severe cases – Page 3 – Communicable Diseases Research

Host genomics of SARS-CoV-2 infection

SARS-CoV-2 감염의 숙주 유전체학

Review

Published on 2022-08-012022-09-11
Journal: European Journal of Human Genetics [Category] COVID19(2023년), SARS, 바이오마커, 변종, 신약개발, 유전자 메커니즘, 치료제,

SARS-CoV-2 infection induces soluble platelet activation markers and PAI-1 in the early moderate stage of COVID-19

SARS-CoV-2 감염은 COVID-19의 초기 중등도 단계에서 가용성 혈소판 활성화 마커 및 PAI-1을 유도합니다

Article

Published on 2022-08-012022-09-11
Journal: International journal of laboratory hematology [Category] MERS, SARS, 바이오마커,

[키워드] activated activated partial thromboplastin time activation of platelet activation of platelets Analysis aPTT CD40 ligand Coagulation coagulation dysfunction coagulation factor Coagulation factors Coagulation system coagulation test coagulation tests Comorbidity correlated COVID-19 COVID-19 patient COVID-19 patients COVID-19 severity D-dimer dysfunction dysregulated elevated Factor fibrinogen flow cytometry FXIII help hospitalized COVID-19 patient hospitalized COVID-19 patients induce inhibitor intensive care limit marker moderate Moderate COVID-19 molecular Multiplex assay P-selectin partial thromboplastin time Pathogenesis pathogenesis of COVID-19 pathway performed plasma plasminogen Platelet platelet activation Platelets Pneumonia progression prothrombin Prothrombin time recruited reduction in required SARS-COV-2 infection severe cases severe COVID-19 severe patients severity significantly Stage TFPI the disease Thromboembolism THROMBOPLASTIN Thromboprophylaxis tissue Tissue Factor tissue factor pathway inhibitor tissue plasminogen activator
[DOI] 10.1111/ijlh.13829 PMC 바로가기 [Article Type] Article

Human adenovirus (HAdV) infection in children with acute respiratory tract infections in Guangzhou, China, 2010-2021: a molecular epidemiology study

2010-2021년 중국 광저우에서 급성 호흡기 감염이 있는 어린이의 인간 아데노바이러스(HAdV) 감염: 분자 역학 연구

Article

Published on 2022-08-012022-09-11
Journal: World Journal of Pediatrics [Category] 유전자 메커니즘, 치료기술,

[키워드] acute hepatitis acute respiratory illness acute respiratory tract infection Adenovirus adenovirus infection ARI average mortality center children China Community conducted COVID-19 COVID-19 outbreak demonstrated described diagnosed Diseases distribution dominant dropped epidemic peak Epidemiology FIVE foundation Frequency Guangzhou Guangzhou, China Hepatitis Human Human adenovirus Infection Intervention life-threatening lowest Molecular epidemiology pathogen peaking pediatric Phylogenetic analysis proportion provide ranged Real-time PCR reduced respiratory tract respiratory tract infection Retrospective study risk Severe acute hepatitis severe cases severe disease shift shifting significant increase southern China specimen subtype Subtypes summer Transmission variety was recorded was used
[DOI] 10.1007/s12519-022-00590-w PMC 바로가기 [Article Type] Article

Evaluation of Intervention Policies for the COVID-19 Epidemic in the Seoul/Gyeonggi Region through a Model Simulation

모델 시뮬레이션을 통한 서울·경기 지역 코로나19 대응 정책 평가

Article

Published on 2022-08-012022-09-11
Journal: Yonsei medical journal [Category] SARS, 변종,

Efficacy and effectiveness of SARS-CoV-2 vaccines for death prevention: A protocol for a systematic review and meta-analysis

사망 예방을 위한 SARS-CoV-2 백신의 효능 및 효과: 체계적인 검토 및 메타 분석을 위한 프로토콜

Article

Published on 2022-07-282022-09-11
Journal: PLoS ONE [Category] COVID19(2023년), MERS, meta-analysis, SARS,

[키워드] adverse event all-cause mortality analyzed approved assessment Bia calculated case-control studies case-control study Cohort controlled trials COVID-19 death deaths effective Effectiveness Efficacy Egger eligible Evidence exploratory for inclusion forest plot forest plots funnel plot hazard hazard ratios heterogeneity Hospitalization incident independent intervals Intervention Meta-analysis Mortality Observational data outcome Placebo Prevent Primary outcome PROSPERO protocol Publication bia publication bias randomized control trial Randomized controlled trials RCT Record reducing Registered risk reduction SARS-CoV-2 vaccine SARS-CoV-2 vaccines Secondary outcomes Severe case severe cases statistical statistical test systematic review the vaccine the vaccines university vaccination Vaccination Status Vaccine visual inspection York
[DOI] 10.1371/journal.pone.0265414 PMC 바로가기 [Article Type] Article

Effect of Qingfei Paidu decoction combined with Western medicine treatments for COVID-19: A systematic review and meta-analysis

Covid-19에 대한 서양 의학 치료와 결합 된 Qingfei Painu 달인의 영향 : 체계적인 검토 및 메타 분석

Review

Published on 2022-07-202022-08-31
Journal: Phytomedicine : international journal of phytother [Category] 임상, 치료법, 치료제,

