Sequencing analysis – Page 3 – Communicable Diseases Research

Evidence of a SARS-CoV-2 double Spike mutation D614G/S939F potentially affecting immune response of infected subjects

Research Article

Published on 2022-01-212022-10-31
Journal: Computational and Structural Biotechnology Journal [Category] COVID-19,

Local occurrence and fast spread of B.1.1.7 lineage: A glimpse into Friuli Venezia Giulia

B.1.1.7 계보의 현지 발생 및 빠른 확산 : Friuli Venezia Giulia를 엿볼 수 있습니다.

Research Article

Published on 2021-12-142022-09-10
Journal: PLoS ONE [Category] MERS, SARS, 변종, 유전자 메커니즘,

Propagation of a hospital-associated cluster of COVID-19 in Malaysia

Research

Published on 2021-12-092022-10-28
Journal: BMC Infectious Diseases [Category] COVID-19, SARS,

[키워드] Analysis approach Cluster Community complement Compliance conducted COVID-19 COVID-19 cases COVID-19 pandemic criteria demonstrated Diagnosis disease transmission effective Epidemic epidemiological Epidemiological investigation event examined excluded healthcare Healthcare system healthcare worker hospital identify imperative implementation increase Incubation period index case infection control Infection prevention initial Malaysia management measure Measures median morbidity and mortality Multidisciplinary nine outbreak Outbreaks patients positive Propagation Real-time PCR Result risk SARS-CoV-2 Sequencing Sequencing analysis subset suggested supplementary material Surveillance Symptom symptomatic the disease Transmission university whole genome Whole genome sequencing with COVID-19
[DOI] 10.1186/s12879-021-06894-y PMC 바로가기 [Article Type] Research

Assessing the potential correlation of polymorphisms in the IL6R with relative IL6 elevation in severely ill COVID-19 patients’

중증 COVID-19 환자에서 IL6R의 다형성과 상대적 IL6 상승의 잠재적 상관 관계 평가

Clinical Trial

Published on 2021-12-012022-09-11
Journal: Cytokine [Category] 바이오마커, 변종, 임상,

[키워드] Affect affecting Analysis Assessing association baseline Baseline assessment baseline level blood sample Blood samples clinical response Clinical studies clinical study clinical variable collected Combination Control correlation COVID-19 COVID-19 patient COVID-19 patients COVID19 COVID19 patients cytokine level cytokine levels Cytokine storm defined determine elevated Elevation Genetic Genetic variant genetic variants Glucose help highest hospitalized COVID-19 patient hospitalized COVID-19 patients hospitalized patient hospitalized patients identify IL-6 IL-6 inhibition IL-6 level IL-6 levels IL6 IL6R interleukin-6 Interpretation mild COVID-19 patient Mortality norm not seen outcome oxygen P-value p-value < 0.01 Participants pathophysiology patient population patients Phase 3 Placebo plasma Plasma levels Pneumonia polymorphism randomized study receiving Regulatory report robust rs2228145 Sequencing analysis serum severe and mild COVID-19 patients severe COVID-19 severe patients severity shown significantly significantly increased supplemental oxygen support tested the patient tradipitant Treatment unlikely variant variants were measured while WHO whole genome Whole genome sequencing
[DOI] 10.1016/j.cyto.2021.155662 PMC 바로가기 [Article Type] Clinical Trial

Exome sequencing and analysis of 454,787 UK Biobank participants

Article

Published on 2021-10-182022-10-04
Journal: Nature [Category] 바이오마커, 유전자 메커니즘,

In-Depth Investigation of Conjunctival Swabs and Tear Fluid of Symptomatic COVID-19 Patients, an Observational Cohort Study

COVID-19 증상 환자의 결막 면봉 및 눈물액에 대한 심층 조사, 관찰 코호트 연구

Observational Study

Published on 2021-10-042022-09-11
Journal: Translational vision science & technology [Category] SARS, 임상, 치료기술,

