Bioactivity Potential of Marine Natural Products from Scleractinia-Associated Microbes and In Silico Anti-SARS-COV-2 EvaluationScleractinia 관련 미생물 및 In Silico Anti-SARS-COV-2 평가에서 해양 천연 제품의 생물학적 활성 가능성Review Published on 2020-12-162022-09-10 Journal: Marine Drugs [Category] SARS, 치료제, [키워드] (RdRp activity ADME ADME analysis Analysis Bacteria biological activity Cancer Compound compounds Coverage determine Diseases drug filtered fungi hierarchy Inflammation investigated leads malaria marine bacteria marine fungi marine natural products methyltransferase microbe molecular docking molecular docking studies natural organism Organisms Physicochemical properties Potential producing product RdRP Research responsible RNA dependent RNA polymerase RNA polymerase RNA-dependent RNA polymerase SAR SARS-CoV-2 SARS-CoV-2 RNA Scleractinia Secondary Metabolite secondary metabolites selected structure activity relationship target these compound Viral diseases zooxanthellae [DOI] 10.3390/md18120645 PMC 바로가기 [Article Type] Review
Grapevine as a Rich Source of Polyphenolic CompoundsReview Published on 2020-11-282024-09-02 Journal: Molecules [Category] 대상포진, [키워드] grapes human health phenolic acids polyphenolic compounds secondary metabolites [DOI] 10.3390/molecules25235604 PMC 바로가기 [Article Type] Review
In silico studies evidenced the role of structurally diverse plant secondary metabolites in reducing SARS-CoV-2 pathogenesisIn silico 연구는 SARS-CoV-2 발병기전을 감소시키는 구조적으로 다양한 식물 2차 대사산물의 역할을 입증했습니다.Article Published on 2020-11-252022-08-31 Journal: Scientific Reports [Category] SARS, 신약개발, 치료제, [키워드] active site anthocyanidins anti-SARS-CoV-2 binding Bioavailability Computational biology and bioinformatics COVID-19 Data analysis Drug discovery drug-likeness enzyme Enzymes evidenced flavonoids flavonol glycoside host cell in vitro in vivo Interaction Ligand lower binding energy molecular docking natural Occurrence plant plants platform present protease Protein provide PSM Receptor binding domain recorded reducing Replication researcher Result RNA polymerase RNA-dependent RNA polymerase SARS-CoV-2 pathogenesis Secondary Metabolite secondary metabolites selected Serine silico study small molecule Small molecules target proteins transformation transmembrane serine protease unique Viral viral pathogenesis Viral RNA viral RNA-dependent RNA polymerase viral spike viral spike protein [DOI] 10.1038/s41598-020-77602-0 PMC 바로가기 [Article Type] Article
In Search of Herbal Anti-SARS-Cov2 CompoundsPlant Science Published on 2020-11-162022-10-31 Journal: Frontiers in Plant Science [Category] COVID-19, [키워드] Antiviral antiviral activity antiviral drug antiviral drugs approach biochemical biochemical methods bioinformatics Cheminformatics Compound confirmed case coronavirus Coronavirus infection Culture drugs effective experiment Genetic genetic engineering Herbal in silico in vitro in vivo information initial management medicinal plants (herbal drugs) New coronavirus pandemic Pathogens plant plant compound reached secondary metabolites Spread supported targets the disease treat Treatment viral disease viruses WHO World Health Organization [DOI] 10.3389/fpls.2020.589998 PMC 바로가기 [Article Type] Plant Science
In silico drug discovery of major metabolites from spices as SARS-CoV-2 main protease inhibitorsArticle Published on 2020-11-012023-07-06 Journal: Computers in biology and medicine [Category] SARS, [키워드] molecular docking molecular dynamics SARS-CoV-2 main protease secondary metabolites spices [DOI] 10.1016/j.compbiomed.2020.104046 PMC 바로가기
