Secondary endpoints – Page 3 – Communicable Diseases Research

COVID-19 Vaccination in Cancer Patients Older Than 70 Years Undergoing Active Treatment. Seroconversion Rate and Safety

Article

Published on 2022-01-212022-10-28
Journal: Vaccines [Category] COVID-19,

Effect of dexamethasone in patients with ARDS and COVID-19 (REMED trial)—study protocol for a prospective, multi-centre, open-label, parallel-group, randomized controlled trial

ARDS 및 COVID-19 환자에서 덱사메타손의 효과(REMED 시험) - 전향적, 다기관, 공개 라벨, 병렬 그룹, 무작위 대조 시험을 위한 연구 프로토콜

Update

Published on 2022-01-152022-09-10
Journal: Trials [Category] SARS, 임상,

[키워드] 1:1 Administered Adult patients adverse event adverse events age ARDS ARMS Barthel Index Charlson Comorbidity Index clinical Comorbidity conducted consequence Corticosteroid Corticosteroids COVID-19 COVID-19 pneumonia CRP level CRP levels Czech Republic deleterious effect Dexamethasone dexamethasone 6 mg different dose dose doses of corticosteroids Effect Efficacy and safety enrolled EudraCT Factor followed by ICUs Independence Inflammatory intensive care unit intensive care units intravenously life marker mechanical ventilation moderate to severe Mortality once daily Open-label outcome oxygen Oxygen therapy parallel-group participant patients with ARDS patients with COVID-19 patients with moderate per day Pneumonia Prevent primary endpoint protocol Quality of life randomisation randomised randomised controlled trial randomization Randomized controlled trial SARS-CoV-2 virus scale secondary endpoint Secondary endpoints severe ARDS Stratification therapeutic potential Treatment Trial Trial registration university hospital ventilator-free day Ventilator-free days WHO
[DOI] 10.1186/s13063-021-05963-6 PMC 바로가기 [Article Type] Update

Awake prone positioning in nonintubated spontaneous breathing ICU patients with acute hypoxemic respiratory failure (PRONELIFE)—protocol for a randomized clinical trial

삽관되지 않은 자발 호흡 중환자 중 급성 저산소성 호흡 부전(PROONELIFE) 환자의 깨어 있는 엎드린 자세 - 무작위 임상 시험을 위한 프로토콜

Study Protocol

Published on 2022-01-102022-09-10
Journal: Trials [Category] 임상,

[키워드] Acute hypoxemic respiratory failure Acute respiratory failure all-cause mortality assigned Awake prone positioning benefit Blinding Clinical management clinical trial complications Composite consecutive patients Critically ill Critically ill patient critically ill patients determine duration of use Dyspnea Effect eligible Endpoint enrolment etiology hospital Hypoxemia hypoxemic Hypoxemic respiratory failure ICU ICU patient ICU Patients include International intubation intubation rate invasive invasive ventilation investigator-initiated ISRCTN lung tissue Mortality multicenter noninvasive respiratory Other Oxygenation parameters Patient Pragmatic Prevent primary endpoint Prone position prone positioning randomized clinical trial Randomized controlled trial Randomly reduction in reference number Registered respiratory Respiratory failure secondary Secondary endpoints spontaneous breathing standard care Support Tolerance tracheal tracheal intubation Trial Ventilation
[DOI] 10.1186/s13063-021-05991-2 PMC 바로가기 [Article Type] Study Protocol

Low-dose corticosteroid therapy for cardiogenic shock in adults (COCCA): study protocol for a randomized controlled trial

