TaiwanPerspective Published on 2004-05-012022-10-31 Journal: Emerging Infectious Diseases [Category] Coronavirus, [키워드] acute respiratory syndrome addition Care Cohort Control Delivery of healthcare disease effort events healthcare Healthcare workers increased risk Infection infection control Intervention limit Measures Outbreaks Patient patients Precaution Retrospective analysis SARS patient Severe acute respiratory syndrome Spread Taiwan Toronto Transmission [DOI] 10.3201/eid1005.030791 PMC 바로가기 [Article Type] Perspective