single-blind – Page 3 – Communicable Diseases Research

A Case-Control Study for the Effectiveness of Oral Zinc in the Prevention and Mitigation of COVID-19

Medicine

Published on 2021-12-132022-10-31
Journal: Frontiers in Medicine [Category] COVID-19,

Efficacy and Safety of Washed Microbiota Transplantation to Treat Patients with Mild-to-Severe COVID-19 and Suspected of Having Gut Microbiota Dysbiosis: Study Protocol for a Randomized Controlled Trial

Randomized Controlled Trial

Published on 2021-12-012022-10-04
Journal: Current medical science [Category] SARS, 임상,

[키워드] accompanied Admission approach Clinical efficacy conducted Controlled Coronavirus disease 2019 COVD-19 patient COVID-19 COVID-19 patient discharge Dysbiosis Effect effective Efficacy and safety evaluated expected Follow-up Frequency gastrointestinal symptoms Gut gut microbiota homeostasis imaging examination Immunity Inflammatory response intestinal Microbiome microbiota mucosal multicenter offer organ function Patient performed Prospective Study protocol Randomized randomly divided receive Safe Safety SARS-CoV-2 virus single-blind Suspected the patient therapeutic effect transplantation Treatment treatment for COVID-19 washed microbiota transplantation.
[DOI] 10.1007/s11596-021-2475-2 PMC 바로가기 [Article Type] Randomized Controlled Trial

Effects of the non-contact cardiopulmonary resuscitation training using smart technology

Randomized Controlled Trial

Published on 2021-11-282022-10-05
Journal: European journal of cardiovascular nursing [Category] SARS, 임상,

Auricular acupressure for adverse events following immunization related to COVID-19 vaccine injection: study protocol for a multicenter, three-arm, blinded randomized controlled trial

COVID-19 백신 주사와 관련된 예방 접종 후 부작용에 대한 귀지압: 다기관, 3군, 맹검 무작위 대조 시험을 위한 연구 프로토콜

Update

Published on 2021-11-272022-09-10
Journal: Trials [Category] MERS, SARS, 임상,

[키워드] Acupressure therapy adverse event adverse events Analysis assigned association Auricular Auricular acupressure auricular acupressure therapy baseline blinded China clinical COVID-19 COVID-19 vaccine COVID-19 vaccines diarrhoea Efficacy enrolled events fatigue Gastrointestinal headache help immunization inclusion criteria injection injection site intention-to-treat Intervention joint joint pain less local pain multicenter multicentre muscle nausea observation outcome Pain participant per day per-protocol performed primary clinical outcome protocol Randomized Randomized controlled trial Randomly registry reported Result secondary Secondary outcomes significance level single-blind Study design Study protocol therapy three groups Trial Vaccine vomiting
[DOI] 10.1186/s13063-021-05837-x PMC 바로가기 [Article Type] Update

Early Convalescent Plasma for High-Risk Outpatients with Covid-19

Covid-19 고위험 외래 환자를 위한 조기 회복기 혈장

Randomized Controlled Trial

Published on 2021-11-182022-09-12
Journal: The New England Journal of Medicine [Category] MERS, SARS, 임상, 진단,

[키워드] acute respiratory syndrome addition administration age All the patient antibody assigned blood donor Care convalescent plasma coronavirus coronavirus disease death died Disease progression Donor enrolled high-risk patient Hospital admission Hospitalization Illness severity management median age multicenter NCT04355767 occurred Older onset of symptom outcome Outpatient Patient Placebo plasma plasma samples posterior probability prevent disease progression Primary outcome progression randomization Randomized receive risk risk factor SARS-CoV-2 SARS-CoV-2 neutralizing antibody secondary seeking severity single-blind Symptom symptom duration symptom onset the median the patient the placebo group treated Trial two groups
[DOI] 10.1056/NEJMoa2103784 PMC 바로가기 [Article Type] Randomized Controlled Trial

Mesenchymal stem cell treatment improves outcome of COVID-19 patients via multiple immunomodulatory mechanisms

중간 엽 줄기 세포 치료는 다중 면역 조절 메커니즘을 통해 COVID-19 환자의 결과를 향상시킵니다

Article

Published on 2021-10-262022-09-11
Journal: Cell Research [Category] MERS, SARS, 비임상, 유전자 메커니즘, 임상, 진단, 치료기술, 치료법, 치료제,

