Designing of peptide aptamer targeting the receptor-binding domain of spike protein of SARS-CoV-2: an in silico studySARS-CoV-2의 스파이크 단백질 수용체 결합 도메인을 표적으로 하는 펩타이드 앱타머 설계: in silico 연구Article Published on 2022-02-012022-09-11 Journal: Molecular diversity [Category] COVID19(2023년), SARS, 치료법, 치료제, [키워드] ACE2 albumin antibodies approach aptamer ATP Bacterial bind CD4 complex coronavirus docked domain ENCODE envelope Genome high affinity host cell in silico membrane metal ions molecular molecular docking molecular dynamic simulation monoclonal antibodies non-allergenic non-hemolytic nucleocapsid peptide Peptide aptamer predicted Protein Proteins Receptor-binding domain SARS-CoV-2 scaffold protein serum albumin specificity spike Spike protein spike receptor-binding domain stability target target protein tertiary structure the receptor-binding domain theophylline Therapeutic treatment thioredoxin thrombin virus [DOI] 10.1007/s11030-020-10171-6 PMC 바로가기 [Article Type] Article
Albumin Binds COVID-19 Spike 1 Subunit and Predicts In-Hospital Survival of Infected Patients—Possible Alteration by GlucoseArticle Published on 2022-01-252022-10-30 Journal: Journal of Clinical Medicine [Category] COVID-19, [키워드] Admission affected age albumin albumin level all-cause mortality alteration analyzed association bind binding ability Community Comorbidity Concentration COVID-19 experiment Glucose glycated albumin Hospitalized In-hospital in-hospital mortality increased mortality Mortality multicenter Native Patient predict Predictive Public Hospital reduced regression analysis retrospective cohort S1 subunit SARS-CoV-2 serum albumin significantly spike spike protein S1 subunit survival the SARS-CoV-2 virus the spike protein [DOI] 10.3390/jcm11030587 PMC 바로가기 [Article Type] Article
The association between serum albumin and depression in chronic liver disease may differ by liver histologyResearch Published on 2022-01-042023-08-28 Journal: BMC Psychiatry [Category] E형 간염, [키워드] chronic liver disease Depression Liver histology serum albumin Vibration controlled transient elastography [DOI] 10.1186/s12888-021-03647-8 PMC 바로가기 [Article Type] Research
Molecular modelling studies unveil potential binding sites on human serum albumin for selected experimental and in silico COVID-19 drug candidate moleculesResearch article Published on 2022-01-012022-10-05 Journal: Saudi Journal of Biological Sciences [Category] 신약개발, 치료제, [키워드] analyzed approach Arbidol bind binding binding energy binding free energy binding site blood plasma calculated Carmofur complexes Compound compounds coronavirus disease COVID-19 daclatasvir demonstrated dihydroergotamine disulfiram drug drug candidate Effects evaluate geometric HAS Human Human serum albumin Hydrogen bond hydrophobic interactions identify in silico inhibitor interacting residue mechanism MM/PBSA moderate molecular molecular docking Molecular dynamics simulation molecular interaction Molecular mechanics P-glycoprotein P450 paritaprevir permeation Pharmacodynamics pharmacokinetic pharmacokinetics pharmacological prevalent Protein saquinavir selected serum albumin Serum protein stability therapeutic therapeutic molecules were used [DOI] 10.1016/j.sjbs.2021.09.042 [Article Type] Research article
Severity of SARS-CoV-2 infection and albumin levels recorded at the first emergency department evaluation: a multicentre retrospective observational studyObservational Study Published on 2022-01-012022-10-04 Journal: Emergency medicine journal : EMJ [Category] Coronavirus, 임상, [키워드] adjusted albumin albumin level analysed Analysis association conducted confounding factors COVID-19 cubic spline death died disease severity Diseases emergency department evaluated hospital identify independent risk factor indicated Infection Infectious diseases Inflammatory Italy marker multicentre Patient patients with SARS-CoV-2 Prognosis recorded retrospective risk SARS SARS-COV-2 infection serum albumin Severe infection severe SARS-CoV-2 severity study outcomes survival was determined was used were measured were used [DOI] 10.1136/emermed-2020-210081 PMC 바로가기 [Article Type] Observational Study
