several variant – Page 3 – Communicable Diseases Research

Comparison of SARS-CoV-2 Evolution in Paediatric Primary Airway Epithelial Cell Cultures Compared with Vero-Derived Cell Lines

Article

Published on 2022-02-052022-10-28
Journal: Viruses [Category] COVID-19, COVID19(2023년), SARS,

The Impact of Accumulated Mutations in SARS-CoV-2 Variants on the qPCR Detection Efficiency

SARS-CoV-2 변이체의 누적 돌연변이가 qPCR 검출 효율에 미치는 영향

Cellular and Infection Microbiology

Published on 2022-01-282022-09-11
Journal: Frontiers in Cellular and Infection Microbiology [Category] SARS, 변종, 치료기술,

[키워드] Delta delta variant demonstrated detection detection efficiency Detection limit Detection sensitivity Genome Impact less mutant Mutation N gene omicron Omicron variants primer Primers probe probes qPCR qPCR detection efficiency quantitative PCR Region SARS-CoV-2 SARS-CoV-2 variants sequence sequenced genome sequences several variant several variants variant variants VoC was reduced wt sequence
[DOI] 10.3389/fcimb.2022.823306 PMC 바로가기 [Article Type] Cellular and Infection Microbiology

Genomic Characterization of SARS-CoV-2 Isolated from Patients with Distinct Disease Outcomes in Mexico

멕시코에서 뚜렷한 질병 결과를 가진 환자로부터 분리된 SARS-CoV-2의 게놈 특성화

Research Article

Published on 2022-01-122022-09-10
Journal: Microbiology Spectrum [Category] COVID19(2023년), MERS, SARS, 변종, 치료기술,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 age Ambulatory care approach association associations asymptomatic infection asymptomatic infections Care categories caused Characteristics characterization characterized circulating clinical condition clinical manifestation clinical manifestations Cluster co-occurrence Comorbidities Comorbidity Complete coronavirus disease Coronavirus disease 2019 Coronavirus-2 COVID-19 death Deceased Demographic factors diagnosed disease disease severity distinct clinical outcomes driven by early stage Epidemic epidemiological Evidence exponential growth exponential growth phase Genetic genetic association genetic background Genome genomic genomic diversity Growth phase Hospitalized Host initial Isolated less Local medical condition Mexico Mild Mild disease Mutation mutations Nonsynonymous mutations nucleotide outcome outcomes Pandemics Patient public health reduce respiratory risk factor Risk factors SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 genomes SARS-CoV-2 variant SARS-CoV-2 variants several variant several variants Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 severe disease shown Single nucleotide variant single nucleotide variants specific disease the patient Transmissibility Viral virus viruses was used Wuhan-Hu-1
[DOI] 10.1128/spectrum.01249-21 PMC 바로가기 [Article Type] Research Article

Inferring the stabilization effects of SARS-CoV-2 variants on the binding with ACE2 receptor

Article

Published on 2022-01-062022-10-04
Journal: Communications Biology [Category] SARS, 변종,

[키워드] ACE2 receptor acute respiratory syndrome addition African amino acid substitution Analysis antigenicity binding characteristic complex complexes contagiousness coronavirus Effect English feature greater help human ACE2 receptor Interaction molecular Molecular conformation Molecular dynamics simulation Molecular modelling MONITOR Mutation negative control no effect observation occur pandemic performed phenotype phenotypic provoke residue SARS-CoV-2 spike protein SARS-CoV-2 spike variant SARS-CoV-2 variant selected selective several variant South specific mutation spike variant spike variants Spread stability stabilizing effect Surveillance the SARS-CoV-2 the spike protein variant variants Variation viral genome virus while wild type
[DOI] 10.1038/s42003-021-02946-w PMC 바로가기 [Article Type] Article

SARS-CoV-2 variants with T135I nucleocapsid mutations may affect antigen test performance

T135I 뉴클레오캡시드 돌연변이가 있는 SARS-CoV-2 변이체가 항원 테스트 성능에 영향을 미칠 수 있음

Article

Published on 2022-01-012022-09-11
Journal: International Journal of Infectious Diseases [Category] MERS, SARS, 변종, 진단, 치료기술, 치료법, 치료제,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus Affect Amino acid amino acid substitutions Antigen antigen tests B.1.1.7 B.1.1.7 variant caused coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 detect determine diagnostic Diagnostic method diagnostic testing Direct exhibiting false-negative False-negative result false-negative results Genome genomes GISAID isolate molecular Mutation mutations N protein negative and positive nucleocapsid Outbreaks PanBio pandemic Patient performed Prevent proliferation Protein Rapid rapid antigen test Rapid antigen tests respiratory reverse transcription PCR risk RT-PCR RT-PCR test SARS-CoV-2 SARS-CoV-2 variant Sequencing several variant several variants severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 the N protein variant variants variations Viral virus strain was performed whole genome Whole genome sequencing
[DOI] 10.1016/j.ijid.2021.11.006 PMC 바로가기 [Article Type] Article