Nanoligomers Targeting Human miRNA for the Treatment of Severe COVID-19 Are Safe and Nontoxic in Mice

심각한 COVID-19 치료를 위해 인간 miRNA를 표적으로 하는 나노 올리고머는 마우스에서 안전하고 독성이 없습니다

Article

Published on 2022-07-112022-09-11
Journal: ACS Biomaterials Science & Engineering [Category] COVID19(2023년), SARS, 치료제,

[키워드] accumulation acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 administration antisense therapy Antiviral strategies Antiviral treatment bind biodistribution biodistribution study body weight Compound coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 disease Effect fatality Histopathology Host Host immune response Human human cell human cells immune immunogenicity Infection Inflammation intranasal intraperitoneal intravenous Intravenous administration kidney kidneys liver Lungs mice microRNA miRNA MOST mouse model organ organs pandemic parameters produced question response Safe Safety SARS-CoV-2 serum biomarker serum biomarkers severe acute respiratory syndrome Coronavirus Severe case severe cases spleen targeting tested Urine with infection
[DOI] 10.1021/acsbiomaterials.2c00510 PMC 바로가기 [Article Type] Article

Gasdermin-D activation by SARS-CoV-2 triggers NET and mediate COVID-19 immunopathology

SARS-CoV-2에 의한 Gasdermin-D 활성화는 NET을 유발하고 COVID-19 면역병리를 매개합니다

Article

Published on 2022-07-072022-09-11
Journal: Critical Care [Category] COVID19(2023년), SARS, 유전자 메커니즘, 진단,

[키워드] activate Activation Analysis analyzed Blood Bronchoalveolar lavage Coagulopathy COVID-19 COVID-19 patients Critical demonstrated disulfiram enrolled expression GSDMD hospitalized patient immunopathology infect Inflammasome Inflammation inhibited Innate Innate immunity live SARS-CoV-2 lung tissue lung tissue sample moderate molecular mechanism molecular mechanisms mouse model NET NETosis NETs neutrophil Neutrophil extracellular trap Neutrophil extracellular traps Neutrophils organ damage pathway Pathways performed Protein reduced SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 virus Severe case severe cases severe COVID-19 signaling pathway single-cell Structure the SARS-CoV-2 virus therapeutic strategy Transcriptome Treatment Trigger triggers
[DOI] 10.1186/s13054-022-04062-5 PMC 바로가기 [Article Type] Article

Multi-Faceted Analysis of COVID-19 Epidemic in Korea Considering Omicron Variant: Mathematical Modeling-Based Study

오미크론 변이를 고려한 국내 코로나19 다면 분석: 수학적 모델링 기반 연구

Article

Published on 2022-07-042022-09-11
Journal: Journal of Korean medical science [Category] COVID19(2023년), SARS, 변종, 치료제,

[키워드] Administered age Analysis antiviral drug antiviral drugs available data average B.1.1.529 booster Border caused Community COVID-19 Effectiveness Endemic examined exceeded Factors force force of infection Formula group Hospital stay incidence influx intensity Intervention likelihood mathematical mathematical model mathematical modeling maximum likelihood estimation measure Nonpharmaceutical interventions NPI NPIs omicron Omicron variant Omicron Variant, Nonpharmaceutical Interventions parameter quantified ranged reduced representing Severe case severe cases Severity rate social distancing Spread the epidemic the timing Transmission transmission rate transmission rates vaccination Vaccine variant was performed
[DOI] 10.3346/jkms.2022.37.e209 PMC 바로가기 [Article Type] Article

In Vitro Exposure of Primary Human T Cells and Monocytes to Polyclonal Stimuli Reveals a Basal Susceptibility to Display an Impaired Cellular Immune Response and Develop Severe COVID-19

다클론 자극에 대한 1차 인간 T 세포 및 단핵구의 체외 노출은 손상된 세포 면역 반응을 표시하고 심각한 COVID-19를 발생시키는 기초 감수성을 나타냅니다

Article

Published on 2022-07-012022-09-11
Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 바이오마커,

[키워드] (PD-1 acute respiratory syndrome acute respiratory syndrome coronavirus Alpha analyzed Anosmia anti-CD3 Antibody titer Antibody titers basal baseline characteristics biochemical blood sample Blood samples CD14 CD16 CD4+ CD8+ T cell CD8+ T cells Cellular immune response cellular immunity classical classical monocytes clinical recovery conducted coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 progression disease display distress drug Evidence exposure expression Fever Follow-up headache healthy volunteer Human Humoral immunity hypoxia IFN-alpha IFN-gamma IL-2 immune function immune response Immunoglobulin Immunoglobulin G Impaired in vitro interferon interleukin interleukin-2 Invasive mechanical ventilation lipopolysaccharide Mild mild cases monocyte monocyte subsets Monocytes Neutralizing no difference no differences non-classical monocyte Non-classical monocytes not differ participant Patient PD-1 Pneumonia polyclonal predisposition programmed cell death programmed cell death protein prospective cohort study Protein receiving Registered required respiratory respiratory distress response S1 protein SARS-CoV-2 SARS-COV-2 infection serum titer Severe case severe cases severe COVID-19 severity significantly subset Symptom T cell T cells virus worsening
[DOI] 10.3389/fimmu.2022.897995 PMC 바로가기 [Article Type] Article