[키워드] analyzed Chain Reaction Conjunctiva conjunctival Conjunctival swab conjunctival swabs correlation COVID-19 COVID-19 disease COVID-19 patient COVID-19 patients Ct values cycle cycle threshold cytokine cytokine level Cytokines determine disease onset elevated examined first visit healthcare worker Healthcare workers healthy control healthy controls hospitalized COVID-19 patient identify IL-1β IL-6 immunoassays investigation laboratory-confirmed large cohort majority multicenter multiplex Nasopharyngeal swab nasopharyngeal swabs nasopharynx Next-generation sequencing no correlation ocular Ocular surface performed Phylogenetic analysis polymerase chain polymerase chain reaction positive reverse transcription reverse transcription polymerase chain reaction risk SARS-CoV-2 SARS-CoV-2 RNA SARS-CoV-2 viral RNA Sequencing Sequencing analysis significantly higher specimen Swab symptomatic Tear threshold tissue tropism viral strain viral strains virus strain
[DOI] 10.1167/tvst.10.12.32 PMC 바로가기 [Article Type] Observational Study

SARS-CoV-2 variant of concern P.1 (Gamma) infection in young and middle-aged patients admitted to the intensive care units of a single hospital in Salvador, Northeast Brazil, February 2021

2021년 2월 브라질 북동부 살바도르에 있는 단일 병원의 중환자실에 입원한 중년 환자의 SARS-CoV-2 변종 우려 P.1(감마) 감염

Article

Published on 2021-10-012022-09-11
Journal: International Journal of Infectious Diseases [Category] SARS, 변종, 치료기술,

[키워드] A significant reduction accompanied acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 age Analysis Brazil changes in characteristics of patient circulation collected Comorbidities Comorbidity confirmation coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient COVID-19 patients Cycle threshold value Cycle threshold values demonstrated evaluate Gamma Genome sequencing ICU ICU patient Infection intensive care intensive care unit Laboratory Lineage Local median age Nasopharyngeal swab nasopharyngeal swab sample Nasopharyngeal swab samples P.1 pandemic Patient patients hospitalized PCR tests profile proportion SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 genome sequencing SARS-CoV-2 RT-PCR test SARS-CoV-2 variant second wave Sequencing analysis severe acute respiratory syndrome Coronavirus severe disease single hospital the median variant variants variants of concern VoC was performed
[DOI] 10.1016/j.ijid.2021.08.003 PMC 바로가기 [Article Type] Article

COVID-19 Outbreaks in Settings With Precarious Housing Conditions in Germany: Challenges and Lessons Learned

Public Health

Published on 2021-09-212022-10-31
Journal: Frontiers in Public Health [Category] COVID-19, MERS, SARS,

Host Genetics and Antiviral Immune Responses in Adult Patients With Multisystem Inflammatory Syndrome

다기관 염증 증후군이 있는 성인 환자의 숙주 유전학 및 항바이러스 면역 반응

Immunology

Published on 2021-08-312022-09-11
Journal: Frontiers in Immunology [Category] MERS, SARS, 변종, 진단,

[키워드] affected affecting analyzed antibody autoantibody autophagy characteristic children classical contributing to Coronavirus disease 2019 Course COVID-19 CXCL10 cytokine Cytokines description disease disease-causing DNA ELISA Exome expression Features FIVE Genetic hallmark hallmarks healthy controls IFNα IL-1β IL-6 immune responses immunological in vitro In vitro infection Inflammatory interferon interferon response interferons Kawasaki disease less MIS mononuclear cell mononuclear cells Multiorgan dysfunction Multisystem inflammatory syndrome organ Pathogenesis Patient patients PBMC PBMCs performed Peripheral blood Peripheral blood mononuclear cells Presence Proinflammatory cytokine proinflammatory cytokines reduced response restriction factor SARS-CoV-2 SARS-COV-2 infection Sequencing Sequencing analysis syndrome systemic inflammation TNFα type I type I and III interferons variant WES whole exome sequencing
[DOI] 10.3389/fimmu.2021.718744 PMC 바로가기 [Article Type] Immunology

Screening of Eurasian Tundra Reindeer for Viral Sequences by Next-Generation Sequencing

차세대 시퀀싱에 의한 바이러스 서열에 대한 유라시아 툰드라 순록의 스크리닝

Article

Published on 2021-06-182022-09-10
Journal: International Journal of Environmental Research an [Category] MERS, SARS, 치료기술,