A Pro-Inflammatory Gut Microbiome Characterizes SARS-CoV-2 Infected Patients and a Reduction in the Connectivity of an Anti-Inflammatory Bacterial Network Associates With Severe COVID-19Cellular and Infection Microbiology Published on 2021-11-172022-10-31 Journal: Frontiers in Cellular and Infection Microbiology [Category] COVID-19, MERS, SARS, [키워드] 16S rRNA gene Actinobacteria analyzed Anti-inflammatory Associate Bacterial Bacteroide Bacteroidete Bifidobacterium Blood Care CD8 characterized connectivity contribute COVID-19 COVID-19 illness COVID-19 severity decrease Dysbiosis dysregulated Enterobacteriaceae exhibited Faecalibacterium Gut gut microbiome composition gut microbiota Health hospital Hyperinflammatory Immune cell immune response immune responses infected with SARS-CoV-2 intestinal microbiota marker Microbiome mild COVID-19 illness network Patient patients pro-inflammatory Prospective Study Proteobacteria quantified reduction in SARS-CoV-2 SARS-CoV-2 infected patient SARS-CoV-2 positive patient Sequencing severe COVID-19 illness severity Streptococcus T cell was increased [DOI] 10.3389/fcimb.2021.747816 PMC 바로가기 [Article Type] Cellular and Infection Microbiology
Analysis of transcriptomic data sets supports the role of IL-6 in NETosis and immunothrombosis in severe COVID-19전 사체 데이터 세트의 분석은 중증 covid-19에서 네토 시스 및 면역 혈증에서 IL-6의 역할을 뒷받침합니다.Research Published on 2021-11-142022-09-10 Journal: BMC Genomic Data [Category] MERS, 유전자 메커니즘, [키워드] Activation Blood Blood oxygen saturation cascade co-expression Coagulation coagulation cascade complement Complement activation Complication contributing to correlated COVID-19 COVID-19 disease COVID-19 illness data sets downstream driving dysfunction enrichment analysis event Evidence evidence of expression functional Gene Expression gene set enrichment analysis Genes IL-6 IL-6 expression IL6 immunothrombosis life-threatening lung moderate Mortality negative correlation NETosis Neutrophil extracellular trap Non-survivors oxygen oxygen saturation Pathogenesis pathological process patients with COVID-19 respiratory Respiratory function Result robust Scientific community severe COVID-19 severe COVID-19 disease severe COVID-19 illness severity severity of illness subject supplementary material Support Temporal the disease therapy transcriptional transcriptomic data transcriptomics Treatment Unsupervised clustering up-regulation was performed with COVID-19 [DOI] 10.1186/s12863-021-01001-1 PMC 바로가기 [Article Type] Research
The predictive value of serum level of cystatin C for COVID-19 severityArticle Published on 2021-11-092022-10-04 Journal: Scientific Reports [Category] MERS, 치료기술, 치료법, [키워드] 95% CI Accuracy adjusted Analysis association characteristic COVID-19 severity COX cut-off value determine evaluated hazard help identify increased risk medical record multivariable participant patients with COVID-19 performed Predictive Prognostic value Regression model retrospective Risk factors ROC ROC Curve Sensitivity and specificity Serum level severe COVID-19 disease severe COVID-19 illness severe COVID-19 patients significantly two group viral infection [DOI] 10.1038/s41598-021-01570-2 PMC 바로가기 [Article Type] Article
COVID-19 health inequities and association with mechanical ventilation and prolonged length of stay at an urban safety-net health system in ChicagoResearch Article Published on 2021-10-132022-10-28 Journal: PLoS ONE [Category] COVID-19, MERS, SARS, [키워드] age American association black Chicago chronic obstructive Community Comorbidity COVID-19 demographic characteristics females Health inequity health system Hispanic infected with COVID-19 investigated Length male mechanical ventilation Patient populations positive pulmonary disease severe COVID-19 illness Sex significantly significantly higher statistically tested variables ventilator [DOI] 10.1371/journal.pone.0258243 PMC 바로가기 [Article Type] Research Article
Both Underweight and Obesity Are Associated With an Increased Risk of Coronavirus Disease 2019 (COVID-19) SeverityNutrition Published on 2021-10-082022-10-31 Journal: Frontiers in Nutrition [Category] COVID-19, [키워드] acute lung injury addition Admission analyzed BMI body mass index C-reactive protein collected confirmed case confounders coronavirus COVID-19 death defined develop global pandemic Ground glass opacity group groups headache higher odd highest Hospitalized human immunoglobulin ICU incidence increase in Increased increased risk Infection intensive care laboratory data lung Lymphocyte count Mortality obese obese patient obesity Patient patients proportion receiving Research SARS-CoV-2 Science Secondary infection severe COVID-19 illness systematic corticosteroid technology the patient Tongji Medical College Treatment underweight Union Hospital university with COVID-19 Wuhan, China [DOI] 10.3389/fnut.2021.649422 PMC 바로가기 [Article Type] Nutrition
