The balancing role of distribution speed against varying efficacy levels of COVID-19 vaccines under variants변종에 따른 COVID-19 백신의 다양한 효능 수준에 대한 유통 속도의 균형 역할Article Published on 2022-05-062022-09-11 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] Accessibility adverse outcome adverse outcomes attack rate caused COVID-19 COVID-19 pandemic COVID-19 vaccine deaths distribution Effectiveness Efficacy evaluated example Hospitalization hospitalizations immunization Infection initial Interaction key factor Mutation occurred pandemic public health raised reduce reducing regions SARS-CoV-2 speed Spread the vaccine understanding vaccination Vaccine variant variants [DOI] 10.1038/s41598-022-11060-8 PMC 바로가기 [Article Type] Article
Efficacy and safety of two neutralising monoclonal antibody therapies, sotrovimab and BRII-196 plus BRII-198, for adults hospitalised with COVID-19 (TICO): a randomised controlled trialCOVID-19(TICO)로 입원한 성인을 위한 두 가지 중화 단일클론항체 치료제인 소트로비맙과 BRII-196과 BRII-198의 효능 및 안전성: 무작위 대조 시험Randomized Controlled Trial Published on 2022-05-012022-09-12 Journal: The Lancet. Infectious Diseases [Category] COVID19(2023년), SARS, 임상, 진단, [키워드] addition adjusted adjusted odds ratio Administered analyses Analysis assigned Biotechnology Clinical outcome clinical recovery clinical trial Complication complications of COVID-19 COVID-19 COVID-19 symptom death defined Denmark died discharge double-blind Efficacy Efficacy and safety eligible enrolled enrolment female hospital hospitalised Inpatient Interim intravenously laboratory-confirmed SARS-CoV-2 infection male matching placebo median age modified intention-to-treat monoclonal antibody neutralising operation Organ failure outcome participant Patient Placebo placebo group placebo-controlled Poland Primary outcome randomisation randomised randomised controlled trial Randomly recruited Registered Serious Adverse Events significantly higher single dose speed Standard of care stratified study drug sustained Switzerland the placebo group Therapeutics Therapies therapy Treatment Trial USA were assessed with COVID-19 [DOI] 10.1016/S1473-3099(21)00751-9 PMC 바로가기 [Article Type] Randomized Controlled Trial
Vaccinating Australia: How long will it take?호주 백신 접종: 얼마나 걸립니까?Article Published on 2022-04-142022-09-11 Journal: Vaccine [Category] COVID19(2023년), SARS, 변종, [키워드] Administered Analysis assumption Australia Cluster Community costly Coverage COVID-19 COVID-19 vaccination demographics dose Epidemic essence Government highlight initial key factor Local lockdown Logistic National per day Population Prevalence public health messaging reopening risk schedule speed supply the vaccine transmissible variant vaccinate Vaccinating vaccination Vaccine vaccine administration vaccine dose vaccine doses vaccine eligibility Vaccine hesitancy [DOI] 10.1016/j.vaccine.2021.07.006 PMC 바로가기 [Article Type] Article
The mutational dynamics of the SARS-CoV-2 virus in serial passages in vitro시험관 내 연속 계대에서 SARS-CoV-2 바이러스의 돌연변이 역학Article Published on 2022-04-012022-09-11 Journal: Virologica Sinica [Category] COVID19(2023년), SARS, 변종, [키워드] accumulating acute respiratory syndrome coronavirus adaptation adaptive analysed boost Cell culture cell line change coding Combination Community competition coronavirus 2 directional effective Evolution explained Frequency Gene pool genetic change Genetic changes hotspot immune escape mutation in vitro insertions Mutation Mutational dynamics Neutral outbreak passage path performed potency Replication respiratory RT-qPCR SARS-CoV-2 SARS-CoV-2 strains Sequencing Serial passage in vitro severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 species speed strain Substitution the SARS-CoV-2 the SARS-CoV-2 virus unique variants WGS whole genome Whole genome sequencing Whole genome sequencing (WGS) [DOI] 10.1016/j.virs.2022.01.029 PMC 바로가기 [Article Type] Article
Efficient Identification of Anti-SARS-CoV-2 Compounds Using Chemical Structure- and Biological Activity-Based Modeling화학 구조 및 생물학적 활성 기반 모델링을 사용한 Anti-SARS-CoV-2 화합물의 효율적인 식별Article Published on 2022-03-242022-09-11 Journal: Journal of medicinal chemistry [Category] SARS, 신약개발, 치료제, [키워드] 3CL acting anti-SARS-CoV-2 antiviral activities antiviral activity approach Biological characteristic Chemical chymotrypsin complementary Compound compound screening Drug discovery Efficiency efficient entry of SARS-CoV-2 expand experimental validation fold human host cell human host cells identification identify IMPROVE inhibitor Live virus machine learning model machine learning models modeling protease Protease inhibitor receiver receiver operating characteristic SARS-CoV-2 speed Structure the SARS-CoV-2 viral entry [DOI] 10.1021/acs.jmedchem.1c01372 PMC 바로가기 [Article Type] Article
