Severe COVID‐19 is marked by dysregulated serum levels of carboxypeptidase A3 and serotoninArticle Published on 2021-05-312023-07-02 Journal: Journal of leukocyte biology [Category] SARS, [키워드] carboxypeptidase A3 COVID‐19 mast cell SARS‐CoV‐2 Serotonin [DOI] 10.1002/JLB.4HI0221-087R PMC 바로가기
Vitamin D, Depressive Symptoms, and Covid-19 PandemicNeuroscience Published on 2021-05-132022-10-31 Journal: Frontiers in Neuroscience [Category] COVID-19, [키워드] active form binding blood circulation Brain cholecalciferol Concentration contribute country COVID-10 COVID-19 COVID-19 outbreak COVID-19 pandemic deficiency Depression depressive depressive symptom Depressive symptoms dramatic increase Effect endogenous enzyme expression genomic Government healthcare IMPROVE increased risk induce influence initiate kidney liver lockdown measure mechanism mechanisms melatonin mental health mental health problem metabolism pandemic Pandemics Prevalence protective effect Protein reduction regulate response responsible role Serotonin serum vitamin D Signaling social isolation Stress suggested TPH2 transported VDR Vitamin D vitamin D deficiency Vitamin D receptor [DOI] 10.3389/fnins.2021.670879 PMC 바로가기 [Article Type] Neuroscience
Fluvoxamine: A Review of Its Mechanism of Action and Its Role in COVID-19Pharmacology Published on 2021-04-202022-10-31 Journal: Frontiers in Pharmacology [Category] COVID-19, [키워드] Action acute respiratory distress syndrome aggregation Antiviral effect Cell Clinical deterioration Coagulopathy Control coronavirus disease COVID-19 Cytokine storm degranulation double-blind Effect endolysosomal enzyme fluvoxamine hallmark Inflammation inhibitor Interleukins mechanism melatonin Mild mitigate Patient placebo-controlled Platelet Prevent randomized study receptor reduction in regulate Regulation review role SARS-CoV-2 selective Serotonin severe COVID-19 shown Treatment [DOI] 10.3389/fphar.2021.652688 PMC 바로가기 [Article Type] Pharmacology
Interleukin 6 and depression in patients affected by Covid-19코비드-19에 영향을 받은 환자의 인터루킨 6과 우울증Observational Study Published on 2021-04-092022-09-11 Journal: Medicina clínica [Category] 바이오마커, 임상, [키워드] 95% CI affected changes correlation COVID-19 cytokine Cytokines deficiency Depresión Depression depressive depressive disorder depressive symptom Depressive symptoms disorder IL-1β IL-6 IL-6 level IL-6 levels Infection interleukin interleukin 6 molecular mechanisms neuronal neurotransmitter no correlation noradrenaline observational study Older Patient resulting scale Serotonin Stress sustained TNF-α Vascular was used [DOI] 10.1016/j.medcli.2020.11.010 PMC 바로가기 [Article Type] Observational Study
Abnormal movements in hospitalized COVID-19 patients: A case seriesShort communication Published on 2021-04-012022-10-05 Journal: Journal of the neurological sciences [Category] SARS, 진단, [키워드] Abnormal movement analyzed Care case sery consecutive patient COVID-19 diagnose diagnosed diagnostic etiology evaluate evaluated female Frequency functional Hospitalized hospitalized COVID-19 indication initial male Movement disorder Myoclonus neurologic nine Patient patients performed reported Result Seizure Serotonin Serotonin syndrome syndrome Tremor [DOI] 10.1016/j.jns.2021.117377 [Article Type] Short communication
