Patients with infectious diseases undergoing mechanical ventilation in the intensive care unit have better prognosis after receiving metagenomic next-generation sequencing assayResearch article Published on 2022-09-012022-10-05 Journal: International Journal of Infectious Diseases [Category] 비임상, [키워드] 28-day mortality Analysis analyzed approaches assays assigned baseline Concordance Culture diagnostic evaluate Health hypertension ICU Immunosuppressed independent risk factor Infectious disease intensive care intensive care unit mechanical ventilation medical record metagenomic Metagenomic next-generation sequencing Mortality Next-generation sequencing objective on mechanical ventilation pathogen Pathogens diagnosis Patient polymerase chain Prognosis prognosis of patient receiving reducing Result severe pneumonia single-center the patient traditional methods [DOI] 10.1016/j.ijid.2022.07.062 [Article Type] Research article
Patient-centered outcomes at hospital discharge in mechanically ventilated COVID-19 patients in Kobe, Japan: A single-center retrospective cohort studyResearch article Published on 2022-09-012022-10-05 Journal: Respiratory investigation [Category] 변종, [키워드] Activities of Daily Living adult COVID-19 patient clinical clinically Comorbidity conducted coronavirus disease COVID-19 COVID-19 infection COVID-19 patient Critical care demonstrated died discharge Dyspnea functional hospital discharge Hospitalization ICU in-hospital mortality independent intensive care interquartile range invasive Japan Kobe mechanical ventilation mechanically ventilated median age on mechanical ventilation organ dysfunction organ function outcome Patient receiving required Respiratory Support respiratory symptoms Result retrospective cohort study Retrospective study single-center survived survivor Survivors the patient was related [DOI] 10.1016/j.resinv.2022.06.010 [Article Type] Research article
Factors associated with anti-SARS-CoV-2 spike antibody titers after a second BNT162b2 mRNA COVID-19 vaccination in Japanese hemodialysis patients일본 혈액투석 환자에서 두 번째 BNT162b2 mRNA COVID-19 백신 접종 후 항-SARS-CoV-2 스파이크 항체 역가와 관련된 요인Article Published on 2022-09-012022-09-12 Journal: Clinical and experimental nephrology [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] acute respiratory syndrome age Analysis anti-SARS-CoV-2 Anti-severe acute respiratory syndrome coronavirus 2 spike antibody Antibody titer Blood urea nitrogen BNT162b2 BNT162b2 messenger RNA vaccine BNT162b2 mRNA Concentration coronavirus coronavirus disease Coronavirus disease 2019 correlated COVID-19 COVID-19 vaccination COVID-19 vaccine cross-sectional determine disease enrolled Factor healthcare worker Hemodialysis hemoglobin investigated Japanese Lymphocyte count lymphocyte counts men Messenger RNA Multiple linear regression parameters Patient SARS-CoV-2 second dose severe acute respiratory syndrome coronavirus 2 significantly significantly lower single-center Vaccine [DOI] 10.1007/s10157-022-02223-y PMC 바로가기 [Article Type] Article
Reactivation of EBV and CMV in Severe COVID-19-Epiphenomena or Trigger of Hyperinflammation in Need of Treatment? A Large Case Series of Critically ill Patients심각한 COVID-19-Epiphenomena에서 EBV 및 CMV의 재활성화 또는 치료가 필요한 Hyperinflammation의 트리거? 중환자의 대규모 사례 시리즈Article Published on 2022-09-012022-09-11 Journal: Journal of Intensive Care Medicine [Category] 치료기술, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 analyzed ARDS Chain Reaction Characteristics Clinical deterioration CMV cohort study comparable connection control group coronavirus Corticosteroid Course COVID-19 Critically ill Critically ill patient critically ill patients cytomegalovirus decrease described Diagnosis disease EBV Epstein-Barr virus Follow-up analysis Ganciclovir high risk hyperinflammation ICU in viral incidence increased mortality initiation of treatment intensive care intensive care unit majority Non-COVID-19 non-COVID-19 patient Non-COVID-19 patients outcome Patient polymerase chain polymerase chain reaction Reactivation remains uncertain retrospective rituximab SARS-CoV-2 screened Sepsis sepsis patient Sery severe acute respiratory syndrome Coronavirus severe COVID-19 single-center survived systemic corticosteroid treated Treatment Trigger Viral load viral reactivation virus with COVID-19 [DOI] 10.1177/08850666211053990 PMC 바로가기 [Article Type] Article
Efficacy and safety of ivermectin in the treatment of mild to moderate COVID-19 infection: a randomized, double-blind, placebo-controlled trialRandomized Controlled Trial Published on 2022-08-262022-10-05 Journal: Trials [Category] SARS, 임상, [키워드] acute respiratory syndrome adverse event adverse events age antiparasitic drug assigned caused coronavirus coronavirus disease COVID-19 double-blind duration of hospitalization Effectiveness Efficacy enrolment Frequency group hospitalized patient Ivermectin ivermectin treatment Mild Moderate COVID-19 n=36 negativity no difference outbreak overcome pandemic Patient PCR-positive PCR-positive patient Placebo placebo-controlled placebo-controlled trial polymerase chain Primary outcome proportion Randomized Randomized controlled trial Randomly receiving reported reverse transcription RT-PCR SARS-CoV-2 Secondary endpoints secondary outcome shown Side effects significant difference single-center standard care Standard of care survival symptomatic Symptoms therapeutic Treatment Trial worsening [DOI] 10.1186/s13063-022-06649-3 PMC 바로가기 [Article Type] Randomized Controlled Trial
