SARS-CoV-2-reactive IFN-γ-producing CD4 + and CD8 + T cells in blood do not correlate with clinical severity in unvaccinated critically ill COVID-19 patients혈액 내 SARS-CoV-2 반응성 IFN-γ 생성 CD4 + 및 CD8 + T 세포는 백신 접종을 받지 않은 중환자 COVID-19 환자의 임상 중증도와 상관관계가 없습니다Article Published on 2022-08-222022-09-11 Journal: Scientific Reports [Category] SARS, 바이오마커, 진단, 치료기술, 치료법, [키워드] anti-RBD Anti-RBD IgG association Biomarker Biomarkers Blood blood levels C-reactive protein CD4 CD8 Clinical outcome Clinical severity comparable Concentration correlation COVID-19 patient COVID-19 patients Critically ill critically ill COVID-19 patients D-dimer Deceased detectable died different time point different time points ELISA Enumeration enzyme enzyme-linked immunosorbent assay examined ferritin flow cytometry greater magnitude IFN-γ IgG level increased mortality interleukin interleukin-6 investigated Kinetics Lactose Lower respiratory tract male median age membrane protein Mortality no correlation Patient patients Peripheral blood predict respiratory RNA loads SARS-CoV-2 SARS-CoV-2 RNA SARS-CoV-2 S sera Serum level serum levels specimens spike Spike protein survived Survivors T cell T cell subset T cells T-cell T-cell Response T-cell responses tracheal aspirate Viral viral clearance [DOI] 10.1038/s41598-022-18659-x PMC 바로가기 [Article Type] Article
Clinical and immunological features associated to the development of a sustained immune humoral response in COVID-19 patients: Results from a cohort studyArticle Published on 2022-08-152022-11-15 Journal: Frontiers in Immunology [Category] SARS, 진단, [키워드] abnormality acute infection acute respiratory syndrome anti-cellular antibodies anti-SARS-CoV-2 IgG antibodies antibody Antibody Response Antiviral baseline blood sample CD8 changes in characterized chemokine chemokines clinical cohort study coronavirus coronavirus disease COVID-19 Critical Critical disease Critical illness cytokine Cytokines defined Diagnosis evaluated feature flow cytometry Follow-up humoral humoral immune response Humoral response IgG IgGs IL-13 IL-2 IL-4 immune Immune profile immunological IP-10 key factor lymphocyte Lymphocytes lymphopenia Measures Neutrophil extracellular trap outcome Patient patients with COVID-19 positive Primary outcome Quantitative recruitment regulatory T cells Research Result SARS-CoV-2 serum serum cytokine Serum level serum titer strongly related sustained T cell T cells the patient variable were assessed [DOI] 10.3389/fimmu.2022.943563 PMC 바로가기
Sputnik-V reactogenicity and immunogenicity in the blood and mucosa: a prospective cohort study혈액 및 점막의 스푸트니크-V 반응원성과 면역원성: 전향적 코호트 연구Article Published on 2022-08-012022-09-11 Journal: Scientific Reports [Category] SARS, 임상, 진단, 치료기술, 치료법, [키워드] adverse event adverse events alteration assays baseline Blood blood platelet collected condition correlated COVID-19 COVID-19 vaccine COVID-19 vaccines detectable diagnostic dose Effect Efficacy Elevation elicited Gam-COVID-Vac growth Heterologous immune immunization immunology injection Kazakhstan Local Mild-to-moderate mucosal nasal Nasopharyngeal swab nasopharyngeal swabs oncogene outcome participant performed Platelet count populations potentially life-threatening proportion prospective cohort study Questionnaires reactogenic reactogenicity reduced regimen regulated reported SARS-CoV-2 SARS-CoV-2 immunity seroconversion rate Serum level serum levels subject systemic adverse event systemic reactions the vaccine vaccination Vaccine vector Virus neutralization while [DOI] 10.1038/s41598-022-17514-3 PMC 바로가기 [Article Type] Article