Low-Cost, Real-Time Polymerase Chain Reaction System for Point-of-Care Medical Diagnosis현장 진료 의료 진단을 위한 저비용, 실시간 중합효소 연쇄반응 시스템Article Published on 2022-03-172022-09-11 Journal: Sensors (Basel, Switzerland) [Category] 치료제, [키워드] addition alternative Analysis approach Bill of materials can be used Care chain Chain Reaction circumvent clinics comparable Concentration coronavirus disease Coronavirus disease 2019 COVID-19 described diagnostic disease DNA amplification environmental monitoring faster Fluorescence fluorescence detection fluorescence sensing food food quality gel electrophoresis Health Health care help hospital initial low-cost PCR Measures medical diagnostics optical pandemic PCR performed PID point-of-care point-of-care diagnostics polymerase chain polymerase chain reaction Polymerase chain reaction (PCR) proportional–integral–derivative (PID) controller reaction reagents Real-time PCR real-time PCR system reducing selective sensitivity speed System tested water water quality [DOI] 10.3390/s22062320 PMC 바로가기 [Article Type] Article
COVID-19 Surveillance Updates in US Metropolitan Areas: Dynamic Panel Data Modeling미국 대도시 지역의 COVID-19 감시 업데이트: 동적 패널 데이터 모델링Article Published on 2022-02-242022-09-11 Journal: JMIR Public Health and Surveillance [Category] COVID19(2023년), SARS, 변종, [키워드] 7-Day persistence acceleration Analysis analyzed appear average Baltimore Boston calculated conducted coronavirus COVID-19 COVID-19 case COVID-19 pandemic cumulative data Data model declined declining delta variant Delta wave descent Detroit Diego dynamic dynamic panel data model Effectiveness elevated epidemiological example Factors form Health policy help highest Houston identify incidence information Interpretation jerk Los Angeles Mask Metrics Miami modeling monitoring pandemic Panel peaked per day persistence positive positive acceleration public health rapidity reported response San Francisco SARS-CoV-2 speed Spread statistical analysis Surveillance surveillance system Transmission United States USAFacts Vaccine Vaccines variants Variation Washington while [DOI] 10.2196/28737 PMC 바로가기 [Article Type] Article
Structure- and Interaction-Based Design of Anti-SARS-CoV-2 AptamersAnti-SARS-CoV-2 앱타머의 구조 및 상호 작용 기반 설계Article Published on 2022-02-242022-09-11 Journal: Chemistry (Weinheim an Der Bergstrasse, Germany) [Category] COVID19(2023년), SARS, 변종, [키워드] approach aptamer Aptamers binding binding affinity blueprint complexes computational method Computational methods Cytometry develop Directed mutagenesis DNA docking drug design ENhance fragment molecular orbitals method functional IMPROVE in silico Infection Interaction iterative methodology molecular molecular docking molecular dynamics molecules Mutagenesis nucleic acids offer pathogen probes Protein protein structure Receptor-binding domain SARS-CoV-2 SARS-CoV-2 spike protein SAXS scratch speed Spike protein Structure synergy target target protein tertiary structure the receptor-binding domain the SARS-CoV-2 time-consuming variants X-ray scattering [DOI] 10.1002/chem.202104481 PMC 바로가기 [Article Type] Article
Partisan Differences in Legislators’ Discussion of Vaccination on Twitter During the COVID-19 Era: Natural Language Processing AnalysisOriginal Paper Published on 2022-02-182022-10-30 Journal: Jmir Infodemiology [Category] COVID-19, [키워드] aligned changes in characterized communication concerning contribute COVID-19 difference Evidence examined Hesitancy Influenza language linguistic natural natural language processing NLP objective operation partisanship pattern polarization Politicization processing produced public health messaging Research Result SARS-CoV-2 vaccine social media speed study period the vaccine to define Twitter vaccination Vaccine Vaccine hesitancy [DOI] 10.2196/32372 PMC 바로가기 [Article Type] Original Paper
Responses to a Neutralizing Monoclonal Antibody for Hospitalized Patients With COVID-19 According to Baseline Antibody and Antigen Levels : A Randomized Controlled Trial기준 항체 및 항원 수준에 따른 COVID-19 입원 환자의 중화 단일클론항체에 대한 반응: 무작위 대조 시험Randomized Controlled Trial Published on 2022-02-012022-09-11 Journal: Annals of internal medicine [Category] COVID19(2023년), MERS, SARS, 바이오마커, 임상, 진단, 치료기술, 치료법, 치료제, [키워드] allergy Analysis analyzed Anti-spike antibodies antibody Antigen bamlanivimab baseline benefit clinical trial collected Combination Controlled COVID-19 death defined detectable discharge elevated end-organ evaluate evidenced favor futility Government greater hazard hazard ratios hospitalized patient hospitalized patients Hypothesis immune IMPROVE independent Infectious diseases Interaction Level limited sample size median median time monoclonal antibody mounted Multicenter trial NAb NAbs nasal neutralizing antibody not differ operation Organ failure outcome participant Patient patients with COVID-19 Placebo placebo group placebo-controlled placebo-controlled trial plasma Randomized receiving Remdesivir required response SARS-CoV-2 nucleocapsid Serious Adverse Events serious infections serostatus small sample size specimen speed subgroup subgroup analysis sustained the median therapy Trial Viral Viral RNA with COVID-19 [DOI] 10.7326/M21-3507 PMC 바로가기 [Article Type] Randomized Controlled Trial