sequencing data – Page 3 – Communicable Diseases Research

Both simulation and sequencing data reveal coinfections with multiple SARS-CoV-2 variants in the COVID-19 pandemic

Research article

Published on 2022-03-182022-10-05
Journal: Computational and Structural Biotechnology Journal [Category] 변종, 유전자 메커니즘,

Comparative transmissibility of SARS-CoV-2 variants Delta and Alpha in New England, USA

미국 뉴잉글랜드에서 SARS-CoV-2 변종 Delta 및 Alpha의 비교 전염성

Article

Published on 2022-03-112022-09-11
Journal: Cell Reports Medicine [Category] COVID19(2023년), SARS, 변종,

Unusual SARS-CoV-2 intrahost diversity reveals lineage superinfection

특이한 SARS-CoV-2 숙주 내 다양성이 혈통 중복 감염을 나타냅니다

Article

Published on 2022-03-012022-09-11
Journal: Microbial Genomics [Category] SARS, 변종, 치료기술,

[키워드] abundance acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition Analysis approach characterized codetection Coinfection coronavirus 2 COVID-19 COVID-19 disease dataset defined detect difficulty distribution epidemiological data Factor Genomics Infection infections investigated Lineage Mutation mutations nine number of sample pandemic phenotype phylogenetically precluded profiles progression provide raw sequencing data Recombination representing respiratory reveal SARS-CoV-2 SARS-CoV-2 lineage sequenced Sequencing sequencing data Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus Variability viral lineage viral lineages viral recombination window
[DOI] 10.1099/mgen.0.000751 PMC 바로가기 [Article Type] Article

Genotype-phenotype correlation identified a novel SARS-CoV-2 variant possibly linked to severe disease

유전형-표현형 상관관계가 심각한 질병과 관련될 수 있는 새로운 SARS-CoV-2 변이를 확인했습니다

Article

Published on 2022-03-012022-09-11
Journal: Transboundary and emerging diseases [Category] MERS, SARS, 변종, 진단,

[키워드] Adults age analysed Asia carried Clinical data Cluster Clustering conditions correlation COVID-19 COVID-19 patient D614G mutation database Diabetic diabetic patient diabetic patients disease severity Dubai Europe European Evidence First wave Fisher Fisher's exact test genomes geographic location Health healthy heterogeneous higher infectivity highlight hospital Hospital admission Hospitalized ICU independent India intensive care Iran laboratory-confirmed majority medical record medical records Mild Missense moderate disease molecular Molecular epidemiology molecular phylogeny Mortality Mutation N proteins Nasopharyngeal swab nasopharyngeal swab PCR nasopharyngeal swabs obese Older age outbreak overweight overweight/obese Patient positive Q271R SARS-CoV-2 SARS-CoV-2 genome sequence SARS-CoV-2 genome sequences SARS-CoV-2 variant selected sequenced Sequencing sequencing data severe COVID-19 severe disease Sex significantly strain synonymous Test Transmission unique United Arab Emirates Viral viral strain viral strains whole genome Whole genome sequencing women
[DOI] 10.1111/tbed.14004 PMC 바로가기 [Article Type] Article

Integrating single-cell sequencing data with GWAS summary statistics reveals CD16+monocytes and memory CD8+T cells involved in severe COVID-19

Research

Published on 2022-02-172022-10-31
Journal: Genome Medicine [Category] COVID-19, MERS,

[키워드] ABO airways alteration association calculate CCR1 CD8+ T cell CD8+T cell Cell cell types Cell-mediated immunity cells chemotaxis collected contribute Control COVID-19 COVID-19 infection COVID-19 pandemic CXCR6 cytokine detrimental disease severity dysregulated immune response Effect effective vaccine elevated epithelial cell expressed expressed gene expression facilitate Factor feature functional Genes Genetic genetic architecture genetic determinant GWAS GWAS summary statistics healthy control higher risk Host host genetics IFITM1 Immune cell immune cells immune response Immunity immunological increase in independent Inflammatory Inflammatory cytokines inflammatory storm Interaction involved lung tissues memory Migration Mild moderate mononuclear cell notable Patient PBMC Peripheral blood progression proliferation provide recruitment Result reveal risk S100A12 S100A8 S100A9 scRNA-seq dataset sequencing data severe COVID-19 Severe infection Severe patient severe patients severity of COVID-19 significantly single-cell single-cell sequencing subpopulation subset subtype supplementary material Symptom T cell understanding up-regulated
[DOI] 10.1186/s13073-022-01021-1 PMC 바로가기 [Article Type] Research