성인의 심인성 쇼크에 대한 저용량 코르티코스테로이드 요법(COCCA): 무작위 대조 시험을 위한 연구 프로토콜

Study Protocol

Published on 2022-01-032022-09-10
Journal: Trials [Category] SARS, 임상,

[키워드] 1:1 Administered Adrenal insufficiency Adult patients all-cause mortality alteration Analysis approach Cardiogenic shock catecholamine caused characterized conducted consequence control group Corticosteroid corticosteroid therapy corticotropin discharge double-blind dysfunction effective Effectiveness Endothelial dysfunction Endpoint etomidate evaluate Evidence Fludrocortisone France Hydrocortisone hypothalamic-pituitary-adrenal axis ICU IMPROVE include Inflammation intensive care unit intention-to-treat basis intravenous intravenous bolus life-threatening low dose low-dose low-dose corticosteroid morbidity Myocardial infarction outcome Parallel Arm pathophysiological Patient Placebo placebo-controlled trial primary endpoint profile randomization Randomized Randomized controlled trial Randomly recruit recruited secondary Secondary endpoints Shock stimulation test Study protocol subgroup therapeutic therapy tissue treat Treatment treatment group Trial Trial registration
[DOI] 10.1186/s13063-021-05947-6 PMC 바로가기 [Article Type] Study Protocol

Vitamin D Status and SARS-CoV-2 Infection and COVID-19 Clinical Outcomes

Public Health

Published on 2021-12-222022-10-31
Journal: Frontiers in Public Health [Category] COVID-19, MERS, SARS,

[키워드] 25OHD 95% confidence interval 95%CI adjusted Admission ARDS association calculate Caucasian patients clinical coronavirus disease-2019 COVID-19 COVID-19 hospitalization COVID-19 related mortality COVID-19 severity death deficiency defined estimates Google Scholar Hospitalization ICU ICU admission identify increased risk individuals Infection intensive care intensive care unit Measures Meta-analysis Mortality observational study Odds ratio outcome primary endpoint primary endpoints reported Repository respiratory Respiratory distress syndrome risk SARS-CoV-2 SARS-COV-2 infection SARS-CoV2 infection Secondary endpoints serum 25-hydroxyvitamin D severe deficiency severity status subgroup susceptibility Vitamin D vitamin D level Vitamin D status was performed Web of Science
[DOI] 10.3389/fpubh.2021.736665 PMC 바로가기 [Article Type] Public Health

Convalescent plasma for treatment of COVID-19: study protocol for an open randomised controlled trial in Sweden

Covid-19의 치료를위한 회복기 혈장 : 스웨덴의 공개 무작위 대조 시험을위한 연구 프로토콜

Infectious Diseases

Published on 2021-12-072022-09-10
Journal: BMJ Open [Category] Fulltext, SARS, 임상,

[키워드] airway Analysis antibody antibody levels article authority benefit block Block randomisation Blood blood bank & transfusion medicine blood sample Blood samples clinical study control arm convalescent plasma COVID-19 dissemination dose doses Endpoint enrolled Ethical approval Ethics group hospital include infection control intensive & critical care literature review Mortality neutralising antibody titre open participant Patient patients with COVID-19 plasma positive primary endpoint public health randomisation randomised controlled trial reduced registration number Result review SARS-CoV-2 secondary Secondary endpoints standard care study inclusion Study protocol Swedish Swedish Ethical Review Authority the patient therapy titre Treatment treatment of COVID-19 Trial Trial Registration Number Viraemia Virology virus
[DOI] 10.1136/bmjopen-2020-048337 PMC 바로가기 [Article Type] Infectious Diseases

Colchicine in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial

Covid-19 (회복)로 병원에 입원 한 환자의 콜히친 : 무작위, 통제, 오픈 라벨, 플랫폼 시험

Randomized Controlled Trial

Published on 2021-12-012022-08-13
Journal: The Lancet. Respiratory Medicine [Category] MERS, SARS, 임상,

[키워드] (Medical Research Council) 1:1 28-day mortality allocation concealment Analysis anti-inflammatory actions assigned baseline both groups by mouth clinically suspected clinician Colchicine colchicine 1 mg colchicine group composite endpoint CYP3A4 CYP3A4 inhibitor death died Diltiazem discharge discharged Efficacy and safety eligible enrolled estimated glomerular filtration rate evaluate filtration rate finding followed by for inclusion Frequency funding glomerular filtration rate had no hospital Hospital stay hospitalised hospitals in Indonesia hospitals in Nepal in both groups Indonesia Innovation Intention intention-to-treat Invasive mechanical ventilation ISRCTN Laboratory less medical history Medical Research Council moderate nasogastric tube Nepal no significant difference Open-label open-label trial opinion participant Patient Platform trial Primary outcome proportion randomisation randomised Randomly rate ratio receive receiving RECOVERY trial reductions reductions in Registered risk risk ratio SARS-COV-2 infection secondary endpoint Secondary endpoints significant difference Standard of care subgroups of patients the patient Treatment treatment for COVID-19 Trial twice a day usual care usual care group web-based simple Wellcome Trust with COVID-19
[DOI] 10.1016/S2213-2600(21)00435-5 PMC 바로가기 [Article Type] Randomized Controlled Trial

