spike glycoproteins – Page 3 – Communicable Diseases Research

Identification of 22 N-glycosites on spike glycoprotein of SARS-CoV-2 and accessible surface glycopeptide motifs: Implications for vaccination and antibody therapeutics

SARS-CoV-2의 스파이크 당단백질에 있는 22개의 N-글리코사이트 및 접근 가능한 표면 글리코펩타이드 모티프 식별: 백신 접종 및 항체 치료제에 대한 시사점

Article

Published on 2021-01-092022-09-12
Journal: Glycobiology
[Category] 진단,

The role of cysteine peptidases in coronavirus cell entry and replication: The therapeutic potential of cathepsin inhibitors

코로나바이러스 세포 진입 및 복제에서 시스테인 펩티다제의 역할: 카텝신 억제제의 치료 가능성

Review

Published on 2020-11-022022-08-13
Journal: PLoS Pathogens
[Category] Biochemistry, COVID-19,

[키워드] Activation antiviral drug cathepsin inhibitor Cathepsins cell entry cells chymotrypsin Coronaviral coronavirus coronavirus CoV CoVs cysteine Diseases generate Host host cell humans inhibitor involved lysosomal nonstructural protein nonstructural proteins Nsps outcomes over Papain peptidase positive-sense prevalent processed replicase polyprotein replicase polyproteins Replication respiratory respiratory diseases RNA viruses severe respiratory diseases single-stranded spike glycoprotein spike glycoproteins Spike protein targets therapeutic potential treatment strategy utilization Viral Viral RNA viral RNA synthesis virus attenuation
[DOI] 10.1371/journal.ppat.1009013 PMC 바로가기 [Article Type] Review

The COVID-19 pandemic: a global health crisis

COVID-19 팬데믹: 글로벌 보건 위기

Review

Published on 2020-11-012022-09-10
Journal: Physiological Genomics
[Category] SARS, 유전자 메커니즘, 치료제,

[키워드] ACE2 ACE2 receptors acute respiratory distress acute respiratory distress syndrome age amplify angiotensin angiotensin converting enzyme Angiotensin converting enzyme-2 ARDS Atypical cardiovascular disease causative agent cause Comorbidities Comorbidity Complication COVID-19 COVID-19 infection crown Cytokine storm degrade destruction diabetes disease Disease progression envelope protein epithelial cells Ethnicity event Extracellular fibrosis genetics geographic location GTPases Health Health Organization Host Hypercoagulation hypertension include induce Infection inflammatory immune response lead Lung epithelial cells mechanism membrane morbidity Novel coronavirus novel coronavirus SARS-CoV-2 pandemic Pathogenesis pathophysiology patients positive-sense prevalent Prevent pulmonary fibrosis receptor reduce respiratory Respiratory disease respiratory diseases respiratory distress Respiratory distress syndrome risk factor RNA genome route SARS-CoV-2 Sepsis severe cases Severity of infection single-stranded spike glycoprotein spike glycoproteins subsequent Symptom syndrome The United States therapeutic approach thrombosis Transmission understanding United States upregulation Vaccine Vascular Viral viral envelope proteins World Health Organization Wuhan Wuhan, China
[DOI] 10.1152/physiolgenomics.00089.2020 PMC 바로가기 [Article Type] Review

Decline of Humoral Responses against SARS-CoV-2 Spike in Convalescent Individuals

Observation

Published on 2020-10-162022-10-29
Journal: mBio
[Category] COVID-19, MERS, SARS,

[키워드] absence acute COVID-19 acute respiratory syndrome analysis approach Clinical efficacy clinical trial collected convalescent convalescent individual convalescent plasma convalescent plasma trial coronavirus coronavirus disease COVID-19 COVID-19 patient cross-reactivity D614G variant Decline Donor effective vaccine Efficacy ELISA evaluate for inclusion globe glycoprotein Humoral response IgA IgG IgM individual Infection interval neutralization neutralization activity neutralize Neutralizing activity neutralizing antibody Neutralizing titer onset of symptom patients performed plasma plasma neutralization activity positive Prevent PROTECT pseudoparticle RBD repeated required resolution of symptoms response Safe SARS-CoV-2 SARS-COV-2 infection significant decrease spike spike glycoproteins Symptoms therapeutic options therapy thought transfer transfusion treat Treatment Vaccine while wild-type SARS-CoV-2
[DOI] 10.1128/mBio.02590-20 PMC 바로가기 [Article Type] Observation