SARS-CoV-2 Delta Variant (AY.3) in the Feces of a Domestic Cat

SARS-COV-2 델타 변형 (AY.3) 국내 고양이의 대변

Article

Published on 2022-02-172022-09-01
Journal: Viruses [Category] COVID19(2023년), Fulltext, MERS, SARS, 변종, 진단, 치료기술,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus animals AY.3 cats Cohort collected Comparisons coronavirus COVID-19 COVID-19 pandemic Delta delta variant Fecal sample fecal samples Fece feces feline Health highlight Human inception infect Infection knowledge Lineage Mutation nucleotide one health Pairwise comparison Phylogenetic analysis positive respiratory SARS-CoV-2 SARS-CoV-2 delta SARS-CoV-2 variant sequence sequenced sequences Sequencing sequencing data severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Single nucleotide polymorphism single nucleotide polymorphisms tested The United States unique United States variant Viral viral genome viral genomes Viral RNA whole genome Whole genome sequencing wild animal wild animals
[DOI] 10.3390/v14020421 PMC 바로가기 [Article Type] Article

Rapid and accurate detection of SARS-CoV-2 mutations using a Cas12a-based sensing platform

Cas12a 기반 센싱 플랫폼을 사용한 SARS-CoV-2 돌연변이의 빠르고 정확한 검출

Article

Published on 2022-02-152022-09-11
Journal: Biosensors & bioelectronics [Category] COVID19(2023년), SARS, 변종, 치료기술,

Ongoing Recombination in SARS-CoV-2 Revealed through Genealogical Reconstruction

족보 재구성을 통해 밝혀진 SARS-CoV-2의 진행 중인 재조합

Discoveries

Published on 2022-02-022022-09-10
Journal: Molecular Biology and Evolution [Category] COVID19(2023년), MERS, SARS, 변종, 치료기술,

The role of viral genomics in understanding COVID-19 outbreaks in long-term care facilities

장기 요양 시설에서 COVID-19 발병을 이해하는 데 바이러스 유전체학의 역할

Review

Published on 2022-02-012022-09-11
Journal: The Lancet. Microbe [Category] COVID19(2023년), SARS, 유전자 메커니즘, 치료기술,

Aging whole blood transcriptome reveals candidate genes for SARS-CoV-2-related vascular and immune alterations

노화된 전혈 전사체는 SARS-CoV-2 관련 혈관 및 면역 변화에 대한 후보 유전자를 나타냅니다

Article

Published on 2022-02-012022-09-11
Journal: Journal of Molecular Medicine (Berlin, Germany) [Category] COVID19(2023년), SARS, 유전자 메커니즘,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition adhesion affected age aging alteration anti-apoptotic BAG3 Blood Blood clots blood component blood components candidate candidate gene cascade cathepsin Cathepsins CCL4L2 CD14 CD4 CD8 Cell changes in clinical manifestation coronavirus COVID-19 CTSE CTSW database DEGs differentially expressed gene Differentially expressed genes DUSP4 expressed expression expression levels expression profile FASL FASLG female genders gene expression profile high viral load highest HLA-DRA Hyperinflammatory identify IFN IFN signaling immune immune response increase increase in increased expression individual Inflammation interact Interaction interferon investigated involved LAG3 Monocytes naïve T cells natural killer cell Natural killer cells Older older patient older patients overexpress overexpression PDCD1 Peripheral blood Platelet prediction Protein reveal RGS2 risk SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2-infected patient SARS-CoV-2-infected patients sequencing data severe acute respiratory syndrome Coronavirus severe COVID-19 Signaling Single-cell RNA-sequencing T cell T cell exhaustion T cells T lymphocytes target targets therapeutic TIGIT TOX Transcriptome translated type I interferon Vascular VCAM1 Viral load Viral protein Viral proteins Whole blood whole blood transcriptome
[DOI] 10.1007/s00109-021-02161-4 PMC 바로가기 [Article Type] Article