Female-biased effects of aging on a chimeric hemagglutinin stalk-based universal influenza virus vaccine in miceArticle Published on 2022-03-082023-06-24 Journal: Vaccine [Category] 신종인플루엔자, [키워드] aging estradiol flu vaccine influenza A virus Sex difference Testosterone [DOI] 10.1016/j.vaccine.2020.11.057 PMC 바로가기
Sex-specific effects of age and body mass index on antibody responses to seasonal influenza vaccines in healthcare workersArticle Published on 2022-03-082023-06-24 Journal: Vaccine [Category] 신종인플루엔자, [키워드] aging body mass index neutralizing antibody obesity Sex difference vaccine efficacy [DOI] 10.1016/j.vaccine.2021.02.047 PMC 바로가기
Sexual dimorphism in COVID-19: potential clinical and public health implicationsCOVID-19의 성 이형성: 잠재적인 임상 및 공중 보건 영향Review Published on 2022-03-012022-09-12 Journal: The lancet. Diabetes & endocrinology [Category] Fulltext, MERS, 임상, 진단, [키워드] Acute stress binding chromosome Comorbidities complement COVID COVID-19 current difference disease Endocrine Evidence explain expression pattern Follow-up help immune implication increased risk Infectious disease mechanism men Mortality outcomes pandemic Patient patients with COVID-19 progression Protein public health public health measures reaction Reinfection SARS-CoV-2 infections severity severity of COVID-19 Sex Sex difference Sex hormones sexual dimorphism Stratification Surveillance Treatment Vaccines View virus women [DOI] 10.1016/S2213-8587(21)00346-6 PMC 바로가기 [Article Type] Review
Young age, female sex, and presence of systemic adverse reactions are associated with high post-vaccination antibody titer after two doses of BNT162b2 mRNA SARS-CoV-2 vaccination: An observational study of 646 Japanese healthcare workers and university staffBNT162b2 mRNA SARS-CoV-2 백신 2회 접종 후 어린 나이, 여성, 전신 부작용이 높은 백신 접종 후 항체가와 관련이 있습니다. 일본 의료 종사자 및 대학 직원 646명을 대상으로 한 관찰 연구Observational Study Published on 2022-02-112022-09-12 Journal: Vaccine [Category] COVID19(2023년), MERS, SARS, 임상, 진단, [키워드] acquisition Adverse reaction Adverse reactions age Analysis analyzed Antibody Response Antibody titer Characteristics collected Complete demonstrated dose fatigue female Fever first dose healthcare worker healthy hospital Humoral immunity indicate individual Japan Japanese knowledge male median titer mRNA of BNT162b2 participant Participants prospective observational study questionnaire receiving reported SARS-CoV-2 SARS-CoV-2 vaccination second dose serum serum sample Sex Sex difference systemic systemic adverse reaction systemic adverse reactions the receptor-binding domain the spike protein the vaccine Tokyo vaccination Vaccine vaccine response were measured [DOI] 10.1016/j.vaccine.2022.01.002 PMC 바로가기 [Article Type] Observational Study
124 I-Iodo-DPA-713 Positron Emission Tomography in a Hamster Model of SARS-CoV-2 InfectionArticle Published on 2022-02-012023-06-19 Journal: Molecular imaging and biology [Category] COVID19(2023년), MERS, SARS, [키워드] COVID-19 immune response Macrophage molecular imaging PET/CT SARS-CoV-2 Sex difference [DOI] 10.1007/s11307-021-01638-5 PMC 바로가기
Men are the main COVID-19 transmitters: behavior or biology?Brief Communication Published on 2022-01-242022-11-01 Journal: Discover Mental Health [Category] COVID-19, [키워드] Adult couples affected Analysis Asymptomatic Behavior biological pathway clinical manifestation close contact collected data Combination Contact couple COVID-19 COVID-19 infection COVID-19 susceptibility COVID-19 transmission death epidemiological survey explained Factors Gender genders higher risk household transmission immune response in viral infected individual Infection Measures men Mild not differ outcome performed presence or absence proportion Protective remained Result RT-PCR Saliva SARS-CoV-2 serology Severe case severe COVID-19 Sex difference susceptibility susceptible symptomatic Transmission transmission potential transmission rate vaccination virus was performed were infected women [DOI] 10.1007/s44192-022-00004-3 PMC 바로가기 [Article Type] Brief Communication