Host Receptors of Influenza Viruses and Coronaviruses—Molecular Mechanisms of Recognition

Review

Published on 2020-10-062022-10-28
Journal: Vaccines
[Category] COVID-19,

Interaction of Human ACE2 to Membrane-Bound SARS-CoV-1 and SARS-CoV-2 S Glycoproteins

Communication

Published on 2020-09-292022-10-28
Journal: Viruses
[Category] COVID-19, SARS,

Coronavirus Infections in Companion Animals: Virology, Epidemiology, Clinical and Pathologic Features

Review

Published on 2020-09-132022-10-28
Journal: Viruses
[Category] COVID-19, Fulltext, 조류인플루엔자,

[키워드] acute respiratory syndrome animal coronavirus bat coronaviruses canine cellular Characteristics clinical Clinical severity Coronaviral coronavirus coronavirus COVID-19 Cross-species transmission disease enveloped RNA virus equine facilitate Feline infectious peritonitis ferret ferrets genetic information Host host cell membranes host range immuno-inflammatory impacts include Infection initiate mammalian MERS Middle East mutated nine Pandemics pathologic recent Respiratory Coronavirus respiratory infection responsible SARS virus spike glycoproteins Spike protein syndrome systemic disease thought tissue tropism variety Virology virus zoonoses zoonotic zoonotic coronaviruses
[DOI] 10.3390/v12091023 PMC 바로가기 [Article Type] Review

SARS-CoV-2: Structural diversity, phylogeny, and potential animal host identification of spike glycoprotein

SARS-CoV-2: 스파이크 당단백질의 구조적 다양성, 계통 발생 및 잠재적 동물 숙주 식별

Article

Published on 2020-09-012022-09-11
Journal: Journal of medical virology
[Category] MERS, SARS, 유전자 메커니즘, 진단,

Inhibition of SARS-CoV-2 Infections in Engineered Human Tissues Using Clinical-Grade Soluble Human ACE2

Article

Published on 2020-04-242023-06-15
Journal: Cell
[Category] MERS, SARS,

[키워드] angiotensin converting enzyme 2 blood vessels COVID-19 human organoids kidney severe acute respiratory syndrome Coronavirus spike glycoproteins Treatment
[DOI] 10.1016/j.cell.2020.04.004 PMC 바로가기 [Article Type] Article

Pharmacological Therapeutics Targeting RNA-Dependent RNA Polymerase, Proteinase and Spike Protein: From Mechanistic Studies to Clinical Trials for COVID-19

Review

Published on 2020-04-152022-10-30
Journal: Journal of Clinical Medicine
[Category] COVID-19,

[키워드] ACE2 acute respiratory syndrome addition angiotensin-converting enzyme 2 approach Calu-3 Camostat mesylate Chloroquine clinical clinically compassionate use Coronavirus infection Coronavirus-2 country COVID-19 demonstrated develop enzyme human lung cells in vitro Infection infection with SARS-CoV-2 inhibit Interaction management Novel coronavirus novel coronavirus SARS-CoV-2 outbreak patients with COVID-19 pharmacological Pneumonia Prevent Protease inhibitor Protein proteinase RdRP Remdesivir Replication RNA RNA-dependent RNA polymerase S protein SARS-CoV-2 SARS-COV-2 infection shown spike spike glycoproteins Spread systemically targeting the S protein The United States therapeutic approach Therapeutics Transmission treated Treatment viability
[DOI] 10.3390/jcm9041131 PMC 바로가기 [Article Type] Review