Extracorporeal Membrane Oxygenation for SARS-CoV-2 Acute Respiratory Distress Syndrome: A Retrospective Study From Hubei, ChinaMedicine Published on 2021-01-122022-10-31 Journal: Frontiers in Medicine [Category] COVID-19, [키워드] 30-Day mortality accompanied acute respiratory distress syndrome age analyses Blood China Clinical features collected complications COVID-19 ECMO Extracorporeal extracorporeal membrane oxygenation hemorrhage information intensive care unit Invasive mechanical ventilation IQR Laboratory tests males median median age Mortality occurred on mechanical ventilation outcome Patient patients Prognosis Prone position proportion receiving replaced respiratory Retrospective study SARS-CoV-2 severe hypoxemia severe respiratory failure Support symptom onset treated Treatment Ventilation [DOI] 10.3389/fmed.2020.611460 PMC 바로가기 [Article Type] Medicine
A Multiple-Hit Hypothesis Involving Reactive Oxygen Species and Myeloperoxidase Explains Clinical Deterioration and Fatality in COVID-19Review Published on 2021-01-012022-10-29 Journal: International Journal of Biological Sciences [Category] COVID-19, MERS, [키워드] activate activated neutrophil binding clinical Clinical deterioration contribute coronavirus disease Coronavirus. COVID-19 COVID-19 COVID-19 patients Critical Critically ill develop explain Factor Free iron hallmark hemoglobin HOCl immune response include infections Inflammation Inflammatory Involving lung lung mechanics mechanism microvascular injury Mortality MPO myeloperoxidase myeloperoxidase, HOCl natural immune response nitric oxide oxidative pathology preserved pulmonary hypertension rapid clinical deterioration reaction Reactions reactive oxygen species reactive oxygen specy ROS severe COVID-19 severe hypoxemia severe hypoxia Specy subsequent therapeutic strategy Thromboembolism tissue damage tissue injury understanding unique vasoconstriction [DOI] 10.7150/ijbs.51811 PMC 바로가기 [Article Type] Review
What Open-Lung Biopsy Teaches Us about ARDS in COVID-19 Patients: Mechanisms, Pathology, and Therapeutic ImplicationsResearch Article Published on 2020-12-092022-10-27 Journal: BioMed Research International [Category] COVID-19, [키워드] alveolar damage Analysis Anticoagulant ARDS assist Atypical Berlin biopsy cause caused chain Coagulopathy Compliance COVID-19 Culture dead difficulty Glucocorticoids High dose hyaline membrane Hypoxemia Injury intensive care lung lung tissue mechanical ventilation meet microthrombi pathophysiology Patient patients physician Protective pulmonary parenchyma reaction researcher respiratory RT-PCR SARS-CoV-2 severe hypoxemia Shunt specimens Therapeutic approach thrombotic understanding vascular congestion Ventilation-perfusion ratio was performed [DOI] 10.1155/2020/2909673 PMC 바로가기 [Article Type] Research Article
What Open-Lung Biopsy Teaches Us about ARDS in COVID-19 Patients: Mechanisms, Pathology, and Therapeutic ImplicationsResearch Article Published on 2020-12-092022-10-27 Journal: BioMed Research International [Category] Coronavirus, COVID-19, MERS, SARS, [키워드] alveolar damage Analysis Anticoagulant ARDS assist Atypical Berlin biopsy cause caused chain Coagulopathy Compliance COVID-19 Culture dead difficulty Glucocorticoids High dose hyaline membrane Hypoxemia Injury intensive care lung lung tissue mechanical ventilation meet microthrombi pathophysiology Patient patients physician Protective pulmonary parenchyma reaction researcher respiratory RT-PCR SARS-CoV-2 severe hypoxemia Shunt specimens Therapeutic approach thrombotic understanding vascular congestion Ventilation-perfusion ratio was performed [DOI] 10.1155/2020/2909673 PMC 바로가기 [Article Type] Research Article
What Open-Lung Biopsy Teaches Us about ARDS in COVID-19 Patients: Mechanisms, Pathology, and Therapeutic Implications개폐 생검이 COVID-19 환자의 ARDS에 대해 가르치는 것: 기전, 병리학 및 치료적 의미Research Article Published on 2020-12-092022-09-10 Journal: BioMed Research International [Category] 치료기술, [키워드] acute respiratory distress syndrome alveolar damage Analysis Anticoagulant ARDS assist Atypical Berlin biopsy cause caused chain Chain Reaction Coagulopathy Compliance COVID-19 Culture dead Dead space difficulty dual FIBRIN Glucocorticoids High dose hyaline membrane hyaline membranes Hypoxemia Injury intensive care intensive care unit lung lung tissue mechanical ventilation meet microthrombi pathophysiology Patient patients physician pleural fluid polymerase chain reaction Protective pulmonary parenchyma reaction researcher respiratory respiratory distress Respiratory distress syndrome RT-PCR SARS-CoV-2 severe hypoxemia Shunt shunt effect specimens Therapeutic approach thrombotic tissue biopsy two patients understanding vascular congestion Ventilation-perfusion ratio was performed [DOI] 10.1155/2020/2909673 PMC 바로가기 [Article Type] Research Article