Antibodies: what makes us stronger항체: 우리를 더 강하게 만드는 것Article Published on 2021-10-032022-09-12 Journal: Human vaccines & immunotherapeutics [Category] MERS, SARS, 진단, [키워드] analyzed anti-viral antibody antibody Antibody Response Antibody titer approved assumption B cell B cell response B cells Cell contribute correlation Course demonstrated disease disease severity Donor effective explained inhibiting memory B Mild mild COVID-19 patients mild infection Neutralizing Neutralizing antibodies pathogen Pathogens Prophylactic Protective responses SARS coronavirus 2 SARS-CoV-2 severe COVID-19 illness the antibody the disease Tuberculosis Vaccine Viral load [DOI] 10.1080/21645515.2021.1929034 PMC 바로가기 [Article Type] Article
Incidence, co-occurrence, and evolution of long-COVID features: A 6-month retrospective cohort study of 273,618 survivors of COVID-19Research Article Published on 2021-09-282022-10-29 Journal: PLoS Medicine [Category] COVID-19, SARS, [키워드] acute phase Adults affected affecting age analyzed atopic dermatitis calculated clinical feature co-occurrence co-occurrence network cognitive Cohort cohort of patient conducted COVID-19 COVID-19 diagnosis demographics described diagnosed diagnosed with COVID-19 diagnosis of COVID-19 effective EHR data Electronic health record estimate Evolution Factor feature Features female group had more had no hazard ratio headache healthcare help Illness severity incidence include Infection infection with SARS-CoV-2 Influenza inherent Kaplan–Meier analysis limitation long-COVID majority myalgia negative control occurred organ Pain Patient persistence profile receive receiving recorded reported Research researcher retrospective cohort study risk robust seeking severe COVID-19 illness Severity of infection Sex Significant significantly higher specificity subgroups survivor Survivors Symptom Symptoms the patient Treatment used data variety viral infection was used white [DOI] 10.1371/journal.pmed.1003773 PMC 바로가기 [Article Type] Research Article
Complement levels at admission as a reflection of coronavirus disease 2019 (COVID-19) severity state코로나바이러스 질병 2019(COVID-19) 심각도 상태를 반영하여 입원 시 보완 수준Article Published on 2021-09-012022-09-11 Journal: Journal of medical virology [Category] SARS, 바이오마커, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus 2 ADAMTS13 Admission adverse outcome adverse outcomes analyzed association benefit Blood blood sample Blood samples C3a C3a/C3 Clinical improvement complement complement system confounders coronavirus coronavirus disease Coronavirus disease 2019 correlated correlation correlations Course COVID-19 COVID-19 illness COVID-19 patient COVID-19 severity disease severity displaying elevated emergency department enrolled Evidence evidence of fibrinogen highest Hyperactivation hyperinflammation Hyperinflammatory implicated infected patients inflammatory biomarkers investigated moderate organ damage over parameter Patient phenotype plasminogen predict presenting Primary outcome progression Research respiratory SARS-CoV-2 SARS-CoV-2 hyperinflammation secondary outcome severe acute respiratory syndrome Coronavirus severe COVID-19 illness severe disease severity significantly therapy thrombotic thrombotic microangiopathy tissue [DOI] 10.1002/jmv.27077 PMC 바로가기 [Article Type] Article
Retrospective study of COVID-19 seroprevalence among tissue donors at the onset of the outbreak before implementation of strict lockdown measures in France프랑스에서 엄격한 폐쇄 조치를 시행하기 전 발병 초기 조직 기증자 사이의 COVID-19 혈청 유병률에 대한 후향적 연구Article Published on 2021-09-012022-09-12 Journal: Cell and tissue banking [Category] MERS, SARS, 진단, [키워드] age anti-S anti-SARS-CoV-2 antibodies Bank co-morbidity COVID-19 COVID-19 pandemic Donor donors France help higher risk IgG implementation Infection lockdown measure MOST organ outbreak positive Probability Protein Result risk SARS-CoV-2 SARS-CoV-2 antibody SARS-CoV-2 RNA serological test Seroprevalence serum sample severe COVID-19 illness specimen tested tissue Tissue donors total Ig Transmission [DOI] 10.1007/s10561-021-09901-3 PMC 바로가기 [Article Type] Article
National Early Warning Score 2 and laboratory predictors correlate with clinical deterioration in hospitalized patients with COVID-19Research Article Published on 2021-07-212022-10-28 Journal: Biomarkers in Medicine [Category] COVID-19, MERS, [키워드] Abstract Admission albumin analyzed Clinical course Clinical deterioration correlated COVID-19 COVID-19 pandemic defined determine highest Hospitalization Hospitalized hospitalized patient ICU admission In-hospital death in-hospital mortality intensive care knowledge Laboratory laboratory parameter lack material neutrophil/lymphocyte ratio NEWS2 Odds ratio Patient patients with COVID-19 Predictive predictor procalcitonin Prognostic value provide score severe COVID-19 illness with COVID-19 [DOI] 10.2217/bmm-2021-0061 PMC 바로가기 [Article Type] Research Article