The serotonin reuptake inhibitor Fluoxetine inhibits SARS-CoV-2 in human lung tissue세로토닌 재흡수 억제제 Fluoxetine은 인간 폐 조직에서 SARS-CoV-2를 억제합니다Article Published on 2021-03-152022-09-10 Journal: Scientific Reports [Category] SARS, 치료제, [키워드] approved circumvent clinical trials Concentration cytokine cytokine release decrease dominant drug EC50 effective inhibitor Fluoxetine Gene Expression groups herpes simplex herpes simplex virus herpesvirus Human human lung human lung tissue in viral inhibit inhibited inhibitor isomer medication medications off-label protein expression Rabies virus Raby racemate reduced Remdesivir Replication respiratory syncytial virus risk SARS-CoV-2 SARS-CoV-2 infected patient SARS-CoV-2 infected patients SARS-CoV-2 treatment screened screenings Serotonin severe infections significantly time-consuming tissue Treatment Viral viral epidemiology viral infection viral infectivity virus was determined [DOI] 10.1038/s41598-021-85049-0 PMC 바로가기 [Article Type] Article
Breastfeeding importance and its therapeutic potential against SARS‐CoV‐2Short Review Published on 2021-02-132022-10-28 Journal: Physiological Reports [Category] COVID-19, MERS, [키워드] ACE2 affecting bind Breastfeeding breastmilk Caseins Cell cell membrane cell types ciliated cell colostrum component coronavirus COVID‐19 decrease diarrhea disease symptoms disorder Effect element Enterocyte enzyme expressed growth factor Gut highly active Host immunostimulatory impair incidence include Infant Infants Inflammation intestinal inflammation intestine lung maintain metabolism milk mucins mucosa Newborn Novel coronavirus organism postnatal development processed PROTECT Protein Proteins Replication Respiratory disease respiratory tract response SARS SARS‐CoV‐2 SARS‐CoV‐2 infection secretory immunoglobulin A Serotonin therapeutic potential virus [DOI] 10.14814/phy2.14744 PMC 바로가기 [Article Type] Short Review
Fluoxetine Can Inhibit SARS-CoV-2 In VitroArticle Published on 2021-02-092022-10-29 Journal: Microorganisms [Category] COVID-19, [키워드] acute infection acute respiratory syndrome added Administered affecting Antiviral antiviral activity Can controls coronavirus coronavirus disease Cytopathic effect Diseases drug explain Fluoxetine Health in vitro in vivo inhibit inhibit SARS-CoV-2 inhibitor inhibitors of SARS-CoV-2 investigated limit of detection mechanism outbreak pandemic Particle Post-infection Replication RNA viruses SARS-CoV-2 SARS-CoV-2 infections selective Serotonin supernatant the disease treat Treatment strategies VERO E6 cells virus [DOI] 10.3390/microorganisms9020339 PMC 바로가기 [Article Type] Article
Cannabis sativa L. as a Natural Drug Meeting the Criteria of a Multitarget Approach to TreatmentReview Published on 2021-01-142022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, [키워드] Cannabis Bioavailability cannabis Clinical use Compound coronavirus disease Diseases drug epilepsy expressed G protein-coupled receptor glycine group implication include Inflammatory bowel disease knowledge meeting multiplex multitarget natural nausea Pain Parkinson’s disease penetration pharmacological phytocannabinoids (THC and CBD) provide receptor receptors Schizophrenia selected Serotonin structures syndrome synergism synergistic terpenes these compound Treatment TRP vomiting [DOI] 10.3390/ijms22020778 PMC 바로가기 [Article Type] Review
Drug repurposing for opioid use disorders: integration of computational prediction, clinical corroboration, and mechanism of action analyses Research Published on 2021-01-112022-10-05 Journal: Molecular Psychiatry [Category] 신약개발, [키워드] accelerate Activation adjusted Analysis approach BDNF candidate drug candidate drugs comorbid conditions CYP2D6 disorder Drug repurposing Electronic health record FIVE functional G-protein HTR1B mechanism mechanism of action medication Mortality OPRD1 OPRK1 OPRM1 Pathways Patient patients POMC public health crisis receptors Serotonin Signaling SLC6A4 Substance use disorder treat urgency [DOI] 10.1038/s41380-020-01011-y [Article Type] Research