Erythrocytes increase endogenous sphingosine 1-phosphate levels as an adaptive response to SARS-CoV-2 infectionArticle Published on 2021-12-222022-10-06 Journal: Clinical Science (London, England : 1979) [Category] SARS, 진단, [키워드] adaptive adaptive mechanism carriers coronavirus disease COVID-19 COVID-19 patient COVID-19 patients Critically ill patient Culture down-regulation Endothelial cell endothelial cell barrier erythrocyte erythrocytes experiment expression HDL healthy control high-density High-density lipoprotein hypoxia Immunity Infection lymphopenia metabolite observation plasma prevented producing RBC RBCs red blood cell reduced SARS-CoV-2 SARS-COV-2 infection serum albumin Signaling significantly increased sphingosine supported tissue Total vasculature [DOI] 10.1042/CS20210666 PMC 바로가기 [Article Type] Article
Lung histopathologic clusters in severe COVID-19: a link between clinical picture and tissue damageObservational Study Published on 2021-12-132022-10-04 Journal: Critical Care [Category] 임상, [키워드] affected analyzed applied Autopsies Clinical data clinical picture Cluster Clustering Clusters Comorbidity Complete conducted correlation COVID-19 COVID-19 patients described died Diffuse alveolar damage distribution Duration Evidence Hierarchical highlight histology hospitalized patient ICU Infectious disease Intervention Italy kidney knowledge large cohort long-lasting lung Lung histopathology Lung injury overlap pathophysiology Patient PEEP Pneumonia Positive end-expiratory pressure Positive-pressure ventilation proliferative Result retrospective cohort scored serum albumin severe COVID-19 patients severe SARS-CoV-2 SOFA supplementary material tissue damage Treatment Ventilation ventilatory [DOI] 10.1186/s13054-021-03846-5 PMC 바로가기 [Article Type] Observational Study
Hemophagocytic histiocytosis in severe SARS-CoV-2 infection: A bone marrow study중증 SARS-CoV-2 감염에서 혈구포식세포 조직구증: 골수 연구Comparative Study Published on 2021-12-012022-09-11 Journal: International journal of laboratory hematology [Category] MERS, SARS, 바이오마커, [키워드] albumin analyzed BME Bone marrow bone marrow examination CD25 Cell clinical and laboratory features Corticosteroid corticosteroid therapy COVID-19 infection criteria CRP cytopenia cytopenias D-dimer Diagnostic Criteria disorder eight elevated Fever FIVE four of eight hemophagocytic lymphohistiocytosis Hemophagocytosis High-dose histiocytosis histiocytosis. HLH Hyperferritinemia hyperfibrinogenemia Hyperinflammatory hypertriglyceridemia Hypofibrinogenemia immune response initiated laboratory feature LDH Leukocytosis lymph nodes lymphocytopenia lymphocytosis marrow examination natural killer neutrophilia organomegaly overlap Patient patients plasma raised required SARS-CoV-2 serum albumin serum CRP Serum ferritin Severe COVID-19 Infection severe SARS-CoV-2 soluble CD25 spleen syndrome therapy transaminase transaminases Triglyceride triglycerides Viral viral infections [DOI] 10.1111/ijlh.13619 PMC 바로가기 [Article Type] Comparative Study
Neutrophil-mediated oxidative stress and albumin structural damage predict COVID-19-associated mortality호중구 매개 산화 스트레스와 알부민 구조적 손상은 COVID-19 관련 사망률을 예측합니다Research Article Published on 2021-11-252022-09-12 Journal: eLife [Category] MERS, 진단, [키워드] accumulated albumin analyzed Anti-inflammatory anticoagulation antioxidant Blood blood sample candidate COVID-19 mortality COVID-19 treatment critically ill COVID-19 patients critically ill patients died Evidence faster Fatty acid functions healthy individual Human human serum albumin damage hydrogen peroxide in-hospital mortality indicated Kaplan–Meier survival analysis marker means median Mortality neutrophil Neutrophils non-survivor Non-survivors outcome oxidative stress parameter Patient plasma predict predicted Protein recruited reduced risk serum albumin severe patients significantly subject survivor the mean Transport Whole blood [DOI] 10.7554/eLife.69417 PMC 바로가기 [Article Type] Research Article
A rapid, ultrasensitive voltammetric biosensor for determining SARS-CoV-2 spike protein in real samplesArticle Published on 2021-11-152022-11-16 Journal: Biosensors & bioelectronics [Category] 치료기술, [키워드] Accuracy acute respiratory syndrome antibody Antigen applied bovine coronavirus coronavirus disease COVID-19 demonstrated detect diagnosing early diagnosis electrochemical biosensor evaluated Interaction oropharyngeal swab pandemic polymerase chain positive Protein provide public health system RT-PCR Saliva SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 spike protein sensitivity serum albumin specificity Spike protein the SARS-CoV-2 Viral detection viral outbreak virus spike protein voltammetry [DOI] 10.1016/j.bios.2021.113497 PMC 바로가기