[키워드] addition adverse events Analysis B cell subset B cell subsets breath C-reactive protein CD28 Cell chemotaxis Chest Clinical symptoms clinical trial conducted coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient Critical CSF3R CX3CR1 Cytokines exhibited expressing expression Hospital stay immune cells Immune homeostasis immune system immunomodulatory IMPROVE in vitro in vivo infusion L-selectin less maintenance mechanism Mechanisms of disease mesenchymal stem cell Mesenchymal stem cells modulate MSC MSC-treated MSCs NET NETs neutrophil Neutrophil extracellular trap Neutrophil extracellular traps outcome Patient patients treated Peripheral blood Placebo placebo-controlled potential mechanisms proinflammatory cytokines promoted PTPRE Randomized reduced regulated required SARS-CoV-2-specific antibodies selectin Signaling single-blind Single-cell RNA sequencing stem cell subpopulation suppressed Symptom T cell T cells thrombosis treated Treatment umbilical upregulated upregulating Venous thrombosis VNN2
[DOI] 10.1038/s41422-021-00573-y PMC 바로가기 [Article Type] Article

Low-field thoracic magnetic stimulation increases peripheral oxygen saturation levels in coronavirus disease (COVID-19) patients: A single-blind, sham-controlled, crossover study

Clinical Trial

Published on 2021-10-082022-10-05
Journal: Medicine [Category] SARS, 임상,

Computerised cognitive remediation to enhance mobility in older adults: a single-blind, single-centre, randomised trial

Randomized Controlled Trial

Published on 2021-09-082022-10-04
Journal: The Lancet. Healthy longevity [Category] 임상,

[키워드] 95% CI adjusted affecting age aging assigned baseline battery black block randomised Brain clinical trials cognitive condition confounders control group control groups COVID-19 pandemic criteria Decline defined Dementia determine diagnosed Efficacy ENhance enrolled evaluated executive finding Frequency function funding greater group Health Hispanic illnesses IMPROVE improvement in both group individual intensity intention-to-treat analysis intention-to-treat principle Intervention intervention group investigator less limitation linear mixed model Musculoskeletal nine no significant difference Older optimal dose outcome Pain participant Patient performance physical planned surgery post-intervention prevented randomisation Randomised trial Randomly Registered reported required severe adverse event significantly single-blind Stratification Trial USA were excluded women
[DOI] 10.1016/s2666-7568(21)00173-2 PMC 바로가기 [Article Type] Randomized Controlled Trial

Safety and immunogenicity of heterologous versus homologous prime-boost schedules with an adenoviral vectored and mRNA COVID-19 vaccine (Com-COV): a single-blind, randomised, non-inferiority trial

아데노바이러스 벡터화 및 mRNA COVID-19 백신(Com-COV)을 사용한 이종 대 상동 프라임-부스트 일정의 안전성 및 면역원성: 단일 맹검, 무작위, 비열등성 시험

Clinical Trial

Published on 2021-09-042022-09-11
Journal: Lancet (London, England) [Category] Fulltext, MERS, 임상, 진단,

[키워드] (ChAdOx1 nCoV-19 Administered age anti-Spike IgG approved assigned AstraZeneca baseline blood test blood tests BNT BNT162b2 boost ChAd ChAdOx1 ChAdOx1 nCoV-19 Cohort Comorbidity comparison Concentration COVID-19 COVID-19 disease COVID-19 vaccine COVID-19 vaccines criteria dose Efficacy eight eligible eligible participant Eligible participants ELISA enrolled evaluate facilitate female participant force geometric mean geometric mean concentration geometric mean ratio GMR greater groups Heterologous heterologous prime-boost heterologous schedule heterologous schedules homologous homologous schedule hospitalisation immune immune responses immunisation immunogenicity immunology inferiority ISRCTN laboratory confirmation limit majority mRNA mRNA vaccine non-inferiority non-inferiority trial occurred Older participant per-protocol population Pfizer-BioNTech primary analysis primary endpoint prime-boost interval prime-boost intervals randomised Randomly reactogenic reactogenicity receive receiving recipient recruited referred to regimen Registered reported Safety safety analyses safety analysis SARS-CoV-2 anti-spike IgG SARS-COV-2 infection Serious Adverse Event seronegative serum single-blind subset Support Task Force the SARS-CoV-2 the vaccine These data Trial vaccination Vaccine Vaccines vectored vaccine was done
[DOI] 10.1016/S0140-6736(21)01694-9 PMC 바로가기 [Article Type] Clinical Trial

A Randomized, Single-Blind, Crossover Study Evaluating the Impact of OnabotulinumtoxinA Treatment on Mood and Appearance During the COVID-19 Pandemic

Randomized Controlled Trial

Published on 2021-08-132022-10-05
Journal: Aesthetic surgery journal [Category] SARS, 임상,

[키워드] administration Allergan amplify appearance both groups Botox caused COVID-19 COVID-19 pandemic crossover demonstrated Efficacy evaluate Evaluating groups Impact Ireland mood outbreak pandemic Patient placebo group Randomized receiving reported Satisfaction severe disease single-blind subject survey the placebo group Treatment treatment group unique
[DOI] 10.1093/asj/sjab196 PMC 바로가기 [Article Type] Randomized Controlled Trial