Molecular insights into receptor binding energetics and neutralization of SARS-CoV-2 variants

Article

Published on 2021-11-302022-10-04
Journal: Nature Communications [Category] MERS, SARS, 변종,

A review of epidemiology, clinical features and disease course, transmission dynamics, and neutralization efficacy of SARS-CoV-2 variants

Reviews

Published on 2021-11-062022-10-31
Journal: The Egyptian Journal of Bronchology [Category] COVID-19,

[키워드] addition article association available data Body Characteristics Clinical characteristics clinical feature clinical trial Comparative containment measures convalescent sera COVID 19 COVID-19 cross-protection described disease course Effectiveness Efficacy Epidemiology Evidence finding Genome geographical distribution heat map hindrance immune evasion Immunity literature review mAb mAbs methodology MONITOR monoclonal antibody Mutation neutralization neutralization potency pandemic provided resulting RNA viruses SARS CoV-2 SARS-CoV-2 SARS-CoV-2 variant sera several variant severity Spread therapeutic option Transmissibility Transmission dynamics Vaccination strategy Vaccine vaccine immunity Vaccines variant variants variants of interest Viral load virulence virus VoC was performed Wuhan strain
[DOI] 10.1186/s43168-021-00090-x PMC 바로가기 [Article Type] Reviews

SARS-CoV-2 beta variant substitutions alter spike glycoprotein receptor binding domain structure and stability

SARS-CoV-2 베타 변이체 치환은 스파이크 당단백질 수용체 결합 도메인 구조 및 안정성을 변경합니다

Research Article

Published on 2021-10-292022-09-10
Journal: The Journal of Biological Chemistry [Category] MERS, SARS, 변종, 진단,

[키워드] ACE2, angiotensin converting enzyme 2 acute respiratory syndrome Alpha Alter amino-acid angiotensin angiotensin converting enzyme angiotensin converting enzyme 2 B.1.1.7 B.1.351 Beta Beta variant bis-ANS, 4,4′-dianilino-1,1′-binaphthyl-5,5′-disulfonic acid coronavirus COVID-19 pandemic death disease domain Effect effective vaccine Effects Efficacy effort enzyme form forms HRP-RBD, horseradish preroxidase-labeled RBD mutations P.1 pandemic RBD, receptor-binding domain Receptor binding domain reduce respiratory SARS-CoV-2 SARS-CoV-2, severe acute respiratory syndrome-related coronavirus 2 selected several variant several variants Severe acute respiratory syndrome Severe acute respiratory syndrome-related coronavirus spike glycoprotein stability subsequent Substitution the receptor-binding domain the SARS-CoV-2 Vaccines variant variants of concern virus VOC, variants of concern
[DOI] 10.1016/j.jbc.2021.101371 PMC 바로가기 [Article Type] Research Article

Detailed phylogenetic analysis tracks transmission of distinct SARS-COV-2 variants from China and Europe to West Africa

상세한 계통발생학적 분석은 중국과 유럽에서 서아프리카로의 뚜렷한 SARS-COV-2 변이체의 전파를 추적합니다.

Article

Published on 2021-10-262022-09-10
Journal: Scientific Reports [Category] MERS, SARS, 변종,

Host Response to SARS-CoV2 and Emerging Variants in Pre-Existing Liver and Gastrointestinal Diseases

기존 간 및 위장 질환의 SARS-CoV2 및 새로운 변이체에 대한 숙주 반응

Review

Published on 2021-10-252022-09-11
Journal: Frontiers in Cellular and Infection Microbiology [Category] MERS, SARS, 변종, 치료기술,

[키워드] accumulation ACE2 receptor Alpha Alter Altered B.1.1.28.1 B.1.1.7 B.1.351 Beta binding Brazil changes in characteristic CLARITY cleavage condition coronavirus COVID-19 cytokine Cytokine storm Definitive determinant diabetes disease Diseases disorder disorders distribution drastic E484K emerging variants expression feature finding First wave Gastrointestinal gastrointestinal disease Generation GI Tract Host Host immune response host protease host protease TMPRSS2 host response hypertension Immune escape Immune status immunocompromised condition immunomodulation implicated incidence India indicate Infection Inflammation L452R lack less liver liver failure Liver injury manifestation Manifestations mechanism Mild Mortality Mutation N501Y novel Novel coronavirus obesity occur organs outcome outcomes P681R pandemic Patient predominant Protein binding radiologic receptor Receptor binding Replication reported required response risk factor RNA SARS-CoV2 selection pressure several variant several variants severe COVID-19 shown South Africa Spike protein Stool Symptoms systemic inflammation the disease the spike protein tissue expression TMPRSS2 Transmissibility Transmission underlying disease underlying diseases variant variants variants of concern Viral viral entry viral genome Viral proteins Viremia virulence virus virus clearance VoC
[DOI] 10.3389/fcimb.2021.753249 PMC 바로가기 [Article Type] Review