Rescue therapy with inhaled nitric oxide and almitrine in COVID-19 patients with severe acute respiratory distress syndromeResearch Published on 2020-11-042022-10-28 Journal: Annals of Intensive Care [Category] COVID-19, [키워드] acute respiratory distress Almitrine ARDS association baseline Blood caused Combination Compliance conducted COVID-19 COVID-19 patient evaluate females hemodynamic highlight hypoxic increase in Inhaled iNO intubated patient male mechanism median median age nitric oxide no correlation Oxygenation PaO pathophysiology Patient patients performed pilot study preserved primary endpoint proning rescue respiratory Respiratory system Result severe COVID-19 severe hypoxemia syndrome therapy Variation vascular dysfunction Vascular function vasoconstriction were assessed [DOI] 10.1186/s13613-020-00769-2 PMC 바로가기 [Article Type] Research
Emerging Mechanisms of Pulmonary Vasoconstriction in SARS-CoV-2-Induced Acute Respiratory Distress Syndrome (ARDS) and Potential Therapeutic TargetsReview Published on 2020-10-292022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, MERS, SARS, [키워드] 1918 influenza acute lung injury acute respiratory distress acute respiratory syndrome ARDS Atypical caused characterized clinically coronavirus coronavirus disease COVID-19 COVID-19 patient cytokine release storm described disease Endothelin exacerbate hallmark highlight hypoxic-adenosinergic response increase in International Kallikrein–Kinin System Lung injury mechanism Novel coronavirus outbreak pandemic Potential potential treatment option promote pulmonary pulmonary hypertension recent renin angiotensin system respiratory Respiratory illness respiratory viral infection SARS-CoV-2 SARS-COV-2 infection severe hypoxemia spread to syndrome target tested Vascular vascular dysfunction vasoconstriction [DOI] 10.3390/ijms21218081 PMC 바로가기 [Article Type] Review
Extremely high-dose insulin requirement in a diabetic patient with COVID-19: a case reportCase Report Published on 2020-10-162022-10-28 Journal: BMC Endocrine Disorders [Category] COVID-19, MERS, SARS, [키워드] acute respiratory distress Admission approach average Bronchoalveolar lavage Care Case report caused chronic condition clinician complications of COVID-19 COVID-19 defined diabete diabetes Diabetic diabetic patient doses Dyspnea dysregulation elevated extreme Glucose help High-dose homeostasis hyperglycemia infected with SARS-CoV-2 Infection insulin insulin resistance intensive care intravenous intubation knowledge management mechanical ventilation support mechanism medical condition mortality rate Myocardial infarction pandemic Patient patient with COVID-19 patients hospitalized patients with COVID-19 patients with diabete plasma positive presenting reduced report reported RT-qPCR SARS-CoV-2 Sepsis severe hypoxemia Switzerland syndrome transfer Transient treated Treatment type 2 diabete type 2 diabetes was performed worsening [DOI] 10.1186/s12902-020-00632-2 PMC 바로가기 [Article Type] Case Report
Alveolar cells under mechanical stressed niche: critical contributors to pulmonary fibrosisReview Published on 2020-10-142022-10-30 Journal: Molecular Medicine [Category] Coronavirus, MERS, SARS, [키워드] Activation Alter alveolar cells alveolar epithelium arise capillary Cell cellular COVID-19 patient Critical cytoskeletal Effect endothelial cells Epigenetic epithelial epithelial cells Extracellular matrix fibroblast fibroblasts fibrosis Gas exchange generate Injury Local Lung fibrosis Macrophage Mast cells mechanical stress Mechanical stress niche mechanical ventilation Mild pathology pulmonary pulmonary fibrosis receive Regulation repeated severe hypoxemia stages stem cells subject subsequent Supportive treatment tissue variety vascular permeability [DOI] 10.1186/s10020-020-00223-w PMC 바로가기 [Article Type] Review
Severe COVID-19 in Third Trimester Pregnancy: Multidisciplinary ApproachCase Report Published on 2020-10-142022-10-31 Journal: Case Reports in Critical Care [Category] COVID-19, [키워드] acute respiratory syndrome Admission approach Asthma asynchrony Care caused convalescent plasma coronavirus coronavirus disease Course COVID-19 COVID-19 patient Critical care Critically ill discharged fetal gestation highlight hospital Hospitalization intensive care Intubated intubation malignancy management membrane morbidly obese Neonatal outcomes Oxygen requirements Patient PCR polymerase chain populations positive Pregnancy Pregnant woman pregnant women progression public health crisis recent rehabilitation facility Remdesivir resource respiratory respiratory symptom rupture SARS-CoV-2 severe hypoxemia systemic steroids tested the disease the patient transferred trimester with COVID-19 [DOI] 10.1155/2020/8889487 PMC 바로가기 [Article Type] Case Report