Repositioning microbial biotechnology against COVID‐19: the case of microbial production of flavonoids코로나19에 맞서는 미생물 생명공학의 포지셔닝: 플라보노이드의 미생물 생산 사례Review Published on 2020-10-132022-09-10 Journal: Microbial Biotechnology [Category] SARS, 신약개발, 치료제, [키워드] 3CL activities activity Antiviral antiviral activity approach approved drug approved drugs Community Compound computational studies Coronaviral coronavirus COVID‐19 develop disease division division of labour Docking studies docking study flavonoids help inhibiting investigated microbial pandemic protease Protein repositioning researcher RNA‐dependent RNA polymerase SARS‐CoV‐2 secondary metabolites Spike protein Synthetic biology Test the disease the spike protein Viral [DOI] 10.1111/1751-7915.13675 PMC 바로가기 [Article Type] Review
Chemically Diverse and Biologically Active Secondary Metabolites from Marine Phylum chlorophytaReview Published on 2020-09-262022-10-30 Journal: Marine Drugs [Category] Coronavirus, SARS, [키워드] activities alkaloids biological properties Cancer Capsosiphon Caulerpa chlorophytes Codium Compound develop domain drug Efficiency expected Fatty acid functional glycerides group HIV investigator lipids pathology phylum probe Research resulting SARS-CoV-2 secondary Secondary Metabolite secondary metabolites Steroids Structure terpenes terrestrial Treatment Ulva [DOI] 10.3390/md18100493 PMC 바로가기 [Article Type] Review
Anti-SARS-CoV Natural Products With the Potential to Inhibit SARS-CoV-2 (COVID-19)Pharmacology Published on 2020-09-252022-10-31 Journal: Frontiers in Pharmacology [Category] COVID-19, [키워드] coronavirus acute respiratory syndrome against SARS-CoV colds Compound computational method conducted coronavirus Coronavirus-2 coughs COVID-19 drug drugs Ethnomedicine Fever greater HCoV highlight host receptor Human in vitro in vivo Infection Influenza information inhibit mitigate natural natural products novel drug candidates Numerous pandemic plant Potential product Proteases required respiratory viral infection RNA genome SARS-CoV SARS-CoV infection SARS-CoV-2 screened Secondary Metabolite secondary metabolites shown similarity Symptom target the disease viral infections [DOI] 10.3389/fphar.2020.561334 PMC 바로가기 [Article Type] Pharmacology
Biochemical and Computational Approach of Selected Phytocompounds from Tinospora crispa in the Management of COVID-19Article Published on 2020-08-282022-10-30 Journal: Molecules [Category] COVID-19, MERS, [키워드] Tinospora crispa Analysis analyzed anti-SARS-CoV-2 biological activity caused COVID-19 died enzyme GC-MS host immune responses impede inhibitors M pro molecular docking natural products nine Novel coronavirus pandemic pharmacological target phytochemicals protease provide reported responsible SARS-CoV-2 secondary metabolites the SARS-CoV-2 therapy Treatment Wuhan, China [DOI] 10.3390/molecules25173936 PMC 바로가기 [Article Type] Article
Plants Metabolites: Possibility of Natural Therapeutics Against the COVID-19 PandemicMedicine Published on 2020-08-072022-10-31 Journal: Frontiers in Medicine [Category] COVID-19, [키워드] Against Analysis Antibiotics Antiviral antiviral activities antiviral activity Antiviral assays approved boost Candidates caused Compound compounds COVID-19 disease Diseases Drug discovery effective Efficacy Health include MDR medicinal plants Medicine metabolite microbe multidimensional natural natural therapeutics/alternative medicine pandemic Pandemics plant reported Research Resistant respiratory SARS-CoV-2 Scientific community screened Secondary Metabolite secondary metabolites stimulate Structure suggested susceptible therapeutic therapeutic potential Therapeutics therapy treat Treatment viral pathogens viruses worldwide pandemic [DOI] 10.3389/fmed.2020.00444 PMC 바로가기 [Article Type] Medicine