A Scoping Review of Registered Clinical Trials of Convalescent Plasma for COVID-19 and a Framework for Accelerated Synthesis of Trial Evidence (FAST Evidence)Review article Published on 2020-07-012022-10-05 Journal: Transfusion Medicine Reviews [Category] SARS, 임상, [키워드] accelerated acute respiratory distress syndrome Analysis Antibody titer anticipated approval Blood clinical clinical trial clinical trials clinically complicate conducted Control convalescent plasma COVID-19 Critical case detect determine effective sample size Effectiveness Efficacy enrolment expected feasibility framework implementation improvement intensive care investigator majority mechanical ventilation Meta-analysis Mortality operator outcome outcomes Patient Placebo plasma Prevent rates of admission reductions in Registered registry reported review searched similar study Statistical power subjects Support synthesis systematic review tested the WHO treat Treatment Trial [DOI] 10.1016/j.tmrv.2020.06.005 [Article Type] Review article
Structural Basis for the Ubiquitin-Linkage Specificity and deISGylating Activity of SARS-CoV Papain-Like ProteaseResearch Article Published on 2014-05-222022-10-29 Journal: PLoS Pathogens [Category] Coronavirus, MERS, [키워드] 3D structure abrogated activate activated activity acute respiratory syndrome amino acid residue B-cell Basis binding cleaving complex coronavirus distal domain DUB ENCODE enzyme function Genome help higher affinity highlight Host host cell hydrolysis identify in viral inhibited innate immune response interact Interaction interferon involved ISG15 mechanism MERS Middle East molecular mutant mutated NFκB nuclear Papain-like protease Pathogenesis PLPro polyprotein post-translational modification Protease activity Protein Proteins provide reduced required residue residues respiratory reveal SARS virus SARS-CoV short circuit signaling molecule signaling pathway significantly similar study specificity stimulated substrate substrates thumb unique viral replication virus was determined X-ray [DOI] 10.1371/journal.ppat.1004113 PMC 바로가기 [Article Type] Research Article