Female Sex Is a Risk Factor Associated with Long-Term Post-COVID Related-Symptoms but Not with COVID-19 Symptoms: The LONG-COVID-EXP-CM Multicenter StudyArticle Published on 2022-01-142022-10-30 Journal: Journal of Clinical Medicine [Category] COVID-19, [키워드] 95%CI association clinical collected coronavirus disease COVID-19 depressive discharge disorders Dyspnea eight Factor fatigue female FIVE hospital Hospital admission Hospitalization hospitalized COVID-19 identify individual Infection investigated male males management medical record multicenter cohort study multicenter study multivariate logistic regression ocular Pain Patient Post-COVID post-COVID fatigue problem Public Hospital risk factor Risk factors Sex Sex difference sleep quality Spain survivor Survivors Symptom Symptoms variables were assessed were used with COVID-19 women [DOI] 10.3390/jcm11020413 PMC 바로가기 [Article Type] Article
Paradoxical sex-specific patterns of autoantibody response to SARS-CoV-2 infectionSARS-CoV-2 감염에 대한 자가항체 반응의 역설적인 성별 특정 패턴Research Published on 2021-12-302022-09-10 Journal: Journal of Translational Medicine [Category] SARS, 진단, 치료법, [키워드] AABs absence Activation acute response age analyses antibody Antigen antigens assigned asymptomatic infection autoantibody autoantigen Autoantigen selectivity Autoimmune Autoimmune disease Autoimmune diseases autoreactivity blood draw breadth classic clinical disease Clustering Cohort collected COVID-19 COVID-19 illness demographic data effective intervention effective interventions Evidence evidence of exhibit extreme greater healthy control homology Immune-mediated inflammatory activity lead men men and women modulating molecular multivariable analyses nucleocapsid protein number of symptom participant presence or absence Prevalence reactivity reported symptom reported symptoms Result SARS-CoV-2 SARS-COV-2 infection serological severe COVID-19 illness Sex difference sex differences socio-demographic supplementary material susceptibility Symptom symptomatic infection Symptoms trajectory triggered within 6 months women [DOI] 10.1186/s12967-021-03184-8 PMC 바로가기 [Article Type] Research
Sex differences in the immune response to acute COVID-19 respiratory tract infectionResearch Published on 2021-12-202022-10-28 Journal: Biology of Sex Differences [Category] COVID-19, [키워드] acute COVID-19 Adaptive immune response age anti-inflammatory cytokine B cell blood sample circulating neutrophil Cohort cohorts collected conducted control group control patient COVID COVID-19 cytokine Cytometry demographics diagnosed with COVID-19 disease severity ELISA Ethnic groups female Female patients females Flow group Hospital admission hospitalized patient IL-10 IL-6 IL-8 immune response implicated increasingly infection rate inflammatory mediator Inflammatory response innate immune response leukocyte leukocytes male males MCP-1 mechanism men Mild MIP-1β moderate monocyte mortality rate Patient plasma pro-inflammatory cytokine respiratory tract infection response Result robust severe disease severity Sex difference significantly higher significantly increased significantly more supplementary material the disease three group were used [DOI] 10.1186/s13293-021-00410-2 PMC 바로가기 [Article Type] Research
Attenuation of Antibody Titers from 3 to 6 Months after the Second Dose of the BNT162b2 Vaccine Depends on Sex, with Age and Smoking Risk Factors for Lower Antibody Titers at 6 MonthsArticle Published on 2021-12-182022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] affected age Analysis analyzed Antibody titer Antibody titers attenuation blood sample BNT162b2 changes in Characteristics clinical epidemiology clinical variable collected coronavirus disease COVID-19 determine different time points enrolled Factor healthcare worker Japan Lower men Month mRNA vaccine participant Pfizer/BioNTech reduced SARS-CoV-2 second second dose Sex Sex difference significantly significantly lower smoking titer viral infection were used women [DOI] 10.3390/vaccines9121500 PMC 바로가기 [Article Type] Article