Sex-biased expression of the TLR7 gene in severe COVID-19 patients: Insights from transcriptomics and epigenomicsArticle Published on 2022-12-012022-11-16 Journal: Environmental research [Category] 유전자 메커니즘, [키워드] acute phase analyzed Blood Cohort coronavirus disease COVID-19 COVID-19 patient CpG DNA DNA methylation dose downregulated embryogenesis epidemiological data epigenomic epigenomics Evidence expression female females gene product Genetic variation Genome-wide association studies Host inactivation incidence incidence of COVID-19 independent insight long-COVID-19 male males Methylation n-Counter. nasal patients Post-infection RNAseq Saliva Severe case severe COVID-19 severity Sex significantly higher stratified suggested timepoint TLR7 TLR7 gene transcriptomics with COVID-19 [DOI] 10.1016/j.envres.2022.114288 PMC 바로가기
Clinical course of novel COVID-19 infection in pregnant womenObservational Study Published on 2022-12-012022-10-05 Journal: The journal of maternal-fetal & neonatal medicine [Category] COVID19(2023년), SARS, 임상, 치료기술, [키워드] alanine aminotransferase analyzed Anemia Anosmia antimicrobial APGAR score Asymptomatic C-reactive protein carbapenem change clinical Clinical course clinical symptom contribute coronavirus cough Course COVID-19 COVID-19 infection CPAP therapy creatinine CRP decrease demographic disease drug Elimination epidemiological erythrocyte excluded form Immunity increase in Infection interferon Laboratory lactate dehydrogenase LDH leukopenia low molecular weight lymphocyte manifestation maternal and perinatal outcomes. mechanical ventilation Mild moderate morbidity Neonatal Neonatal COVID-19 Neonate no evidence of occurred outcome outcomes Oxygenation PCR polymerase chain predictor Pregnancy pregnant women preterm delivery prospective observational study recommendations reported required SARS-CoV-2 Severe case severe COVID-19 Spontaneous Transmission virus women [DOI] 10.1080/14767058.2020.1850683 PMC 바로가기 [Article Type] Observational Study
Sputum characteristics of patients with severe COVID-19: report of two cases with immunocytochemical detection of SARS-CoV-2 spike proteinArticle Published on 2022-12-012022-11-15 Journal: Medical molecular morphology [Category] COVID19(2023년), SARS, 치료기술, [키워드] aggregation alveolar Analysis can be used CD68 Cell cells characteristics of patient chromatin COVID-19 cytological cytoplasmic definitive diagnosis double infection epithelial evaluated exclusion expression Herpe herpes simplex herpes simplex virus immunocytochemistry Inclusion infected cell Infection intranuclear multinuclear nuclear nuclei Patient performed pneumocyte positive protein A SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike SARS-CoV-2 spike protein severe COVID-19 simplex specimen sputum Sputum sample staining These cells Treatment viral infection virus [DOI] 10.1007/s00795-022-00326-9 PMC 바로가기
Intention to participate in COVID-19 vaccine clinical trials in May 2021: a cross-sectional survey in the general French populationArticle Published on 2022-11-302022-11-16 Journal: Human vaccines & immunotherapeutics [Category] COVID19(2023년), SARS, 변종, [키워드] 95% CI 95% confidence interval adjusted Attitude Attitudes Clinical research clinical trial conducted contribute COVID 19 COVID-19 COVID-19 vaccination COVID-19 vaccine cross-sectional cross-sectional survey Factor female gender France French Government Health healthcare worker immunization increase in Intention media new SARS-CoV-2 Participation predict reduction in risk severe COVID-19 Trial vaccination Vaccine vaccine availability variant [DOI] 10.1080/21645515.2022.2072630 PMC 바로가기
Phase II/III trial of hyperimmune anti-COVID-19 intravenous immunoglobulin (C-IVIG) therapy in severe COVID-19 patients: study protocol for a randomized controlled trialArticle Published on 2022-11-082022-11-16 Journal: Trials [Category] SARS, 변종, [키워드] adaptive anti-COVID-19 IVIG antivirals clinical evidence clinical trial collected convalescent convalescent plasma COVID-19 cumulative death Efficacy eligibility criteria evaluate Health hyperimmune immunization immunomodulators intravenous Intravenous immunoglobulin low dose monoclonal antibodies Neutralizing non-specific novel Novel coronavirus outcome Passive passive immunization Patient phase Pneumonia polyclonal polyclonal antibodies Pooled convalescent plasma Potential treatment Randomized Randomized controlled trial receive Recovered COVID-19 patients reported SARS CoV-2 SARS-CoV-2 sealed Secondary outcomes severe COVID-19 severe COVID-19 patient severe COVID-19 patients Standard of care Steroids Study protocol therapeutic option therapy treat Treatment Trial variant variants of concern virus virus particles World Health Organization [DOI] 10.1186/s13063-022-06860-2 PMC 바로가기