Serological findings following the second and third SARS-CoV-2 vaccines in lung transplant recipients폐 이식 환자에서 2차 및 3차 SARS-CoV-2 백신에 따른 혈청학적 소견Article Published on 2022-08-012022-09-12 Journal: Immunity, Inflammation and Disease [Category] SARS, 진단, [키워드] acute respiratory syndrome age antibody Antibody titer average BBIBP-CorV booster Booster vaccine ChAdOx1 Clinical data coronavirus coronavirus disease COVID COVID-19 died difference dose doses effective enrolled evaluated had no highest ICU IgG immunization Immunocompromised patients Immunoglobulin Immunological response induce Infection injection intensive care lung transplant median men Messenger RNA mRNA mRNA vaccine mRNA-1273 mRNA-based non-mRNA vaccine pandemic Patient patients positive recipient SARS-CoV-2 SARS-CoV-2 vaccine second dose serology Serum level significantly higher STABLE Support therapy third vaccination Transplant U/mL Vaccine was measured were given [DOI] 10.1002/iid3.646 PMC 바로가기 [Article Type] Article
The Prospective Effect of Allopurinol on the Oxidative Stress Index and Endothelial Dysfunction in Covid-19코로나19의 산화 스트레스 지수와 내피 기능 장애에 대한 알로퓨리놀의 전향적 효과Article Published on 2022-08-012022-09-11 Journal: Inflammation [Category] COVID19(2023년), SARS, 바이오마커, [키워드] addition Admission allopurinol antioxidant Biomarker Biomarkers clinical outcomes cohort study correlated COVID-19 patients COVID-19 severity CRP CT scan Cytokines Cytopathic effect D-dimer dimer discharge Effect endothelial Endothelial dysfunction Endothelin Endothelin-1 enzyme ET-1 evaluated ferritin Gout Hospitalization index Inflammatory Inflammatory biomarker inflammatory biomarkers inflammatory disorder inflammatory disorders inflammatory disorders. inflammatory reaction LDH lymphocyte metabolism neutrophil NLR oxidative oxidative stress Patient pro-inflammatory cytokine pro-inflammatory cytokines procalcitonin procalcitonin) Propagation Prospective protective effect purine recruited reduced reported SARS-CoV-2 Serum level severe COVID-19 severe COVID-19 patients severity significantly single-center Standard therapy standard treatment standard treatment alone three groups Treatment triggered uric acid Viral viral infections xanthine [DOI] 10.1007/s10753-022-01648-7 PMC 바로가기 [Article Type] Article
Serum concentration of extracellular cold-inducible RNA-binding protein is associated with respiratory failure in COVID-19Observational Study Published on 2022-07-292022-10-05 Journal: Frontiers in Immunology [Category] 임상, [키워드] adjusted age aggravate association BMI Chest computed tomography Chest CT CIRP Cohort Comorbidity Concentration contribute correlated correlation COVID-19 damage-associated molecular pattern DAMP DAMPs defined determine disease dysregulated eCIRP evaluate external validation Extracellular extracellular CIRP FiO2 HFNO High-flow nasal oxygen highest Hospitalized hospitalized patient Host immune response Hypoxemia induce Inflammation inflammatory biomarkers Linear regression lung involvement mechanical ventilation Mild oxygen Pathogenesis Patient patients with COVID-19 peak prospective observational study Protein pulmonary involvement reduce Respiratory failure Respiratory Support risk Sepsis serum Serum level severe COVID-19 severe hypoxemia severity Severity of disease Sex suggested symptom duration tissue injury Treatment uncontrolled university was used were used [DOI] 10.3389/fimmu.2022.945603 PMC 바로가기 [Article Type] Observational Study
Six-Month Follow-Up of Immune Responses after a Rapid Mass Vaccination against SARS-CoV-2 with BNT162b2 in the District of Schwaz/AustriaSchwaz/Austria 지역에서 BNT162b2를 사용한 SARS-CoV-2에 대한 신속한 대량 백신 접종 후 면역 반응의 6개월 추적Article Published on 2022-07-272022-09-11 Journal: Viruses [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료기술, [키워드] age Analysis antibody Antibody Response B-cell response B.1.351 Beta BNT162b2 carried correlated COVID-19 detect District enrolment evaluate immune response immune responses Infection mass mass vaccination natural infection new SARS-CoV-2 no correlation outbreak participant participated preserved provide Rapid reduction in response robust SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infections second dose Seropositivity Serum level serum levels specific antibodies spring study participant subject Support T cell T cell response T cell responses T-cell Response the District the SARS-CoV-2 vaccination variant waned was measured [DOI] 10.3390/v14081642 PMC 바로가기 [Article Type] Article