Plasma microRNA and metabolic changes associated with pediatric acute respiratory distress syndrome: a prospective cohort study Research Published on 2022-08-262022-10-05 Journal: Scientific Reports [Category] 바이오마커, [키워드] acute respiratory distress ARDS Bacterial infection Biomarker Biomarkers both groups change circulating circulation Clinical characteristics conducted control patient correlated Critically ill defined differential expression differentially expressed distress evaluate heterogeneous identify intensive care patients metabolite metabolomics microRNA MicroRNAs miRNA miRNA expression morbidity and mortality non-coding RNA pathophysiological Patient pediatric Pediatric patient Pediatric patients pilot study prognostic biomarker progression prospective cohort study provide Random forest random forest classification responsible risk selected single-center sub-cohort subset syndrome therapeutic intervention [DOI] 10.1038/s41598-022-15476-0 [Article Type] Research
Effects of lymphocyte and neutrophil counts and their time courses on mortality in patients with postoperative pneumonia Research Published on 2022-08-262022-10-05 Journal: Scientific Reports [Category] 바이오마커, [키워드] Absolute lymphocyte count absolute neutrophil count ALC analyzed ANC change characteristic community-acquired pneumonia Course Diagnosis difference Effect evaluate evaluated feature highlight Hospitalization immunological increase in information lymphocyte lymphopenia Mortality neutrophil neutrophil count non-survivor Patient patients Pneumonia post-hoc analysis postoperative prognostic prognostic effect Prognostic factor Prolonged prospective observational study Research severe lymphopenia single-center survival survival rate survivor were assessed [DOI] 10.1038/s41598-022-18794-5 [Article Type] Research
Incidence of thromboembolic complications in hospitalized COVID-19 patients in a medical ward in Japan: A single-center retrospective and prospective observational studyObservational Study Published on 2022-08-192022-10-05 Journal: Medicine [Category] 임상, [키워드] 95% CI addition Admission age Asian Asymptomatic body mass index complications of COVID-19 conducted COVID-19 COVID-19 patient Critical determine died events hallmark higher risk hospital hospitalized COVID-19 patient identify incidence intensive care IQR Ischemia Japan Japanese limb median Mild moderate Myocardial infarction occurred Patient Prevalence Primary outcome prospective cohort study prospective observational study Prospective Study retrospective Severe case severe COVID-19 severe COVID-19 patient severity of COVID-19 single-center stroke symptomatic the median thromboembolic complication thromboembolic complications transferred Venous Thromboembolism women [DOI] 10.1097/MD.0000000000029933 PMC 바로가기 [Article Type] Observational Study
Psychological Distress among Hospitalized COVID-19 Patients in Denmark during the First 12 Months of the Pandemic팬데믹의 첫 12개월 동안 덴마크에서 입원한 COVID-19 환자의 심리적 고통Observational Study Published on 2022-08-152022-09-11 Journal: International Journal of Environmental Research an [Category] SARS, 임상, 치료기술, [키워드] Admission Anxiety changes in conducted COVID-19 COVID-19 diagnosis Denmark Depression discharge distress Hospitalization Hospitalized HRQoL improvement Insomnia life Mental Month pandemic participant Patient patients hospitalized physical Post-traumatic stress disorder proportion Psychological distress PTSD Quality of life significantly single-center Stress Symptom symptoms of depression [DOI] 10.3390/ijerph191610097 PMC 바로가기 [Article Type] Observational Study
Evaluating the effect of Edaravone on clinical outcome of patients with severe COVID-19 admitted to ICU: a randomized clinical trialRandomized Controlled Trial Published on 2022-08-012022-10-04 Journal: Inflammopharmacology [Category] COVID19(2023년), SARS, 임상, [키워드] accompanied addition administration admitted to ICU anti-inflammatory properties antioxidant Characteristics clinical complications Clinical improvement Clinical outcome control group coronavirus disease COVID-19 decrease Edaravone Endotracheal intubation Endpoint evaluate the effect Evaluating groups hallmark hospital ICUs immune response induce Injury intensive care unit intervention arms intervention group intravenous intubation Laboratory test mechanical ventilation Medical Science Mortality mortality rate National outcome overactive Patient Pneumonia Primary outcome Randomized randomized clinical trial receiving reduce secondary secondary endpoint severe COVID-19 severe COVID-19 patient single-center stimulate Tabriz therapy university viral infection [DOI] 10.1007/s10787-022-01001-2 PMC 바로가기 [Article Type] Randomized Controlled Trial