Intestinal Infarction in COVID-19 Pandemic: A Case SeriesOriginal Article Published on 2022-11-072022-10-29 Journal: Iranian Journal of Pathology [Category] COVID-19, [키워드] Abdominal CT Scan blood flow Clinical data coagulation disorder collected Complication coronavirus coronavirus disease COVID-19 described digestive system disrupt events Evidence headache Health Imam include Infection infection process intestinal Iran Ischemia Mashhad Medical Sciences mesenteric ischemia Necrosis novel operative organs pathological finding Patient patients hospitalized physician reported respiratory symptoms Reza risk factor Sery severe COVID-19 Severe COVID-19 Infection Severe COVID-19 pneumonia Spread suggested Symptom thrombosis university Vascular visceral with COVID-19 [DOI] 10.30699/IJP.2021.525280.2600 PMC 바로가기 [Article Type] Original Article
Reduced circulating FABP2 in patients with moderate to severe COVID-19 may indicate enterocyte functional change rather than cell deathArticle Published on 2022-11-052022-11-15 Journal: Scientific Reports [Category] SARS, 바이오마커, 진단, [키워드] acid Alter alteration Biomarker caused cell death change circulating Cohort contribute COVID-19 COVID-19 patient disease dysfunction Europe exclusion FABP2 functional Gut immune include increase in Infection Inflammation Inflammatory responses inhibited marker median metabolites microbial product Mild moderate NMR outliers pathology Patient patients with moderate plasma Plasma marker positive correlation reduced reduction in route of infection SARS-CoV-2 SARS-COV-2 infection severe COVID-19 severe disease severe group Severity of disease shown systemic [DOI] 10.1038/s41598-022-23282-x PMC 바로가기
High vaccine effectiveness against severe COVID-19 in the elderly in Finland before and after the emergence of OmicronArticle Published on 2022-11-052022-11-16 Journal: BMC Infectious Diseases [Category] SARS, 변종, [키워드] 95% CI Admission caused Cohort cohort analysis COVID-19 COVID-19 hospitalization COVID-19 vaccines dose doses Effectiveness elderly Elderly cohort evaluated Follow-up hazard ratio Heterologous homologous Hospitalization ICU ICU treatment Immunity individuals intensive care omicron outcome protection reduced remained restored SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 Omicron variant severe COVID-19 vaccination Vaccine waned Waning vaccine effectiveness. [DOI] 10.1186/s12879-022-07814-4 PMC 바로가기
Immunogenicity and efficacy of COVID-19 vaccines in people living with HIV: a systematic review and meta-analysisArticle Published on 2022-11-012022-11-15 Journal: International Journal of Infectious Diseases [Category] COVID19(2023년), SARS, 진단, [키워드] affected Antibody titer booster vaccination both groups Cochrane Library comparable COVID-19 COVID-19 vaccine COVID-19 vaccines effective Efficacy healthy controls healthy individuals HIV immunogenicity IMPROVE in healthy individuals inclusion criteria increased risk less Messenger RNA Meta-analysis participant patients PLWH random-effect reduced risk ratio SARS-CoV-2 SARS-CoV-2 antibody searched second dose Seroconversion severe COVID-19 significantly subject systematic review vaccination vaccine dose was performed with HIV [DOI] 10.1016/j.ijid.2022.10.005 PMC 바로가기
Cardiac megakaryocytes in SARS-CoV-2-positive autopsiesArticle Published on 2022-11-012022-11-15 Journal: Histopathology [Category] SARS, 치료기술, [키워드] addition Autopsies Autopsy average cardiac Cell Cohort Comorbidity correlated Course COVID-19 COVID-19 cohort evaluated groups Increasing Infection inflammatory markers Inflammatory response Laboratory management megakaryocytes nonspecific parameter Patient performed Platelet Platelets precursor pulmonary disease Pulmonary emboli reported Respiratory Coronavirus SARS-CoV-2 SARS-CoV-2-positive patient selected severe COVID-19 significantly higher statistically significant supported the disease thromboembolic thrombotic complication viral infections were assessed [DOI] 10.1111/his.14734 PMC 바로가기