Longitudinal Serum Proteome Characterization of COVID-19 Patients With Different Severities Revealed Potential Therapeutic Strategies다양한 중증도를 가진 COVID-19 환자의 세로 혈청 프로테옴 특성이 잠재적인 치료 전략을 드러냄Article Published on 2022-07-262022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] Activation alteration Analysis Asymptomatic asymptomatic patient asymptomatic patients caused characterization cholesterol cholesterol metabolism Cluster cluster analysis coagulation cascade collected complement Complement activation control group control groups COVID-19 COVID-19 pandemic COVID-19 patient COVID-19 patients disease Disease progression dysregulation effective expand global healthcare heterogeneity Hierarchical hierarchical cluster analysis immune response individuals involved longitudinal metabolism Mild moderate Moderate COVID-19 moderate COVID-19 patients molecular Non-COVID-19 not recovered Pathogenesis pathophysiological Patient patients performed PLGLB1 Potential potential therapeutic target potential therapeutic targets progression Protein Proteins proteomic proteomics restored Revealed SARS-CoV-2 serum serum biomarker serum biomarkers Serum level serum sample serum samples severity Strategy symptomatic Treatment understanding [DOI] 10.3389/fimmu.2022.893943 PMC 바로가기 [Article Type] Article
[Change in serum IgG antibody during the recovery stage of Omicron variant infection in children: an analysis of 110 cases][소아 오미크론 변이체 감염 회복기 혈청 IgG 항체 변화 : 110건 분석]Article Published on 2022-07-152022-09-11 Journal: Zhongguo dang dai er ke za zhi = Chinese journal o [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 age Analysis antibody BBIBP-CorV Beijing Biological Biological products booster vaccination caused Child children China Chinese citation Clinical data Complete coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 diagnosed Diagnosis disease dose doses English four group four groups groups IgG IgG antibody inactivated Inactivated vaccine Infection journal no significant difference no significant differences Nucleic acid detection omicron pediatrics protective effect RBD IgG Recovery stage reduction in respiratory Retrospective analysis route SARS-CoV-2 SARS-CoV-2 IgG antibody SARS-CoV-2 nucleic acid SARS-CoV-2 vaccination SARS-CoV-2 vaccine serum IgG Serum level severe acute respiratory syndrome Coronavirus Sex significant difference significant differences significantly higher significantly lower Sinopharm status the vaccine Tianjin Transmission two group two groups vaccination Vaccine variant was performed [DOI] 10.7499/j.issn.1008-8830.2204074 PMC 바로가기 [Article Type] Article
Photobiomodulation Improves Serum Cytokine Response in Mild to Moderate COVID-19: The First Randomized, Double-Blind, Placebo Controlled, Pilot StudyRandomized Controlled Trial Published on 2022-07-082022-10-04 Journal: Frontiers in Immunology [Category] 임상, [키워드] approved blood sample both groups classical Complication conducted Controlled COVID-19 cytokine Cytokine storm detect evaluate the effect help hospitalized patients ICU admission IL-10 IL-6 IL-6/IL-10 ratio IL-8 increase in Inflammatory cytokines inhibit inhibiting no decrease organ damage parameters pathophysiology Patient Photobiomodulation Ratio reduction reported response serum Serum level severe disease progression significant decrease study period therapeutic strategy therapy TNF-α treated Treatment [DOI] 10.3389/fimmu.2022.929837 PMC 바로가기 [Article Type] Randomized Controlled Trial