Structural heterogeneity and precision of implications drawn from cryo-electron microscopy structures: SARS-CoV-2 spike-protein mutations as a test caseArticle Published on 2022-12-012023-07-10 Journal: European Biophysics Journal [Category] COVID19(2023년), [키워드] Computer models Cryo-electron microscopy mutations Spike protein Structural heterogeneity. [DOI] 10.1007/s00249-022-01619-8 PMC 바로가기
How to correct relative voxel scale factors for calculations of vector-difference Fourier maps in cryo-EMArticle Published on 2022-12-012023-07-10 Journal: Journal of structural biology [Category] COVID19(2023년), [키워드] Absolute EM Magnification Center of Mass Cryo-EM maps Monomeric Apo-Photosystem II pH-Dependent Structural Transition. SARS-CoV-2 Spike protein Volumetric Expansion/Contraction Coefficients Voxel Scaling [DOI] 10.1016/j.jsb.2022.107902 PMC 바로가기
SARS-CoV-2 shedding dynamics and transmission in immunosuppressed patients면역 억제 환자의 SARS-CoV-2 발산 역학 및 전파Article Published on 2022-12-012022-09-11 Journal: Virulence [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus adjust analysed anatomic site characterized collected conducted coronavirus Diagnosis Diversity dominant E484K first positive fitness genetic change Genome genomic Host hosts household transmission Immunosuppressed immunosuppressed patient immunosuppressed patients in urine in vivo Infection Interaction knowledge long-term viral shedding mother mutate Mutation mutation dynamics N501Y occurred P681R Patient replicate residue residues SARS-CoV-2 SARS-CoV-2 evolution selective Sequencing severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 specific treatment Spike protein spread to Substitution temporal dynamics Transmission two patients Urine variant variant of concern variants variants of concern virus whole genome Whole genome sequencing whole genome sequencing. whole-genome sequencing [DOI] 10.1080/21505594.2022.2101198 PMC 바로가기 [Article Type] Article
Effects of boosted mRNA and adenoviral-vectored vaccines on immune responses to omicron BA.1 and BA.2 following the heterologous CoronaVac/AZD1222 vaccinationArticle Published on 2022-12-012022-11-15 Journal: Journal of medical virology [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] acute respiratory syndrome addition adenoviral-vectored vaccine antibody AZD1222 binding antibody BNT162b2 booster booster vaccination Booster vaccine comparable Complete coronavirus Coronavirus 2019 COVID-19 demonstrated develop dose Effect enrolled enzyme-linked immunosorbent Heterologous highest immune evasion immune response Immunogenicity analysis individual induce interferon-γ Messenger RNA Mild moderate mRNA mRNA vaccine mRNA-1273 mutations NAb titer NAbs neutralization neutralize Neutralizing Neutralizing activity neutralizing antibody observé Omicron variant Omicron. overcome participant raise receive receiving reduction response Serious Adverse Events significant increase Spike protein T-cell activation T-cell Response T-cell responses vaccination Vaccine waning immunity was recorded were measured [DOI] 10.1002/jmv.28044 PMC 바로가기
Transmembrane serine protease TMPRSS2 implicated in SARS-CoV-2 infection is autoactivated intracellularly and requires N-glycosylation for regulationArticle Published on 2022-12-012023-07-10 Journal: The Journal of Biological Chemistry [Category] COVID19(2023년), [키워드] HAI-1 HAI-2 N-glycosylation SARS-CoV-2 Spike protein TMPRSS2 TTSP zymogen activation. [DOI] 10.1016/j.jbc.2022.102643 PMC 바로가기
Ultrarapid and ultrasensitive detection of SARS-CoV-2 antibodies in COVID-19 patients via a 3D-printed nanomaterial-based biosensing platformArticle Published on 2022-12-012022-11-15 Journal: Journal of medical virology [Category] COVID19(2023년), SARS, 진단, 치료기술, [키워드] 3D biosensor 3D printing Additive manufacturing antibody Antibody detection coated with Concentration COVID-19 COVID-19 antibodies COVID-19 patient COVID-19 patients Critical detected antibody disease domain Efficacy Epidemics Epidemiology evaluate Gold nanoparticle Graphene oxide human plasma samples immune response Immunity Infection Interaction manuscript nucleocapsid Outbreaks Patient patients without COVID-19 platform Quantitative Rapid rapid antibody detection. rapid antibody test RBD reported SARS-CoV-2 SARS-CoV-2 antibody SARS-CoV-2 antigens serological Spike protein the antibodies the N protein vaccination Vaccine Viral protein were used [DOI] 10.1002/jmv.28075 PMC 바로가기
Spike mutations contributing to the altered entry preference of SARS-CoV-2 omicron BA.1 and BA.2Article Published on 2022-12-012022-11-16 Journal: Emerging Microbes & Infections [Category] COVID19(2023년), SARS, 변종, [키워드] change changes in Characteristics circulating cleavage contribute contributing to demonstrated dependent on determinant endosomal entry endosomal entry pathway endosomal pathway Entry facilitate feature Fusogenicity H655Y identify increase investigated less Mutation omicron Omicron BA.1 and BA.2 Pathogenesis pathogenicity plasma membrane predominant Proteases recent reduce reduced retained SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants SARS-CoV-2 WT serine protease spike spike mutation Spike protein spike protein cleavage. subsequent the spike protein TMPRSS2 transmembrane serine protease Virological virus entry [DOI] 10.1080/22221751.2022.2117098 PMC 바로가기
Explaining COVID-19 postvaccination-related immune thrombotic thrombocytopenia: a hypothesis-generating in-silico approachArticle Published on 2022-11-302023-07-08 Journal: Human vaccines & immunotherapeutics [Category] COVID19(2023년), [키워드] BLAST chimpanzee adenovirus Cross reactivity signaling peptide. Spike protein vaccine-induced immune thrombotic thrombocytopenia Vaxzevria [DOI] 10.1080/21645515.2022.2050654 PMC 바로가기
High-Throughput Assay for Identifying Diverse Antagonists of the Binding Interaction between the ACE2 Receptor and the Dynamic Spike Proteins of SARS-CoV-2Article Published on 2022-11-112023-07-10 Journal: ACS Infectious Diseases [Category] COVID19(2023년), [키워드] COVID-19 High-throughput inhibitor SARS-CoV-2 Spike protein trimer. [DOI] 10.1021/acsinfecdis.2c00297 PMC 바로가기
Induction of pulmonary HLA-G expression by SARS-CoV-2 infectionArticle Published on 2022-11-052022-11-15 Journal: Cellular and Molecular Life Sciences [Category] SARS, 치료기술, 치료제, [키워드] accompanied Antigen Autopsy biopsies CD8 Cell changes in correlated distribution epithelial cell Evidence expressed expression expression level Frequency heart muscle HLA-G Hyperactivation Immune cell Immune cell infiltration immune cells Immune escape immune response induction information kidney leukocyte lung lung alveolar lung epithelia lung epithelial cell lung tissue Macrophage marker microRNA microRNA. miRNA miRNA expression modulating organs other organ patients protein expression SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infections SARS-CoV-2 nucleocapsid SARS-CoV-2- SARS-CoV-2-infected patient specimen Spike protein surgical T cell responses T cells therapeutic target tissue tissues Treatment Tumor virus-infected cells while [DOI] 10.1007/s00018-022-04592-9 PMC 바로가기