Low-dose whole-lung irradiation in severe COVID-19 pneumonia: a controlled clinical trial

Randomized Controlled Trial

Published on 2021-12-012022-10-05
Journal: Journal of Medical Radiation Sciences [Category] SARS, 임상,

Safety and efficacy of the mRNA BNT162b2 vaccine against SARS-CoV-2 in five groups of immunocompromised patients and healthy controls in a prospective open-label clinical trial

5 개의 면역 저하 환자 및 전향 적 개방형 임상 시험에서 건강한 대조군에서 SARS-COV-2에 대한 mRNA BNT162B2 백신의 안전성 및 효능

Research paper

Published on 2021-11-302022-08-13
Journal: EBioMedicine [Category] MERS, SARS, 임상,

[키워드] Adverse adverse events Adverse reaction Allogeneic allogeneic hematopoietic stem cell transplantation Antibody titre antibody titres BNT162b2 BNT162b2 mRNA BNT162b2 mRNA vaccination CAR T, Chimeric antigen receptor T CAR-T Cell Cell therapy certain immunocompromised patient groups chronic lymphocytic leukemia clinical trial clinical trials CLL CLL, Chronic lymphocytic leukemia Control controls Council COVID-19, Coronavirus disease 2019 disorder Efficacy event excluded finding FIVE five group foundation funding generally mild group healthy control healthy controls Hematopoietic stem cell highlight HIV HIV, Human immunodeficiency virus HSCT, Allogeneic hematopoietic stem cell transplantation Human immunodeficiency virus human stem-cell transplantation Ibrutinib Immunity Immunocompromised Immunocompromised patient immunocompromised patient group Immunocompromised patients immunodeficiency disorder immunodeficiency disorders IMPROVE Infection ITT, Intention to treat Knut leukemia Lymphocytic leukemia mPP, Modified per protocol mRNA BNT162b2 vaccine mRNA vaccination mycophenolate mycophenolate mofetil occurred of BNT162b2 Open-label organ transplantation organization organizations Patient patient group patient groups PID, Primary immunodeficiency disorders PP, Per protocol primary endpoint Primary Immunodeficiency Prospective clinical trial Rate Region Safe Safety SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2, Severe acute respiratory syndrome coronavirus 2 second dose secondary endpoint Secondary endpoints selected serious adverse reaction Seroconversion seroconversion rate seroconverted solid organ solid organ transplantation SOT SOT, Solid organ transplantation stem cell subgroups subject Swedish T cell therapy Treatment vaccination against COVID-19 vaccine dose virus infection
[DOI] 10.1016/j.ebiom.2021.103705 PMC 바로가기 [Article Type] Research paper

Knowledge Update on the Economic Evaluation of Pacemaker Telemonitoring Systems

심박 조율기 원격 모니터링 시스템의 경제성 평가에 대한 지식 업데이트

Review

Published on 2021-11-182022-09-10
Journal: International Journal of Environmental Research an [Category] MERS, SARS, 치료기술,

[키워드] absence accelerated addition age Analysis applied Atrioventricular block Author cardiovascular event Cardiovascular events Characteristics coded Complete Cost-benefit analysis COVID-19 pandemic database effective Effectiveness enrolled follow-up studies Formal Google Scholar growth Health health-related quality of life healthcare worker Healthcare workers healthy hospital implantation inclusion criteria increasingly knowledge language life long term measurement medium Methodological quality MOST no significant difference no significant differences outcomes pacemaker pacemakers Patient patients performed physical contact presence or absence primary endpoints problems Quality of life randomized clinical trials reduced reduction in reliability remote telemonitoring Sample size searched Secondary endpoints Sex significantly study duration System systematic review Telemedicine treated variable without affecting
[DOI] 10.3390/ijerph182212120 PMC 바로가기 [Article Type] Review